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Clinical allergy and immunology最新文献

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Impact of chronic rhinosinusitis on quality of life and health care expenditure. 慢性鼻窦炎对生活质量和医疗保健支出的影响。

Clinical allergy and immunology Pub Date : 2007-01-01 DOI: 10.3109/9781420014020-6

V. Lund

引用次数: 26

Role of inflammatory T cells and eosinophils in chronic rhinosinusitis. 炎性T细胞和嗜酸性粒细胞在慢性鼻窦炎中的作用。

Clinical allergy and immunology Pub Date : 2007-01-01 DOI: 10.3109/9781420014020-9

S. Foley, Q. Hamid

引用次数: 4

The nonallergic rhinitis of chronic fatigue syndrome. 慢性疲劳综合征的非过敏性鼻炎。

Clinical allergy and immunology Pub Date : 2007-01-01

James N Baraniuk, Uyenphuong Ho Le

引用次数: 0

Role of mast cells and basophils in chronic rhinosinusitis. 肥大细胞和嗜碱性粒细胞在慢性鼻窦炎中的作用。

Clinical allergy and immunology Pub Date : 2007-01-01

Ruby Pawankar, Kun Hee Lee, Manabu Nonaka, Ryuta Takizawa

{"title":"Role of mast cells and basophils in chronic rhinosinusitis.","authors":"Ruby Pawankar, Kun Hee Lee, Manabu Nonaka, Ryuta Takizawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mast cells and basophils contribute to induction and/or maintenance of eosinophilic inflammation by a variety of mechanisms, including IgE-dependent and IgE-independent processes. The latter include a variety of stimuli that have only recently been elucidated, including mechanisms triggered by bacteria, virus, fungi, complement, or autoantibodies. MCs, and basophils contribute to inflammation both directly through the release of inflammatory mediators, cytokines and growth factors and indirectly through the activation of structural cells. Accumulating evidence places MCs (and most probably basophils) in a position of importance in the pathogenesis of CRS, particularly in the pathogenesis and progression of NP (Fig. 1). Mechanisms other than conventional IgE-dependent activation of MCs are intriguing as potential mechanisms of eosinophilic inflammation in non-allergic CRS/NP. Although it is not possible using current pharmacologic approaches to completely isolate the effects of MCs or basophils in CRS and NP pathogenesis, it seems most likely that such approaches will eventually be available. It might be expected that one or both of these cells will be shown to play important roles, particularly considering their potential for activation by IgE and non-IgE mechanisms, their production of a broad array of inflammatory mediators, cytokines and growth factors, and their unique assortment of proteases.</p>","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 ","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26747833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial infection and antibiotic treatment in chronic rhinosinusitis. 慢性鼻窦炎的细菌感染与抗生素治疗。

Clinical allergy and immunology Pub Date : 2007-01-01

Itzhak Brook

{"title":"Bacterial infection and antibiotic treatment in chronic rhinosinusitis.","authors":"Itzhak Brook","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Incomplete resolution of acute rhinosinusitis leading to CRS is associated with a corresponding change in the microbiology of the disease. The shift in microbiology from acute to CRS favors infection with S. aureus, S. epidermidis, anaerobic bacteria (including beta-lactamase-producing strains), and gram-negative bacteria. With the exception of S. epidermidis, there is substantial evidence supporting the role of these organisms in the pathogenesis of CRS. It is worth noting that not all CRS patients are chronically infected. In fact, other inflammatory factors in the disease may predominate in the clinical presentation. This creates a clinical conundrum in which it is difficult to ascertain whether bacteria are involved. In general, a chronic bacterial infection is more likely if there is: underlying immune deficiency, one or more opacified sinuses on sinus CT in the absence of polyps, the presence of frank purulence draining from one or more sinus cavities, or the presence of gram-negative or antibiotic-resistant organisms (e.g., MRSA) on sinus culture. For patients seen for the first time, the approach to antibiotic treatment is usually empiric, following the guidelines outlined in this chapter and directing treatment at both aerobic and anaerobic bacteria. Whenever possible, the choice of antibiotics should be guided by properly obtained sinus cultures. In cases where empiric antibiotics have failed, the need for bacterial cultures is even more critical to assure proper treatment and to minimize antibiotic side effects.</p>","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 ","pages":"147-62"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26747836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonallergic rhinitis in children. 儿童非过敏性鼻炎。

Clinical allergy and immunology Pub Date : 2007-01-01

William E Berger, J Ellen Schonfeld

引用次数: 0

Rhinitis in the menstrual cycle, pregnancy, and some endocrine disorders. 鼻炎发生在月经周期、孕期，还有一些内分泌紊乱。

Clinical allergy and immunology Pub Date : 2007-01-01

Eva K Ellegård, N Göran Karlsson, Lars H Ellegård

引用次数: 0

Relationship between nonallergic upper airway disease and asthma. 非过敏性上呼吸道疾病与哮喘的关系。

Clinical allergy and immunology Pub Date : 2007-01-01

Jonathan Corren, Rita Kachru

引用次数: 0

Pharmacological provocation in nonallergic rhinitis. 非变应性鼻炎的药理刺激。

Clinical allergy and immunology Pub Date : 2007-01-01 DOI: 10.3109/9781420021172-21

R. V. van Wijk

引用次数: 0

Differential diagnosis of persistent nonallergic rhinitis and rhinosinusitis syndromes. 持续性非过敏性鼻炎与鼻鼻窦炎综合征的鉴别诊断。

Clinical allergy and immunology Pub Date : 2007-01-01 DOI: 10.3109/9781420021172-7

M. Staevska, J. Baraniuk

引用次数: 12

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