[患者与假肢不匹配:神话还是现实?]

P Pibarot
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引用次数: 0

摘要

当假体的有效瓣膜表面积与患者的体表面积相比太小时,就会出现患者-假体不匹配(PPM)。PPM是主动脉瓣置换术后常见的问题(20% ~ 70%)。PPM与症状状态和生活质量改善较小、左心室肥厚消退较小、冠状动脉储备恢复不完全、心脏不良事件发生率较高以及主动脉瓣置换术后生存率降低相关。然而,PPM的效果因其严重程度和患者的情况而有很大差异。特别是年轻患者,以及左心室功能差和/或严重左心室肥厚的患者更容易发生PPM。与大多数其他风险因素不同,PPM可以通过在操作时实施预防策略来避免或或多或少地降低其严重程度。这种策略应该优先考虑现代假体的环上植入,优化血流动力学前沿,而不是倾向于扩大主动脉根部。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Patient-prosthesis mismatch: myth or reality?].

Patient-prosthesis mismatch (PPM) is present when the effective valvular surface area of the prosthesis is too small compared to the patient's body surface area. PPM is a frequent problem following aortic valvular replacement (20 to 70%). PPM is associated with a lesser improvement in symptomatic state and quality of life, less regression in left ventricular hypertrophy, incomplete recuperation of coronary reserve, a higher incidence of adverse cardiac events, and reduced survival following aortic valvular replacement. However, the effect of PPM varies significantly depending on its severity and the patient's profile. Young patients in particular, as well as those with poor left ventricular function and/or severe left ventricular hypertrophy are more vulnerable to PPM. Unlike most of the other risk factors, PPM can be avoided or its severity can be more or less reduced by putting in place a prevention strategy at the time of the operation. This strategy should be oriented as a priority towards supra-annular implantation of modern prostheses, optimised on the hemodynamic front rather than leaning towards enlargement of the aortic root.

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