Archives of Disease in Childhood最新文献_第2页

Unusual cause of a swollen hand in a neonate. 新生儿手肿的不寻常原因。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-24 DOI: 10.1136/archdischild-2025-329444

Zoe Oakley, Shreeya Kotecha, Vidhoo Rajamoorthy, Jody MacLachlan

引用次数: 0

Home blood pressure measurement in children and adolescents: an issue not to be neglected. 儿童和青少年的家庭血压测量：一个不容忽视的问题。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-22 DOI: 10.1136/archdischild-2024-328441

Artur Mazur

引用次数: 0

'A useful space', 'Real steep learning': professionals' perspectives on new models of integrated care for children and young people in North West London. “一个有用的空间”，“真正的陡峭学习”：专业人士对伦敦西北部儿童和青少年综合护理新模式的看法。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-19 DOI: 10.1136/archdischild-2025-329013

Kajl Zafar Ahmad, Mitch Blair, Steven Hope, Dougal Hargreaves, Bina Ram

引用次数: 0

Hospital Dog-effective, patient-safe, side-effect-free, environmentally safe, cost-effective integrated medicine. 医院犬有效、患者安全、无副作用、环保、性价比高的综合医疗。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-19 DOI: 10.1136/archdischild-2025-328795

Anitha Risberg, Åsa Melhus, Hans Grönlund, Ann Edner

引用次数: 0

Prevalence and clinical characteristics of children with coexisting coeliac disease and inflammatory bowel disease. 小儿乳糜泻与炎症性肠病合并的患病率及临床特点

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-18 DOI: 10.1136/archdischild-2025-328470

Christopher Bakewell, James John Ashton, Bhumita Vadgama, R Mark Beattie, Akshay Batra

{"title":"Prevalence and clinical characteristics of children with coexisting coeliac disease and inflammatory bowel disease.","authors":"Christopher Bakewell, James John Ashton, Bhumita Vadgama, R Mark Beattie, Akshay Batra","doi":"10.1136/archdischild-2025-328470","DOIUrl":"10.1136/archdischild-2025-328470","url":null,"abstract":"Objective: Growing evidence suggests that coeliac disease (CeD) is more common in patients with inflammatory bowel disease (IBD) but diagnostic confusion remains due to overlapping histological and clinical features. Few studies have investigated this relationship in children. We aimed to assess the prevalence of CeD in our paediatric IBD cohort and define the characteristics of IBD when CeD coexists.Methods: We conducted a retrospective study of all patients <18 years old diagnosed with IBD in Southampton Children's Hospital between January 2019 and December 2023. Patients were identified using our IBD database, and data were collected on diagnosis, endoscopy, histopathology, serology, IBD treatment and surgery using electronic patient records.Results: 18 of the 479 children with IBD were also diagnosed with CeD (3.75%). 14 underwent duodenal biopsy on gluten, with 13 fulfilling Marsh classification 2-3. Eight children had Crohn's disease, five had ulcerative colitis and five had IBD-unclassified. 16 out of 18 demonstrated colonic disease; 11 out of 18 had pancolitis. There was no significant difference in the rate of biological therapy use between the IBD-CeD and non-coeliac groups (50% vs 68%). No patients with IBD-CeD underwent IBD surgery.Conclusions: 1 in 25 children with IBD had coexisting CeD. Pancolitis was the most prominent IBD phenotype but a diagnosis of CeD was not associated with increased escalation to biological therapy, and no patients required surgery. These findings help to describe the paediatric IBD-coeliac phenotype and demonstrate the importance of considering IBD in children with refractory CeD and screening for CeD in children presenting with IBD.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"800-804"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public health burden of magnet ingestion in the UK. 英国磁铁摄入的公共卫生负担。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-18 DOI: 10.1136/archdischild-2024-328451

Dhanya Mullassery

引用次数: 0

Magnet ingestion in children in the United Kingdom: a national prospective observational surveillance study. 英国儿童磁铁摄入：一项全国前瞻性观察性监测研究。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-18 DOI: 10.1136/archdischild-2024-328195

Jonathan J Neville, Mark D Lyttle, Shrouk Messahel, Shabnam Parkar, Julie Mytton, Nigel J Hall

{"title":"Magnet ingestion in children in the United Kingdom: a national prospective observational surveillance study.","authors":"Jonathan J Neville, Mark D Lyttle, Shrouk Messahel, Shabnam Parkar, Julie Mytton, Nigel J Hall","doi":"10.1136/archdischild-2024-328195","DOIUrl":"10.1136/archdischild-2024-328195","url":null,"abstract":"Objective: Magnet ingestion in children and young people (CYP) is associated with significant harm. We aimed to describe the incidence, circumstances and outcomes of magnet ingestion in CYP in the United Kingdom (UK).Design: Prospective multicentre observational surveillance study.Setting: UK secondary and tertiary level hospitals in urban and rural settings.Patients: CYP ≤16 years of age who ingested ≥1 magnet.Interventions: Data were collected regarding demographics, circumstances surrounding ingestion, clinical features and management. The primary outcome was the incidence of magnet ingestion in the UK.Results: Between 1 May 2022 and 30 April 2023, 366 cases of magnet ingestion were recorded, of which 314 met eligibility (median age 8.7 years (IQR 5.1-12.0)). The incidence of magnet ingestion in the UK was at least 2.4/100 000 (95% CI 2.2 to 2.7) CYP per year. CYP sourced magnets from toys (38%), and magnet products were predominantly purchased by parents or caregivers (19%). Magnet-related injuries occurred in 23 (7%) cases, and surgery was undertaken in 32 (10%). Single magnet ingestions did not cause magnet-related injury. Swallowing greater numbers of magnets associated with an increased risk of injury (OR 1.1 (95% CI 1.0 to 1.2), p=0.002). CYP were asymptomatic in 75% of cases, but clinical features on presentation were associated with an increased risk of injury (OR 3.8 (95% CI 1.4 to 10.3), p=0.008).Conclusions: While magnet ingestion in children is uncommon, ingestion of multiple magnets can cause injuries requiring surgery. Greater public and clinician awareness of the associated risks is warranted. This study can inform public health interventions and evidence-based guidelines.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"778-785"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality outcomes of children and young people who have spent time in care: evidence from Children's Health in Care in Scotland, a population-wide administrative data cohort study. 接受过护理的儿童和年轻人的死亡率结果：来自苏格兰儿童保健的证据，这是一项全人口的行政数据队列研究。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-18 DOI: 10.1136/archdischild-2024-327854

Denise Brown, Edit Gedeon, Marion Henderson, Alastair H Leyland, Philip Wilson, Mirjam Allik

{"title":"Mortality outcomes of children and young people who have spent time in care: evidence from Children's Health in Care in Scotland, a population-wide administrative data cohort study.","authors":"Denise Brown, Edit Gedeon, Marion Henderson, Alastair H Leyland, Philip Wilson, Mirjam Allik","doi":"10.1136/archdischild-2024-327854","DOIUrl":"10.1136/archdischild-2024-327854","url":null,"abstract":"Objective: Individuals who spend time in care during childhood/adolescence face a higher risk of premature mortality compared with those who have not been in care. However, it is unclear whether this risk applies to both external causes of death (eg, accident or suicide) and internal causes (eg, disease), as well as the role of potential confounders.Design: A descriptive, population-wide cohort study linking administrative data on state school pupils in Scotland with social care records and vital event data for children and young people with (n=12 367) and without (n=6 49 711) experience of care.Outcome: Premature mortality between 2010 and 2016.Analysis: Poisson regression, with robust SEs, was used to calculate mortality rate ratios, adjusting for confounders age group, sex, area deprivation, disability, and sociodemographic characteristics at birth.Results: Of 745 deaths, 58 were among those with care experience. Of these, 66% were due to external causes, compared with 43% in those without care experience. The unadjusted mortality rate was 4.5 (95% CI 2.6 to 7.7) times as high for those with care experience. After adjusting for confounders, the rate ratio (RR) was 3.0 (95% CI 2.0 to 4.4). Adjusting for confounders did not account for differences in external causes; RR 6.5 (95% CI 4.5 to 9.5), but did account for differences in internal causes; RR 1.4 (95% CI 0.9 to 2.3).Conclusions: Individuals with care experience have higher premature mortality rates, particularly from external causes, compared with those without care experience, a difference not fully accounted for by the confounders considered here. Further research is needed to explore factors contributing to excess external deaths in this population.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"837-843"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Children and adolescents attending for a forensic medical examination at a regional centre in Ireland: a 5-year retrospective cohort study of patients, alleged perpetrators and service provision. 在爱尔兰的一个区域中心接受法医检查的儿童和青少年：对病人、被指控的犯罪者和提供的服务进行的5年回顾性队列研究。

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-18 DOI: 10.1136/archdischild-2025-328561

Naomi Bergin, Abrar Alzaabi, Michael Barrett, Susan Roe, Aideen Walsh, Aisling R Geoghegan, Sinead Harty

{"title":"Children and adolescents attending for a forensic medical examination at a regional centre in Ireland: a 5-year retrospective cohort study of patients, alleged perpetrators and service provision.","authors":"Naomi Bergin, Abrar Alzaabi, Michael Barrett, Susan Roe, Aideen Walsh, Aisling R Geoghegan, Sinead Harty","doi":"10.1136/archdischild-2025-328561","DOIUrl":"10.1136/archdischild-2025-328561","url":null,"abstract":"Objective: This study examines the forensic medical examination (FME) service provided to children in a regional centre in Dublin, Ireland, over 5 years. It reports on patient characteristics, alleged perpetrators and service provision. The goal is to inform future service provision and prevention strategies.Design: The retrospective cohort study included all children and adolescents who underwent FME from January 2018 to December 2022. Data was collected from encrypted child protection reports and analysed with descriptive statistics SETTING: The study was undertaken in the Laurels Clinic, one of the three regional Irish centres for FME.Results: Of 448 patients, 79% were female, with 37.3% aged 5-11 years. Vaginal penetration occurred in 46% of cases, with digital penetration (vaginal or anal) being the most common method. Anal penetration was reported in 26%, and 6.3% had anogenital findings suggestive of child sexual abuse (CSA). CSA was most often perpetrated in the home, with nearly half of patients showing behavioural changes. About 18% had developmental concerns, and 30% lived in blended families. Alleged perpetrators were mainly male (90.1%), with over 20% being teenagers and 12.8% under 13. Over half of cases involved repeated abuse. Disclosure rates were higher with age, with 69% of disclosures made to a parent.Conclusion: This study highlights CSA risk factors, including blended families and developmental concerns. A worrying finding was that many perpetrators were adolescents or children. Prevention programmes must address risks related to smartphone use and exposure to pornography. These findings can guide clinicians, policymakers and institutions in strengthening CSA prevention and response efforts.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"805-810"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma-glutamyltransferase testing in paediatric inflammatory bowel disease to screen for primary sclerosing cholangitis: a diagnostic study based on routinely collected electronic healthcare data. γ -谷氨酰转移酶检测在儿童炎症性肠病中筛查原发性硬化性胆管炎：一项基于常规收集的电子医疗数据的诊断研究

IF 3.2 3区医学

Archives of Disease in Childhood Pub Date : 2025-09-18 DOI: 10.1136/archdischild-2024-327998

Besrat Berhane, Wouter Sjoerd van de Put, Patrick Ferry van Rheenen

{"title":"Gamma-glutamyltransferase testing in paediatric inflammatory bowel disease to screen for primary sclerosing cholangitis: a diagnostic study based on routinely collected electronic healthcare data.","authors":"Besrat Berhane, Wouter Sjoerd van de Put, Patrick Ferry van Rheenen","doi":"10.1136/archdischild-2024-327998","DOIUrl":"10.1136/archdischild-2024-327998","url":null,"abstract":"Objective: To investigate, among children with inflammatory bowel disease (IBD) and elevated liver enzymes, what threshold of gamma-glutamyltransferase (GGT) best distinguishes those with and without primary sclerosing cholangitis (PSC).Method: Delayed-type diagnostic study with a paired design. Children with IBD were regularly screened with GGT (index test). Confirmation of PSC was based on magnetic resonance cholangiopancreatography (MRCP) and/or liver histology (preferred reference standard). Children at low risk of PSC continued regular GGT testing for latent PSC to become visible (alternative reference test). The primary outcome was the negative predictive value (NPV) using three predefined test thresholds, respectively, 1, 2 and 5× the upper limit of normal (ULN). The secondary outcome was the GGT threshold based on receiver operating characteristic analysis.Results: 132 of 469 children (28.1%) had elevated GGT levels at their first colonoscopy or during follow-up. Eventually, 34 children (7.2%) were diagnosed with PSC. Median GGT (IQR) for children with and without PSC was 227 (127-345) and 77 (59-138) U/L, respectively. Of the predefined GGT thresholds, 2× ULN (ie, 100 U/L) had the best test characteristics, including an NPV of 98% and a negative likelihood ratio of 0.04 (95% CI 0.01 to 0.31). The area under the curve was 0.83 (95% CI: 0.75 to 0.90) and the optimal GGT threshold was 103.5 U/L.Conclusion: In children with IBD who have GGT elevations less than 2× ULN, the likelihood of PSC is extremely low. In such cases, MRCP and liver biopsy can be omitted. Regular GGT monitoring is advised, as PSC may develop over time.","PeriodicalId":8150,"journal":{"name":"Archives of Disease in Childhood","volume":" ","pages":"819-823"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0