Archives of Disease in Childhood最新文献_第9页

Design and evaluation of a visual genomic explainer: a mixed-methods study. 可视化基因组解释器的设计与评估：一项混合方法研究。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-24 DOI: 10.1136/archdischild-2024-327650

Grainne Butler, Camilla Andersen, Jim Buttery, Asheeta Gupta, Melissa M Martyn, Zornitza Stark, Ella Wilkins, Kushani Jayasinghe, Catherine Quinlan

{"title":"Design and evaluation of a visual genomic explainer: a mixed-methods study.","authors":"Grainne Butler, Camilla Andersen, Jim Buttery, Asheeta Gupta, Melissa M Martyn, Zornitza Stark, Ella Wilkins, Kushani Jayasinghe, Catherine Quinlan","doi":"10.1136/archdischild-2024-327650","DOIUrl":"10.1136/archdischild-2024-327650","url":null,"abstract":"Objective: To design and assess a visual genomic explainer focusing on plain language and engaging imagery. The explainer aimed to support doctors' comprehension of complex genomic concepts and results and act as a resource promoting the integration of genomic testing into mainstream care.Design: Prospective genomic resource development and questionnaire.Setting: Regional and tertiary hospitals in Australia and Ireland, private and community-based clinicians in Australia.Participants: Recruitment of paediatricians and nephrologists in Australia and paediatricians in Ireland was multi-faceted. Emails with survey links were circulated through training bodies, advanced trainee networks, departmental heads, and professional societies.Main outcome measures: Comprehension, engagement and perception of the visual explainer.Results: Most clinicians surveyed (95% (53) Australian group, 100% (29) Irish group) felt that genomics would be a useful tool in their practice. 77% of Australian paediatric respondents and 73% of Irish paediatric respondents felt that genomics was underutilised. Challenges encountered with genomic testing included poor patient comprehension of the testing process and results along with difficulties perceived by clinicians in explaining complex results. 89% of Australian paediatricians and 100% of Irish paediatricians surveyed would recommend the use of the explainer to other professionals in their field.Conclusion: This genomic resource was acceptable to clinicians and could be a useful tool to support paediatricians integrating genomic testing into mainstream care.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"151-157"},"PeriodicalIF":4.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transport of critically ill children to paediatric intensive care units in the UK and Ireland: 2013-2022. 英国和爱尔兰将重症儿童送往儿科重症监护室的情况：2013-2022 年。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-24 DOI: 10.1136/archdischild-2024-327088

Padmanabhan Ramnarayan, Dora Wood, Elizabeth Draper, Lyn Palmer, Richard Feltbower, Hannah L Buckley, Michael J Griksaitis, Daniel Henry Lutman, Constantinos Kanaris, Deirdre O'Shea, Sarah E Seaton

{"title":"Transport of critically ill children to paediatric intensive care units in the UK and Ireland: 2013-2022.","authors":"Padmanabhan Ramnarayan, Dora Wood, Elizabeth Draper, Lyn Palmer, Richard Feltbower, Hannah L Buckley, Michael J Griksaitis, Daniel Henry Lutman, Constantinos Kanaris, Deirdre O'Shea, Sarah E Seaton","doi":"10.1136/archdischild-2024-327088","DOIUrl":"10.1136/archdischild-2024-327088","url":null,"abstract":"Objective: To explore the trends and changes in the transport of children to paediatric intensive care units (PICUs) between 2013 and 2022.Design: Retrospective analysis of routinely collected data.Patients: Children transported for care in a PICU in the UK and Ireland aged<16 years.Interventions: None.Measurements and main results: There were 43 058 transports to a PICU involving 36 438 children from 2013 to 2022 with the majority of children requiring only one transport. The number of transports increased from 4131 (2013) to 4792 (2022). Over the study period the percentage of children aged under 1 year who were transported decreased from 50.2% to 45.2% and similarly, the percentage who were invasively ventilated also decreased from 81.1% to 70.2%. Conversely, the use of non-invasive ventilation during transports increased slightly from 4.0% to 7.0%. The percentage of transports where a parent was able to accompany the child increased over time (2013: 66.2% to 2019: 74.9%), although there were reductions due to the COVID-19 pandemic and requirements for social distancing (2020: 52.4%).Conclusions: We have demonstrated an increased use of specialist paediatric transport services and changes in the PICU population over time. Routine data collection from the transport services provide a means to measure improvements and changes over time in the service provided to critically ill children and young people who need transport to the PICU.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"127-132"},"PeriodicalIF":4.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should next-generation sequencing be considered as a first-line genetic investigation for children with early developmental impairment? 下一代测序是否应被视为早期发育障碍儿童的一线基因检测？

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-24 DOI: 10.1136/archdischild-2024-327752

Frederica Sarantis, Aisosa Osas Guobadia, Marwa A Bebars, Rachana Varma, Jonathon A A Holland, Thiloka Ratnaike

引用次数: 0

Redefining the role of near-peer student volunteers in children's hospitals as paediatric patient mentors. 重新定义儿童医院近距离学生志愿者作为儿科病人导师的角色。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-24 DOI: 10.1136/archdischild-2023-326778

Elaissa Trybus Hardy, Wilbur A Lam

引用次数: 0

Performance of blood enterovirus and parechovirus polymerase chain reaction testing in young febrile infants: a prospective multicentre observational study. 发热幼儿血液肠道病毒和帕累托病毒聚合酶链反应检测结果：一项前瞻性多中心观察研究。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-24 DOI: 10.1136/archdischild-2024-327367

Jose Antonio Alonso-Cadenas, Roberto Velasco, Nuria Clerigué Arrieta, Jone Amasorrain Urrutia, Maria Suarez-Bustamante Huélamo, Santiago Mintegi, Borja Gomez

{"title":"Performance of blood enterovirus and parechovirus polymerase chain reaction testing in young febrile infants: a prospective multicentre observational study.","authors":"Jose Antonio Alonso-Cadenas, Roberto Velasco, Nuria Clerigué Arrieta, Jone Amasorrain Urrutia, Maria Suarez-Bustamante Huélamo, Santiago Mintegi, Borja Gomez","doi":"10.1136/archdischild-2024-327367","DOIUrl":"10.1136/archdischild-2024-327367","url":null,"abstract":"Objectives: To analyse the performance of blood enterovirus and parechovirus PCR testing (ev-PCR) for invasive bacterial infection (IBI) (isolation of a single bacterial pathogen in a blood or cerebrospinal fluid culture) when evaluating well-appearing infants ≤90 days of age with fever without a source (FWS).Methods: We describe the well-appearing infants ≤90 days of age with FWS and normal urine dipstick. We performed a prospective, observational multicentre study at five paediatric emergency departments between October 2020 and September 2023.Results: A total of 656 infants were included, 22 (3.4%) of whom were diagnosed with an IBI (bacteraemia in all of them and associated with meningitis in four). The blood ev-PCR test was positive in 145 (22.1%) infants. One patient with positive blood ev-PCR was diagnosed with an IBI, accounting for 0.7% (95% CI 0.02 to 3.8) compared with 4.1% (95% CI 2.6 to 6.2) in those with a negative test (p=0.04). All four patients with bacterial meningitis had a negative blood ev-PCR result. Infants with a positive blood ev-PCR had a shorter hospital stay (median 3 days, IQR 2-4) compared with 4 days (IQR 2-6) for those with negative blood ev-PCR (p=0.02), as well as shorter duration of antibiotic treatment (median 2 days, IQR 0-4 vs 2.5 days, IQR 0-7, p=0.01).Conclusions: Young febrile infants with a positive blood ev-PCR are at a low risk of having an IBI. Incorporating the blood ev-PCR test into clinical decision-making may help to reduce the duration of antibiotic treatments and length of hospital stay.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"106-110"},"PeriodicalIF":4.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethanol in biliary atresia. 乙醇用于胆道闭锁。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-19 DOI: 10.1136/archdischild-2024-328338

Vandana Jain, Emma C Alexander, Charlotte Burford, Mark Davenport, Matthew J Dalby, Lindsay J Hall, Anil Dhawan

引用次数: 0

Disparities in health outcomes of infants born to teenage birthing individuals: a cross-sectional study. 青少年生育个体所生婴儿健康结果的差异：一项横断面研究。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-19 DOI: 10.1136/archdischild-2024-328129

Katherine Erin Douglas, Sunah S Hwang, Michael C Monuteaux, Lois K Lee

引用次数: 0

Non-therapeutic circumcision of boys: a family matter. 男孩的非治疗性包皮环切术：一个家庭问题。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-19 DOI: 10.1136/archdischild-2024-328364

Robert Wheeler

引用次数: 0

Acute rheumatic fever in the UK and Ireland: a BPSU surveillance study. 英国和爱尔兰的急性风湿热：一项BPSU监测研究。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-19 DOI: 10.1136/archdischild-2024-328277

Māia Gourlay-Gudex, Mary Salama, Rosie Crane, Elizabeth Whittaker, Tom Parks

引用次数: 0

Damp and mouldy home: impact on lung health in childhood. 潮湿和发霉的家庭：对儿童肺部健康的影响。

IF 4.3 3区医学

Archives of Disease in Childhood Pub Date : 2025-01-15 DOI: 10.1136/archdischild-2023-326035

Charles Moorcroft, Abigail Whitehouse, Jonathan Grigg

引用次数: 0