Semih Başcı, Ersin Bozan, Samet Yaman, Bahar Uncu Ulu, Mehmet Bakırtaş, Tuğçe Nur Yiğenoğlu, Ali Kılınç, Nurgül Özcan, Mehmet Sinan Dal, Merih Kızıl Çakar, Fevzi Altuntaş
{"title":"Is neutropenic fever an obstacle to effective stem cell harvesting?","authors":"Semih Başcı, Ersin Bozan, Samet Yaman, Bahar Uncu Ulu, Mehmet Bakırtaş, Tuğçe Nur Yiğenoğlu, Ali Kılınç, Nurgül Özcan, Mehmet Sinan Dal, Merih Kızıl Çakar, Fevzi Altuntaş","doi":"10.4103/ajts.ajts_152_21","DOIUrl":"10.4103/ajts.ajts_152_21","url":null,"abstract":"<p><strong>Introduction: </strong>Autologous stem cell transplantation (ASCT) is a well-established consolidation treatment for many hematologic cancers which delivers prolonged survival. A subset of patients' adequate stem cell harvest is not achievable with a solitary use of granulocyte colony-stimulating agents (G-CSF). Generally, chemomobilization is employed for patients failing G-CSF and its most feared complication febrile neutropenia (FN).</p><p><strong>Materials and methods: </strong>Here, we aimed to investigate the impact of the FN in chemomobilization on apheresis outcomes and engraftment. One hundred and eighty-three patients with the diagnosis of lymphoma or myeloma who underwent chemomobilization between 2015 and 2020 were included in the study.</p><p><strong>Results: </strong>Forty-three patients experienced FN. All patients received G-CSF. All myeloma patients were mobilized with 4 g/m<sup>2</sup> cyclophosphamide, but it was heterogeneous for lymphoma patients. The precollection blood counts, harvested CD34+ hematopoietic stem cells (HSCs)/kg, apheresis count, and engraftment durations were recorded. Preapheresis leukocyte and platelet were lower in the FN group (<i>P</i> = 0,004 and <i>P</i> = 0,001). Peripheral CD34 HSCs and total harvested CD34 HSCs were similar among groups (<i>P</i> = 0.25 and <i>P</i> = 0.9). More apheresis was needed in the FN group, but it was not significant (<i>P</i> = 0.07). Undergoing ASCT was similar (<i>P</i> = 0.7); however, platelet and neutrophil engraftment durations were slower in the FN group (<i>P</i> = 0.05 and <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Harvesting sufficient CD34+ HSCs from patients with FN is still feasible; however, FN treatment should begin promptly, and further apheresis sessions may be required.</p>","PeriodicalId":80888,"journal":{"name":"Cardiac electrophysiology review","volume":"2 1","pages":"21-26"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78992470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fundamentals of Electrophysiology: Basic Science and Ion Channels","authors":"Milind G. Parikh","doi":"10.1007/978-3-030-75326-9_1","DOIUrl":"https://doi.org/10.1007/978-3-030-75326-9_1","url":null,"abstract":"","PeriodicalId":80888,"journal":{"name":"Cardiac electrophysiology review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91151493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Alobid, C Álvarez Rodríguez, M Blanco Aparicio, J Ferreira, G García, A Gómez-Outes, F Gómez Ruiz, A Hidalgo Requena, J Korta Murua, J Molina París, F J Pellegrini Belinchón, M Pérez Encinas, V Plaza Moral, J Plaza Zamora, M Praena Crespo, S Quirce Gancedo, J Sanz Ortega
{"title":"GEMA5.0 - SPANISH GUIDELINE ON THE MANAGEMENT OF ASTHMA.","authors":"I Alobid, C Álvarez Rodríguez, M Blanco Aparicio, J Ferreira, G García, A Gómez-Outes, F Gómez Ruiz, A Hidalgo Requena, J Korta Murua, J Molina París, F J Pellegrini Belinchón, M Pérez Encinas, V Plaza Moral, J Plaza Zamora, M Praena Crespo, S Quirce Gancedo, J Sanz Ortega","doi":"10.18176/jiaci.0664","DOIUrl":"10.18176/jiaci.0664","url":null,"abstract":"","PeriodicalId":80888,"journal":{"name":"Cardiac electrophysiology review","volume":"1 1","pages":"1-130"},"PeriodicalIF":7.2,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79006865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}