Metastases from Unknown Primary Tumor

Clinical positron imaging : official journal of the Institute for Clinical P.E.T Pub Date : 2000-07-01 DOI:10.1016/S1095-0397(00)00053-4

Max Lonneux MD, Abdel-Malek Reffad MD

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引用次数: 37

Abstract

Purpose: To analyze the efficacy and impact on management of PET-FDG in patients with metastases from unknown primary tumor.

Procedures: Retrospective analysis of 24 patients referred to the PET center for metastasis of unknown primary after a negative imaging workup. PET results were validated by means of oriented imaging, follow-up or biopsy when ethically justified.

Results: PET identified the primary tumor in 13/24 (54%) of patients: breast (n = 1), lung (n = 9), colon (n = 1), stomach (n = 1) and mouth (n = 1). The false positive rate of PET was 21% (5/24). PET was shown to affect the management of 10/24 patients (42%).

Conclusion: Whole body PET-FDG was more effective than conventional imaging methods in detecting unknown primary tumors. PET altered patient management in 42% of cases. PET should be performed prior to other investigations in such patients and could avoid unnecessary and often unfruitful diagnostic procedures.

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未知原发肿瘤转移

目的:分析PET-FDG在不明原发肿瘤转移患者治疗中的疗效及影响。方法:回顾性分析24例在影像学检查为阴性后因未知原发转移而转诊到PET中心的患者。PET结果通过定向成像、随访或活检等方法进行验证。结果PET检出原发肿瘤13/24(54%)，分别为乳腺(n = 1)、肺(n = 9)、结肠(n = 1)、胃(n = 1)、口腔(n = 1)， PET假阳性率为21%(5/24)。PET对10/24例(42%)患者的治疗有影响。结论:全身PET-FDG对未知原发肿瘤的检测效果优于常规影像学检查。PET改变了42%病例的患者管理。PET应在此类患者的其他检查之前进行，可以避免不必要且往往无效的诊断程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical positron imaging : official journal of the Institute for Clinical P.E.T

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