Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology最新文献

For Application to Human Spaceflight and ISS Experiments: VESGEN Mapping of Microvascular Network Remodeling during Intestinal Inflammation. 应用于载人航天和国际空间站实验:肠道炎症过程中微血管网络重构的VESGEN制图。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2012-10-01

Patricia Parsons-Wingerter, Hans-Christian Reinecker

{"title":"For Application to Human Spaceflight and ISS Experiments: VESGEN Mapping of Microvascular Network Remodeling during Intestinal Inflammation.","authors":"Patricia Parsons-Wingerter, Hans-Christian Reinecker","doi":"","DOIUrl":"","url":null,"abstract":"Challenges to long-duration space exploration and colonization in microgravity and cosmic radiation environments by humans include poorly understood risks for gastrointestinal function and cancer. Nonetheless, constant remodeling of the intestinal microvasculature is critical for tissue viability, healthy wound healing, and successful prevention or recovery from vascular-mediated inflammatory or ischemic diseases such as cancer. Currently no automated image analysis programs provide quantitative assessments of the complex structure of the mucosal vascular system that are necessary for tracking disease development and tissue recovery. Increasing abnormalities to the microvascular network geometry were therefore mapped with VESsel GENeration Analysis (VESGEN) software from 3D tissue reconstructions of developing intestinal inflammation in a dextran sulfate sodium (DSS) mouse model. By several VESGEN parameters and a novel vascular network linking analysis, inflammation strongly disrupted the regular, lattice-like geometry that defines the normal microvascular network, correlating positively with the increased recruitment of dendritic cells during mucosal defense responses.","PeriodicalId":81348,"journal":{"name":"Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology","volume":"26 2","pages":"2-12"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136394/pdf/nihms616501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32601990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Space Radiation and Bone Loss. 空间辐射与骨质流失。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2011-01-01

Jeffrey S Willey, Shane A J Lloyd, Gregory A Nelson, Ted A Bateman

{"title":"Space Radiation and Bone Loss.","authors":"Jeffrey S Willey, Shane A J Lloyd, Gregory A Nelson, Ted A Bateman","doi":"","DOIUrl":"","url":null,"abstract":"Exposure to ionizing radiation may negatively impact skeletal integrity during extended spaceflight missions to the moon, Mars, or near-Earth asteroids. However, our understanding of the effects of radiation on bone is limited when compared to the effects of weightlessness. In addition to microgravity, astronauts will be exposed to space radiation from solar and cosmic sources. Historically, radiation exposure has been shown to damage both osteoblast precursors and local vasculature within the irradiated volume. The resulting suppression of bone formation and a general state of low bone-turnover is thought to be the primary contributor to bone loss and eventual fracture. Recent investigations using mouse models have identified a rapid, but transient, increase in osteoclast activity immediately after irradiation with both spaceflight and clinically-relevant radiation qualities and doses. Together with a chronic suppression of bone formation after radiation exposure, this acute skeletal damage may contribute to long-term deterioration of bone quality, potentially increasing fracture risk. Direct evidence for the damaging effects of radiation on human bone are primarily demonstrated by the increased incidence of fractures at sites that absorb high doses of radiation during cancer therapy: exposures are considerably higher than what could be expected during spaceflight. However, both the rapidity of bone damage and the chronic nature of the changes appear similar between exposure scenarios. This review will outline our current knowledge of space and clinical exploration exposure to ionizing radiation on skeletal health.","PeriodicalId":81348,"journal":{"name":"Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology","volume":"25 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401484/pdf/nihms-332986.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30785198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORRELATION BETWEEN MICRO-CT SECTIONS AND HISTOLOGICAL SECTIONS OF MOUSE SKULL DEFECTS IMPLANTED WITH ENGINEERED CARTILAGE. 工程软骨植入小鼠颅骨缺损的显微ct切片与组织学切片的相关性研究。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2009-09-01

P J Duke, L Doan, H Luong, C Kelley, W Leboeuf, Q Diep, E Johnson, D D Cody

{"title":"CORRELATION BETWEEN MICRO-CT SECTIONS AND HISTOLOGICAL SECTIONS OF MOUSE SKULL DEFECTS IMPLANTED WITH ENGINEERED CARTILAGE.","authors":"P J Duke, L Doan, H Luong, C Kelley, W Leboeuf, Q Diep, E Johnson, D D Cody","doi":"","DOIUrl":"","url":null,"abstract":"One advantage of using cartilage to replace/repair bone is that the implant disappears as bone is formed by endochondral ossification. Previously, we showed that cartilage spheroids, grown in a rotating bioreactor (Synthecon, Inc.) and implanted into a 2 mm skull defect, contributed to healing of the defect. Skulls with or without implants were subjected to microCT scans. Mineralized regions from microCT sections correlated with regions of bone in histological sections of the defect region of demineralized skulls. Recently, sections from microCT scans of live mice were compared to histological sections from the same mice. The area of the defect staining for bone in histological sections of demineralized skulls was the same region shown as mineralized in microCT sections. Defects without implants were not healed. This study demonstrates that microCT scans are an important corollary to histological studies evaluating the use of implants in healing of bony defects.","PeriodicalId":81348,"journal":{"name":"Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology","volume":"22 2","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902829/pdf/nihms541570.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32073527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing of Saccharomyces cerevisiae morphological fixatives and fixed samples stored at ambient temperature. 酿酒酵母形态固定剂和常温保存固定样品的检验。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2005-06-01

Diana Ly, Diane Yu, Beverly Girten, Jacob Cohen

引用次数: 0

Erythropoietin and IL-3 receptor cell surface expression is decreased under conditions that model some aspects of microgravity. 促红细胞生成素和IL-3受体细胞表面表达在微重力条件下降低。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2005-06-01

Kun Xu, Laurie Feldman, Kerry L Davis, Arthur J Sytkowski

引用次数: 0

Gravity and light: integrating transcriptional regulation in roots. 重力和光:整合根的转录调控。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2005-06-01

Raul Salinas-Mondragon, Anna Brogan, Nicholas Ward, Imara Perera, Wendy Boss, Christopher S Brown, Heike Winter Sederoff

引用次数: 0

Cell behavior in simulated microgravity: a comparison of results obtained with RWV and RPM. 模拟微重力下的细胞行为:用RWV和RPM获得的结果的比较。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2005-06-01

A Villa, S Versari, J A M Maier, S Bradamante

引用次数: 0

Polyamines protect against radiation-induced oxidative stress. 多胺可以防止辐射引起的氧化应激。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2005-06-01

Albert W von Deutsch, Clarence D Mitchell, Chris E Williams, Kamla Dutt, Natalia A Silvestrov, Brenda J Klement, Imad K Abukhalaf, Daniel A von Deutsch

{"title":"Polyamines protect against radiation-induced oxidative stress.","authors":"Albert W von Deutsch, Clarence D Mitchell, Chris E Williams, Kamla Dutt, Natalia A Silvestrov, Brenda J Klement, Imad K Abukhalaf, Daniel A von Deutsch","doi":"","DOIUrl":"","url":null,"abstract":"Astronauts and cosmonauts are exposed to a wide variety of different hazards while in space that include radiation, which presents one of the most critical barriers to long-term missions. A major deleterious effect directly associated with ionizing radiation is the production of reactive oxygen species (ROS) such as peroxides and hydroxyl radicals. The free radicals generated by ultraviolet (UV) or ionizing radiation can attack cellular lipids, proteins and DNA. Endogenous free radical scavengers such as glutathione and the polyamines (e.g, spermidine and spermine) can inhibit the action of ROS. In particular, heme oxygenase-1 (HO-1), the enzyme involved in heme protein metabolism, can provide antioxidant protection through the production of the antioxidant bilirubin. Furthermore, polyamines have been shown to indirectly increase HO-1 content and antioxidant protection. The beta2-adrenoceptor agonist clenbuterol has been shown to stimulate polyamine synthesis and by extension, might provide a margin of antioxidant protection through increasing HO-1 content. However, it is unclear whether the polyamines are acting as a tertiary messengers for antioxidant protection in the be beta2-adrenoceptor signal transduction pathway. The purpose of this study was to study the role of the polyamine pathway in attenuating free radical-induced damage.","PeriodicalId":81348,"journal":{"name":"Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology","volume":"18 2","pages":"109-10"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25213113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of the EMCS hardware for multigenerational growth of Drosophila melanogaster in space. 黑腹果蝇多代空间生长EMCS硬件的研制。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2005-06-01

M E Sanchez, M Shenasa, A Kakavand, R S Stowers, D Leskovsky, S Bhattacharya

引用次数: 0

The yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe: models for cell biology research. 酿酒酵母菌和裂糖酵母菌:细胞生物学研究的模型。

Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Pub Date : 2005-06-01

Susan L Forsburg

引用次数: 0