Current directions in autoimmunity最新文献_第10页

Molecular mimicry and Lyme arthritis. 分子模拟和莱姆病。

Current directions in autoimmunity Pub Date : 2001-07-01 DOI: 10.1159/000060515

D. Gross, B. Huber, A. Steere

引用次数: 13

Exploring the pathogenesis of rheumatoid arthritis in transgenic and mutant mice. 类风湿关节炎在转基因和突变小鼠中的发病机制探讨。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060514

A. Cope

引用次数: 1

Genetics of human type 1 diabetes mellitus. 人类1型糖尿病的遗传学。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060532

J. Bach, H. Garchon, P. van Endert

引用次数: 12

Structural basis for the HLA-DR association of rheumatoid arthritis. 类风湿关节炎HLA-DR关联的结构基础。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060512

F. Sinigaglia, Z. Nagy

引用次数: 3

Innate response cytokines in inflammatory synovitis: a role for interleukin-15. 炎性滑膜炎中的先天反应细胞因子:白细胞介素-15的作用。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060523

I. McInnes, B. Leung

引用次数: 7

How beta cells die in type 1 diabetes. 1型糖尿病中β细胞如何死亡。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060536

H. Thomas, T. Kay

引用次数: 13

Human T-cell responses to islet cell antigens. 人类t细胞对胰岛细胞抗原的反应。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060540

G. Sønderstrup, I. Durinovich-Belló

引用次数: 2

T cell homeostasis and autoreactivity in rheumatoid arthritis. 类风湿关节炎中的T细胞稳态和自身反应性。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060516

J. Goronzy, C. Weyand

{"title":"T cell homeostasis and autoreactivity in rheumatoid arthritis.","authors":"J. Goronzy, C. Weyand","doi":"10.1159/000060516","DOIUrl":"https://doi.org/10.1159/000060516","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic inﬂammatory disease that prima-rily aVects the synovial membrane and causes irreversible joint damage. Theprevailing pathogenetic model of RA assumes an autoimmune mechanism.Considerable evidence exists that the disease is mediated or at least regulatedby abnormal T cell responses. The most important and, so far, the onlyuniversallyimplicateddiseaseriskgenesareallelicpolymorphismsoftheHLA-DRB1 genes that serve as ligands for the T cell receptor (TCR) of CD4 T cells[1–3]. CD4 T cells are a major component of the inﬂammatory inﬁltrate inthe rheumatoid synovium. In many patients, CD4 T cells and B cells inthe synovial inﬁltrates are organized into lymphoid structures that resemblegerminal centers [4, 5]. Clonally expanded T cell populations are easily detect-able within synovial lesions and identical TCR sequences have been identiﬁedin distinct joints of the same patient, strongly suggesting that CD4 T cellsrecognize antigens in the synovium [6, 7].In spite of this unequivocal evidence of antigen-driven T cell responses, itappearsincreasinglyunlikelythatRAisanantigen-speciﬁcautoimmunedisease.In the strictest sense, autoimmunity is deﬁned as the loss of tolerance and thegeneration of an adaptive immune response to an autoantigen. Such a singleautoantigen has not been identiﬁed in RA. In contrast, recent data suggest thatrecognitionofamultitudeofself-antigensmaybeinvolvedinthediseaseprocess.RA patients have global abnormalities in the peripheral T cell repertoire thatare associated with increased T cell turnover and a contraction of repertoirediversity.Theseaberrationsmaynotonlyreﬂecttherecognitionofmultipleself-antigens but by themselves are likely to have a negative impact on peripheral","PeriodicalId":81058,"journal":{"name":"Current directions in autoimmunity","volume":"3 1","pages":"112-32"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000060516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65042276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Biologics in the treatment of rheumatoid arthritis: mechanisms of action. 治疗类风湿性关节炎的生物制剂:作用机制。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060525

A. Kavanaugh, P. Lipsky

引用次数: 2

The mucosal interface between 'self' and 'non-self' determines the impact of environment on autoimmune diabetes. “自我”和“非自我”之间的粘膜界面决定了环境对自身免疫性糖尿病的影响。

Current directions in autoimmunity Pub Date : 2001-01-01 DOI: 10.1159/000060531

N. R. Solly, M. Honeyman, L. Harrison

引用次数: 8