Anticancer research最新文献

{"title":"Synergistic Effect of Antimicrobial Resistance and Cytogenetic Risk on Mortality in Acute Myeloid Leukemia.","authors":"Deivide DE Sousa Oliveira, Flávia Melo Cunha DE Pinho Pessoa, Isadora Lima Pontes, Kaira Mara DE Albuquerque Cordeiro, Beatriz Maria Dias Nogueira, Guilherme Passos DE Morais, Rodrigo Monteiro Ribeiro, Fabiana Aguiar Carneiro Silva, Lívia Andrade Gurgel, Manoel Odorico DE Moraes Filho, Maria Elisabete Amaral DE Moraes, Caroline Aquino Moreira-Nunes","doi":"10.21873/anticanres.17690","DOIUrl":"https://doi.org/10.21873/anticanres.17690","url":null,"abstract":"<p><strong>Background/aim: </strong>Acute myeloid leukemia (AML) is an aggressive hematological malignancy requiring intensive chemotherapy, which induces profound immunosuppression. Multidrug-resistant Gram-negative (MDRGN) bacterial colonization and infection are an emerging challenge in AML management, potentially worsening survival outcomes. This retrospective single-center cohort study evaluated the impact of MDRGN colonization and infection on overall survival (OS) in patients with AML undergoing chemotherapy.</p><p><strong>Materials and methods: </strong>MDRGN status was determined <i>via</i> routine cultures, while infection was defined by positive sterile-site cultures accompanied by clinical symptoms. Cytogenetic risk was stratified according to ELN 2022 criteria. Survival analysis was performed using the Kaplan-Meier method.</p><p><strong>Results: </strong>A total of 64 patients with AML were analyzed, with a median OS of 8.03 months. MDRGN-colonized patients had significantly shorter OS (3.53 months) than non-colonized patients (18.83 months; <i>p</i>=0.024). High-risk cytogenetics independently reduced OS (4.63 <i>vs.</i> 18.93 months; <i>p</i>=0.011). Patients with both high-risk cytogenetics and MDRGN colonization had the poorest prognosis, with a median OS of 1.47 months. MDRGN colonization was associated with significantly increased infection risk, treatment-related complications, and reduced survival in AML. The combined effect of antimicrobial resistance and high-risk cytogenetics suggests a synergistic impact on prognosis. Delayed targeted antibiotic therapy, chemotherapy modifications, and increased septic episodes likely contributed to the observed mortality.</p><p><strong>Conclusion: </strong>MDRGN colonization is a critical negative prognostic factor in AML, particularly in patients with adverse cytogenetics. Strengthening infection control measures, implementing rapid molecular diagnostics, and optimizing antimicrobial stewardship are essential to improve outcomes.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3295-3304"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosing Time-Dependent Effects of Paclitaxel on Peripheral Neuropathy in Mice.","authors":"Yoshihiro Seto, Koichi Miyamoto, Daisuke Inoue, Fumiyasu Okazaki, Hideto To","doi":"10.21873/anticanres.17691","DOIUrl":"https://doi.org/10.21873/anticanres.17691","url":null,"abstract":"<p><strong>Background/aim: </strong>Paclitaxel (PTX) is a widely used anticancer drug that frequently causes peripheral neuropathy, particularly mechanical allodynia, which is the sensation of pain from mechanical stimuli that are not normally painful, as an adverse effect. In this study, we investigated the effectiveness of chronotherapy on PTX-induced mechanical allodynia in mice.</p><p><strong>Materials and methods: </strong>Male C57BL/6J mice were intravenously administered PTX at 1:00, 5:00, 9:00, 13:00, 17:00 or 21:00 of the day, and mechanical allodynia was assessed using the Von Frey test.</p><p><strong>Results: </strong>Significant circadian variations were observed at the 50% withdrawal threshold, with the lowest values observed in the PTX 9:00 group. When PTX was administered at 9:00 or 21:00, the 50% withdrawal threshold of the PTX 9:00 group was significantly lower than that of the control group. In contrast, the PTX 21:00 group recovered from mechanical allodynia earlier. Repeated administration of PTX showed that the PTX 21:00 group recovered from mechanical allodynia earlier than the PTX 9:00 group. The plasma concentrations of PTX 12 h after administration were significantly higher in the PTX 9:00 group than in the PTX 21:00 group, suggesting the involvement of circadian variations in drug metabolism. No significant differences were found in body weight changes or ALT levels among the control, PTX 9:00, and PTX 21:00 groups.</p><p><strong>Conclusion: </strong>Chronotherapy can ameliorate PTX-induced mechanical allodynia in mice, potentially contributing to improved cancer treatment in humans. Further studies on the pharmacokinetics and antitumor effects of PTX are required to understand the implications of chronotherapy fully.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3305-3314"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methionine Deprivation-induced Cancer Cell Death and Methylation Changes in Key Genes and Gene Promoters of Prostate Cancer Cell Lines.","authors":"Yatin Srinivash Ramesh Babu, Kallidaikurichi V Venkatachalam","doi":"10.21873/anticanres.17683","DOIUrl":"https://doi.org/10.21873/anticanres.17683","url":null,"abstract":"<p><strong>Background/aim: </strong>While normal cells are highly regulated, cancer cells take a dysregulated path which bolsters their survival. Currently, a limited number of uniform treatments are available for cancer cure. Our goal was to deprive cancer cells of the key nutrient methionine and determine what effect it would have on cell death and alterations in DNA methylation of prostate cancer cells.</p><p><strong>Materials and methods: </strong>PC3 and other cell lines were transfected with plasmid gene constructs for methionine gamma lyase deaminase (<i>MEGL</i>), a methionine-degrading enzyme, targeted for expression in the cytoplasm (cMEGL) or the nucleus (nMEGL). For assessing cell death due to <i>MEGL</i>-mediated methionine deprivation, a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used. PC3, and DU145 prostate cancer cells were selected for whole-methylome sequencing to determine the effects of <i>MEGL</i> expression. Key gene products comprising the Prolaris Molecular Score, specifically 31 cell-cycle progression genes, were chosen for assessing putative differences in methylome.</p><p><strong>Results: </strong>Treatment with <i>MEGL</i> gene targeted for expression in either the cytoplasm or nucleus caused significant cell death, similar to that due to the anticancer drug methotrexate. Azacytidine showed no effect on PC3 cell death. Propargylglycine, an inhibitor of MEGL, prevented cell death. Methylome analysis showed increased methylation of two genes: Spindle and kinetochore-associated complex subunit 1 (<i>SKA1</i>), origin recognition complex subunit 6 (<i>ORC6L</i>), and reduced methylation of six promoters: BUB1 mitotic checkpoint serine/threonine kinase B (<i>BUB1B</i>), PDZ binding kinase (<i>PBK</i>), baculoviral IAP repeat-containing 5 (<i>BIRC5</i>), centromere protein M (<i>CENPM</i>), DNA topoisomerase II alpha (<i>TOP2A</i>), minichromosome maintenance 10 replication initiation factor (<i>MCM10</i>), upon forced expression of <i>MEGL</i>.</p><p><strong>Conclusion: </strong>Methionine deprivation through <i>MEGL</i>-targeted gene therapy may be a viable option for inducing cancer cell death compared to unrestricted levels of methionine.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3209-3219"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-floating Culture for Cancer Research: A Mini-review.","authors":"Akiko Fukuyama, Takanori Kitaguchi, Kazumasa Yoshida, Taichi Matsumoto, Kazuhiro Koikawa, Michitaka Nakano, Gen Maruta, Hisanori Maeoka, Shuhei Ishikura, Senji Shirasawa, Toshiyuki Tsunoda","doi":"10.21873/anticanres.17702","DOIUrl":"https://doi.org/10.21873/anticanres.17702","url":null,"abstract":"<p><p>Unlike conventional two-dimensional cell cultures, three-dimensional (3D) culture systems can more accurately replicate key gene expression and drug sensitivity features of the <i>in vivo</i> tumor environment. Of the various 3D culture techniques, 3D-floating (3DF) culture has the unique ability to facilitate high-throughput screening while enabling both visual and quantitative appraisal of the interactions between cancer and immune cells in the presence of exogenous drugs. In this study, we used this method to evaluate treatment against adhesive and non-adhesive cancer cells and found Pyra-Metho-Carnil to be a promising new anticancer drug for refractory cancers. Thus, in this study, we discuss how the use of 3DF cultures can advance cancer research.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3401-3408"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial Cancer Metastatic to the Sigmoid Colon and Pelvic Retroperitoneal Space: A Case Report.","authors":"Junko Mukohyama, Itaru Saito, Satoshi Mochizuki, Yasunori Ota, G O Ito, Jun Imaizumi, Satoko Monma, Naoki Sakuyama, Susumu Aikou, Dai Shida","doi":"10.21873/anticanres.17718","DOIUrl":"https://doi.org/10.21873/anticanres.17718","url":null,"abstract":"<p><strong>Background/aim: </strong>The majority of colorectal tumors are primary colorectal cancers (CRCs), which commonly develop distant metastases in advanced stages. In contrast, secondary involvement of the colon by tumors originating from other organs is rare. Endometrial cancer (EC) typically metastasizes to the vagina, lungs, and peritoneum, with colonic metastasis being exceedingly uncommon.</p><p><strong>Case report: </strong>A 76-year-old female patient presented with abdominal pain. Her medical history was notable for multiple malignancies, including Stage I left breast cancer, Stage IA endometrial cancer, and Stage IIA right breast cancer. Laboratory tests showed elevated levels of cancer antigen (CA)125 (234.5 U/ml) and CA19-9 (110.0 U/ml) were elevated. Contrast-enhanced computed tomography revealed large pelvic cystic tumor and irregular wall thickening of the sigmoid colon. Intraoperative findings showed that the small intestine and sigmoid colon were adherent to the pelvic tumor, forming a large single mass. To achieve en bloc and R0 resection, pelvic tumor resection, high anterior resection, enterectomy, and temporary ileostomy were performed. The histopathological diagnosis confirmed metastasis of EC to the sigmoid colon and pelvic retroperitoneal space, with 2 of 12 lymph nodes positive for metastasis. All surgical margins were negative, and no recurrences were observed nine months post-discharge.</p><p><strong>Conclusion: </strong>We present a rare case of EC metastasis to the colon and pelvic retroperitoneal space with lymph node metastases, successfully treated with en bloc surgical resection. Because EC and CRC exhibit morphological and pathological similarities, laboratory testing for tumor markers, including CA125, may be useful for the preoperative diagnosis of colonic tumors in patients with a history of EC.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3567-3573"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol Enhances Sulfasalazine-induced Ferroptosis by Promoting Iron Ion Accumulation and Lipid Peroxidation in Cancer Cells.","authors":"Takumu Yamada, Takumi Iwasawa, Yui Shimizu, Kazunori Kato","doi":"10.21873/anticanres.17685","DOIUrl":"https://doi.org/10.21873/anticanres.17685","url":null,"abstract":"<p><strong>Background/aim: </strong>Sulfasalazine (SSZ) has traditionally been used as an immunomodulator; however, recent studies have highlighted its potential as a novel anticancer agent due to its ability to induce ferroptosis, an iron-dependent form of cell death. Resveratrol (RSV), a plant-derived bioactive compound commonly marketed as a dietary supplement, is known for its antioxidant and metabolic regulatory properties. This study aimed to investigate whether the combination of SSZ and RSV enhances antitumor activity and to elucidate their effects on ferroptosis.</p><p><strong>Materials and methods: </strong>Human melanoma cell lines expressing CD44 variant 9 and xCT, a transporter for SSZ, were used in this study. Cell viability was assessed using metabolic assays and flow cytometry. The accumulation of intracellular iron ions and lipid peroxides in cancer cells was analyzed <i>via</i> fluorescence microscopy.</p><p><strong>Results: </strong>The combination of SSZ and RSV significantly reduced the viability of melanoma cell lines. Treatment with SSZ led to an increase in reactive oxygen species (ROS) levels and a decrease in reduced glutathione (GSH) levels, both of which were further exacerbated by RSV. Furthermore, the combination of SSZ and RSV enhanced the accumulation of divalent iron ions and lipid peroxides within the mitochondria of cancer cells.</p><p><strong>Conclusion: </strong>SSZ and RSV exhibit a synergistic antitumor effect against cancer cells and enhance iron-dependent cell death, ferroptosis.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3231-3244"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel UF-5000-based Detection, Integrating Inflammatory Parameters, for Urothelial Carcinoma of the Urinary Bladder.","authors":"Kazuhiro Okada, Yoshiki Naito, Saori Irie, Chika Nakamoto, Kenji Kuboyama, Toshiki Tarumizu, Misaki Ikeda, Yuko Takuma, Ryo Makino, Akihiko Kawahara, Hiroyuki Kawano","doi":"10.21873/anticanres.17714","DOIUrl":"https://doi.org/10.21873/anticanres.17714","url":null,"abstract":"<p><strong>Background/aim: </strong>Urothelial carcinoma (UC) is the most common epithelial bladder malignancy. Although urine cytology is widely used for screening, its sensitivity in detecting low-grade UC is limited. This study evaluated the diagnostic accuracy of the research-use parameter \"Atyp.C\" from the fully automated urine particle analyzer UF-5000, in combination with the neutrophil-to-lymphocyte ratio (NLR), for UC detection.</p><p><strong>Patients and methods: </strong>Urine samples from 57 noninvasive UC, 41 invasive UC, and 61 non-UC cases (n=159) were examined at Kurume University Hospital between 2020 and 2023. Specimens with atypical cells were excluded from the study. Receiver operating characteristic curve analysis was conducted using Atyp.C data from the UF-5000 to determine the optimal cutoff value. An UC detection algorithm incorporating the NLR was examined using the AI platform DataRobot, and its diagnostic accuracy was assessed.</p><p><strong>Results: </strong>The diagnostic accuracy for invasive UC was assessed using an Atyp.C cut-off of 0.1/μl, yielding an area under the curve (AUC) of 0.824, sensitivity 70.7%, and specificity 90.3%. Noninvasive UC showed lower accuracy (AUC=0.565; sensitivity, 22.8%; specificity, 90.3%). Incorporating NLR improved invasive UC detection (AUC=0.892; sensitivity, 75.0%; specificity, 100%). NLR was the most influential factor in UC detection.</p><p><strong>Conclusion: </strong>The UF-5000, when combined with the NLR, may enhance UC screening and contribute to a more effective diagnostic strategy.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3531-3541"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface.","authors":"Takeo Fukushima","doi":"10.21873/anticanres.17701","DOIUrl":"https://doi.org/10.21873/anticanres.17701","url":null,"abstract":"","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3399"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Somatostatin Receptors by Ligand Derivative Staining in Breast Tumors.","authors":"Kento Iida, Erina Iwabuchi, Yasuhiro Miki, Koki Hasegawa, Yasuyo Ohi, Yoshiaki Rai, Yasuaki Sagara, Takanori Ishida, Hironobu Sasano, Takashi Suzuki","doi":"10.21873/anticanres.17684","DOIUrl":"https://doi.org/10.21873/anticanres.17684","url":null,"abstract":"<p><strong>Background/aim: </strong>Somatostatin receptors (SSTRs) are G protein-coupled receptors that inhibit tumor cell proliferation. SSTRs are also expressed in breast cancer cells, and examination of clinical breast cancer specimens has revealed that SSTRs are more prevalent in patients with lower malignancy rates. However, in clinical trials of breast cancer, no significant differences in survival rates were detected upon administration of somatostatin analogs, highlighting the importance of detecting SSTRs in tumor tissues. Herein, we determined the expression of SSTRs in breast tumors using immunohistochemistry and ligand derivative staining (LDS) and examined the relevance of SSTR expression.</p><p><strong>Patients and methods: </strong>Pathological tissues from breast tumors diagnosed as invasive ductal carcinomas (n=85) or breast neuroendocrine tumors (NETs) (n=20) were used. Immunohistochemistry and LDS using fluorescein isothiocyanate (FITC)-labeled octreotide were performed to detect SSTR expression.</p><p><strong>Results: </strong>Immunohistochemistry of SSTR2 in breast cancer tissues revealed a significant positive association with estrogen receptor (ER) (<i>p</i><0.001) status, a significant negative association with stage (<i>p</i>=0.023), and a negative association with pN (<i>p</i>=0.055), which did not reach statistical significance. LDS in breast cancer demonstrated a significant positive association (<i>p</i>=0.027) with SSTR2 immunohistochemistry, a positive tendency with ER (<i>p</i>=0.065), and a negative association with pN (<i>p</i>=0.061). LDS in breast NETs was not associated with SSTR2 expression.</p><p><strong>Conclusion: </strong>Our findings revealed that immunohistochemistry allows specific detection of SSTR isoforms, whereas LDS could comprehensively evaluate SSTR expression. To the best of our knowledge, this is the first study to detect SSTR expression in breast cancer tissues using LDS, and the results suggest LDS as a new mode of evaluating SSTR status in clinical specimens.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3221-3230"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset Colonic Graft and Overlying Skin Necrosis 15 Years After Esophagectomy and Gastrectomy: A Case Report.","authors":"Koki Fujiwara, Junko Mukohyama, Fumihiko Kato, Ayu Kato, Sojun Hoshimoto, Masahiro Shinoda, Yoshifumi Ikeda, Osamu Itano","doi":"10.21873/anticanres.17717","DOIUrl":"https://doi.org/10.21873/anticanres.17717","url":null,"abstract":"<p><strong>Background/aim: </strong><i>C</i>olonic interposition following esophagectomy for esophageal cancer is a relatively uncommon reconstructive procedure, primarily indicated in patients who have undergone or require gastrectomy. Graft loss predominantly results from compromised perfusion due to feeding vessel insufficiency, generally occurring within weeks after surgery. We present the first case of delayed necrosis of colonic graft and skin occurring 15 years after subtotal esophagectomy and total gastrectomy.</p><p><strong>Case report: </strong>A 67-year-old female patient had a history of subtotal esophagectomy and total gastrectomy 15 years ago for early-stage esophageal and gastric cancer. She presented with acute chest wall swelling and constipation. Contrast-enhanced computed tomography demonstrated marked distension of the colonic graft and poor contrast in the colonic graft wall under the necrotic skin. The patient underwent a two-stage surgical intervention, using a left colonic graft for reconstruction. After being discharged 83 days after her initial admission, the patient remained asymptomatic six months later.</p><p><strong>Conclusion: </strong>This report presents a case of delayed necrosis of a colonic graft that occurred 15 years after the primary surgery, which was successfully treated through drainage surgery and two-stage reconstruction using a left colonic graft. It should be kept in mind that colonic graft necrosis, a rare late complication of esophagectomy, can progress rapidly.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 8","pages":"3561-3566"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}