{"title":"Varix of the vortex ampulla: a dynamic phenomenon","authors":"Dawn N. Tomasini","doi":"10.1016/S0953-4431(00)00050-3","DOIUrl":"10.1016/S0953-4431(00)00050-3","url":null,"abstract":"<div><p>A vortex varix consists of a bulging of the vortex ampulla and overlying retina. This dynamic retinal finding can change with the patient's direction of gaze. The clinician can often visualize a red, elevated lesion that appears and disappears thus, making the diagnosis confusing. An overview of vortex varices, methods of diagnosis and differential diagnoses will be discussed.</p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 151-154"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00050-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21958691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chloroquine retinopathy and secondary trauma","authors":"Joan K. Portello","doi":"10.1016/S0953-4431(00)00044-8","DOIUrl":"10.1016/S0953-4431(00)00044-8","url":null,"abstract":"<div><p><span><span>This report describes a patient who initially presented with established chloroquine retinopathy resulting in reduced distance </span>visual acuity<span>, color vision anomalies and maculopathy<span> in each eye. Subsequent trauma to the left side of the head produced a further decline in vision, accompanied by iritis and </span></span></span>macula edema. A differential diagnosis, classification and treatment plan for patients with chloroquine retinopathy is presented.</p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 161-165"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00044-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21958693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progressive outer retinal necrosis syndrome: a comprehensive review of its clinical presentation, relationship to immune system status, and management","authors":"Robert B Austin","doi":"10.1016/S0953-4431(00)00052-7","DOIUrl":"10.1016/S0953-4431(00)00052-7","url":null,"abstract":"<div><p><span>Progressive outer retinal necrosis (PORN) syndrome is a form of the </span><em>Varicella zoster</em><span><span><span><span> virus (VZV) chorioretinitis<span> found almost exclusively in people with the acquired immunodeficiency syndrome (AIDS). This destructive infection has an extremely rapid course that may lead to no light perception in affected eyes within days or weeks. Attempts at its treatment have had limited success. </span></span>Rhegmatogenous retinal detachments often occur after the development of atrophic retinal holes, and </span>silicone oil<span> temponade has been found to be the most successful reattachment procedure. Unfortunately, cataract formation is common after such surgery. PORN needs to be differentiated from acute retinal necrosis (ARN) syndrome, a necrotizing </span></span>retinitis<span><span> that can also be caused by VZV. PORN and ARN are found at opposite ends of the spectrum of necrotizing herpetic </span>retinopathies (NHR), where its clinical presentation depends upon immune system status. After a brief case presentation, the distinguishing clinical characteristics of PORN, its differentiation from ARN, attempts at its treatment, the role of the immune system status on its clinical appearance and treatment, and management of complications such as retinal detachment and subsequent cataracts are discussed.</span></span></p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 119-129"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00052-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21958688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ocular immune privilege: a review","authors":"Steven B Koevary","doi":"10.1016/S0953-4431(00)00041-2","DOIUrl":"10.1016/S0953-4431(00)00041-2","url":null,"abstract":"<div><p>The definition of the term ‘immune privilege’ has evolved over the last century. Current usage refers to a state within a particular organ or tissue in which elements of normal immunity are absent. The fact that this deficiency is thought to be generally beneficial has compelled others to go a step further and venture that immune privilege acts to minimize expression of immunopathology<span>. The purpose of this article is to review which parts of the eye hold immune privileged status, what mechanisms contribute to it, and what clinical benefits may have driven the development of these unique immune environments. The article ends with an examination of recent studies which have sought to use components of ocular immune privilege<span> to prevent systemic autoimmune disease.</span></span></p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 97-106"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00041-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21959353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin T. Corcoran , Matthew M. Marsich , David C. Ward
{"title":"Potentially life-threatening primary acquired melanosis","authors":"Kevin T. Corcoran , Matthew M. Marsich , David C. Ward","doi":"10.1016/S0953-4431(00)00048-5","DOIUrl":"10.1016/S0953-4431(00)00048-5","url":null,"abstract":"<div><p><span><span>Primary acquired melanosis is an acquired conjunctival </span>pigmentation<span> seen in Caucasians. It presents as a diffuse, patchy, unilateral area of pigmentation that can be flat or nodular. Other melanotic lesions such as ocular melanosis, argyrosis, congenital conjunctival melanosis can be confused with primary acquired melanosis. Diagnosis and management of primary acquired melanosis is critical since it is potential life-threatening. A 51-year-old while male presented with unilateral, diffuse, patchy pigmentation first noted 10 years prior. Slit lamp examination<span> revealed a 4 mm ×2 mm area of temporal bulbar conjunctival pigmentation extending to the limbus in the right eye. A biopsy was performed and pathologic examination disclosed primary acquired melanosis with atypia. Topical mitomycin-C therapy was initiated. Because of the large size and diffuse nature of the pigmentation, mitomycin-C was preferred since surgical excision would be destructive and has related risks of scarring, </span></span></span>goblet cell<span> loss, and associated side effects such as dry eye and ulceration<span>. Two months, following treatment with mitomycin-C, significant clinical improvement was observed. A careful patient history is key in diagnosis primary acquired melanosis including a detailed history including onset, duration, stability, and progression of the pigmentation. All cases of primary acquired melanosis should be referred for biopsy. If atypia is found, traditional treatment includes surgical removal or cryotherapy. However, if the area is large side effects can occur. Mitomycin-C eliminates these potential side effects and can be used to successfully treat primary acquired melanosis.</span></span></p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 185-188"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00048-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21958697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroretinitis: a clinical syndrome of cat-scratch disease","authors":"Susan Rost Monahan","doi":"10.1016/S0953-4431(00)00043-6","DOIUrl":"10.1016/S0953-4431(00)00043-6","url":null,"abstract":"<div><p><span>Cat-scratch disease is usually a benign self-limited illness, characterized by regional lymphadenopathy lasting between 3 and 6 weeks. The causative organism is </span><span><em>Bartonella henselae</em></span><span><span>, a small gram-negative rod. Between 1 and 2% of patients who contract the illness experience blurred vision, metamorphopsia and scotomas as a result of </span>neuroretinitis, an associated clinical syndrome. The classical clinical findings in cat-scratch neuroretinitis include disc edema and a stellate pattern of exudates in the macula. However, a myriad of other signs has been documented, suggesting a much wider spectrum of intra-ocular disease. The following case report presents a young patient with neuroretinitis, and a history of lymphadenopathy secondary to cat-scratch disease.</span></p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 155-159"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00043-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21958692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retinitis pigmentosa: distribution of inheritance patterns in a VA blind rehabilitation center population","authors":"Janis Ecklund Winters","doi":"10.1016/S0953-4431(00)00051-5","DOIUrl":"10.1016/S0953-4431(00)00051-5","url":null,"abstract":"<div><p><em>Objectives:</em><span><span> This purpose of this study was to characterize retinitis pigmentosa (RP) patients at the Southeastern Blind </span>Rehabilitation Center (SBRC) by inheritance pattern, and compare the results with similar studies. </span><em>Study Design:</em> Records of all RP patients who were in the blind rehabilitation program at the SBRC between 1989 and 1993 were reviewed (<em>n</em>=50). Patients were included in the study who could be personally contacted and whose records were complete (<em>n</em>=43). Pedigrees were obtained through review of records and patient interviews. <em>Results:</em><span><span> The analysis showed 24 patients (55.8%) were simplex (no family history of RP), 8 patients (18.6%) were autosomal dominant, 4 patients (9.3%) were probable autosomal dominant, 4 patients (9.3%) were </span>autosomal recessive, 2 patients (4.7%) were probable autosomal recessive and 1 patient (2.3%) was X-linked recessive. </span><em>Conclusions:</em> Unique trends were apparent in the distribution of inheritance patterns. Clinicians should be aware of the large number of simplex patients found in this and the majority of similar studies.</p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 107-112"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00051-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21959354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Side effects of chemotherapeutic oculo-toxic agents: a review","authors":"Dominick M. Maino, Saly Tran, Faresh Mehta","doi":"10.1016/S0953-4431(00)00053-9","DOIUrl":"10.1016/S0953-4431(00)00053-9","url":null,"abstract":"<div><p>Patients with cancer are often prescribed chemotherapeutic substances that can be extremely oculo-visual-toxic in nature. Over the past several years, advances in cancer treatment have resulted in increased survival rates and patient longevity. Unfortunately, greater survival rates and longevity mean increased exposure to potentially harmful oculo-toxic substances and a higher incidence of oculo-visual side effects. Patients receiving chemotherapy may complain of symptoms that can imitate functional disorders such as blurred vision and photophobia (i.e. disorders of accommodation) and also include dry eyes or other symptomology commonly associated with disorders of the primary eye care system. These deleterious side effects affect the patient's quality of life and warrant our attention. It is essential that eye and vision care professionals appropriately diagnose and manage these induced disorders. This review presents the oculo-visual side effects of commonly used chemotherapeutic agents, the available treatment options when these unwanted side effects occur, and when known, the mechanism by which these agents cause oculo-visual toxicity.</p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 113-117"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00053-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21959355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Persistent hyperplastic primary vitreous","authors":"Mira Silbert, Andrew S. Gurwood","doi":"10.1016/S0953-4431(00)00054-0","DOIUrl":"10.1016/S0953-4431(00)00054-0","url":null,"abstract":"<div><p><span><span>Persistent hyperplastic primary vitreous<span> (PHPV) is a common congenital developmental anomaly of the eye that results following failure of the embryological, primary vitreous and hyaloid vasculature to regress. It typically presents unilaterally without associated systemic findings. Although the etiology is assumed to be identical in each of its three variants, PHPV is still subclassified into three presentations. The purely anterior presentation of PHPV is also known as persistent tunica vasculosa lentis and persistent posterior fetal fibrovascular sheath of the lens. It occurs in eyes with pathology of the anterior segment. This form typically involves cataract, glaucoma and a retrolenticular membrane. The purely posterior presentation of PHPV is termed falciform retinal septum and ablatio falcicormis congentia. It occurs in eyes with abnormalities confined to the posterior segment such as </span></span>retinal folds<span>, vitreal stalk, vitreal membranes, macular abnormalities and optic disc abnormalities. A combination of anterior and posterior presentations is the most commonly seen clinical presentation. </span></span><em>Case report.</em><span> We present a case in which an 11-year old male was referred to our office for reevaluation of a large angle esotropia<span>, strabismic and deprivational amblyopia and previously diagnosed PHPV, OD. </span></span><em>Conclusion.</em><span><span> Without treatment, PHPV can produce recurrent intraocular hemorrhage, </span>secondary glaucoma<span> and eventually require enucleation<span>. Early surgical intervention is necessary to prevent progressive pathologic changes and to obtain the best visual results. Finally, while PHPV is a documented source of leukocoria<span><span>, clinicians should be aware of differential diagnoses which involve the white pupil (congenital cataract, retinoblastoma<span>, Norrie's disease, </span></span>retinopathy of prematurity<span>, retinal detachment and Coat's disease).</span></span></span></span></span></p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 131-137"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00054-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21958689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corneal crystals","authors":"Thu-Ha Dao Easter, Chung Yong Song","doi":"10.1016/S0953-4431(00)00045-X","DOIUrl":"10.1016/S0953-4431(00)00045-X","url":null,"abstract":"<div><p>A limited number of conditions are associated with corneal crystals. This clinical challenge discusses a patient who presented with fine, refractile, crystalline deposits throughout the entire depth of corneal stroma in a limbal to limbal pattern. The differential diagnoses of corneal crystals are presented and discussed, along with the causative condition in this case.</p></div>","PeriodicalId":80266,"journal":{"name":"Clinical eye and vision care","volume":"12 3","pages":"Pages 167-170"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0953-4431(00)00045-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21958694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}