{"title":"Keyword Index to Volume 3","authors":"","doi":"10.1016/S1522-1865(03)00135-5","DOIUrl":"https://doi.org/10.1016/S1522-1865(03)00135-5","url":null,"abstract":"","PeriodicalId":80261,"journal":{"name":"Cardiovascular radiation medicine","volume":"3 3","pages":"Pages 270-271"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1522-1865(03)00135-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137090020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgios Sianos , William Wijns , Pim J de Feyter , Ron van Domburg , Patrick W Serruys
{"title":"Geographical miss and restenosis during catheter-based intracoronary β-radiation for de novo lesions","authors":"Georgios Sianos , William Wijns , Pim J de Feyter , Ron van Domburg , Patrick W Serruys","doi":"10.1016/S1522-1865(03)00101-X","DOIUrl":"10.1016/S1522-1865(03)00101-X","url":null,"abstract":"<div><p><strong>Objectives:</strong> We sought to determine the impact of geographical miss (GM) on restenosis rates after intracoronary β-radiation therapy for de novo lesions. <strong>Background:</strong> GM is the situation in which injured vessel segments (VSs) are receiving low-dose radiation and is accounted for edge restenosis. Its impact on the overall restenosis rates remains to be determined. <strong>Methods:</strong> We analyzed 330 patients (356 vessels) treated according to the Beta Radiation in Europe (BRIE) and the Dose Finding study protocols. Using quantitative coronary angiography (QCA), the effective irradiated segment (EIRS), its edges and the total VS were analysed. The edges of the EIRS that were injured constituted the GM edges. Restenosis was defined as diameter stenosis >50% at follow-up. GM was determined by the simultaneous electrocardiographic-matched, side-by-side projection of the source and balloons deflated and surrounded by contrast, at the site of injury, in identical angiographic projections. <strong>Results:</strong> In 20.5% of the vessels, GM was non-interpretable due to inadequate filming. GM occurred at 30.4% of the interpretable edges and 53% of the interpretable vessels that were analysed. Edge restenosis was significantly increased in the GM compared to non-GM edges (13.16% vs. 4.17%, respectively, <em>P</em>=.001), both in the proximal (<em>P</em>=.03) and the distal (<em>P</em>=.001) edges. GM associated with stent injury significantly increased edge restenosis (<em>P</em>=.006). GM related to balloon injury tended to be associated with increment in edge restenosis (<em>P</em>=.07). The restenosis in the EIRS was similar between vessels with and without GM (17.78% and 14.85%, respectively, <em>P</em>=.6). GM was associated with significant increment in the restenosis at the analyzed VS (31.85% vs. 21.48%, <em>P</em>=.05). <strong>Conclusions:</strong> GM is strongly associated with edges and restenosis in the analysed VS. GM does not increase restenosis in the EIRS.</p></div>","PeriodicalId":80261,"journal":{"name":"Cardiovascular radiation medicine","volume":"3 3","pages":"Pages 138-146"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1522-1865(03)00101-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22576161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jodie L. Polan , Brian Morse , Suzanne Wetherold , Rosa E. Villanueva-Vedia , Clyde Phelix , Edwin Barera-Roderiquiz , Douglas Waggoner , Nilesh Goswami , Oscar Munoz , C.Mauli Agrawal , Steve R. Bailey
{"title":"VEGF analysis induced by endothelialized gas-plasma treated d,l-PLA scaffolds","authors":"Jodie L. Polan , Brian Morse , Suzanne Wetherold , Rosa E. Villanueva-Vedia , Clyde Phelix , Edwin Barera-Roderiquiz , Douglas Waggoner , Nilesh Goswami , Oscar Munoz , C.Mauli Agrawal , Steve R. Bailey","doi":"10.1016/S1522-1865(03)00100-8","DOIUrl":"10.1016/S1522-1865(03)00100-8","url":null,"abstract":"<div><p><strong>Purpose:</strong> Vascular endothelial growth factor (VEGF) isoforms play different roles in the temporal sprouting of endothelial-lined vessels in a nude mouse peritoneal model as cells respond to nontreated control and gas-plasma-treated bioresorbable poly-<span>d</span>,<span>l</span>-lactide acid 3D scaffolds with human aortic endothelial cells (HAEC). <strong>Methods and materials:</strong> Nude mice peritoneums were incubated with HAEC (CW=control; TW=gas-plasma treated) or polymer scaffolds (C<sub>p</sub>=control; T<sub>p</sub>=treated) for 12, 24 and 72 days. Cytoplasmic and nuclear protein fractions were isolated using NER, electrophoresized using NuPAGE–MES and analyzed by WesternBreeze Chemiluminescent. <strong>Results:</strong> Prominent VEGF bands included 28, 45 and 62 kDa; 52-kDa VEGF observed in cytoplasmic TW fractions contributed about 18.6% at 12 days, 20.0% at 24 days and 13.1% at 72 days of the total VEGF signal. Yet, it was only noted in CW at 72 days where it accounted for 6.9%. A unique 32-kDa band appeared in both C<sub>p</sub> (24.6%) and T<sub>p</sub> (18.3%). Significant differences between band densities occurred for cytoplasmic nuclear CW24–TW24 (<em>P</em>=.022), CW72–TW72 (<em>P</em>=.011) and, also, cytoplasmic C<sub>p</sub>24–T<sub>p</sub>24 (<em>P</em>=.038). <strong>Conclusions:</strong> The temporal and spatial organization of the TW isoforms results in more angiogenesis.</p></div>","PeriodicalId":80261,"journal":{"name":"Cardiovascular radiation medicine","volume":"3 3","pages":"Pages 176-182"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1522-1865(03)00100-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22576649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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