Annals of Neonatology Journal最新文献_第4页

Annals of Neonatology Journal Pub Date : 2021-10-17 DOI: 10.21608/anj.2021.100450.1038

N. Gomaa, Ahmed M. EL-SHEWY

{"title":"Relationship between Retinopathy of Prematurity (ROP) and Broncho-Pulmonary Dysplasia (BPD): A Retrospective-Analytical Study","authors":"N. Gomaa, Ahmed M. EL-SHEWY","doi":"10.21608/anj.2021.100450.1038","DOIUrl":"https://doi.org/10.21608/anj.2021.100450.1038","url":null,"abstract":"Background: Retinopathy of prematurity (ROP) and Bronchopulmonary dysplasia (BPD) share the common risk factors of perinatal inflammation and oxidative stress exposure. Moreover, both diseases have a genetic background. Aim of work: is to explore the ROP prevalence and severity among preterm infants diagnosed with BPD and to identify and examine the shared risk factors. Patients and methods: This was a retrospective case-control study consisting of 44 preterm infants with BPD and 62 gestational age-matched controls. Infants’ birth and postnatal medical records were revised. Results: BPD and ROP corresponded with the duration of administration of CPAP, oxygen blender, head box, incubator oxygen, mechanical ventilation, duration of admission, oxygenation, caffeine citrate, TPN, administration and duration of inhaled steroids, inotropic support, surfactant administration, PDA, ICH, PRBCs and plasma transfusion, LOS and infectious episodes. Severe cases of ROP occurred in BPD cases, and this connection extended to varying grades in both diseases. The use of inotropic support was the most predisposing factor to BPD. By contrast, utilizing mechanical ventilation was the most predisposing factor to ROP. Conclusions: BPD and ROP share common risk factors, and there is a connection between them in regard to the varying grades of severity. Though, hemodynamic instability, longer inotropic support, hemodynamically significant PDA, prolonged mechanical ventilation act as cofactors.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82295178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Screening for Thyroid Dysfunction among Preterm Infants at Manfalout General Hospital, Assiut, Egypt 在埃及Assiut的Manfalout总医院筛查早产儿甲状腺功能障碍

Annals of Neonatology Journal Pub Date : 2021-09-18 DOI: 10.21608/anj.2021.94162.1036

Amr Abo Eleyon Mohamed, H. El-Masry, Alaa-eldin Hassan, M. Younis, M. Aladawy, A. M. Hashem

{"title":"Screening for Thyroid Dysfunction among Preterm Infants at Manfalout General Hospital, Assiut, Egypt","authors":"Amr Abo Eleyon Mohamed, H. El-Masry, Alaa-eldin Hassan, M. Younis, M. Aladawy, A. M. Hashem","doi":"10.21608/anj.2021.94162.1036","DOIUrl":"https://doi.org/10.21608/anj.2021.94162.1036","url":null,"abstract":"Background: Neonatal hypothyroidism is a serious endocrinal disorder that must be diagnosed promptly to avoid irreversible neurological deficits. Aim of work: screening of all preterm infants for thyroid dysfunction. Patients and methods: All preterm infants enrolled to this study were subjected to thorough history taking and complete physical examinations. Investigations: initially screening for hypothyroidism was done according to Egyptian screening program and serum TSH, T4, and free T4 were done within the 1st week of life and repeated at the end of 2nd and 4th week of life for those with abnormal results only. Results: Abnormal thyroid function was detected in 178 (50%) preterm infants. Twenty-two infants were excluded from the study. Mean serum levels of TSH, T4 and free T4 were higher among group II infants (more mature) than 1st group (less mature). The mean levels of T4 and free T4 were higher at the end of 4th week of life than their levels during the 1st week of life. Transient hypothyroxinemia was more frequent thyroid dysfunction disorders among both groups (52.5 % and 38 % for 1st and 2nd groups respectively). Neonatal hypothyroidism, transient primary neonatal hypothyroidism, and transient hyperthyrotropinemia were detected in 9 (11.25%), 18 (22.5%), and 11 neonates (13.75%), respectively for the 1st group and observed in 7 (9.2%), 14 (18.4%), and 9 neonates (11.8%), respectively for the second group Conclusions: Thyroid dysfunction was moderately common among preterm neonates. Protocol for thyroid function tests among preterm infants is essential.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81837161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Incidence and Risk Factors for Neonatal Thrombocytopenia among Newborns admitted to Neonatal Intensive Care Unit of Assiut University Children's Hospital-A Prospective Observational Study 阿苏特大学儿童医院新生儿重症监护病房新生儿血小板减少发生率及危险因素:一项前瞻性观察研究

Annals of Neonatology Journal Pub Date : 2021-09-04 DOI: 10.21608/anj.2021.89757.1035

Sylvia R. Zekry, E. Hamed, F. Hassanen, Safwat M. Abdel-Aziz

{"title":"Incidence and Risk Factors for Neonatal Thrombocytopenia among Newborns admitted to Neonatal Intensive Care Unit of Assiut University Children's Hospital-A Prospective Observational Study","authors":"Sylvia R. Zekry, E. Hamed, F. Hassanen, Safwat M. Abdel-Aziz","doi":"10.21608/anj.2021.89757.1035","DOIUrl":"https://doi.org/10.21608/anj.2021.89757.1035","url":null,"abstract":"Background: Thrombocytopenia is frequent hematological diseases affecting neonates hospitalized to neonatal intensive care unit (NICU). Several maternal and neonatal factors contribute to thrombocytopenia development. Aim of work: To identify the incidence and possible risk factors for neonatal thrombocytopenia. Patients and methods: This prospective observational study included all newborns aged from 1- 28 days with thrombocytopenia (platelet count <150,000 /L) either full term or preterm, inborn or outborn cases admitted to NICU in Assiut University Children's Hospital from 1 st of February 2019 to 31 st of January 2020. Thrombocytopenia frequency, as well as associated maternal risk factors as pregnancy-induced hypertension (PIH), diabetes mellitus, premature rupture of membranes (PROM), eclampsia, immunological diseases, and neonatal risk factors as sepsis, birth hypoxia, intrauterine growth retardation (IUGR), and prematurity were evaluated. Results: A total of 1590 neonates were enrolled, of them, 420 cases developed thrombocytopenia. Thrombocytopenia incidence was 26.4%. Maternal risk factors linked with neonatal thrombocytopenia were pregnancy-induced hypertensive disorders (PIH), PROM, and immune thrombocytopenia; neonatal risk factors were sepsis, prematurity, necrotizing enterocolitis (NEC), intrauterine growth retardation (IUGR), asphyxia, Toxoplasmosis, Rubella, Cytomegalovirus, and Herpes viruses infection (TORCH), and prolonged hospital stays. Among newborns with thrombocytopenia, 84.5% had late onset thrombocytopenia (> 72 hours of life). Thrombocytopenia was mild in 41.9%, moderate in 37.9%, and severe in 20.2%. Mortality rate was 20.2%. Conclusions: Thrombocytopenia frequency was 26.4% of neonates hospitalized in our NICU. The most common etiology associated with thrombocytopenia was PIH, PROM, and immune disorders, followed by neonatal sepsis, prematurity, NEC, and IUGR.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88001826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protective Effect of Trans-placental Transferred Immunoglobulins against Neonatal Morbidities in A Tertiary Level Intensive Care Unit 经胎盘转移免疫球蛋白对三级重症监护病房新生儿发病率的保护作用

Annals of Neonatology Journal Pub Date : 2021-08-01 DOI: 10.21608/anj.2021.83662.1033

W. Ahmed, W. Kabiel, Dalia Mohamed

{"title":"Protective Effect of Trans-placental Transferred Immunoglobulins against Neonatal Morbidities in A Tertiary Level Intensive Care Unit","authors":"W. Ahmed, W. Kabiel, Dalia Mohamed","doi":"10.21608/anj.2021.83662.1033","DOIUrl":"https://doi.org/10.21608/anj.2021.83662.1033","url":null,"abstract":"Background: The levels of transplacental transferred immunoglobulins (Ig) carry protective effect to the neonate and varies by many factors as gestational age, maturity, body weight, hemodynamics and maternal diseases. Aim: This study aimed to measure the serum levels of Ig A and Ig G in neonates in different settings and to correlate their levels with neonatal morbidities. Methods: The study conducted during the period from June 2020 to January 2021 in a tertiary level NICU and included a total number of fifty one neonates. The measurement of serum Ig G and Ig A levels were measured by mininef method. Results: The mean value of Ig G and Ig A were 898 mg g/l and 16.3 g/l respectively. Ig G was directly correlated with the maturity, weight, early starting of feeding (p-value 0.001) while they correlated inversely with respiratory and inotropic support and CRP levels (p=value 0.001). Ig G was correlated inversely with the respiratory support whether CPAP or mechanical ventilation; being higher in neonates who didn't receive assisted ventilation. A cut off level of 512 g/l of Ig G was needed to detect increased risk of neonates to sepsis. Preterm babies had lower values than full term ones (p-value 0.001). Conclusion: Transplacental transferred immunoglobulins had a protective effect for neonates and their levels were inversely correlated with neonatal morbidities either in preterm or fullterm neonates","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83951754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evolution of Hemostasis in Neonates and Children 新生儿和儿童止血的演变

Annals of Neonatology Journal Pub Date : 2021-07-01 DOI: 10.21608/ANJ.2021.183374

S. Mousa

引用次数: 0

Extubation Bundle, Is It Applicable to Reduce The Rate of Reintubation, Among Preterm Neonates? 拔管束，是否适用于降低早产婴儿的再插管率?

Annals of Neonatology Journal Pub Date : 2021-07-01 DOI: 10.21608/ANJ.2021.183384

Mohammad Abdelmaaboud

引用次数: 1

The effect of Fenofibrate and Antioxidant Vitamins [D, E and C] in Treatment of Uncomplicated Neonatal Hyperbilirubinemia 非诺贝特联合抗氧化维生素[D, E, C]治疗非并发症新生儿高胆红素血症的疗效观察

Annals of Neonatology Journal Pub Date : 2020-01-28 DOI: 10.21608/anj.2020.69366

Sawsan M. Al-Banna, Asmaa Riad, Sozan Anis

引用次数: 3

Familial hyperekplexia: Lessons from the other face of the coin 家族性多动症:硬币另一面的教训

Annals of Neonatology Journal Pub Date : 2020-01-28 DOI: 10.21608/anj.2020.69360

S. Mounir

{"title":"Familial hyperekplexia: Lessons from the other face of the coin","authors":"S. Mounir","doi":"10.21608/anj.2020.69360","DOIUrl":"https://doi.org/10.21608/anj.2020.69360","url":null,"abstract":"In this issue, we represent a case which may posse special interest to many neonatologists. Apparently healthy female neonate was born by spontaneous vaginal delivery as a sixth offspring to a third-degree consanguineous Egyptian parent. No significant neonatal problems occurred necessitate NICU admission. She had come to our outpatient neurology clinic at age 15th day with episodic transient generalized stiffness, hypertonia and tonic spasms. These episodes were existed from the first days of life as a result of sudden acoustic or tactile stimulation. Both general and neurological examinations were normal. Routine laboratory workup, electroencephalography (EEG) and MRI brain were normal. Father told us about her two brothers who aged 8 and 6 years old, both have had the same story and diagnosed faultily as epileptics. On next visit, we examined her brothers and found them suffering from repeated fallings, injuries and myoclonic jerks only as a reflex to unexpected various sensory stimuli. Although normal EEG and brain imaging, anti-epileptic combinations drugs, not included oral clonazepam, were prescribed to both without improvement. Good to mention that both of them were short and cognitively impaired. The case was one of neonatal conditions mimic epilepsy (CME) called (hereditary hyperekplexia). Recognition of hyperekplexia in the neonatal period is critical to avoid erroneous diagnoses like epilepsy. In conclusion: Neonatologists should be aware of CME in neonatal period. hyperekplexia teaches us simply three unique lessons in neonatology: First, not all CME are benign as known, hyperekplexia may be fatal. Second, some CME like hyperekplexia may be inherited. Lastly, some antiepileptic medications as clonazepam may be used in treatment of non-epileptic conditions like hyperekplexia","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75547938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red blood cell transfusion in preterm neonates: a huge debate on tiny patients 早产儿红细胞输注:关于小病人的巨大争论

Annals of Neonatology Journal Pub Date : 2020-01-28 DOI: 10.21608/anj.2020.69361

S. Mousa

引用次数: 0

Familial hyperekplexia: Lessons from the other face of the coin 家族性多动症:硬币另一面的教训

Annals of Neonatology Journal Pub Date : 2020-01-22 DOI: 10.21608/anj.2020.68927

Samir Monir

{"title":"Familial hyperekplexia: Lessons from the other face of the coin","authors":"Samir Monir","doi":"10.21608/anj.2020.68927","DOIUrl":"https://doi.org/10.21608/anj.2020.68927","url":null,"abstract":"In this issue, we represent a case which may posse special interest to many neonatologists. Apparently healthy female neonate was born by spontaneous vaginal delivery as a sixth offspring to a third-degree consanguineous Egyptian parent. No significant neonatal problems occurred necessitate NICU admission. She had come to our outpatient neurology clinic at age 15th day with episodic transient generalized stiffness, hypertonia and tonic spasms. These episodes were existed from the first days of life as a result of sudden acoustic or tactile stimulation. Both general and neurological examinations were normal. Routine laboratory workup, electroencephalography (EEG) and MRI brain were normal. Father told us about her two brothers who aged 8 and 6 years old, both have had the same story and diagnosed faultily as epileptics. On next visit, we examined her brothers and found them suffering from repeated fallings, injuries and myoclonic jerks only as a reflex to unexpected various sensory stimuli. Although normal EEG and brain imaging, anti-epileptic combinations drugs, not included oral clonazepam, were prescribed to both without improvement. Good to mention that both of them were short and cognitively impaired. The case was one of neonatal conditions mimic epilepsy (CME) called (hereditary hyperekplexia). Recognition of hyperekplexia in the neonatal period is critical to avoid erroneous diagnoses like epilepsy. In conclusion: Neonatologists should be aware of CME in neonatal period. hyperekplexia teaches us simply three unique lessons in neonatology: First, not all CME are benign as known, hyperekplexia may be fatal. Second, some CME like hyperekplexia may be inherited. Lastly, some antiepileptic medications as clonazepam may be used in treatment of nonepileptic conditions like hyperekplexia.","PeriodicalId":8054,"journal":{"name":"Annals of Neonatology Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84956094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0