Clinical positron imaging : official journal of the Institute for Clinical P.E.T最新文献_第5页

16. FDG-PET in the Detection of Recurrence in Colorectal Cancer Based on Rising CEA Level. Experience in 72 Patients 16. 基于CEA升高的FDG-PET检测结直肠癌复发。72例体会

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00082-0

Maldonado A , Sancho F , Cerdan J , Lozano A , Mohedano N , Jiménez J , Moya F , Zomeño M

{"title":"16. FDG-PET in the Detection of Recurrence in Colorectal Cancer Based on Rising CEA Level. Experience in 72 Patients","authors":"Maldonado A , Sancho F , Cerdan J , Lozano A , Mohedano N , Jiménez J , Moya F , Zomeño M","doi":"10.1016/S1095-0397(00)00082-0","DOIUrl":"10.1016/S1095-0397(00)00082-0","url":null,"abstract":"<div>Purpose: A rising CEA level after the resection of colorectal cancer is an early indicator of tumour recurrence. However, conventional imaging techniques have limited sensitivity for detecting recurrent disease in such patients. Our group has evaluated the role of Positron Emission Tomography with 18F-Fluorodeoxiglucose (FDG-PET) in this clinical situation.Material and Methods: Seventy-two patients with abnormal CEA levels and normal results of conventional methods of tumour detection were studied with FDG-PET. The PET results were compared with pathologic findings (n = 25) long-term radiological (n = 9) and clinical follow-up (n = 38). Influence of PET findings in therapeutic management was also considered in this study.Results: PET detected lesions in 63/72 patients (87.1%). Metabolic imaging showed metastases in the liver (44.1%), ganglionar nodes (27.5%), local recurrence (20.4%) and lung metastases (8%). Overall, the sensitivity of PET was 94.4%, specificity was 83.3%, the positive-predictive value was 97.1%, the negative-predictive value was 71.4% and the diagnostic accuracy was 92.8%. FDG-PET findings change therapeutic decision in 68/72 patients (94.1%)Conclusion: When conventional examinations are normal, FDG-PET is a valuable imaging tool in patients who have rising CEA level after colorectal surgery. Metabolic imaging represents a very cost-effectiveness diagnostic procedure in this clinical situation, avoiding unnecessary invasive techniques.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 170"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00082-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87003706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Metastases from Unknown Primary Tumor 未知原发肿瘤转移

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00053-4

Max Lonneux MD, Abdel-Malek Reffad MD

引用次数: 37

30. Follow-up of Patients with Single Pulmonary Nodules and Negative 18F-Fluorodeoxyglucose Positron Emission Tomography Scans 30.单发肺结节及18f -氟脱氧葡萄糖正电子发射断层扫描阴性患者的随访

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00096-0

Abou-Zied M, Zubeldia JM, Nabi HA

{"title":"30. Follow-up of Patients with Single Pulmonary Nodules and Negative 18F-Fluorodeoxyglucose Positron Emission Tomography Scans","authors":"Abou-Zied M, Zubeldia JM, Nabi HA","doi":"10.1016/S1095-0397(00)00096-0","DOIUrl":"10.1016/S1095-0397(00)00096-0","url":null,"abstract":"<div>Purpose: Positron Emission Tomography with 18F-Fluorodeoxyglucose (18FDG-PET) is becoming the noninvasive test of choice to evaluate patients with single pulmonary nodules (SPN). While positive scans yield a high sensitivity for malignancy, the significance of negative scans remains unclear. The purpose of this study was to evaluate the prognostic value of negative 18FDG-PET in patients with SPN.Methods: From January 1998 to January 2000, 59 patients with non-calcified parenchymal SPN underwent 18FDG-PET evaluations. From a total of 14 pathologically proven tumors 12 patients had positive 18FDG-PET scans (sensitivity 86%, PPV 100%) with a mean SUV of 5.6. A total of 24 patients (41%) with negative 18FDG-PET scans were followed up with serial chest x-ray (CXR) and/or Computed tomography (CT) for a period of 6 to 24 months (mean 10.4 months). Histology specimens were available in 5 patients. Two patients had a second PET scan.Results: Nineteen of the 24 negative 18FDG-PET patients (79.2%) had no evidence of intrathoracic neoplasia at subsequent follow up by CT and/or CXR, for an overall NPV of 86.3%. Two patients (8.3%) had transthoracic needle biopsies that were positive for malignancy after the PET scan. The remaining 3 patients developed intrathoracic malignancies during the follow up period (6, 6, and 9 months respectively) by CT and/or CXR. Repeat 18FDG-PET scans were positive in 2 patients.Conclusion: 18FDG-PET appears to effectively characterize patients at low risk for malignant transformation of SPN discovered by CT. Blinded, randomized controlled trials are needed for further evaluation.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 184"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00096-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79381669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

4. Preliminary Findings of a Prospective Study of FDG-PET in Patients with Possible Lung Cancer 4. FDG-PET在可能肺癌患者中的前瞻性研究的初步结果

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00070-4

Mortensen J, Enevoldsen H, Friberg L, Backer V, Olesen K, Eigtved A, Ottorai P, Hansen H, Clementsen P, Nybo B, Nielsen HW, Brenø J

{"title":"4. Preliminary Findings of a Prospective Study of FDG-PET in Patients with Possible Lung Cancer","authors":"Mortensen J, Enevoldsen H, Friberg L, Backer V, Olesen K, Eigtved A, Ottorai P, Hansen H, Clementsen P, Nybo B, Nielsen HW, Brenø J","doi":"10.1016/S1095-0397(00)00070-4","DOIUrl":"10.1016/S1095-0397(00)00070-4","url":null,"abstract":"<div>Purpose: To examine the value of PET in diagnosis and staging of suspected lung cancer.Methods: 20 (13 male; mean age: 56 yr., range: 22-83 yr.) patients with chest X-ray findings suspicious of malignancy were staged a) “clinically” (X-ray, history/physical examination, lung function), b) by chest CT of thorax/upper abdomen, and c) by whole-body PET (GE Advance, visual analysis). The CT and PET studies were performed within 2 weeks of admission and read blinded to all information except the chest X-ray report. The decision to refer to mediastinoscopy/thoracotomy was made by a tumor board using clinical information, CT and PET findings. In principle, suspected metastatic lesions were biopsied before surgery. The gold standard was histology from biopsy or thoracotomy, or resolution of the X-ray findings and symptoms.Results: One patient was excluded because of uncertain diagnosis. In 3 (15%) patients surgery was avoided mainly because of the PET findings. In one SCLC patient and one lymphoma patient, PET showed extensive disease, which changed the chemotherapy regime. Accuracy was 83% for clinical stage, 79% for CT and 77% for PET. Four (20%) false positive PET findings were caused by granuloma, pneumonia and BOOP. These nodules were only 1 to <3 cm, while malignant nodules were 2-8 cm. There were no false negative PET or CT studies.Conclusion: FDG-PET is valuable in patients suspected for pulmonary malignancy, since thoracotomy was avoided in 15% of patients and in 10% of patients more extensive disease was found which changed the chemotherapy regime.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 158"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00070-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87741446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

23. Improving Reproducibility of SUV by FDG Dose Adjusted for Body Size and Serum Glucose Level 23. 根据体型和血糖水平调整FDG剂量提高SUV的再现性

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00089-3

Yeung , Dwc , Yeung , Myf , Chan Ho GCL

{"title":"23. Improving Reproducibility of SUV by FDG Dose Adjusted for Body Size and Serum Glucose Level","authors":"Yeung , Dwc , Yeung , Myf , Chan Ho GCL","doi":"10.1016/S1095-0397(00)00089-3","DOIUrl":"10.1016/S1095-0397(00)00089-3","url":null,"abstract":"<div>Purpose: The study evaluates whether adjusting the dose of FDG injected by the patient's body surface area and the serum glucose level will produce a SUV with less standard error.Methods: The study is a prospective study. For the period of 4/1999–5/1999, the patient received various dose of FDG as available from radiopharmacy. The Standardized Uptake Value Maximum (SUVmax) and Standardized Uptake Value Average (SUVavg) of the liver were calculated for PET scans at 40-50 minutes after injection. This is the control group. For the period of 6/1999–10/1999, the patients receiving a standard dose of FDG normalized by adjusting 15 mCi. per 1.73 sq.m. body surface area (BSA) and a proportional adjustment factor for serum glucose (serum glucose level / 5 mMol.). BSA is calculated by the formula = 0.007184 × (cm. height)0.725 × (kg. weight)0.425. The SUVmax and SUVavg of the liver at 40-50 minutes after injection. This is the study group.Results and Conclusion: There are 29 subjects in the control group (CG) and 32 subjects in the study group (SG). Dose of FDG given ranges from 7.8–15 mCi in the CG, to 15.5–16.5 mCi in the SG. In the CG, liver SUVmax = (2.3 +/− s.d.0.37), SUVavg = (1.72 +/− s.d. 0.38). In the SG, liver SUVmax = (2.13 +/− s.d. 0.26), SUVavg = (1.88 +/− 0.22). The study shows that the liver SUVmax and SUVavg has a 42%, 72% respectively narrower standard deviation when the dose is adjusted for patient's body surface area and serum glucose level. This implies that such approach gives a more reproducible measurement of SUVmax and SUVavg in assessing tumor lesion.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 177"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00089-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80847103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

2. Diagnostic Utility of FDG-PET in the Clinical Management of Patients with Suspected Recurrent Pancreatic Carcinoma after Whipple Procedure 2. FDG-PET在惠普尔手术后疑似复发胰腺癌患者临床诊断中的应用

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00068-6

Jadvar H, Fischman AJ

{"title":"2. Diagnostic Utility of FDG-PET in the Clinical Management of Patients with Suspected Recurrent Pancreatic Carcinoma after Whipple Procedure","authors":"Jadvar H, Fischman AJ","doi":"10.1016/S1095-0397(00)00068-6","DOIUrl":"10.1016/S1095-0397(00)00068-6","url":null,"abstract":"<div>Purpose: We evaluated the usefulness of FDG-PET in the assessment of patients with suspected pancreatic carcinoma who have previously undergone a Whipple procedure.Methods and Materials: Attenuation-corrected FDG-PET was performed in 11 patients (5 males, 6 females, age range 52–76 years), with suspected recurrent pancreatic carcinoma after Whipple procedure. Recurrence was suspected based on clinical, laboratory (CA19-9 serum tumor marker level), or abdominal CT findings. Diagnostic validation was by histology in 2 patients and radiologic or clinical follow-up (5 to 48 months) in 9 patients. Changes in therapeutic management that were prompted by PET were tabulated.Results: PET was concordant with the findings of abdominal CT in 7 patients (6 true-positive, 1 true-negative). PET detected unsuspected lung lesions in 1 of these patients that was subsequently confirmed by a chest CT. PET was discordant with abdominal CT in 4 patients. PET detected tumor recurrence in 3 of 4 patients in this group (27% of total) who had non-diagnostic CT and elevated CA19-9 serology. Chemotherapy was initiated in 2 of these 3 patients (18% of total), while the other patient died shortly after the PET study from pneumonia and recurrent tumor was confirmed at autopsy. The remaining 1 of 4 patients in the discordant group had a false-positive PET study due to relatively high FDG localization in a displaced loop of bowel.Conclusion: PET is useful in localizing the tumor in post-Whipple patients with suspected recurrent pancreatic carcinoma and can impact their clinical management.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 156"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00068-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87431118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

9:30—9:45 9:30—9:45

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00065-0

Mullani NA, Herbst RS, Abbruzzese JL, Barron B, Lamki L, Charnsangavej C, Kim E, Tran HT, Jiwani A, Gould KL

{"title":"9:30—9:45","authors":"Mullani NA, Herbst RS, Abbruzzese JL, Barron B, Lamki L, Charnsangavej C, Kim E, Tran HT, Jiwani A, Gould KL","doi":"10.1016/S1095-0397(00)00065-0","DOIUrl":"10.1016/S1095-0397(00)00065-0","url":null,"abstract":"<div>The purpose of this study was to determine if the first-pass of FDG can be used to measure regional blood flow in tumors in the absence of perfusion imaging with a known blood flow tracer.PET scans were obtained in patients being evaluated for tumor perfusion and metabolism in a Phase I dose escalating protocol for Endostatin, a novel antiangiogenic agent. A two minutes perfusion scan was done with a bolus injection of 60 mCi of O-15 labeled water followed by a 10 mCi dose of FDG and four sequential scans consisting of a first pass two minutes scan and three 15 minutes scans. Regions of interest were drawn on two tumor sites for each scan. Blood flow was computed using a one-compartment model previously published by the authors. Linear regression analysis was carried out between the first pass FDG measured blood flow and O-15 measured blood flow (Figure 1)<figure><img><ol><li>Download : Download high-res image (49KB)</li><li>Download : Download full-size image</li></ol>Figure 1. </figure>.Blood flow estimated from the first pass of FDG was linearly correlated with O-15 measured blood flow with an intercept of 0.01, slope of 0.86, and r squared regression coefficient of 0.74 (R = 0.86) for blood flow values of up to 0.6 ml/min/gm of tissue. These results suggests that in the absence of a perfusion tracer, the first pass of FDG provides an estimate of perfusion in a tumor within the limitations of incomplete extraction of FDG compared to O-15 water.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 153"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00065-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85505816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

19. Correlation between FDG PET data and EEG dipole modeling 19. FDG PET数据与EEG偶极子模型的相关性研究

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00085-6

Pozo MA , Pascau J , Rojo P , Maldonado A , Gonzalez FJ , Desco M , Sola RG

{"title":"19. Correlation between FDG PET data and EEG dipole modeling","authors":"Pozo MA , Pascau J , Rojo P , Maldonado A , Gonzalez FJ , Desco M , Sola RG","doi":"10.1016/S1095-0397(00)00085-6","DOIUrl":"10.1016/S1095-0397(00)00085-6","url":null,"abstract":"<div>Purpose: FDG-PET images and EEG dipole modelling were used to localization of interictal epileptogenic foci. A multimodality approach with the analysis of FDG-PET images, EEG dipoles and anatomical images (MRI) were applied to patients with drug-resistant epilepsy.Methods: Source location was determined using Brain Electromagnetic Source Analysis (BESA) program. The dipole location provided by BESA was then transformed into PET co-ordinates using the patient's MRI previously registered with the PET image. As a difference with other methods, no external markers are necessary.Results: The study group includes ten drug-resistant epileptic patients. FDG hypometabolism was found in all patients. Abnormalities in glucose uptake were always ipsilateral to the EEG dipole. However, quantitative analysis of FDG-PET within hypometabolic areas showed no significant correlation between decrease glucose uptake and location of EEG-dipole source. The comparison of the results using both methods shows that the dipole location matches the FDG-PET hypometabolic area for all the patients. Combining the spatial localization on FDG-PET with the temporal accuracy of EEG dipole source aids in the exact localization of the epileptogenic focus.Conclusion: As a conclusion, the results show that projection of EEG dipole data onto FDG-PET may play a key role in the indication of surgery for the treatment of drug-resistant epileptic patients, provided it is simple and easy to perform.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 173"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00085-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72420274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

7. Survey of Results of Whole Body Imaging Using the PET/CT at the University of Pittsburgh Medical Center PET Facility 7. 匹兹堡大学医学中心PET设施PET/CT全身成像结果调查

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00073-X

MA Martinelli, D Townsend, CC Meltzer, V Villemagne

{"title":"7. Survey of Results of Whole Body Imaging Using the PET/CT at the University of Pittsburgh Medical Center PET Facility","authors":"MA Martinelli, D Townsend, CC Meltzer, V Villemagne","doi":"10.1016/S1095-0397(00)00073-X","DOIUrl":"10.1016/S1095-0397(00)00073-X","url":null,"abstract":"<div>Purpose: At the University Of Pittsburgh Medical Center, over 100 oncology studies have been performed using a combined PET/CT scanner. The scanner is a prototype, which combines clinical PET and clinical CT imaging in a single unit. The sensitivity achieved using three-dimensional PET imaging as well as the use of the CT for attenuation correction and image fusion make the device ideal for clinical oncology. Clinical indications imaged on the PET/CT scanner include, but are not limited to, tumor staging, solitary pulmonary nodule evaluation, and evaluation of tumor reoccurrence in melanoma, lymphoma, colorectal cancer, lung cancer, pancreatic cancer, head and neck cancer, and renal cancer.Methods: For all studies, seven millicuries of F18-fluorodeoxyglucose is injected and a forty-five minute uptake period is allowed prior to positioning the patient in the scanner. A helical CT scan is acquired over the region, or regions of interest followed by a multi-bed whole body PET scan for the same axial extent. The CT scan is used to correct the PET data for attenuation. The entire imaging session lasts 1–1.5 hours depending on the number of beds acquired, and is generally well tolerated by the patient.Results and Conclusion: Based on our experience in over 100 studies, combined PET/CT imaging offers significant advantages, including more accurate localization of focal uptake, distinction of pathology from normal physiological uptake, and improvements in evaluating therapy. These benefits will be illustrated with a number of representative, fully documented studies.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 161"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00073-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73311321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

14. FDG CDET (2D Dual-Head Coincidence Gamma Camera) in the Primary Staging of Oesophageal Cancer 14. FDG - CDET (2D双头重合伽马照相机)在食管癌初级分期中的应用

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI: 10.1016/S1095-0397(00)00080-7

F. Montravers , D. Grahek , K. Kerrou , V. de Beco , N. Younsi , A. Barrier , S. Houry , F. Lacaine , M. Huguier , J.N. Talbot

{"title":"14. FDG CDET (2D Dual-Head Coincidence Gamma Camera) in the Primary Staging of Oesophageal Cancer","authors":"F. Montravers , D. Grahek , K. Kerrou , V. de Beco , N. Younsi , A. Barrier , S. Houry , F. Lacaine , M. Huguier , J.N. Talbot","doi":"10.1016/S1095-0397(00)00080-7","DOIUrl":"10.1016/S1095-0397(00)00080-7","url":null,"abstract":"<div>Purpose: The aim of this study was to evaluate the role of FDG-CDET for the detection of primary oesophageal tumour, lymph node involvement and distant extension before surgery.Methods and patients: In patients fasting for 6h or more, 150-250 MBq of 18F-FDG were injected i.v. and 2D imaging (whole-body scan and at least a tomoscintigram) was started 45 min. later, using a PICKER gamma camera. We studied 14 patients (pts). All of them were operated on (mean time between FDG and surgery: 5.4 ± 3.8 days) and staging results were correlated with post surgical histology.Results: The primary lesion took up FDG in all cases but one (FN in a 5 mm lesion). The primary NM staging of these 14 pts was negative with FDG-CDET in 7 cases (4 TN and 3 FN corresponding to an invasion of satellite lymph nodes in 2 cases and to a metastatic infracentimetric subdiaphragmatic lymph node in one case) and positive in 7 cases (7 TP corresponding to 10 foci), revealing in 4 cases a sub-diaphragmatic lymph node extension unknown prior to FDG-CDET. One pt referred for characterisation of an oesophageal lesion (failure of multiple biopsies) had an intense focus of FDG uptake in this area (TP confirmed by surgery). The overall sensitivity was 13/14 = 93% on a per patient basis and 21/25 = 84% on a per lesion basis. Specificity on a per lesion basis was 5/5 = 100%.Conclusion: These first results, obtained in an indication of FDG not frequently evaluated even with dedicated PET systems, seem very promising, the oesophageal neoplastic lesions appearing to take up FDG with a high intensity.</div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 168"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00080-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77486634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1