Annals of Oncology最新文献

{"title":"Comparative genomic landscape of acquired resistance in pancreatic cancer treated with pan-RAS or KRAS^G12C inhibitors.","authors":"F Castet, T V Tian, T Macarulla","doi":"10.1016/j.annonc.2025.06.018","DOIUrl":"10.1016/j.annonc.2025.06.018","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":" ","pages":""},"PeriodicalIF":56.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of early on-treatment evolution of circulating tumor DNA in advanced ER+/HER2- breast cancer.","authors":"A Mamann, Y Pradat, F C Bidard, S Delaloge, L Cabel, I Faull, S Marques, T Bachelot, F Dalenc, T DE LA Motte Rouge, B Pistilli, J Samaniego, J S Frenel, C Levy, J M Ferrero, R Sabatier, S Ladoire, C Chakiba, A C Hardy, J Lemonnier, Y Mahi, F Andre, P H Cournede, S Michiels, E Bernard","doi":"10.1016/j.annonc.2025.06.015","DOIUrl":"https://doi.org/10.1016/j.annonc.2025.06.015","url":null,"abstract":"<p><strong>Background: </strong>Patients with advanced estrogen receptor-positive, HER2-negative (ER+/HER2-) breast cancer commonly develop resistance to treatment with hormone therapy and cyclin-dependent kinases 4/6 (CDK4/6) inhibitors. Responders cannot be distinguished from non-responders after the first cycle of treatment under current practice. We assessed circulating tumor DNA (ctDNA) measures at early time-points as prognostic markers.</p><p><strong>Patients and methods: </strong>Paired plasma samples were collected at baseline and early on-treatment (median 28 days) from 369 patients with advanced ER+/HER2- breast cancer treated in the PADA-1 trial with hormone therapy and a CDK4/6 inhibitor. Cell-free DNA was profiled with a 497-gene panel (Guardant360 LDT).</p><p><strong>Results: </strong>Baseline ctDNA levels including the mean variant allele frequency (VAF) (progression-free survival [PFS] HR = 1.07 [1.05, 1.09] P<0.001, overall survival [OS] HR = 1.08 [1.05, 1.11] P<0.001) and the number of driver somatic mutations (PFS HR = 1.13 [1.07, 1.19], P<0.001 and OS HR = 1.16 [1.07, 1.24], P<0.001) were prognostic. Early on-treatment ctDNA dynamics were also associated with outcomes, including the number of driver somatic mutations with VAF>0.5% at both timepoints (PFS HR = 1.39 [1.27,1.53] P<0.001 and OS HR = 1.51 [1.35,1.68] P<0.001) and the number of driver somatic mutations with a VAF increase (PFS HR = 1.31 [1.19,1.44] P<0.001 and OS HR = 1.10 [1.02,1.18] P=0.02). A ctDNA-based risk model incorporating baseline and dynamic ctDNA features was independently prognostic from RECIST in multivariable models (Test set: OS HR = 4.10 [1.93,8.72], P<0.001, PFS HR = 1.86 [1.16,2.97], P=0.009). The integration of ctDNA features into a clinical model improved survival discrimination for PFS (C-index 64.7% [s.d. 2.5] for a ctDNA & clinical model vs. 59.3% [s.d. 2.2] for a clinical only model, p=0.027) and for OS (C-index 70.0% [s.d 3.4] vs. 60.3% [s.d. 4.2], p=0.035).</p><p><strong>Conclusions: </strong>Early on-treatment evolution of ctDNA is prognostic for both PFS and OS in advanced ER+/HER2- breast cancer. A ctDNA-based risk model improves upon traditional RECIST and clinical parameters, advocating for ctDNA as a prognostic biomarker in clinical practice.</p>","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":" ","pages":""},"PeriodicalIF":56.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"80P Tumor immune microenvironment in young, multi-ethnic colorectal cancer patients","authors":"M.E. Salem ,&nbsp;P. Zhang ,&nbsp;N. Steuerwald ,&nbsp;A. Patrick ,&nbsp;F. Guo ,&nbsp;L. Liang ,&nbsp;L. Miller ,&nbsp;S. Chai ,&nbsp;J. Hill ,&nbsp;J. Hwang ,&nbsp;K. Kadaki ,&nbsp;W. Zhang ,&nbsp;D. Foureau","doi":"10.1016/j.annonc.2025.05.092","DOIUrl":"10.1016/j.annonc.2025.05.092","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S41"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"32P A novel imaging biomarker, quantitative vessel tortuosity, captures the antiangiogenic effect of fruquintinib in metastatic colorectal cancer","authors":"S. Lonardi ,&nbsp;O. Yardibi ,&nbsp;N.A. Dasari ,&nbsp;L. Chen ,&nbsp;V. Sundaresan ,&nbsp;A. Madabhushi ,&nbsp;J. Narang","doi":"10.1016/j.annonc.2025.05.044","DOIUrl":"10.1016/j.annonc.2025.05.044","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S19"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"21P Real-world genomic profiles in patients with HER2-positive metastatic colorectal cancer","authors":"Y. Matsubara ,&nbsp;H. Bando ,&nbsp;Y. Nakamura ,&nbsp;T. Misumi ,&nbsp;D. Ng ,&nbsp;E. Tajima ,&nbsp;H. Pittell ,&nbsp;C. Cho-Phan ,&nbsp;T. Yoshino ,&nbsp;A. Ohtsu","doi":"10.1016/j.annonc.2025.05.033","DOIUrl":"10.1016/j.annonc.2025.05.033","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S14"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"23P Prognostic impact of secondary actionable alterations in dMMR/MSI-H digestive tumors","authors":"N. Martinez Lago ,&nbsp;M. Sanchez Ares ,&nbsp;A. Carral Maseda ,&nbsp;M. Perez Martelo ,&nbsp;M. Covela ,&nbsp;A. Fernandez Montes ,&nbsp;J. de la Camara Gomez ,&nbsp;P. González Villarroel ,&nbsp;M. Reboredo López ,&nbsp;M.E. Padin Iruegas ,&nbsp;I. Abdulkader Nallib","doi":"10.1016/j.annonc.2025.05.035","DOIUrl":"10.1016/j.annonc.2025.05.035","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S15"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"58P Surgery versus ablation for colorectal liver metastases: A tertiary referral hospital experience","authors":"F.R. Verdasca ,&nbsp;I.T. Furtado ,&nbsp;M. Seladas ,&nbsp;A. Fernandes ,&nbsp;L.M. Coelho ,&nbsp;J. Boavida Ferreira ,&nbsp;I.M.C. Guerreiro ,&nbsp;J. Gramaça","doi":"10.1016/j.annonc.2025.05.070","DOIUrl":"10.1016/j.annonc.2025.05.070","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S32"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"60P No liver metastases vs liver metastases in metastatic colorectal cancer (mCRC)","authors":"E. Osterlund ,&nbsp;S. Aho ,&nbsp;A. Uutela ,&nbsp;K.I. Lehtomaki ,&nbsp;L. Nunes ,&nbsp;P. Pfeiffer ,&nbsp;H. Sorbye ,&nbsp;T.T. Muhonen ,&nbsp;E. Heerva ,&nbsp;A. Algars ,&nbsp;R. Ristamaki ,&nbsp;H.P. Stedt ,&nbsp;A. Lamminmäki ,&nbsp;R. Kallio ,&nbsp;T. Salminen ,&nbsp;P. Halonen ,&nbsp;A. Nordin ,&nbsp;H. Isoniemi ,&nbsp;B. Glimelius ,&nbsp;P.J. Osterlund","doi":"10.1016/j.annonc.2025.05.072","DOIUrl":"10.1016/j.annonc.2025.05.072","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S33"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"72P Early-onset colorectal cancer patients exhibits a distinct molecular fingerprint: Insights from a study of 1209 patients using NGS","authors":"A. Pretta ,&nbsp;V. Nasca ,&nbsp;F. Marmorino ,&nbsp;R. Intini ,&nbsp;P. Ziranu ,&nbsp;G. Randon ,&nbsp;M. Carullo ,&nbsp;K. Cerma ,&nbsp;C. Donisi ,&nbsp;C. Damonte ,&nbsp;A. Taravella ,&nbsp;C. Gaiani ,&nbsp;S. Mariani ,&nbsp;I. Montroni ,&nbsp;P. Ciracì ,&nbsp;A. De Rosa ,&nbsp;F. Bergamo ,&nbsp;C. Cremolini ,&nbsp;F. Pietrantonio ,&nbsp;M. Scartozzi","doi":"10.1016/j.annonc.2025.05.084","DOIUrl":"10.1016/j.annonc.2025.05.084","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S39"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"89P Development of methylation-based biomarkers to predict metastases, treatment effect, and microsatellite status in colorectal cancer","authors":"J.P.Y-C. Shen ,&nbsp;M.C. Cobanoglu ,&nbsp;Y. Jiang ,&nbsp;S. Dashner ,&nbsp;V. Aushev ,&nbsp;H. Mickalide ,&nbsp;F. Mendez ,&nbsp;J. Rodriguez-Medina ,&nbsp;J.N. Burton ,&nbsp;T. Constantin ,&nbsp;S.L. Bristow ,&nbsp;A. Jurdi ,&nbsp;A. Aleshin ,&nbsp;T. Kawli ,&nbsp;J.G. Reiter","doi":"10.1016/j.annonc.2025.05.101","DOIUrl":"10.1016/j.annonc.2025.05.101","url":null,"abstract":"","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":"36 ","pages":"Page S44"},"PeriodicalIF":56.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}