发布求助
文献互助 智能选刊 最新文献

Annual Reports in Medicinal Chemistry最新文献

筛选
英文 中文
Series Page 系列页面
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-7743(21)00024-5
{"title":"Series Page","authors":"","doi":"10.1016/s0065-7743(21)00024-5","DOIUrl":"https://doi.org/10.1016/s0065-7743(21)00024-5","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55791672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Design of Covalent-Based Inhibitors 共价基抑制剂的设计
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-7743(21)x0002-4
{"title":"The Design of Covalent-Based Inhibitors","authors":"","doi":"10.1016/s0065-7743(21)x0002-4","DOIUrl":"https://doi.org/10.1016/s0065-7743(21)x0002-4","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55791691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Preface 前言
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-08-25 DOI: 10.1016/s0065-7743(20)30040-3
S. Neidle
{"title":"Preface","authors":"S. Neidle","doi":"10.1016/s0065-7743(20)30040-3","DOIUrl":"https://doi.org/10.1016/s0065-7743(20)30040-3","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"54 1","pages":"xiii - xiv"},"PeriodicalIF":0.0,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-7743(20)30040-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44030462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Series Page 系列页面
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-01-01 DOI: 10.1016/s0065-7743(20)30035-x
{"title":"Series Page","authors":"","doi":"10.1016/s0065-7743(20)30035-x","DOIUrl":"https://doi.org/10.1016/s0065-7743(20)30035-x","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-7743(20)30035-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55791500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy. 病毒 G-四聚体：病毒发病机制和抗病毒疗法的新前沿。
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-01-01 Epub Date: 2020-05-18 DOI: 10.1016/bs.armc.2020.04.001
Emanuela Ruggiero, Sara N Richter
{"title":"Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy.","authors":"Emanuela Ruggiero, Sara N Richter","doi":"10.1016/bs.armc.2020.04.001","DOIUrl":"10.1016/bs.armc.2020.04.001","url":null,"abstract":"<p><p>Viruses are the most abundant organisms on our planet, affecting all living beings: some of them are responsible for massive epidemics that concern health, national economies and the overall welfare of societies. Although advances in antiviral research have led to successful therapies against several human viruses, still some of them cannot be eradicated from the host and most of them do not have any treatment available. Consequently, innovative antiviral therapies are urgently needed. In the past few years, research on G-quadruplexes (G4s) in viruses has boomed, providing powerful evidence for the regulatory role of G4s in key viral steps. Comprehensive bioinformatics analyses have traced putative G4-forming sequences in the genome of almost all human viruses, showing that their distribution is statistically significant and their presence highly conserved. Since the genomes of viruses are remarkably variable, high conservation rates strongly suggest a crucial role of G4s in the viral replication cycle and evolution, emphasizing the possibility of targeting viral G4s as a new pharmacological approach in antiviral therapy. Recent studies have demonstrated the formation and function of G4s in pathogens responsible for serious diseases, such as HIV-1, Hepatitis B and C, Ebola viruses, to cite a few. In this chapter, we present the state of the art on the structural and functional characterization of viral G4s in RNA viruses, DNA viruses and retroviruses. We also present the G4 ligands that provide further details on the viral G4 role and which, showing promising antiviral activity, which could be exploited for the development of innovative antiviral agents.</p>","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"54 ","pages":"101-131"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37951424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers 调节eb病毒核抗原1 (EBNA1) mRNA翻译的四重相互作用化合物:预防和治疗ebv相关癌症的新策略
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-01-01 DOI: 10.1016/bs.armc.2020.05.001
A. Granzhan, R. P. Martins, R. Fåhraeus, M. Blondel, M. Teulade‐Fichou
{"title":"Quadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers","authors":"A. Granzhan, R. P. Martins, R. Fåhraeus, M. Blondel, M. Teulade‐Fichou","doi":"10.1016/bs.armc.2020.05.001","DOIUrl":"https://doi.org/10.1016/bs.armc.2020.05.001","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.armc.2020.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54061376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Fundamentals of G-quadruplex biology. g -四重体生物学基础。
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-01-01 Epub Date: 2020-07-30 DOI: 10.1016/bs.armc.2020.06.004
F Brad Johnson
{"title":"Fundamentals of G-quadruplex biology.","authors":"F Brad Johnson","doi":"10.1016/bs.armc.2020.06.004","DOIUrl":"10.1016/bs.armc.2020.06.004","url":null,"abstract":"<p><p>Several decades elapsed between the first descriptions of G-quadruplex nucleic acid structures (G4s) assembled <i>in vitro</i> and the emergence of experimental findings indicating that such structures can form and function in living systems. A large body of evidence now supports roles for G4s in many aspects of nucleic acid biology, spanning processes from transcription and chromatin structure, mRNA processing, protein translation, DNA replication and genome stability, and telomere and mitochondrial function. Nonetheless, it must be acknowledged that some of this evidence is tentative, which is not surprising given the technical challenges associated with demonstrating G4s in biology. Here I provide an overview of evidence for G4 biology, focusing particularly on the many potential pitfalls that can be encountered in its investigation, and briefly discuss some of broader biological processes that may be impacted by G4s including cancer.</p>","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"54 ","pages":"3-44"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.armc.2020.06.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38298275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Hepatoprotective natural products 保护肝脏的天然产品
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-01-01 DOI: 10.1016/bs.armc.2020.06.003
S. C. Bachar, R. Bachar, K. Jannat, R. Jahan, M. Rahmatullah
{"title":"Hepatoprotective natural products","authors":"S. C. Bachar, R. Bachar, K. Jannat, R. Jahan, M. Rahmatullah","doi":"10.1016/bs.armc.2020.06.003","DOIUrl":"https://doi.org/10.1016/bs.armc.2020.06.003","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.armc.2020.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54061788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medicinal Natural Products: A Disease-Focused Approach 天然药物:以疾病为中心的方法
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-01-01 DOI: 10.1016/s0065-7743(20)x0003-0
{"title":"Medicinal Natural Products: A Disease-Focused Approach","authors":"","doi":"10.1016/s0065-7743(20)x0003-0","DOIUrl":"https://doi.org/10.1016/s0065-7743(20)x0003-0","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55791578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Copyright 版权
4区 化学
Annual Reports in Medicinal Chemistry Pub Date : 2020-01-01 DOI: 10.1016/s0065-7743(20)30057-9
{"title":"Copyright","authors":"","doi":"10.1016/s0065-7743(20)30057-9","DOIUrl":"https://doi.org/10.1016/s0065-7743(20)30057-9","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-7743(20)30057-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55791538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信