Archives of Biological Sciences最新文献_第4页

Distribution of interstitial cells of Cajal and nerve fibers in rat stomach in streptozotocin-nicotinamide-induced diabetes mellitus 链脲霉素-烟酰胺致糖尿病大鼠胃Cajal和神经纤维间质细胞的分布

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2023-01-01 DOI: 10.2298/abs230220012v

A. Veličkov, V. Petrovic, B. Djordjevic, Asen Velickov, A. Petrović, Milica Lazarevic, Julija Cvetkovic

{"title":"Distribution of interstitial cells of Cajal and nerve fibers in rat stomach in streptozotocin-nicotinamide-induced diabetes mellitus","authors":"A. Veličkov, V. Petrovic, B. Djordjevic, Asen Velickov, A. Petrović, Milica Lazarevic, Julija Cvetkovic","doi":"10.2298/abs230220012v","DOIUrl":"https://doi.org/10.2298/abs230220012v","url":null,"abstract":"Diabetic peristalsis disorders are common complications in diabetes mellitus type 2. Disturbance of interstitial cells of Cajal (ICC) caused by metabolic changes in diabetes could explain the symptoms of diabetic gastroenteropathy. Although heterogenous interstitial cell types represent only 5% of the cell population of the muscle layer in the gastrointestinal tract (GIT), they are important for conducting electrical signals and regulating muscle excitability. The aim of this study was to investigate the alterations of the myenteric and intramuscular ICCs in the gaster of rats with diabetes mellitus type 2 (DMT2), as well as determine their distribution in relation to smooth muscle cells and enteric nerve structures. Male Wistar rats were used and DT2 was induced by streptozotocin-nicotinamide (STZ-NA) application. The stomach specimens were exposed to type III transmembrane tyrosine kinase (c-KIT), neurofilament (NF-M) protein and desmin antibodies to investigate the ICC, enteric neurons and smooth muscle cells. Morphological changes of the cells were quantified by the numerical areal density of intramuscular ICC, the ICC score of myenteric ICC and the volume density of nerve fibers. In conclusion, a statistically significant decrease in the number of intramuscular ICC and myenteric ICC without nerve fiber loss were observed in all stomach regions in rats with STZ-NA-induced DMT2.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amelioration of the adverse effects of thiram by 24- epibrassinolide in tomato (Solanum lycopersicum Mill.) 24-表油菜素内酯改善番茄(Solanum lycopersicum Mill.)的不良反应

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2023-01-01 DOI: 10.2298/abs230201015d

E. Dalyan

{"title":"Amelioration of the adverse effects of thiram by 24- epibrassinolide in tomato (Solanum lycopersicum Mill.)","authors":"E. Dalyan","doi":"10.2298/abs230201015d","DOIUrl":"https://doi.org/10.2298/abs230201015d","url":null,"abstract":"This study investigated thiram fungicide-induced-stress effects in tomato plants and the possible protective role of 24-epibrassinolide (24-EBL) in response to thiram (tetramethyl thiuram disulfide) toxicity. Tomato seedlings pretreated with 0, 10-11, 10-9 and 10-7 M 24-EBL were treated with 6.6 mM thiram. Tomato leaves harvested 5 and 11 days after thiram treatment (DAT) were used for analysis. Thiram application caused oxidative stress by increased hydrogen peroxide and malondialdehyde levels, whereas the chlorophyll a, b and carotenoid amounts and total protein content decreased. In addition, the activities of antioxidant enzymes such as catalase, ascorbate peroxidase and glutathione reductase decreased in the thiram-treated tomato plants on DAT 5 and 11 while pesticide detoxification enzymes (peroxidase and glutathione-S-transferase) activities increased. The thiraminduced oxidative stress was alleviated after pretreatments with different concentrations of 24-EBL. The hydrogen peroxide and malondialdehyde levels decreased and the amounts of photosynthetic pigments and total protein content increased after 24-EBL pretreatments. In addition, the activities of antioxidant enzymes and pesticide detoxification enzymes further increased as the concentration of 24- EBL decreased in tomato under thiram stress, and the most effective concentration was determined as 10-11 M 24-EBL. The results suggested that 24-EBL could effectively alleviate thiram-induced phytotoxicity in tomato plants.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of arbuscular mycorrhiza on physiological and biochemical parameters and capsaicinoid production in Capsicum annuum L.: A comparative study of extraction methods and solvents 丛菌根对辣椒生理生化指标及辣椒素产生的影响:提取方法和溶剂的比较研究

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2023-01-01 DOI: 10.2298/abs230601027c

Şükrü Canpolat, C. İşlek

{"title":"The effect of arbuscular mycorrhiza on physiological and biochemical parameters and capsaicinoid production in Capsicum annuum L.: A comparative study of extraction methods and solvents","authors":"Şükrü Canpolat, C. İşlek","doi":"10.2298/abs230601027c","DOIUrl":"https://doi.org/10.2298/abs230601027c","url":null,"abstract":"This study aimed to determine the effect of two mycorrhizal fungi, Funneliformis mosseae (Fm) and Rhizophagus intraradices (Ri), on capsaicinoid production in Capsicum annuum L. by gas chromatography-mass spectrometry (GC-MS) via two different extraction approaches, magnetic stirring and ultrasound-assisted extraction with three different solvents, ethanol (EtOH), ethyl acetate (EtAce), and acetonitrile (AceN). The effect of mycorrhizal fungi on some physiological properties and biochemical activity, the content of total phenolic compounds, and antioxidant activity were also investigated. For all investigated parameters, the plants inoculated with mycorrhizal fungi showed significantly higher values than the non-mycorrhizal control plants, except for malondialdehyde (MDA), which was an indicator of lipid peroxidation due to damage that occurred in the cell membrane. It was concluded that inoculation with mycorrhizal fungi increased both capsaicin and dihydrocapsaicin production up to 4-fold in C. annuum compared to the control. Results also indicated that ultrasoundassisted extraction with EtAce was the most effective method for the determination of capsaicin by GCMS.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of an intermediate concentration of cyclophosphamide does not specifically deplete regulatory T cells in a mouse experimental model 在小鼠实验模型中，应用中等浓度的环磷酰胺不会特异性地耗尽调节性T细胞

4区生物学

Archives of Biological Sciences Pub Date : 2023-01-01 DOI: 10.2298/abs230715032r

Natasa Radulovic, Ivan Pilipovic, Ivana Stojanovic

{"title":"Application of an intermediate concentration of cyclophosphamide does not specifically deplete regulatory T cells in a mouse experimental model","authors":"Natasa Radulovic, Ivan Pilipovic, Ivana Stojanovic","doi":"10.2298/abs230715032r","DOIUrl":"https://doi.org/10.2298/abs230715032r","url":null,"abstract":"Cyclophosphamide (CP) is a cytostatic, widely used to treat different carcinomas and autoimmune diseases. It is commonly used in experimental designs modeling immunosuppression in laboratory animals, with different approaches for CP treatment but without a consensus on the dose, timing, and route of administration. We aimed to establish if treatment with CP in C57BL/6 mice depletes regulatory T cells (Tregs). Tregs are a crucial component of the immune system that helps maintain immune tolerance and prevent excessive immune reactions. They are significant in autoimmune diseases, allergies, and immune-related therapies. CP was applied intraperitoneally (i.p.) twice in a 5-day interval in doses of 100 mg/kg. Monitoring of Treg prevalence in peripheral blood after each treatment and in the spleen after the second treatment with CP revealed a drop in the number of Tregs after two doses of CP because of the decreased number of total lymphocytes but not as a specific response of the Tregs. The prevalence of Tregs in peripheral blood after CP treatment mirrored the change in Treg number in the spleen. CP treatment induced a decrease in the number of CD3+ cells in the spleen while increasing their proportion, indicating that CP affected the B lymphocyte population rather than T cells. Our results suggest that CP treatment cannot be used as a specific Treg-depleting agent in the C57BL/6 animal model.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135549417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seselin promotes cisplatin-induced apoptosis of AGS gastric cancer cells by inhibiting β-catenin expression Seselin通过抑制β-catenin的表达促进顺铂诱导的AGS胃癌细胞凋亡

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2023-01-01 DOI: 10.2298/abs230314023s

R. Shyu, Chun-Hua Wang, Chang-Chieh Wu, Lu-Kai Wang, F. Tsai

{"title":"Seselin promotes cisplatin-induced apoptosis of AGS gastric cancer cells by inhibiting β-catenin expression","authors":"R. Shyu, Chun-Hua Wang, Chang-Chieh Wu, Lu-Kai Wang, F. Tsai","doi":"10.2298/abs230314023s","DOIUrl":"https://doi.org/10.2298/abs230314023s","url":null,"abstract":"Gastric cancer is a commonly diagnosed form of cancer, and cisplatin is commonly used as a chemotherapy drug for treating it. However, the side effects of cisplatin may reduce patients? willingness to use it. Seselin, a derivative of coumarin, has been found to have anticancer properties as well as anticoagulant effects. In this study, we investigated the effect of seselin on promoting cisplatininduced gastric cancer cell death using the cell proliferation reagent WST-1, BrdU incorporation and lactate dehydrogenase release. The role of seselin and cisplatin in the apoptosis of gastric cancer cells was analyzed using a phospho-kinase array and Western blot analysis. Seselin did not affect G2/M stasis, but it promoted cell death in AGS cells treated with cisplatin. Phospho-kinase array analysis revealed that cisplatin regulates intracellular p53 phosphorylation, while seselin regulates intracellular ?-catenin expression by affecting the phosphorylation of glycogen synthase kinase-3 beta (GSK-3?), extracellular-signal-regulated kinase (ERK) and Src tyrosine kinase. Seselin and cisplatin promote the apoptosis of gastric cancer cells by the synergistic effect of two distinct signaling pathways. These findings suggest that seselin may be used as a complementary therapy to reduce the clinical dose of chemotherapy.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trauma and displacement in Ukraine: the challenge to medicine and politics. 乌克兰的创伤和流离失所：对医学和政治的挑战。

IF 7.3 4区生物学

Archives of Biological Sciences Pub Date : 2022-05-10 DOI: 10.1093/qjmed/hcac090

B D Kelly

引用次数: 0

Dysregulation of PER3 clock gene and its only pseudogene in colorectal cancer and type 2 diabetes 结直肠癌和2型糖尿病中PER3时钟基因及其唯一假基因的失调

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220223009n

Parisa Najari-Hanjani, Rana Najafi, Sorush Akbar

{"title":"Dysregulation of PER3 clock gene and its only pseudogene in colorectal cancer and type 2 diabetes","authors":"Parisa Najari-Hanjani, Rana Najafi, Sorush Akbar","doi":"10.2298/abs220223009n","DOIUrl":"https://doi.org/10.2298/abs220223009n","url":null,"abstract":"The period (PER) family genes (PER1, PER2, and PER3) play a fundamental role in regulating the day/night cycle. PER3 has a pseudogene variant, PER3P1 or PER4, whose role and expression pattern is unclear in human health and diseases. This study was performed to evaluate the expression levels of normal PER family members and the PER3P1 pseudogene in colorectal cancer (CRC) and type 2 diabetes (T2D). Blood samples were taken from 50 diabetic patients and analyzed using real-time PCR for quantification of PER3 and PER3P1 expression. Colorectal tumor tissues of 50 individuals were also used to evaluate the expression of PER members. All PER members, including PER3P1, were found to be downregulated in colorectal tumor samples. Blood samples collected from diabetic subjects revealed an opposite expression pattern; both PER3 and its pseudogene were found to be upregulated when compared to the control group. Our results reveal coordination between the expression pattern of PER3P1 and normal PER family genes. Based on our findings and the pathological importance of this pseudogene, it can be suggested that PER3P1 may be one of the key regulators of the molecular clock network and PER family expression. This hypothesis needs to be confirmed by further studies.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68389717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes 维甲酸在人表皮角质形成细胞中通过klotho介导的EGFR信号通路诱导透明质酸的产生

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220215007c

Hyangtae Choi, Yonghee Lee, W. Park, B. Kim, C. Lee

{"title":"Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes","authors":"Hyangtae Choi, Yonghee Lee, W. Park, B. Kim, C. Lee","doi":"10.2298/abs220215007c","DOIUrl":"https://doi.org/10.2298/abs220215007c","url":null,"abstract":"All-trans retinoic acid (RA) is an effective anti-aging chemical substance widely used in skin-care products. RA compromises epidermal differentiation and induces keratinocyte proliferation, causing hyaluronic acid production through mechanisms that are not completely understood. Klotho protein causes the differentiation of human epidermal keratinocytes. Klotho gene expression is mediated by epidermal growth factor (EGF), which inhibits cell apoptosis in aging-related diseases. The klotho gene causes human aging syndrome, including short lifespan, skin atrophy, and osteoporosis. We investigated the relationship between RA and klotho in epidermal keratinocytes for the first time. In human epidermal keratinocytes, RA induced klotho gene expression. Treatment with both RA and recombinant klotho induced hyaluronic acid production in human epidermal keratinocytes. However, in klotho small interfering RNA (siRNA)-transfected keratinocytes, RA produced less hyaluronic acid than in the control group, indicating that RA may partially regulate hyaluronic acid production through a klotho-dependent pathway. Knockdown of klotho gene expression inactivated the EGFR-extracellular signal-regulated kinase (ERK) signaling pathway, which is involved in hyaluronic acid production. We concluded that the effect of RA on hyaluronic acid production is partly regulated through the klothomediated EGFR signaling pathway in human epidermal keratinocytes.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal and metalloid bioaccumulation in three centipedes (Chilopoda) 三种蜈蚣(足足纲)的金属和类金属生物积累

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220514019m

B. Mitić, Slavica Borković-Mitić, A. Stojsavljević, D. Stojanović, S. Pavlovic, L. Vasiljević, N. Ristić

{"title":"Metal and metalloid bioaccumulation in three centipedes (Chilopoda)","authors":"B. Mitić, Slavica Borković-Mitić, A. Stojsavljević, D. Stojanović, S. Pavlovic, L. Vasiljević, N. Ristić","doi":"10.2298/abs220514019m","DOIUrl":"https://doi.org/10.2298/abs220514019m","url":null,"abstract":"Three centipede species (Clinopodes flavidus, Cryptops anomalans and Eupolybothrus transsylvanicus) were used as bioindicators of trace metal and metalloid pollution in Belgrade, Serbia. The concentrations of 13 elements (the metals Mn, Co, Ni, Cu, Zn, Rb, Sr, Cd, Tl, Pb and U and metalloids As, Se) in whole animals and soil were measured by inductively coupled plasma mass spectrometry (ICP-MS). Differences in the concentrations of some elements in the analyzed species were observed, both in response to the sites and between species. In most cases, the trace element concentrations were higher in centipedes from a polluted site (an industrial area near a busy street with heavy traffic) but C. anomalans and E. transsylvanicus had higher Mn concentrations at an unpolluted site (a deciduous woodland on Mt. Avala). C. flavidus was a good bioindicator for detecting differences between Zn, Se and Cd. C. flavidus and C. anomalans were more efficient in accumulating Zn than E. transsylvanicus. It appears that C. anomalans poorly accumulated Cd, unlike C. flavidus and E. transsylvanicus, which accumulated Cd according to the high bioaccumulation factor (BAF) values. We conclude that the centipedes C. flavidus, C. anomalans and E. transsylvanicus can be used as suitable bioindicators of trace element exposure. Their ability to accumulate trace elements was different and depends on their physiology and lifestyle as well as the route of exposure.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68390165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Combined analysis of KARS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy 局部晚期直肠癌术前放化疗中KARS突变与p16INK4a和p14ARF甲基化的联合分析

IF 0.8 4区生物学

Archives of Biological Sciences Pub Date : 2022-01-01 DOI: 10.2298/abs220222011k

Bojana Kožik, Milena Krajnovic, Nikola Kokanov, S. Jovanovic-Cupic, A. Božović, Lidija Todorović, V. Mandušić

{"title":"Combined analysis of KARS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy","authors":"Bojana Kožik, Milena Krajnovic, Nikola Kokanov, S. Jovanovic-Cupic, A. Božović, Lidija Todorović, V. Mandušić","doi":"10.2298/abs220222011k","DOIUrl":"https://doi.org/10.2298/abs220222011k","url":null,"abstract":"Current management of locally advanced rectal carcinoma (LARC) involves preoperative chemoradiotherapy (preCRT) before surgery. Despite improved local control rate, the response to preCRT of individual patients is variable and may reflect heterogeneous biological properties among tumors of the same clinical stage. Identifying novel molecular parameters with predictive and/or prognostic value is of great clinical importance for a personalized therapeutic approach. In this study, KRAS mutation status was analyzed by direct sequencing, while methylation-specific polymerase chain reaction (MSP) was used to examine p16INK4a and p14ARF gene methylation status in pretreatment tumor biopsies of 60 patients with LARC. The examined molecular changes of KRAS, p16INK4a and p14ARF genes were mutually independent (p16INK4a/KRAS, P=0.272; p14ARF/KRAS, P=0.923; p16INK4a/p14ARF, P=0.715). However, the simultaneous presence of p14ARF methylation and KRAS mutation was associated with a more frequent appearance of local recurrences and distant metastasis (P=0.027). Moreover, patients with the simultaneous presence of p16INK4a and p14ARF methylation and KRAS mutation had significantly shorter overall survival (P=0.011). The obtained results strongly suggest that combined analyses of examined genetic and epigenetic molecular alterations could contribute to the identification of LARC patient subgroups with more aggressive tumor behavior and worse disease outcome.","PeriodicalId":8145,"journal":{"name":"Archives of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68389657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0