Clinical positron imaging : official journal of the Institute for Clinical P.E.T最新文献

{"title":"31. Clinical Application of [C-11]acetate in Oncology","authors":"R.S. Liu","doi":"10.1016/S1095-0397(00)00097-2","DOIUrl":"10.1016/S1095-0397(00)00097-2","url":null,"abstract":"<div><p><strong>Background and Purpose:</strong> [F-18]FDG has long been used for detection of the malignant tumors and assessment of the metabolic activity of the tumors. However, there are several drawbacks of FDG including hyperglycemic effect, nonspecific uptake on inflammation, sink phenomenon due to high accumulation of FDG in urinary tract, and physiologic uptake of FDG in the bowels and muscles, which may cause false positive as well as false negative results. [C-11]acetate, as a metabolic substrate of β-oxidation, precursors of amino acid, fatty acid and sterol, has been proved useful in detecting various malignancies. The aim of this study is to assess the feasibility of clinical application of [C-11]acetate in oncology.</p><p><strong>Methods:</strong> High quality whole body images could be obtained by using large dosage (20 mCi) of [C-11]acetate and modern PET scanner. In the recent years, [C-11]acetate PET studies have been performed in 513 patients with various malignancies.</p><p><strong>Results:</strong> The results showed that [C-11]acetate is more accurate in detecting meningioma (accuracy 97%), glioma (91%), nasopharyngeal cancer (93%), lymphoma (85%), non-small cell cancer (81%), colon cancer (78%), renal cell cancer (80%), ovarian cancer (76%), than in detecting small cell cancer of lung, thyroid cancer, and pancreas cancer. The advantages of [C-11]acetate are less time consuming (whole procedure completed within 45 min after injection), no hyperglycemic effect and no sink phenomenon. The disadvantages are increased uptake in salivary glands, pancreas, and sometimes the bowels, which may cause either false positive or false negative results, and on-site-cyclotron dependent.</p><p><strong>Conclusion:</strong> In summary, [C-11]acetate is clinically useful in detecting various malignant tumors clinically and may play a complementary role to FDG.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 185"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00097-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56450052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10. Positron Emission Tomography in the Presurgical Evaluation of Patients with Resectable Liver Metastases from Colorectal Carcinoma Detected by Computed Tomography with Arterial Portography","authors":"Zubeldia JM,&nbsp;Bednarczyk EM,&nbsp;Nabi HA","doi":"10.1016/S1095-0397(00)00076-5","DOIUrl":"10.1016/S1095-0397(00)00076-5","url":null,"abstract":"<div><p><strong>Purpose:</strong> To assess the cost of implementing ¹⁸F-Fluorodeoxyglucose (¹⁸FDG) PET scan in the presurgical evaluation of patients with hepatic metastases from colorectal cancer (CRC) detected by Computed Tomography with arterial portography (CTAP).</p><p><strong>Methods:</strong> We performed a cost analysis of two diagnostic pathways based on a population of CRC patients with metastatic disease limited to the liver by (CTAP). The payers' perspective was utilized. The algorithms compared ¹⁸FDG-PET with Computed Tomography (CT) versus CT alone. Patients found to have extrahepatic disease by ¹⁸FDG-PET or CT were assigned to palliative care. Patients found to be negative for extrahepatic extension were assumed to be surgically resectable. The prevalence of extrahepatic disease, true and false positives and negatives for CT and ¹⁸FDG-PET were extracted from published reports (Medline, 1991 to 1999). Three possible outcomes for surgery were considered: uncomplicated, complicated, and death. Surgical complications considered were: urinary tract infection, wound sepsis, intra-abdominal abscess, septicemia, pneumonia, deep venous thrombosis, pulmonary embolism, anemia requiring transfusion, and myocardial infarction. Complication rates, costs for CT, CTAP, ¹⁸FDG-PET, surgery and post-surgical complications were obtained from HCFA published data (1997-2000). Palliative care costs were assumed to be identical in both branches.</p><p><strong>Results:</strong> Average expected cost per patient with ¹⁸FDG-PET was $16,921, compared to $21,693 for a patient without PET scan. This represents net savings of $4,772 if PET is included in the diagnostic work up.</p><p><strong>Conclusion:</strong> Integration of ¹⁸FDG-PET in the presurgical evaluation of patients with liver metastases from CRC by CTP would substantially reduce overall costs.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 164"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00076-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84122345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"21. Increased FDG uptake in Childhood CNS Tumors is Associated with Tumor Malignancy","authors":"L. Borgwardt,&nbsp;H. Carstensen,&nbsp;K. Schmiegelow,&nbsp;L. Højgaard","doi":"10.1016/S1095-0397(00)00087-X","DOIUrl":"10.1016/S1095-0397(00)00087-X","url":null,"abstract":"<div><p><strong>Background:</strong> In adults PET scanning of CNS tumors with the tracer FDG (¹⁸F-flourodeoxyglucose) can provide information about the degree of malignancy, tumor extent, and dissemination. FDG PET can also be able to assess tumor response to therapy and to differentiate recurrence from necrosis. Although CNS tumors are the most common solid tumor in childhood, so far only few PET-studies have been reported. Pre-operative assessment of malignancy would facilitate surgical planning and the use of pre-operative chemotherapy.</p><p><strong>Materials and Methods:</strong> 21 children with CNS tumors were referred to clinical FDG PET prior to therapy (M/F = 12/9, median age: 9 (range 0-16)), (4 PNET/medulloblastomas; 1 gr. III ependymoma, 16 benign tumors)). Image processing included co-registration with MRI and image fusion. The FDG uptake in the tumors was ranked 0-5 by a hotspot/cortex-ratio by two observers independently. The FDG uptake in grey and white matter was used as reference for the grading system with FDG uptakes defined as 4 and 2 respectively.</p><p><strong>Results:</strong> 15 of 16 patients with tumors WHO gr. I-II had FDG-uptake of 1-2, and all 5 patients with tumors WHO gr. III-IV had FDG-uptake of 3-4. A WHO gr. I papilloma, known to have a high metabolism caused by high mitochondrial activity, had FDG uptake of 5. Except for this tumor, the FDG uptake was positively correlated with tumor malignancy. MRI/PET co-registration and image fusion increased the specificity of tumor location, as well as of tumor extent, and of heterogeneity (e.g., areas of necrosis).</p><p><strong>Conclusion:</strong> FDG PET with MRI/PET co-registration and image fusion could be an important adjunct in the diagnostic work up of pediatric CNS tumors, and could help define patients eligible for pre-operative chemotherapy.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 175"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00087-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79975024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8:45—90:00","authors":"Cook B,&nbsp;Cooper D,&nbsp;Fitzpatrick D,&nbsp;Smith S,&nbsp;Tierney D,&nbsp;Mehy S","doi":"10.1016/S1095-0397(00)00062-5","DOIUrl":"10.1016/S1095-0397(00)00062-5","url":null,"abstract":"<div><p><strong>Background:</strong> Cellular changes lead to coronary artery endothelial dysfunction (ED) and precede plaque formation. Clinical events, such as unstable angina and acute coronary syndromes, are common consequences of ED. Coronary artery ED, as characterized by Rb-82 PE, is a perfusion abnormality at rest, which improves following stress. In risk factor modification studies, particularly in cholesterol-lowering trials, coronary artery ED has been demonstrated to be reversible. Other studies have correlated low fat diet modification with improvement in coronary artery disease.</p><p><strong>Purpose:</strong> This study evaluates changes in myocardial perfusion following meals with low versus high TG content, and its influence on post prandial serum TG.</p><p><strong>Methods:</strong> With a randomized, double blind placebo controlled, cross over design, we investigated 19 patients (10 with ED and 9 with normal perfusion) with Rb-82 PET for myocardial blood flow at rest and with adenosine stress. PET images and serum triglycerides were obtained before and after an olestra (OA) meal (2.7g TG, 44g olestra) and a high-fat meal (46.7g TG). Meals were matched for carbohydrate, protein, and cholesterol content.</p><p><strong>Results:</strong> Myocardial perfusion (uCi/cc) increased 11 – 12% following the OA meal compared to the high-fat meal in patients with ED. For all patients combined, serum TG increased significantly (p &lt; 0.01) in the non-OA group with the median change from baseline to 170.0 mg/dl, compared to 21.5 mg/dl in the OA group during the 6 hours following the meal.</p><p><strong>Conclusions:</strong> A single olestra meal significantly diminishes post prandial serum TG levels and improves myocardial perfusion in patients with endothelial disease.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 150"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00062-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89123092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"17. Utility of Metabolic Imaging in Oral Squamous Cell Carcinoma (SCC) Staging. Experience in 30 Patients","authors":"Moya F ,&nbsp;Gómez F ,&nbsp;De Pedro M ,&nbsp;Maldonado A ,&nbsp;Melgarejo M ,&nbsp;Gorospe E ,&nbsp;Ruiz JA ,&nbsp;Jiménez J ,&nbsp;Pozo MA","doi":"10.1016/S1095-0397(00)00083-2","DOIUrl":"10.1016/S1095-0397(00)00083-2","url":null,"abstract":"<div><p><strong>Purpose:</strong> SCC represents nearly 90% of all oral malignancies, with an increasing incidence. Accurate Tumour-Node-Metastasis staging (TNM) is mandatory for planning surgical options and chemotherapy-radiotherapy management. Positron Emission Tomography (PET) using ¹⁸F-Fluorodeoxyglucose (FDG) provides functional information about tumoral tissues that may improve preoperative staging obtained by conventional morphologic procedures (CT-MRI). The purpose of this study is to evaluate the accuracy of FDG-PET in oral SCC staging and to compare those data from conventional and PET studies according to the pathologic results obtained from surgical specimen.</p><p><strong>Methods:</strong> A prospective study of 30 patients was carried out, through a 26 months period. Inclusion criteria include positive biopsy for Oral SCC, no other malignancies during the past 5 year and surgery as preferred therapeutic option. All patients underwent CT, MRI, and FDG-PET studies consecutively. Results obtained from conventional and PET preoperative staging were compared with those from postoperative histopathological studies</p><p><strong>Results:</strong> FDG-PET modified preoperative staging obtained by conventional morphologic studies in 21% cases, which was confirmed postoperatively by histological findings. Kappa test showed higher values for PET studies (0.89) than conventional studies (0.41), when compared with postoperative control</p><p><strong>Conclusion:</strong> FDG-PET may be helpful to improve the accuracy of conventional studies in oral SCC preoperative TNM staging, although no definitive conclusions can be withdrawn due to the limited size of the sample. Modifications of preoperative staging showed by PET are a matter of controversy and must be kept in mind for further studies.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 171"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00083-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83212577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"32. Detection of Recurrence of Ovarian Cancer using [F-18]-FDG Scan Performed on a Dual-Head Coincidence Gamma Camera (CDET)","authors":"K. Kerrou,&nbsp;F. Montravers,&nbsp;D. Grahek,&nbsp;N. Younsi,&nbsp;V. de Beco,&nbsp;J.N. Talbot","doi":"10.1016/S1095-0397(00)00098-4","DOIUrl":"10.1016/S1095-0397(00)00098-4","url":null,"abstract":"<div><p><strong>Purpose:</strong> The aim of this preliminary study was to evaluate the role of FDG-CDET in detection of recurrence of ovarian cancer.</p><p><strong>Methods and patients:</strong> After a fast of 6 hours, the patient (pt) was injected I. V. with 150–250 MBq of [F-18]-FDG and imaging (whole-body scan and at least a tomoscintigram) was started 45 min. later, using a PICKER Prism XP 2000 CDET gamma camera. Between July 1997 and December 1999, 40 patients were studied for ovarian carcinoma. To date, the results of 23 patients are evaluable with reference to histology after surgery or long-term follow-up. From these 23 patients, 18 pts were referred for suspected recurrence of ovarian carcinoma: occult recurrence (OR) defined by an increase in serum CA-125 levels with negative conventional imaging (13 pts) or equivocal aspect at conventional imaging (5 pts).</p><p><strong>Results:</strong> In 13 pts referred for suspicion of OR, FDG-CDET was true positive (TP) in 11 cases all confirmed by histology after surgery and was true negative (TN) in the remaining 2 cases as confirmed by spontaneous normalization of CA-125 levels and no events during a 20-month follow-up. In the 5 pts with equivocal aspect on CT, 4 were (TP) with recurrent foci at FDG-CDET in 1 case and 1 was (TN) corresponding to a leı̈omyoma on histology after surgery. In summary, the overall sensitivity and accuracy on a per patient basis were 18/18 for FDG-CDET while sensitivity and accuracy of conventional imaging was only 6/18.</p><p><strong>Conclusion:</strong> These preliminary results in a clinical setting, which is not frequently evaluated on CDET gamma cameras, seem very promising.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 186"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00098-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83957226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3. Utility of PET and 11C-Methionine in the Paediatric Brain Tumors","authors":"Sörensen J.,&nbsp;Savitcheva I.,&nbsp;Engler H.,&nbsp;Langstrom B.","doi":"10.1016/S1095-0397(00)00069-8","DOIUrl":"10.1016/S1095-0397(00)00069-8","url":null,"abstract":"<div><p><strong>Purpose:</strong> The aim of the study was to examine the utility of PET with ¹¹C-Methionine in diagnosis and evaluation of the treatment efficacy in childhood brain tumors.</p><p><strong>Methods:</strong> 16 PET-studies were performed in 11 children, 4–17years old, 3 boys and 8 girls, with brain tumors or tumor suspicion. Reasons for PET-study were an unclear diagnosis of tumor (7 cases), treatment efficacy definition (5 cases) and identification of tumor recurrence (3 cases). Studies were performed after i.v. injection of ¹¹C-Methionine (6-9 MBq/kg). MRI or CT of brain was done before the PET-study in all patients. Diagnosis was confirmed by clinical follow-up or biopsy.</p><p><strong>Results:</strong> In 2 of 7 patients with suspicion of brain tumor no areas with pathological uptake of ¹¹C-Methionine were found. In a patient with unclear tumor a benign process (ependimoma) was revealed that allowed avoiding a biopsy. A benign tumor detection in 2 patients with malignancy suspicion considerably affected treatment tactics. In 2 patients supposed benign growth was confirmed. In 2 of 3 patients with question of recurrence after surgery or radiotherapy and inconclusive MRI and CT picture malignant growth was found and in 1 patient was rejected. Repeated PET-studies in 2 patients with prolactinoma during therapy allowed prompt (within a few days) control of tumor response.</p><p><strong>Conclusion:</strong> The assessment of tumor metabolic activity in paediatric oncological practice using PET with ¹¹C-Methionine is a reliable method in the correct indication of brain tumor origin and in prompt evaluation of treatment efficacy and control of recurrence.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 157"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00069-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81281481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"9:45—10:00","authors":"Mullani NA ,&nbsp;Brandt M ,&nbsp;Strite D ,&nbsp;Hartz R ,&nbsp;Allbright M ,&nbsp;Boyd D ,&nbsp;Gould KL","doi":"10.1016/S1095-0397(00)00060-1","DOIUrl":"10.1016/S1095-0397(00)00060-1","url":null,"abstract":"<div><p>Calcium localization by Electron Beam CT (EBCT) in the coronary arteries is becoming an important non-invasive method for screening asymptomatic patients for early coronary atherosclerosis. However, the relationship between coronary artery calcium deposits and myocardial perfusion abnormalities has not been established. We have developed software to superimpose location of coronary calcium by EBCT onto PET myocardial perfusion images, so that we can determine the role of location and amount of calcium in the arteries to flow-limiting perfusion defects by PET.</p><p>EBCT and PET transaxial images are each first converted to three-dimensional arrays of 1 mm voxels. The resulting two image volumes sets are displayed so that a vertical line can be drawn from the clavicle to the spine for proper rotation of the body. The rotated images are then displayed superimposed and are shifted in the vertical, horizontal, and the long axis directions to co-register the EBCT and PET images. The EBCT images are windowed for calcium Houndsfield numbers and calcium location is added to the PET images as a maximum intensity value in the image. The modified PET image volume is then translated back to the PET data format and reprocessed using cardiac analysis software such that the calcium location is superimposed on the PET myocardial perfusion images.</p><p>Preliminary results of the PET-EBCT superimposition program correlate with location of coronary calcium by EBCT and PET perfusion defects following stress. This technique may be useful for identifying flow-limiting calcium deposits in the coronary arteries.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 148"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00060-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72758908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"October 17, 2000 8:30—8:45","authors":"Israel O.,&nbsp;Mor M.,&nbsp;Guralnik L.,&nbsp;Gaitini D.,&nbsp;Zachs Y.,&nbsp;Keidar Z.,&nbsp;Kuten A.","doi":"10.1016/S1095-0397(00)00055-8","DOIUrl":"10.1016/S1095-0397(00)00055-8","url":null,"abstract":"<div><p>The purpose of the study was to evaluate a new technology of simultaneous transmission and F-18 FDG emission tomography (FDG-TET) in tumor imaging and its impact on patient management.</p><p>Emission and transmission devices were installed on the same gantry. 167 patients with histologically proven malignancy were evaluated at diagnosis or during follow up. Eight mCi of FDG were injected for PET and a low dose X-ray tube was used for CT. The FDG and CT were first interpreted independently, without knowledge of findings in other imaging modality. Subsequently fusion images were analyzed.</p><p>FDG-TET changed the interpretation of PET or CT in 75 patients (45%). In 60 patients TET allowed for correct localization of lesions on the PET studies. In 15 patients, FDG uptake was found in sites of physiologic activity. In 12 patients lesions previously missed on CT were retrospectively identified. In 21 patients, TET detected 34 previously unknown sites of disease.</p><p>FDG-TET changed the clinical management of 29 patients (17%). The stage of disease was changed in 9 patients. Early diagnosis of recurrence was made in 8 patients. Seven patients were referred for previously unplanned surgery. In 6 patients surgery was cancelled. Fifteen patients received additional chemo- or radiotherapy.</p><p>Diagnosis of cancer on CT is based on a change in size or attenuation of a mass. PET shows the metabolic status of a lesion but lacks anatomical landmarks. FDG-TET improves the diagnostic accuracy in cancer and may have a significant impact on patient management.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 143"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00055-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77793209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"9:30—9:45","authors":"Coleman RE,&nbsp;DeGrado TR,&nbsp;Wang S,&nbsp;Baldwin SW,&nbsp;Orr MD,&nbsp;Reiman RE,&nbsp;Price DT","doi":"10.1016/S1095-0397(00)00059-5","DOIUrl":"10.1016/S1095-0397(00)00059-5","url":null,"abstract":"<div><p>The purpose of this study was to develop and evaluate an F-18 labeled choline tumor imaging agent.</p><p>FCH was synthesized through the intermediate F-18 fluorobromomethane that was used to alkylate dimethylethanolamine. The isolated FCH was evaluated in PC-3 human prostate cancer cells, PC-3 human prostate cancer xenograft studies, and human prostate and brain tumor patients.</p><p>FCH was accumulated at a slightly lower rate than FDG in the cultures of PC-3 cells. Inhibition of choline transport and phosphorylation by hemicholinium-3 resulted in a 90% decrease in FCH uptake without altering FDG uptake. FCH had a similar biodistribution as C-14 choline in mice, with the liver and kidneys being the primary sites of uptake. Tumor uptake of FCH and FDG were comparable at 45-60 mins after injections. The tumor:blood ratio was higher for FCH (5.3 ± 2.4) than for FDG (3.2 ± 0.3). Brain uptake of FCH was 10% that of FDG. FCH-PET studies were compared to FDG-PET studies. In the prostate cancer patients, more lesions have been seen on the FCH studies than on the FDG studies, and the standardized uptake values (SUV) have been higher with the FCH. Decreases in FCH-PET SUV have been noted in patients treated by androgen deprivation. Patients with suspected recurrent brain tumors have had more clearly defined abnormal accumulation on the FCH-PET scans than on the FDG-PET scans. The FCH is not accumulated by normal cortex.</p><p>FCH is a promising imaging agent for the evaluation of metastatic prostate cancer and recurrent brain tumor.</p></div>","PeriodicalId":80267,"journal":{"name":"Clinical positron imaging : official journal of the Institute for Clinical P.E.T","volume":"3 4","pages":"Page 147"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1095-0397(00)00059-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79958601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}