Annals of Noninvasive Electrocardiology最新文献

{"title":"Effect of Dapagliflozin Treatment on Index of Cardiac Electrophysiological Balance in Patients With Heart Failure With Reduced Ejection Fraction","authors":"Yusuf Kayhan,&nbsp;Hakan Kaya,&nbsp;Veysi Kavalci,&nbsp;Sabri Abus,&nbsp;Kadir Biyikli,&nbsp;Sezer Markirt,&nbsp;Cemil Can,&nbsp;Erkan Markirt,&nbsp;Deniz Merde Özdemir","doi":"10.1111/anec.70101","DOIUrl":"https://doi.org/10.1111/anec.70101","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dapagliflozin (DAPA), a sodium-glucose cotransporter-2 (SGLT2) inhibitor, may attenuate the risk of ventricular arrhythmia (VA) through its antiarrhythmic properties in patients with heart failure with reduced ejection fraction (HFrEF). The antiarrhythmic mechanisms of SGLT2 inhibitors are not fully known. Recently, the index of cardiac electrophysiological balance (ICEB) has been posited as a robust indicator for predicting VA risk. ICEB reflects the balance between ventricular depolarization and repolarization. This study was conducted to investigate the effects of DAPA treatment on ICEB in a cohort of patients with HFrEF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 235 HFrEF patients undergoing DAPA treatment were enrolled in the study. Each participant underwent a comprehensive 12-lead electrocardiography (ECG) assessment prior to treatment initiation and approximately 6 months posttreatment. ICEB values were compared before and after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis revealed a statistically significant reduction in the QT interval (427.51 ± 13.87 vs. 347.75 ± 11.21 ms, <i>p</i> &lt; 0.001), corrected QT interval (QTc) (458.34 ± 29.71 vs. 393.37 ± 13.21 ms, <i>p</i> &lt; 0.001), T peak-to-end (Tp-e) interval (85.41 ± 3.52 vs. 71.18 ± 3.16 ms, <i>p</i> &lt; 0.001), Tp-e/QTc ratio (0.186 ± 0.009 vs. 0.180 ± 0.003, <i>p</i> &lt; 0.001), ICEB (4.59 ± 0.65 vs. 3.77 ± 0.15, <i>p</i> &lt; 0.001), following approximately 6 months of DAPA treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In addition to ventricular repolarization distribution indices, the regression of the ICEB values after DAPA treatment in patients with HFrEF shows that DAPA treatment improves the balance between ventricular depolarization and repolarization and reduces the risk of VA in these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 5","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting Alcohol-CV Associations in AF Requires Scrutiny of Drinking Behaviors and Socioeconomic Context","authors":"Yuren Cao","doi":"10.1111/anec.70106","DOIUrl":"https://doi.org/10.1111/anec.70106","url":null,"abstract":"&lt;p&gt;We read with great interest the article by Oraii and colleagues (Oraii et al. &lt;span&gt;2025&lt;/span&gt;). Utilizing a large international cohort (the RE-LY AF registry), the study provides novel insights into the association between different levels of alcohol consumption and cardiovascular outcomes (stroke/systemic embolism, heart failure [HF] hospitalization, major bleeding) in patients with atrial fibrillation (AF). However, when interpreting these important findings, we believe there are noteworthy methodological limitations that warrant attention and improvement in future research.&lt;/p&gt;&lt;p&gt;The study's simplification of alcohol intake to weekly averages, without distinguishing drinking patterns or beverage types, may substantially impact the reliability of its conclusions. Of particular concern is that the concealed risk of binge drinking (≥ 5 drinks per occasion) is obscured by the weekly average grouping. Robust evidence indicates that binge drinking can acutely elevate blood pressure, trigger AF episodes, and promote platelet aggregation, independently increasing stroke risk by approximately 35% (Pooled RR = 1.35) (O'Donnell et al. &lt;span&gt;2010&lt;/span&gt;; Degerud et al. &lt;span&gt;2021&lt;/span&gt;). The “heavy drinker” group (≥ 14 drinks/week) in this study likely included a significant proportion of such high-risk individuals engaging in binge patterns, yet showed only a non-significant reduction in stroke risk (aOR = 0.79). Isolating a binge drinking subgroup might reveal significantly elevated stroke and bleeding risks, especially in the context of anticoagulant therapy, potentially reversing the neutral conclusion that alcohol does not increase thrombotic risk. Concurrently, the confounding effect of beverage type was uncontrolled. The potential cardioprotective effects of polyphenols in wine might dilute the overall observed risk, while a predominance of spirits could amplify harm—this heterogeneity introduces bias into the interpretation of dose–response relationships (Castaldo et al. &lt;span&gt;2019&lt;/span&gt;). While this limitation has a lesser impact on the conclusion regarding HF protection (as chronic benefits may align more with regular, moderate consumption), it likely leads to a systematic underestimation of stroke and bleeding risks, diminishing the study's value for clinical decision-making. Future research urgently needs to integrate dimensions of drinking pattern and beverage type into alcohol categorization; failure to do so risks misleading safety advice for high-risk populations like binge drinkers.&lt;/p&gt;&lt;p&gt;Stratifying the alcohol-heart failure association solely by country income, without adjusting for socioeconomic status (SES), healthcare access, or lifestyle factors, fundamentally weakens the conclusion (Allen et al. &lt;span&gt;2018&lt;/span&gt;). The apparent “protective effect” in high-income countries (aOR = 0.51) likely reflects superior healthcare (e.g., early intervention) and healthier behaviors in high-SES populations, not alcohol itself. Conversely","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 5","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding “Active Compression During External Cardioversion of Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials”","authors":"Yusuf Hosoglu,&nbsp;Mehmet Göl","doi":"10.1111/anec.70095","DOIUrl":"https://doi.org/10.1111/anec.70095","url":null,"abstract":"<p>We read with interest the recent meta-analysis by Taha et al. (<span>2025</span>) on active chest compression during direct current cardioversion (DCCV) for atrial fibrillation (AF), which offers a valuable synthesis of randomized trials. While commendable, certain methodological and clinical aspects deserve closer scrutiny.</p><p>The study by Voskoboinik et al. (<span>2019</span>) markedly differs from others as it compared handheld paddles versus patches in obese patients, demonstrating superior success with paddles. Manual pressure was only evaluated in a substudy. Squara et al. (<span>2021</span>) and Kirchhof et al. (<span>2005</span>) highlighted the benefits of compression, while Ferreira et al. (<span>2024</span>) reported no added advantage.</p><p>Secondly, defibrillator models and waveforms, known to influence success, were not stratified in the meta-analysis. Schmidt et al. (<span>2017</span>) showed biphasic truncated exponential waveforms outperformed pulsed biphasic forms. Kirchhof et al. (<span>2005</span>) similarly found biphasic shocks and paddle electrodes to improve outcomes. These technical nuances are critical for clinical translation but were not considered.</p><p>Antiarrhythmic drug use, a key modifier of cardioversion outcomes, was also not addressed. Squara et al. (<span>2021</span>) and Ferreira et al. (<span>2024</span>) documented baseline drug use but did not adjust for it. Moreover, AF duration is a well-established determinant of success; Gallagher et al. (<span>2001</span>) reported success rates declining from 84% (&lt; 30 days) to 66% (&gt; 180 days), while Carpenter et al. (<span>2019</span>) confirmed that shorter AF history correlates with better long-term outcomes.</p><p>Compression methodology also varied. Only Squara et al. (<span>2021</span>) specified a compression force (~80 N), while other studies lacked standardized parameters. This inconsistency limits reproducibility and comparability.</p><p>Lastly, some included studies, such as Kirchhof et al. (<span>2005</span>), used older-generation defibrillators (e.g., Lifepak 9/12), whereas newer trials like Ferreira et al. (<span>2024</span>) employed advanced biphasic platforms with impedance compensation. This technological evolution is significant and may impact the generalizability of pooled results.</p><p>In conclusion, while Taha et al. (<span>2025</span>) provide valuable insight into active compression during DCCV, future research should rigorously account for procedural variables such as compression parameters, waveform types, antiarrhythmic drug use, AF duration, and defibrillator technology to enhance clinical relevance.</p><p><b>Yusuf Hosoglu:</b> conceptualization, writing – original draft, investigation. <b>Mehmet Göl:</b> writing – review and editing.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract","authors":"","doi":"10.1111/anec.70099","DOIUrl":"https://doi.org/10.1111/anec.70099","url":null,"abstract":"","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 S1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive T-Wave Inversion Associated With Chest Pain: Elucidating the Underlying Truth","authors":"Jing-Xiu Li,&nbsp;Xin-Xin Di,&nbsp;Min Gao,&nbsp;Xue-Qi Li","doi":"10.1111/anec.70102","DOIUrl":"https://doi.org/10.1111/anec.70102","url":null,"abstract":"<p>A patient with episodic chest pain, diaphoresis, amaurosis, and dizziness, along with a history of hypertension, presented with electrocardiographic findings of ST elevation in aVR, diffuse T-wave inversion, and QTc prolongation. Initial diagnosis of NSTEMI was reconsidered after coronary angiography excluded significant stenosis, revealing myocardial bridging. Echocardiography and cardiac MRI showed preserved function without ischemia. Markedly elevated plasma renin and urinary normetanephrine, along with a retroperitoneal mass, suggested paraganglioma. Laparoscopic resection confirmed a 4.0 × 3.5 cm paraganglioma. This case highlights the importance of recognizing atypical ECG patterns that may mimic ischemia in catecholamine-secreting tumors to guide timely diagnosis and intervention.</p>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Modeling of Heart Failure Outcomes Using ECG Monitoring Indicators and Machine Learning","authors":"Jia Liu,&nbsp;Dan Zhu,&nbsp;Lingzhi Deng,&nbsp;Xiaoliang Chen","doi":"10.1111/anec.70097","DOIUrl":"https://doi.org/10.1111/anec.70097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Heart failure (HF) is a major driver of global morbidity and mortality. Early identification of patients at risk remains challenging due to complex, multivariate clinical relationships. Machine learning (ML) methods offer promise for more accurate prognostication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We evaluated the predictive value of electrocardiogram (ECG)–derived features and developed an ML model to stratify HF risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed a public cohort of 1061 patients, of whom 589 (55.5%) developed HF. Records were randomly divided into training (70%, <i>n</i> = 742) and test (30%, <i>n</i> = 319) sets. After preprocessing, we trained a random forest (RF) classifier. Performance on the test set was assessed via accuracy, sensitivity, specificity, F1 score, and area under the receiver operating characteristic curve (AUC). Feature selection employed Gini importance and the Boruta algorithm, while SHAP values provided model interpretability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The RF model achieved an AUC of 0.969, with 91.8% accuracy, 93.8% sensitivity, 89.4% specificity, and a 92.7% F1-score. The top predictors included ST depression (Oldpeak), maximum heart rate (MaxHR), ST-segment slope, and serum cholesterol. Confusion matrix analysis confirmed robust discrimination between HF and non-HF cases. SHAP interpretation reinforced the dominant influence of ECG-related indices and cholesterol on individual risk estimates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>An RF model leveraging ECG features demonstrated excellent performance for HF risk prediction and highlighted key physiologic markers. Future work should integrate comorbidity profiles and detailed biochemical data to further enhance clinical applicability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Transesophageal Echocardiography in Guiding and Evaluating Left Atrial Appendage Occlusion in Patients With Non-Organic Heart Disease","authors":"Xiaoli Long,&nbsp;Xiaohu Guo,&nbsp;Jiwen Xie,&nbsp;Xiaoyong Fan,&nbsp;Dongxia Yang,&nbsp;Xiaoting Mao,&nbsp;Jing Xie","doi":"10.1111/anec.70098","DOIUrl":"https://doi.org/10.1111/anec.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the guiding role of transesophageal echocardiography (TEE) intraoperatively and its evaluative function postoperatively during left atrial appendage occlusion (LAAO) in patients with non-organic heart disease (NOHD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective observational study, a total of 48 patients with NOHD who underwent LAAO in the Department of Cardiology at The First People's Hospital of Lanzhou City from April 2020 to September 2022 were recruited. TEE findings during and after the procedure, cardiac chamber size, and cardiac function parameters at different surgical stages, postoperative occlusion efficacy, and complications were recorded. The application value of TEE in LAAO for patients with NOHD was evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparative analysis TEE-measured the maximum diameter of the LAAO (22.37 ± 3.86 mm) was significantly smaller than X-ray angiographic measurement (23.45 ± 4.22 mm; <i>p &lt;</i> 0.05). One month after radiofrequency ablation, TTE revealed a statistically significant reduction in left atrial diameter (<i>p &lt;</i> 0.05). Four cases (8%) exhibited minor peri-device leak (&lt; 3 mm), and no major complications occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TEE shows significant application value for monitoring anatomical changes, guiding device sizing, and detecting peri-device leaks during and after LAAO for patients with NOHD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Atypical Electrocardiogram Changes in Subtotal Occlusion of the Left Main Coronary Artery","authors":"Honglin Ni,&nbsp;Zhicheng Gao,&nbsp;Jun Yao","doi":"10.1111/anec.70100","DOIUrl":"https://doi.org/10.1111/anec.70100","url":null,"abstract":"<p>Acute occlusion of the left main coronary artery (LMCA) is one of the most severe forms of acute coronary syndrome. Besides the typical electrocardiogram changes, it is important to promptly recognize atypical changes and hasten revascularization therapy without delays. By analyzing specific cases, this work revealed that ST-segment elevation in aVR and aVL leads, accompanied by newly developed bifascicular block that cannot be ruled out as pathological, but without ST-segment deviation in the chest leads, highly indicates a rare electrocardiographic manifestation of complete occlusion of the LMCA. On the other hand, subtotal occlusion represents an even rarer scenario.</p>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum QT Prolongation in a Long QT Syndrome Type 1 Patient","authors":"Lilli C. Wiedenmann,&nbsp;Joachim R. Ehrlich,&nbsp;Ilan Goldenberg","doi":"10.1111/anec.70079","DOIUrl":"https://doi.org/10.1111/anec.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Female LQTS patients are at high risk for arrhythmogenic events during the postpartum period due to hormonal influence on cardiac repolarization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We observed an LQT1 patient with previous cardiac events during pregnancy and 3 weeks postpartum. We obtained ECG recordings and quantified sex hormone levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Peak pregnancy: QTc: 420 ± 7 ms, Estradiol: 24.18 ng/mL, Progesterone: 218 ng/mL. Seven days postpartum: QTc prolongation to 455 ± 5 ms. 22 days postpartum: QTc: 452 ± 5, Estradiol: 0.013 ng/mL, Progesterone: 0.25 ng/mL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Estradiol and Progesterone decline rapidly after birth, correlating to QTc prolongation and elevated risk for arrhythmogenic events. Therefore, modification of pharmacological or device therapy may be considered.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Intake and Cardiovascular Outcomes in Patients With Atrial Fibrillation: RE-LY AF Registry Analysis","authors":"Alireza Oraii,&nbsp;David Conen,&nbsp;Linda S. Johnson,&nbsp;William F. McIntyre,&nbsp;Faith Kirabo,&nbsp;Kumar Balasubramanian,&nbsp;Alexander P. Benz,&nbsp;Jonas Oldgren,&nbsp;Jens Cosedis Nielsen,&nbsp;Jeff Healey","doi":"10.1111/anec.70096","DOIUrl":"https://doi.org/10.1111/anec.70096","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alcohol intake increases recurrence of atrial fibrillation (AF), but its relationship with cardiovascular outcomes is less well characterized. We aimed to study the association between different levels of alcohol intake and cardiovascular outcomes in a global cohort of patients with AF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a cross-sectional analysis of the RE-LY AF registry, including 15,400 patients with AF who visited emergency departments in 47 countries. Patients were categorized into abstainers, light (&lt; 7 standard drinks [SD]/week), moderate (7–13 SD/week), and heavy drinkers (≥ 14 SD/week). Outcomes were stroke/systemic embolism, heart failure (HF) hospitalization, and major bleeding at 1-year follow-up. Logistic mixed-effects regression models were used to calculate multivariable-adjusted odds ratios (aOR) with a 95% confidence interval (CI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total,14,058 patients (mean age = 65.9 ± 14.7 years, 48.0% women) with available alcohol intake level data were included. This consisted of 12,091 (86.0%) abstainers, 1150 (8.2%) light, 458 (3.3%) moderate, and 359 (2.6%) heavy drinkers. The odds of stroke/systemic embolism were not significantly different in light (aOR = 0.88, 95% CI: 0.60–1.28), moderate (aOR = 0.91, 95% CI: 0.53–1.57) or heavy drinkers (aOR = 0.79, 95% CI: 0.41–1.54) compared to abstainers. Major bleedings were numerically, but not statistically significantly, higher among heavy drinkers (aOR = 1.52, 95% CI: 0.82–2.80). Compared to abstainers, alcohol intake was associated with fewer HF hospitalizations (light: aOR = 0.73, 95% CI: 0.58–0.92; moderate: aOR = 0.53, 95% CI: 0.35–0.78; heavy: aOR = 0.63, 95% CI: 0.41–0.98). However, this protective association was observed only in upper-middle and high-income countries (<i>p</i>-interaction &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Alcohol drinking is unlikely to be associated with increased thromboembolic events in patients with AF, but may be associated with a lower risk of HF hospitalizations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8074,"journal":{"name":"Annals of Noninvasive Electrocardiology","volume":"30 4","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anec.70096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}