Current anaesthesia and critical care最新文献_第10页

Adjunctive therapy of severe sepsis and septic shock in adults 成人严重脓毒症及感染性休克的辅助治疗

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.006

T.H. Andersen , T.H. Jensen , L.W. Andersen

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引用次数: 5

Therapeutic adjuncts in sepsis 脓毒症的辅助治疗

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.005

Rick Keays

引用次数: 0

The role of AMPA receptor-mediated excitotoxicity in ALS: Is deficient RNA editing to blame? AMPA受体介导的兴奋性毒性在ALS中的作用:缺陷RNA编辑是罪魁祸首吗?

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.010

Kathryn Duncan

引用次数: 5

Novel targets in pain research: The case for CB2 receptors as a biorational pain target 疼痛研究中的新靶点:CB2受体作为生物疼痛靶点的案例

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.014

Philip W. Brownjohn, John C. Ashton

{"title":"Novel targets in pain research: The case for CB2 receptors as a biorational pain target","authors":"Philip W. Brownjohn, John C. Ashton","doi":"10.1016/j.cacc.2009.07.014","DOIUrl":"10.1016/j.cacc.2009.07.014","url":null,"abstract":"<div><p>The prevalence of neuropathic pain is rising, and is expected to further increase in aging populations. However, drug treatment for neuropathic pain remains inadequate, with the best available treatments having limited efficacy and dose-limiting side effects. Cannabinoids have been shown in clinical trials to be moderately effective at reducing neuropathic pain, but doses of cannabinoids currently in use are severely curtailed by psychoactive side effects through actions on the cannabinoid CB1 receptor. A relatively new class of drugs, selective cannabinoid CB2 receptor agonists, have shown considerable efficacy in a variety of animal models of neuropathic pain. Importantly, these drugs lack the psychoactivity of non-selective cannabinoid receptor agonists. The mechanisms by which CB2 receptor agonists reduce neuropathic pain are under intense investigation, and there are a number of plausible mechanisms by which CB2 agonists have antinociceptive effects. In this article, we review the preclinical evidence for the efficacy of CB2 agonists in the treatment of neuropathic pain. We also review the state of clinical development and trial of CB2 agonists, and argue that the need to test CB2 agonists for neuropathic pain in humans is urgent.</p></div>","PeriodicalId":81055,"journal":{"name":"Current anaesthesia and critical care","volume":"20 5","pages":"Pages 198-203"},"PeriodicalIF":0.0,"publicationDate":"2009-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cacc.2009.07.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72500009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Sodium bicarbonate—the bicarbonate challenge test in metabolic acidosis: A practical consideration 碳酸氢钠-代谢性酸中毒的碳酸氢钠激发试验:一个实用的考虑

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.007

Mark G.A. Palazzo

引用次数: 4

The dopamine and glutamate theories of schizophrenia: A short review 精神分裂症的多巴胺和谷氨酸理论:简要回顾

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.008

A. Bradford

引用次数: 8

AMPA receptors: New targets for psychiatric disorders AMPA受体:精神疾病的新靶点

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.002

P.S. Donoghue

引用次数: 1

Voltage-gated sodium channels in nociception and their potential as targets for new drugs in treatment of chronic neuropathic pain 痛觉中的电压门控钠通道及其作为治疗慢性神经性疼痛新药靶点的潜力

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.06.002

George Lees , Edward Shipton

引用次数: 5

Acid–base disturbances: A need to reunify clinical and scientific medicine 酸碱干扰:需要重新统一临床和科学医学

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/j.cacc.2009.07.011

J.M. Handy

引用次数: 0

Editorial Board & Aims and Scope 编辑委员会和目标和范围

Current anaesthesia and critical care Pub Date : 2009-10-01 DOI: 10.1016/S0953-7112(09)00091-X

引用次数: 0