发布求助
文献互助 智能选刊 最新文献

Antioxidants - Benefits, Sources, Mechanisms of Action最新文献

筛选
英文 中文
Biosynthesis and Regulation of Antioxidant Flavonolignans in Milk Thistle 水飞蓟抗氧化剂黄酮木质素的生物合成及调控
Antioxidants - Benefits, Sources, Mechanisms of Action Pub Date : 2021-09-08 DOI: 10.5772/intechopen.96783
Samantha Drouet, Christophe Hano
{"title":"Biosynthesis and Regulation of Antioxidant Flavonolignans in Milk Thistle","authors":"Samantha Drouet, Christophe Hano","doi":"10.5772/intechopen.96783","DOIUrl":"https://doi.org/10.5772/intechopen.96783","url":null,"abstract":"Mature fruits (achenes) of milk thistle (Silybum marianum (L.) Gaertner, Asteraceae) accumulate high amounts of silymarin, a complex mixture of bioactive antioxidant flavonolignans deriving from taxifolin. Their biological activities in relation with human health promotion and disease prevention have been well described. The conditions of their biosynthesis in planta, however, have long been elusive and thus tend to be a limiting factor for their future applications. Significant advances in understanding their biosynthesis and regulation have been made over the last decade and are outlined in the current chapter.","PeriodicalId":8028,"journal":{"name":"Antioxidants - Benefits, Sources, Mechanisms of Action","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89743927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Endogenous Enzymatic Antioxidant Defense and Pathologies 内源性酶抗氧化防御和病理
Antioxidants - Benefits, Sources, Mechanisms of Action Pub Date : 2021-01-21 DOI: 10.5772/INTECHOPEN.95504
A. Eddaikra, N. Eddaikra
{"title":"Endogenous Enzymatic Antioxidant Defense and Pathologies","authors":"A. Eddaikra, N. Eddaikra","doi":"10.5772/INTECHOPEN.95504","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95504","url":null,"abstract":"Oxidative stress is an important component of various diseases. It manifests as an imbalance caused by an excessive production of reactive oxygen species (ROS) which are associated with a deficit of antioxidant activity. This deficit can be the consequence of genetic factors, environmental ones, metabolic imbalance, toxicity or direct attacks by the accumulation of free radicals. These can induce metabolic dysfunction affecting biological macromolecules in their structures or activities. From a physiological perspective, the neutralization of free radicals is ensured by enzymatic, antioxidant and non-enzymatic defense systems. In the present chapter, we will focus on the endogenous enzymatic antioxidant defense system such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPxs), thioredoxin (Trx) and paraxonase which play an important role in homeostatic redox balance. Also, we will review this set of antioxidants enzymes within different pathological states such as diabetes, cancer, autoimmune diseases, cardiovascular, Alzheimer’s, Parkinson’s or parasitic diseases such as Leishmaniasis and Malaria.","PeriodicalId":8028,"journal":{"name":"Antioxidants - Benefits, Sources, Mechanisms of Action","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80807850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
An Antioxidant Defense System in Radiation-Resistant Bacterium Deinococcus geothermalis against Oxidative Stress 耐辐射地热球菌抗氧化应激的抗氧化防御系统
Antioxidants - Benefits, Sources, Mechanisms of Action Pub Date : 2021-01-19 DOI: 10.5772/INTECHOPEN.95658
Chanjae Lee, Min K. Bae, Sung-Jae Lee
{"title":"An Antioxidant Defense System in Radiation-Resistant Bacterium Deinococcus geothermalis against Oxidative Stress","authors":"Chanjae Lee, Min K. Bae, Sung-Jae Lee","doi":"10.5772/INTECHOPEN.95658","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95658","url":null,"abstract":"A radiation-resistant bacterium, Deinococcus geothermalis has various stress response mechanisms, including antioxidation. Features that maintain vitality at high radiation doses include the following: enzymatic scavengers of ROS such as catalase, SOD, and peroxidase; strain-specific DNA repair systems such as Deinococcal unique proteins; non-enzymatic responses such as manganese complexes, carotenoids, and DNA-binding proteins. This chapter summarizes the primary response mechanism by redox balance centered on the cystine transporter. It also reviews action characteristics of DNA-binding protein Dps and a putative LysR family protein, and effects on loss of function of the carotenoid biosynthesis genes by transposition of insertion sequences. Environmental adaptation and molecular evolution of radiation-resistant bacterium are also considered to explain the potentials of molecular behavior induced by oxidative stress.","PeriodicalId":8028,"journal":{"name":"Antioxidants - Benefits, Sources, Mechanisms of Action","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78739936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evolutionary Strategies of Highly Functional Catalases for Adaptation to High H2O2 Environments 高功能过氧化氢酶适应高H2O2环境的进化策略
Antioxidants - Benefits, Sources, Mechanisms of Action Pub Date : 2021-01-11 DOI: 10.5772/INTECHOPEN.95489
I. Yumoto, Yoshiko Hanaoka, Isao Hara
{"title":"Evolutionary Strategies of Highly Functional Catalases for Adaptation to High H2O2 Environments","authors":"I. Yumoto, Yoshiko Hanaoka, Isao Hara","doi":"10.5772/INTECHOPEN.95489","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95489","url":null,"abstract":"Enzymatic evolutionary strategies for adaptation to a high H2O2 environment have been evaluated using catalases with high catalytic efficiency isolated from two H2O2-tolerant bacteria, Exiguobacterium oxidotolerans and Psychrobacter piscatori. The entrance size of the narrow main channel in catalase has been estimated by determining the formation rate of the intermediate state of peracetic acid (b), which is a larger substrate than H2O2 versus that of catalase activity with H2O2 (a) (calculated as b/a). The ratio of b/a in E. oxidotolerans catalase (EKTA) is much higher than that of P. piscatori catalase (PKTA). To elucidate the structural differences between the catalases, the amino acids present in the main channel have been compared between the two catalases and other catalases in the database. The combination of amino acid residues, which contribute high catalytic efficiency in the narrow main channel of EKTA were different from those in PKTA. In this review, we discuss strategic differences in the elimination of high concentration of H2O2 owing to differences in the phylogenetic positions of catalases. In addition, we describe the relationships between the environmental distributions of genera involved in H2O2-resistant bacteria and their catalase functions based on the main channel structure of catalase.","PeriodicalId":8028,"journal":{"name":"Antioxidants - Benefits, Sources, Mechanisms of Action","volume":"603 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77412451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信