AppliedChem最新文献_第2页

Controlled Nickel Nanoparticles: A Review on How Parameters of Synthesis Can Modulate Their Features and Properties 可控镍纳米颗粒：综述合成参数如何改变纳米粒子的特征和性能

AppliedChem Pub Date : 2024-03-13 DOI: 10.3390/appliedchem4010007

Felipe e Silva, V. Salim, Thenner Rodrigues

引用次数: 0

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation 协同免疫平衡：姜黄素金纳米粒子和超声波照射对巨噬细胞的降调作用

AppliedChem Pub Date : 2024-03-06 DOI: 10.3390/appliedchem4010006

B. Teixeira, K. D. O. Gonçalves, D. P. Vieira, Lilia Coronato Courrol

{"title":"Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation","authors":"B. Teixeira, K. D. O. Gonçalves, D. P. Vieira, Lilia Coronato Courrol","doi":"10.3390/appliedchem4010006","DOIUrl":"https://doi.org/10.3390/appliedchem4010006","url":null,"abstract":"The multifaceted health benefits of curcumin (Curcuma longa), attributed to its antioxidant, antitumor, and anti-inflammatory activities, have drawn significant scientific attention. Curcumin shows promise as a potential modulator of macrophage polarization, offering a natural strategy for managing inflammation and promoting tissue repair. However, a limiting factor for this beneficial molecule is its limited bioavailability due to its low solubility in water. This study aimed to quantify the effect of curcumin gold nanoparticle (CurAuNP)-mediated ultrasound irradiation on THP-1-derived macrophages as potential therapeutic targets. The photoreduction method was applied to synthesize the gold nanoparticles with curcumin as a ligand (CurAu). The effect of adding polyethylene glycol in the synthesis process was studied (CurAuPEG). CurAuNP characterization included UV/Vis, Zeta potential, transmission electron microscopy, and FTIR. The amount of singlet oxygen released by curcumin and CurAuNPs was quantified by observing 1.3-diphenylisobenzofuran quenching upon ultrasound irradiation (1 MHz and 1 W/cm2). The results indicated that ultrasound therapy for 4 min with CurAuNPs significantly enhanced singlet oxygen generation and reduced macrophage viability compared to curcumin alone. The increased sonoluminescence and curcumin delivery facilitated by CurAuNPs led to greater curcumin activation. Consequently, CurAuNPs could offer promising therapeutic options for modulating macrophage polarization in pro-inflammatory and anti-inflammatory stages.","PeriodicalId":8123,"journal":{"name":"AppliedChem","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Extraction of Oleoresin from Pink Pepper Fruits: Effect of Experimental Conditions and Characterization 从粉红胡椒果实中绿色提取油树脂：实验条件和特性的影响

AppliedChem Pub Date : 2024-02-28 DOI: 10.3390/appliedchem4010005

Ana Flávia A. de Mello, J. Hoscheid, D. Raspe, N. Stevanato, Camila da Silva

{"title":"Green Extraction of Oleoresin from Pink Pepper Fruits: Effect of Experimental Conditions and Characterization","authors":"Ana Flávia A. de Mello, J. Hoscheid, D. Raspe, N. Stevanato, Camila da Silva","doi":"10.3390/appliedchem4010005","DOIUrl":"https://doi.org/10.3390/appliedchem4010005","url":null,"abstract":"This work evaluated the green extraction of oleoresin from pink pepper fruits (ORPPF) using ultrasound-assisted extraction (UAE) and ethanol as a solvent. The effects of temperature, ultrasound power intensity, sample to solvent ratio and time on the global extraction yield (YGE) and phenolic compounds yield (YPC) were evaluated. The oleoresin samples were characterized and its antimicrobial activity determined, and the obtained results were compared to conventional extraction in Soxhlet. From the results it was found that the application of the highest levels of the independent variables favored the extraction process. The maximum values of YGE and YPC were 28.60 wt% and 6.37 mg GAE per g fruit, respectively, obtained at 60 °C, 100% of ultrasound power (165 W), 1:20 g mL−1 (sample:solvent) and 45 min. Under maximized conditions, the ORPPF obtained by UAE showed a content of phenolic compounds and antioxidant activity inferior to soxhlet–ethanol extraction. However, the time and solvent consumption were reduced. Oleic and linoleic acids predominated in the fatty acid composition of ORPPF, in addition to sesquiterpenes and gallic and syringic acids. The ORPPF presented weak antibacterial activity, with minimum inhibitory concentration ranging from 31.25 to 125 mg mL−1.","PeriodicalId":8123,"journal":{"name":"AppliedChem","volume":"327 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxyalkyl Amination of Agarose Gels Improves Adsorption of Bisphenol A and Diclofenac from Water: Conceivable Prospects 琼脂糖凝胶的羟烷基胺化可改善水中双酚 A 和双氯芬酸的吸附：可想象的前景

AppliedChem Pub Date : 2024-02-24 DOI: 10.3390/appliedchem4010004

Lennart Ljunggren, Svetlana Ivanova, Alexander E. Ivanov

{"title":"Hydroxyalkyl Amination of Agarose Gels Improves Adsorption of Bisphenol A and Diclofenac from Water: Conceivable Prospects","authors":"Lennart Ljunggren, Svetlana Ivanova, Alexander E. Ivanov","doi":"10.3390/appliedchem4010004","DOIUrl":"https://doi.org/10.3390/appliedchem4010004","url":null,"abstract":"The hydroxyalkyl amination of agarose gels was studied as an approach to improve adsorption of polyphenols and pharmaceuticals from water. Three commercially available agarose gels, Zetarose FlashFlow4, ZetaCell-CL6B and Sepharose 4B were chemically modified using tris-(hydroxymethyl)aminomethane, TRIS, and ethanolamine, EA. The adsorbed amounts of bisphenol A and diclofenac were significantly higher on TRIS- and EA-derivatives compared with the parent gels. Regarding bisphenol A adsorption on TRIS-ZetaCell-CL6B, a maximal adsorption capacity, Q max of 16 μmol/mL gel and an equilibrium dissociation constant KL of 2.7 × 10−4 mol/L were observed. Filtration of diclofenac-contaminated water through TRIS-Zetarose FlashFlow 4 resulted in a 10-fold reduction of the pollutant concentration within 64 column volumes of the effluent. The moderate binding affinity of polyphenols to TRIS- and EA-adsorbents facilitates efficient polyphenol desorption and column regeneration. The effects of TRIS- and EA-substituents in agarose gels, can be harnessed for the development of environmental adsorbents, as well as for the preparative separation of polyphenols and pharmaceuticals. We consider the physical shapes and textures of the prospective adsorbents with a particular focus on spongy macroporous cryogels. These innovative materials hold promise for future applications in liquid and air filtration.","PeriodicalId":8123,"journal":{"name":"AppliedChem","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Thiophene-Fused Siloles through Rhodium-Catalyzed Trans-Bis-Silylation 通过铑催化的反式双硅烷化合成噻吩融合的硅醇

AppliedChem Pub Date : 2024-02-02 DOI: 10.3390/appliedchem4010003

Akinobu Naka, Maho Inoue, Haruna Kawabe, Hisayoshi Kobayashi

引用次数: 0

Synthesis of Thiophene-Fused Siloles through Rhodium-Catalyzed Trans-Bis-Silylation 通过铑催化的反式双硅烷化合成噻吩融合的硅醇

AppliedChem Pub Date : 2024-02-02 DOI: 10.3390/appliedchem4010003

Akinobu Naka, Maho Inoue, Haruna Kawabe, Hisayoshi Kobayashi

引用次数: 0

The Medicinal Moroccan Plant Cladanthus arabicus as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin 摩洛哥药用植物 Cladanthus arabicus 是倍半萜内酯 Cladantholide 和 Sintenin 的主要来源

AppliedChem Pub Date : 2024-01-25 DOI: 10.3390/appliedchem4010002

L. Bouissane, Christian Bailly

{"title":"The Medicinal Moroccan Plant Cladanthus arabicus as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin","authors":"L. Bouissane, Christian Bailly","doi":"10.3390/appliedchem4010002","DOIUrl":"https://doi.org/10.3390/appliedchem4010002","url":null,"abstract":"The yellow-flowering plant Cladanthus arabicus (L.) Cass., commonly called Arabian Cladanthus or palm springs daisy, is typical of the West Mediterranean region and is particularly abundant in Morocco. The plant is used in traditional Moroccan medicine for the treatment of diabetes and other ailments. Over the past 20 years, this abundant wild plant has been neglected from a phytochemical viewpoint. For the first time, the present review provides a survey of the pharmacological properties reported from extracts of C. arabicus and from essential oils derived from the aerial parts, mainly antimicrobial, antioxidant, and anti-inflammatory properties. The main bioactive natural products are discussed, with a focus on two rare sesquiterpenes of major interest, which are abundant in the stems and leaves: the 6,12-guaianolide cladantholide and the germacranolide sintenin. These sesquiterpene lactones and their analogues are presented to highlight their properties, extraction or total synthesis, and their therapeutic benefits. They both represent convenient biosourced precursors for the synthesis of derivatives. Sintenin may be used as a starting material for the design of hemi-synthetic germacradienolide-type costunolide or parthenolide derivatives. The 6,12-guaianolide scaffold of cladantholide offers opportunities to design novel arglabin derivatives. The therapeutic potential of the neglected and under-utilized plant Cladanthus arabicus and its original phytochemicals shall be explored further.","PeriodicalId":8123,"journal":{"name":"AppliedChem","volume":"115 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139596730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction Parameters for the Formation of Mixed Micelles and Partitioning of Solutes in Them: A Review 混合胶束的形成和其中溶质的分隔的相互作用参数：综述

AppliedChem Pub Date : 2024-01-10 DOI: 10.3390/appliedchem4010001

Nozomu Suzuki

引用次数: 0

Aroma Compounds of Carrier Oils 载体油的芳香化合物

AppliedChem Pub Date : 2023-12-08 DOI: 10.3390/appliedchem3040034

Tyler Marshall, Noura Sayed Dosoky, P. Satyal, W. Setzer

引用次数: 0

Light and Shadow in Near-Infrared Spectroscopy: A Powerful Tool for Cannabis sativa L. Analysis 近红外光谱中的光与影：分析大麻的有力工具

AppliedChem Pub Date : 2023-11-29 DOI: 10.3390/appliedchem3040033

M. Díaz-Liñán, Verónica Sánchez de Medina, C. Ferreiro-Vera, María Teresa García-Valverde

{"title":"Light and Shadow in Near-Infrared Spectroscopy: A Powerful Tool for Cannabis sativa L. Analysis","authors":"M. Díaz-Liñán, Verónica Sánchez de Medina, C. Ferreiro-Vera, María Teresa García-Valverde","doi":"10.3390/appliedchem3040033","DOIUrl":"https://doi.org/10.3390/appliedchem3040033","url":null,"abstract":"Cannabis sativa L. is an ancient cultivar that has found applications in various fields, e.g., medicine, due to its beneficial effects. However, due to its psychotropic effects, the regulation of this cultivar has increased throughout the decades. In this context, the need for rapid and reliable analytical methods to ensure the quality control of Cannabis cultivars has become of extreme importance. NIRS has arisen as a powerful tool in this field due to its multiple advantages, e.g., non-destructive, rapid, and cost-effective. In this article, the chemometric techniques commonly employed in NIRS method development are described, along with their application for the analysis of Cannabis samples. Regarding qualitative methods, different mathematical treatments and classification models are explained. As for quantitative methods, the representative linear and non-linear modelling techniques applied for the development of prediction equations are described, alongside their application in the Cannabis field. To the best of our knowledge, this is the first time this type of review is written, since there are several articles which address cannabinoid determination, but the main purpose of this review is to enhance the potential of NIRS over the traditional techniques employed for the analysis of Cannabis samples.","PeriodicalId":8123,"journal":{"name":"AppliedChem","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139213810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0