Molecular urology最新文献_第6页

Abarelix Depot, a GnRH antagonist, v LHRH superagonists in prostate cancer: differential effects on follicle-stimulating hormone. Abarelix Depot study group. Abarelix Depot，一种GnRH拮抗剂，与LHRH超级激动剂在前列腺癌中的作用:促卵泡激素的不同作用。阿巴雷利克斯仓库研究小组。

Molecular urology Pub Date : 2000-01-01

M B Garnick, M Campion

{"title":"Abarelix Depot, a GnRH antagonist, v LHRH superagonists in prostate cancer: differential effects on follicle-stimulating hormone. Abarelix Depot study group.","authors":"M B Garnick, M Campion","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: A Phase II clinical study contrasted the endocrinologic and biochemical efficacy of Abarelix Depot, a gonadotropin-releasing hormone (GnRH) antagonist, with luteinizing hormone releasing-hormone (LHRH) superagonists, with or without additional antiandrogens, in men with prostate cancer.Methods: This study was open-label and treated 242 men. Abarelix Depot 100 mg was administered by intramuscular injection to 209 men, and LHRH, with or without an antiandrogen, was administered to 33 men according to the formulation used. Serum concentrations of follicle-stimulating hormone (FSH) and other hormones were measured at baseline and at specified time points for the first 85 days of the study. Median serum concentrations of FSH at baseline were similar for the two treatment groups.Results: Men treated with LHRH superagonists, with or without an antiandrogen, had a surge in the serum concentration of FSH on day 2 before FSH concentrations started to decline. Men in the Abarelix Depot group had an immediate and sustained decrease in the serum concentration of FSH.Conclusion: Recent data suggest that FSH may be an independent growth factor for prostate cancer. The Abarelix Depot-induced decreased in FSH may have a role in the treatment of men with endocrine- responsive disease or for those men whose disease has escaped from hormone sensitivity.","PeriodicalId":80296,"journal":{"name":"Molecular urology","volume":"4 3","pages":"275-7"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21890489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). β -葡聚糖(舞茸多糖)诱导人前列腺癌细胞凋亡的研究。

Molecular urology Pub Date : 2000-01-01

S A Fullerton, A A Samadi, D G Tortorelis, M S Choudhury, C Mallouh, H Tazaki, S Konno

{"title":"Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide).","authors":"S A Fullerton, A A Samadi, D G Tortorelis, M S Choudhury, C Mallouh, H Tazaki, S Konno","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To explore more effective treatment for hormone-refractory prostate cancer, we investigated the potential antitumor effect of beta-glucan, a polysaccharide of the Maitake mushroom, on prostatic cancer cells in vitro.Materials and methods: Human prostate cancer PC-3 cells were treated with various concentrations of the highly purified beta-glucan preparation Grifron-D(R) (GD), and viability was determined at 24 h. Lipid peroxidation (LPO) assay and in situ hybridization (ISH) were performed to unravel the antitumor mechanism of GD.Results: A dose-response study showed that almost complete (>95%) cell death was attained in 24 h with GD > or = 480 microg/mL. Combinations of GD in a concentration as low as 30 to 60 microg/mL with 200 microM vitamin C were as effective as GD alone at 480 microg/mL, inducing >90% cytotoxic cell death. Simultaneous use with various anticancer drugs showed little potentiation of their efficacy except for the carmustine/GD combination (approximately 90% reduction in cell viability). The significantly (twofold) elevated LPO level and positive ISH staining of GD-treated cells indicated oxidative membrane damage resulting in apoptotic cell death.Conclusion: A bioactive beta-glucan from the Maitake mushroom has a cytotoxic effect, presumably through oxidative stress, on prostatic cancer cells in vitro, leading to apoptosis. Potentiation of GD action by vitamin C and the chemosensitizing effect of GD on carmustine may also have clinical implications. Therefore, this unique mushroom polysaccharide may have great a potential as an alternative therapeutic modality for prostate cancer.","PeriodicalId":80296,"journal":{"name":"Molecular urology","volume":"4 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21694789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and molecular biology of early prostatic neoplasia. 早期前列腺肿瘤的流行病学和分子生物学。

Molecular urology Pub Date : 2000-01-01

W A Sakr, C Ward, D J Grignon, G P Haas

引用次数: 0

Three-dimensional ultrasound analyses of the prostate. 前列腺三维超声分析。

Molecular urology Pub Date : 2000-01-01

E J Feleppa, W R Fair, T Liu, A Kalisz, K C Balaji, C R Porter, H Tsai, V Reuter, W Gnadt, M J Miltner

{"title":"Three-dimensional ultrasound analyses of the prostate.","authors":"E J Feleppa, W R Fair, T Liu, A Kalisz, K C Balaji, C R Porter, H Tsai, V Reuter, W Gnadt, M J Miltner","doi":"","DOIUrl":"","url":null,"abstract":"Although conventional ultrasonography has proven to be clinically useful for depicting many types of cancerous lesions, it cannot distinguish reliably between cancerous and noncancerous tissue of the prostate. Therefore, conventional transrectal ultrasonography (TRUS) is used primarily for general evaluations of the gland and for guiding biopsies based on clearly imaged anatomic features such as the capsule, seminal vesicles, and urethra. Spectrum analysis extracts ultrasound signal parameters associated with biopsy-proven tissue types, and these parameters are then classified using neural network tools such as learning vector quantization, radial basis, and multilayer perceptron algorithms. Classification of cancerous and noncancerous prostate tissue using neural networks produces receiver operating characteristic (ROC) curves of 0.87 +/- 0.04 compared with 0.64 +/- 0.04 for conventional ultrasonography. To image the prostate using these methods, parameter values are computed at each pixel location, then translated into a score for the likelihood of cancer using a look-up table generated using the best classification algorithm. The score for cancer likelihood is expressed as a gray-scale or color value, and the resulting image may be useful to guide biopsies or therapy. Changes in parameter or score values over time potentially can be used to assess progression of disease or efficacy of therapy.","PeriodicalId":80296,"journal":{"name":"Molecular urology","volume":"4 3","pages":"133-9;discussion 141"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21889342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of antisense technology to urologic cancers. 反义技术在泌尿系统肿瘤中的应用。

Molecular urology Pub Date : 2000-01-01 DOI: 10.1089/10915360050138594

Y. Tomita

引用次数: 0

Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy. 局部治疗后前列腺癌生化复发的激素治疗选择。

Molecular urology Pub Date : 2000-01-01

J W Moul

引用次数: 0

High-intensity focused ultrasound: complications and adverse events. 高强度聚焦超声:并发症和不良事件。

Molecular urology Pub Date : 2000-01-01

S Thüroff, C Chaussy

{"title":"High-intensity focused ultrasound: complications and adverse events.","authors":"S Thüroff, C Chaussy","doi":"","DOIUrl":"","url":null,"abstract":"Background: Transrectal high-intensity focused ultrasound (HIFU) is under investigation as a minimally invasive therapeutic option for elderly men with prostatic cancer.Methods: From November 1996 to April 1999, 315 HIFU treatments with the Ablatherm (EDAP/TMS) were performed. A questionnaire including 50 theoretically possible adverse events was developed. Every patient complaint was recorded, including the physician's and patient's assessment, before and after therapy. Start date, end date, and period of every complaint were analyzed.Results: As major adverse events after primary HIFU, there were six cases of stress incontinence grade 1. After repeat treatments with HIFU, rectourethral fistulas occurred in five patients, stress incontinence grade 1 in eight, and, after additive transurethral resection, grade 2 in one and grade 3 in two patients. Post-HIFU rectal mucosa burn decreased from 15% in 1996 to 0 within the last year. In all treatments, obstruction was avoided by suprapubic urinary diversion. Urinary tract infections (UTIs) were recorded initially in 58% of patients but later in only 8%.Conclusion: Transrectal HIFU proved to be a secure, minimally invasive therapeutic option for elderly men to avoid hormonal ablation or to postpone its first use.","PeriodicalId":80296,"journal":{"name":"Molecular urology","volume":"4 3","pages":"183-7;discussion 189"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21889237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicide gene therapy for urogenital cancer: current outcome and prospects. 自杀基因治疗泌尿生殖系统癌:目前的结果和前景。

Molecular urology Pub Date : 2000-01-01 DOI: 10.1089/10915360050138611

Y. Nasu, N. Kusaka, T. Saika, T. Tsushima, H. Kumon

引用次数: 22

Magnetic resonance spectroscopic studies of the prostate. 前列腺的磁共振光谱研究。

Molecular urology Pub Date : 2000-01-01

J A Koutcher, K Zakian, H Hricak

引用次数: 0

Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy. 结合前列腺特异性膜抗原作为治疗靶点的发展策略概述。

Molecular urology Pub Date : 2000-01-01

M C Gong, S S Chang, F Watt, D S O'Keefe, D J Bacich, A Uchida, N H Bander, V E Reuter, P B Gaudin, P L Molloy, M Sadelian, W D Heston

引用次数: 0