Sara Saffar Soflaei, Malihehsadat Abedsaeidi, Eisa Nazar, Naeimeh Varasteh, Alireza Kooshki, AmirAli Moodi Ghalibaf, Farima Farsi, Habibollah Esmaily, Mohsen Moohebati, Gordon A. Ferns, Mahmoud Ebrahimi, Majid Ghayour-Mobarhan
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引用次数: 0
Abstract
Background
The long-term prognostic value of resting electrocardiogram (ECG) in the prediction of ischemic heart disease (IHD) incidence and mortality in the asymptomatic middle-aged population is not well characterized. This study was designed to assess the prognostic value of major and minor ischemic changes in ECG as a potential screening tool in healthy adults.
Methods
A total of 9035 middle-aged subjects with available ECGs were recruited. ECG ischemia was classified using the Minnesota Coding system. All the participants were followed up regarding the occurrence of IHD over 10 years. A cardiologist confirmed IHD, and additional tests were performed if indicated. Multiple logistic regression was applied to estimate the odds of ischemic changes in ECG to predict the occurrence of IHD. A p-value less than 0.05 was considered significant.
Results
Among 9035 participants, 1225 (13.6%) had major ischemic changes and 1088 (12.0%) had minor ischemic changes. After a 10-year follow-up, 747 (8.3%) were confirmed with IHD (124 had died and 623 survived). IHD was more prevalent among men, older people, smokers, and retired subjects (p < 0.001). Both major and minor ischemic changes were significantly higher in participants with IHD (p = 0.001), while only major ischemic changes were associated with IHD-cause mortality (p = 0.004). These relationships remained significant after adjustment for confounding factors.
Conclusion
Both minor and major isolated abnormalities in ECG are associated with an increased risk of long-term IHD incidence in the middle-aged population, while only combined major ischemia increases the odds of death caused by IHD.
期刊介绍：
The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients.
ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation.
ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.
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