Archives des maladies du coeur et des vaisseaux最新文献_第3页

[Gp IIb/IIIa receptor antagonists in acute coronary syndromes with no ST elevation]. [Gp IIb/IIIa受体拮抗剂在无ST段抬高的急性冠脉综合征中的应用]。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01

V Decalf, L Sabbah, A Lafont, N Danchin, E Durand

{"title":"[Gp IIb/IIIa receptor antagonists in acute coronary syndromes with no ST elevation].","authors":"V Decalf, L Sabbah, A Lafont, N Danchin, E Durand","doi":"","DOIUrl":"","url":null,"abstract":"Gp IIb/IIIa receptor antagonists have been the subject of much work in patients presenting with acute coronary syndrome with no ST elevation (ACS ST-). The initial studies (PRISM, PRISM-PLUS, PURSUIT, PARAGON, CAPTURE, GUSTO IV-ACS) were performed at the end of the 1990s and universally showed a significant reduction in an endpoint combining death and myocardial infarction, especially in patients with an elevation of troponin and treated by angioplasty. However, these studies were performed at a time when clopidogrel was not being used regularly for this indication. Four randomised studies have recently re-evaluated the significance of Gp IIb/IIIa blockers prescribed either on admission to coronary intensive care (ELISA-2, PRACTICE) or in the coronary angiography suite during angioplasty (ADVANCE, ISAR-REACT 2) in patients presenting with ACS ST- pre-treated with clopidogrel in association with aspirin and heparin. The results of these studies suggest that Gp IIb/IIIa blockers initiated at the start of angioplasty significantly reduce an endpoint combining death, myocardial infarction and the need for emergency revascularisation. On the other hand, studies in which Gp IIb/IIIa blockers are initiated in coronary intensive care have been negative, but they have only been carried out on small numbers. The results of the ACUITY study comparing bivalirudin and Gp IIb/IIIa blockers in this context have recently been published. Bivalirudin seems to compare well with Gp IIb/IIIa blockers in terms of ischemia, but it significantly reduces the occurrence of hemorrhagic events.","PeriodicalId":8144,"journal":{"name":"Archives des maladies du coeur et des vaisseaux","volume":"100 12","pages":"1006-12"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27220214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The significance and development of quantitative study of the myocardium with echocardiography]. 【超声心动图心肌定量研究的意义及进展】。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01

E Donal

引用次数: 0

[Efficacy of candesartan cilexetil in hypertensive patients with or without diabetes]. 坎地沙坦西列地酯对合并或不合并糖尿病的高血压患者的疗效。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01 DOI: 10.1097/01.HJH.0000298992.09892.A6

R. E. El Feghali, S. Nisse-Durgeat, R. Asmar

{"title":"[Efficacy of candesartan cilexetil in hypertensive patients with or without diabetes].","authors":"R. E. El Feghali, S. Nisse-Durgeat, R. Asmar","doi":"10.1097/01.HJH.0000298992.09892.A6","DOIUrl":"https://doi.org/10.1097/01.HJH.0000298992.09892.A6","url":null,"abstract":"OBJECTIVE\u0000To assess the effect of an ARB, candesartan cilexetil (CC), on blood pressure (BP) from 5 double-blind, randomised, studies in hypertensive patients.\u0000\u0000\u0000METHODS\u0000Similar design was used in the 5 selected studies. Following 2-4 weeks run-in period with placebo, patients were randomised to receive the double-blind treatment. BP were assessed at inclusion, after 4-6 weeks and at the end (8-12 weeks). Depending on the BP response, dosage of CC 8 mg was doubled at the follow-up visit if BP >or=140/90 mmHg.\u0000\u0000\u0000RESULTS\u0000702 patients were randomised in CC group of whom 22% (153) were diabetic. Mean BP was 160 +/- 13/94 +/- 10/65 +/- 14 mmHg for SBP/DBP/PP at inclusion and were significantly reduced to 141 +/- 15/83 +/- 10/58 +/- 13 mmHg (p<0.001) after 8-12 weeks. The results according to the diabetes status are presented in the table below: [table: see text]\u0000\u0000\u0000CONCLUSION\u0000Results of this meta analysis analysis performed on individual data show that CC reduces significantly BP in hypertensive population with a significant decrease in the diabetic patients.","PeriodicalId":8144,"journal":{"name":"Archives des maladies du coeur et des vaisseaux","volume":"1 1","pages":"679-82"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90784262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Patient-prosthesis mismatch: myth or reality?]. [患者与假肢不匹配:神话还是现实?]

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01

P Pibarot

引用次数: 0

[The sympathetic baroreflex is enhanced during emotional stress in rats]. [大鼠在情绪紧张时交感压力反射增强]。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01 DOI: 10.1097/01.HJH.0000298997.04054.35

R. Kanbar, V. Oréa, C. Barrés, C. Julien

{"title":"[The sympathetic baroreflex is enhanced during emotional stress in rats].","authors":"R. Kanbar, V. Oréa, C. Barrés, C. Julien","doi":"10.1097/01.HJH.0000298997.04054.35","DOIUrl":"https://doi.org/10.1097/01.HJH.0000298997.04054.35","url":null,"abstract":"The sympathetic component of the baroreceptor reflex might play a major role in limiting hypertensive effects of emotional stress. However, it has been suggested that this type of stress inhibits or even suppresses the baroreflex. The aim of the present study was, therefore, to determine the effects of emotional stress on the sympathetic baroreflex in conscious rats. In 11 Sprague Dawley rats, arterial pressure (AP) and renal sympathetic nerve activity (RSNA) were recorded simultaneously before and during exposure to a mild emotional stressor (jet of air). Under both conditions, baroreflex function curves relating AP and RSNA were constructed by fitting a sigmoid function to RSNA and AP measured during sequential nitroprusside and phenylephrine administrations. Air-jet stress significantly (P<0.01) increased the mean levels of AP (from 112 +/- 2 to 124 +/- 2 mmHg), heart rate (from 381 +/- 10 to 438 +/- 18 beats/min) and RSNA (from 0.80 +/- 0.14 to 1.49 +/- 0.23 microV). Sympathetic baroreflex function curves were shifted to a higher level of AP, and this was accompanied by an increase (P<0.01) in the maximum gain (from 9.0 +/- 1.3 to 16.2 +/- 2.1 normalized units (NU)/mmHg). The latter effect was a consequence of an increase (P<0.01) in the maximal range of variations of RSNA (from 285 +/- 33 to 619 +/- 59 NU). Finally, the operating range of the sympathetic baroreflex, which corresponds to the AP range over which the reflex is able to alter RSNA, was increased (from 34 +/- 2 to 41 +/- 3 mmHg; P<0.01). In conclusion, the baroreflex control of RSNA is sensitized and operates over a larger range during emotional stress in rats, which suggests that renal vascular tone, and possibly AP, are very efficiently controlled by the sympathetic nervous system under this condition.","PeriodicalId":8144,"journal":{"name":"Archives des maladies du coeur et des vaisseaux","volume":"26 1","pages":"695-8"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83616884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Importance of chromosome 17 in genetically hypertensive rats of the Lyon strain (LH): study of a consomic strain]. [17号染色体在遗传性高血压大鼠里昂菌株(LH)中的重要性:一种经济菌株的研究]。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01 DOI: 10.1097/01.HJH.0000298979.03161.55

S. Gilibert, J. Sassard, A. Bataillard

{"title":"[Importance of chromosome 17 in genetically hypertensive rats of the Lyon strain (LH): study of a consomic strain].","authors":"S. Gilibert, J. Sassard, A. Bataillard","doi":"10.1097/01.HJH.0000298979.03161.55","DOIUrl":"https://doi.org/10.1097/01.HJH.0000298979.03161.55","url":null,"abstract":"Genetically hypertensive rats of the Lyon strain (LH) associate high blood pressure (BP), exaggerated salt-sensitivity, and a metabolic syndrome made of overweight together with increased plasma lipids and insulin/glucose ratio. A genetic mapping study in a large population of F2 rats derived from a cross between hypertensive (LH) and normotensive rats (LN) showed the existence, on chromosome 17, of two clusters of Quantitative Traits Loci (QTLs). The first one was associated to morphological parameters whereas the second influenced blood pressure and plasma lipids level. In order to determine the functional importance of this QTLs, we generated a consomic strain LH-17BN in which the LH chromosome 17 has been fully substituted by a normotensive Brown Norway (BN) one. These LH-17BN, as well as LH and BN male rats of the parental strain were phenotyped. This included radio telemetric measurement of BP during normal and elevated salt intake (1% and then 2% in the drinking water) as well as the determination of morphological, metabolic (triglycerides, cholesterol) and renal (creatinine clearance, proteinuria) parameters. LH-17BN, compared to LH rats, exhibited significant decreases in body weight and blood pressure. Renal functions are improved (decreased of proteinuria). Finally, plasma triglycerides were reduced and reach the level observed in BN rats. In conclusion, the present work demonstrates that, in our model, chromosome 17 contains genes which influence morphology, blood pressure, renal function, and lipid metabolism. Interestingly, chromosome 17 almost completely explains the spontaneous hypertriglyceridemia observed in Lyon Hypertensive rats.","PeriodicalId":8144,"journal":{"name":"Archives des maladies du coeur et des vaisseaux","volume":"13 1","pages":"709-13"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87157964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Platelet response to aspirin and clopidogrel. Biochemical evaluation, clinical impact, and pharmacological modulation]. 血小板对阿司匹林和氯吡格雷的反应。生化评价、临床影响和药理学调节]。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01

O Morel, P Ohlmann, P Bareiss

{"title":"[Platelet response to aspirin and clopidogrel. Biochemical evaluation, clinical impact, and pharmacological modulation].","authors":"O Morel, P Ohlmann, P Bareiss","doi":"","DOIUrl":"","url":null,"abstract":"In the vasculature, platelets contribute to thrombotic and inflammatory responses, key processes in atherothrombosis. During percutaneous coronary interventions, several studies have emphasized the deleterious impact of enhanced platelet aggregation on early clinical outcome. However, despite the significant interest of determining platelet responsiveness appears worth, the clinically accurate and practical platelet function assay is still not widespread available. Furthermore, standardized definitions of platelet \"low-responders\" are still lacking. Up to now, light transmission platelet aggregometry remains the \"gold-standard\". Platelets \"points of care\" assays might overcome the limitations of conventional optical platelet aggregation but need further validation in clinical settings. The most recent ACC/AHA guideline endorses a strategy of platelet monitoring in the highest risk patients (IIb C). In \"low-responders\" patients, clopidogrel dose escalation was demonstrated to improve platelet responsiveness. Others potential pharmacological solutions could include the switch for another thienopyridine. Indeed, prasugrel a P2Y12 receptor inhibitor was demonstrated to provide higher levels of inhibition of ADP-induced platelet aggregation.","PeriodicalId":8144,"journal":{"name":"Archives des maladies du coeur et des vaisseaux","volume":"100 12","pages":"992-1002"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27220212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Intra-cardiac lymphoma with right heart failure: a therapeutic emergency in two patients]. [心脏内淋巴瘤合并右心衰:两例急诊治疗病例]。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01

F Roubille, F Massin, G Cayla, G Gahide, R Gervasoni, J-C Macia, I Serre, J-L Pasquie, C Sportouch, F Leclercq

引用次数: 0

[Microalbuminuria, a marker of artery rigidity and cardiac dysfunction]. 微量白蛋白尿，动脉僵硬和心功能障碍的标志。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-12-01 DOI: 10.1097/01.HJH.0000299001.26925.6D

M. Brahimi, H. le Clésiau, Z. Ouazen, K. Soufi, A. Michault, J. Pariés, E. Cosson, P. Valensi

{"title":"[Microalbuminuria, a marker of artery rigidity and cardiac dysfunction].","authors":"M. Brahimi, H. le Clésiau, Z. Ouazen, K. Soufi, A. Michault, J. Pariés, E. Cosson, P. Valensi","doi":"10.1097/01.HJH.0000299001.26925.6D","DOIUrl":"https://doi.org/10.1097/01.HJH.0000299001.26925.6D","url":null,"abstract":"INTRODUCTION\u0000Microalbuminuria is considered as a marker of endothelial dysfunction and is associated with an increase in cardiovascular risk. The aim of this study was to evaluate this parameter as a potential marker of artery rigidity and left ventricle (LV) function.\u0000\u0000\u0000SUBJECTS AND METHODS\u0000We included 375 subjects referred to a health assessment center. They were 228 men and 147 women aged in means of 52.7 and 53.1 years, respectively. Among this population, 57 had type 2 diabetes, 28 of them with hypertension, 65 were hypertensive but free of diabetes, and 39 were free of diabetes but exhibited a metabolic syndrome (NCEP-ATP III). Urinary albumin excretion rate (UAER) was determined. Artery rigidity was evaluated by pulse pressure of the brachial artery (plethysmographic method), pulse pressure of the radial artery and aorta and pulse wave velocity (PWV) measured by aplanation tonometry (SphygmoCor). LV afterload was appreciated by LV telesystolic pressure and coronary perfusion by the diastolic area/systolic area ratio for aortic pressure curve (Buckberg index).\u0000\u0000\u0000RESULTS\u0000UAER correlated with PWV in the overall population (p<0.0001) and in the diabetic sub-group (p<0.001). In the overall population UAER correlated with LV telesystolic pressure (p=0.006) but not with Buckberg index. In the overall population and the diabetic subgroup, the artery rigidity indexes correlated strongly with LV telesystolic pressure, and radial and aortic pulse pressure correlated negatively with Buckberg index.\u0000\u0000\u0000CONCLUSION\u0000These data suggest that 1) microalbuminuria may be considered as a marker of artery rigidity, in line with experimental data which indicate the deleterious role of endothelial dysfunction on artery compliance; 2) artery rigidity is a potent determinant of LV afterload and coronary perfusion, in particular in diabetic patients.","PeriodicalId":8144,"journal":{"name":"Archives des maladies du coeur et des vaisseaux","volume":"15 1","pages":"673-6"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75144196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

[Case report of a successful pregnancy following thrombolysis for acute myocardial infarction]. 【急性心肌梗死溶栓后妊娠成功一例报告】。

Archives des maladies du coeur et des vaisseaux Pub Date : 2007-11-01

J Bessereau, O Desvignes, B Huon, J-Y Roudaut, L Picault, J-J Blanc

引用次数: 0