Chihaya Ito, Go Kuwahara, Hiromitsu Teratani, Yuichi Morita, Yuta Sukehiro, Masato Furui, Hideichi Wada
{"title":"Femoral Arterial Perfusion Guided by Intraoperative Transesophageal Echocardiography for Mesenteric Malperfusion in Acute Type A Aortic Dissection.","authors":"Chihaya Ito, Go Kuwahara, Hiromitsu Teratani, Yuichi Morita, Yuta Sukehiro, Masato Furui, Hideichi Wada","doi":"10.3400/avd.oa.26-00006","DOIUrl":"10.3400/avd.oa.26-00006","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the outcomes of acute type A aortic dissection (ATAAD) complicated by mesenteric malperfusion managed with femoral arterial perfusion and intraoperative transesophageal echocardiography (TEE).</p><p><strong>Methods: </strong>We retrospectively reviewed 246 patients who underwent surgery for ATAAD between April 2011 and May 2022. Mesenteric malperfusion was identified in 8 of 49 patients (20%) with malperfusion syndrome. Femoral arterial perfusion was initiated to restore true lumen flow, and intraoperative TEE was used to assess abdominal aortic true lumen expansion and superior mesenteric artery (SMA) perfusion. Central aortic repair was performed after confirmation of mesenteric reperfusion.</p><p><strong>Results: </strong>Dynamic and static mesenteric obstructions were present in 5 and 3 patients, respectively. Femoral perfusion improved SMA flow in all dynamic cases and in 2 static cases. Seven patients (87.5%) survived to discharge; 1 patient with preoperative coma, shock, and static SMA obstruction died. In 1 patient with combined SMA and celiac artery obstruction, residual celiac malperfusion was not detected intraoperatively.</p><p><strong>Conclusions: </strong>Femoral arterial perfusion guided by intraoperative TEE is a feasible and effective strategy for mesenteric malperfusion in ATAAD. However, static branch obstruction and limitations of TEE warrant consideration of hybrid approaches.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mediastinal Chyloma after Ascending Aortic Replacement: A Case of Delayed, Localized Chyle Leakage.","authors":"Masato Yamakawa, Jun Yokote, Kei Kurokawa, Takaki Marutani, Hironari Shibahara, Toshikuni Yamamoto, Shinichi Ashida, Masato Mutsuga","doi":"10.3400/avd.cr.25-00150","DOIUrl":"10.3400/avd.cr.25-00150","url":null,"abstract":"<p><p>Graft-related complications, such as pseudoaneurysms and seromas, are rare following aortic replacement. The occurrence of localized chyle leakage is exceptionally uncommon. A 59-year-old male presented with chest pain due to an expanding 5-cm perigraft fluid collection 5 years after emergent ascending aortic replacement for acute aortic dissection. Surgical intervention was indicated as a pseudoaneurysm could not be ruled out. Intraoperatively, a chronic, localized chyle leakage (chyloma) was confirmed around the graft, showing high triglyceride and total cholesterol levels on biochemical analysis. The chyloma wall was resected and cauterized. No recurrence of perigraft fluid accumulation was observed during 5 years.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Outcome of Spontaneous Isolated Dissection of the Superior Mesenteric Artery.","authors":"Zaiqiang Yu, Norihiro Kondo, Yoshiaki Saito, Kazuyuki Daitoku, Ikuo Fukuda, Masahito Minakawa","doi":"10.3400/avd.oa.25-00081","DOIUrl":"10.3400/avd.oa.25-00081","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to elucidate the long-term outcomes of acute symptomatic spontaneous isolated dissection of the superior mesenteric artery (SIDSMA) to inform optimal decision-making during the acute phase.</p><p><strong>Methods: </strong>We retrospectively collected and analyzed data from 14 consecutive patients diagnosed with SIDSMA by using computed tomography angiography (CTA) between January 2010 and August 2024.</p><p><strong>Results: </strong>The cohort comprised 13 males and 1 female, with a mean age of 59.36 ± 14.90 years. All patients presented with acute abdominal pain, and some experienced vomiting. Thirteen patients received conservative treatment, while only 1 patient underwent open surgery with extra-anatomical bypass; this patient required no further intervention 10 years postoperatively. One of the patients, whose abdominal pain worsened with food intake, showed SMA stenosis and decreased intestinal blood flow. His symptoms improved after heparin anticoagulation therapy followed by direct oral anticoagulant therapy. Over a follow-up period of 7.20 ± 3.21 years, none of the patients experienced recurrent SIDSMA-related abdominal pain, and all survived without the need for additional invasive treatment.</p><p><strong>Conclusions: </strong>Conservative treatment effectively manages SIDSMA over the long term without reintervention. Early diagnosis and management of intestinal ischemia are essential for optimal treatment outcomes.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preliminary Observations of Spatial Imbalance between Lymphangiogenesis and Angiogenesis within Carotid Atherosclerotic Plaques: A Pilot Histopathological Study.","authors":"Yohei Tateishi, Hiroaki Otsuka, Daiji Torimura, Aya Yamashita, Yuki Tomita, Takuro Hirayama, Tomoaki Shima, Shunsuke Yoshimura, Teiichiro Miyazaki, Reiko Ideguchi, Yuki Matsunaga, Hajime Maeda, Junya Fukuoka, Yoichi Morofuji, Tsuyoshi Izumo, Akira Tsujino","doi":"10.3400/avd.oa.25-00157","DOIUrl":"10.3400/avd.oa.25-00157","url":null,"abstract":"<p><strong>Objectives: </strong>Atherosclerotic plaque progression involves dynamic interactions between angiogenesis and lymphangiogenesis. This pilot, hypothesis-generating study aimed to explore the spatial balance between blood microvessels and lymphatic vessels in human carotid plaques.</p><p><strong>Methods: </strong>Carotid plaques from 4 patients who underwent carotid endarterectomy were examined histologically. Blood microvessels (CD31+) and lymphatic vessels (Podoplanin+) were quantified in severely and mildly thickened lesions. The blood microvessel-to-lymphatic vessel (BMV/LV) ratio was compared between regions, along with macrophage polarization (CD80+: M1 and CD163+: M2).</p><p><strong>Results: </strong>Severely thickened lesions exhibited a 15.5-fold higher density of blood microvessels than mildly thickened lesions (median 31 vs. 2 vessels; p = 0.012), whereas lymphatic vessel counts were comparable (median 31 vs. 32 vessels; p = 0.978). Consequently, the BMV/LV ratio was 16-fold higher in severely thickened lesions (1.203 vs. 0.121, p = 0.060). CD80-positive areas were larger in severely thickened lesions (0.395% vs. 0.078% area, p = 0.006), whereas CD163-positive areas were comparable between regions (1.036% vs. 0.215%, p = 0.154).</p><p><strong>Conclusions: </strong>Mildly thickened carotid atherosclerotic plaques demonstrated relative lymphatic predominance, whereas severely thickened lesions showed angiogenic predominance accompanied by increased M1 macrophage infiltration. These exploratory findings suggest that regional imbalance between lymphatic vessels and blood microvessels within individual plaques may contribute to localized plaque vulnerability.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erwin Hadi Chandra, Dedy Pratama, Raden Suhartono, Patrianef Darwis, Alexander Jayadi Utama
{"title":"Salvaging the Last Dialysis Access: Cross-Neck Cephalic Arch-to-Contralateral Internal Jugular Vein Bypass for Chronic Total Central Venous Occlusion.","authors":"Erwin Hadi Chandra, Dedy Pratama, Raden Suhartono, Patrianef Darwis, Alexander Jayadi Utama","doi":"10.3400/avd.cr.26-00012","DOIUrl":"10.3400/avd.cr.26-00012","url":null,"abstract":"<p><p>A 65-year-old hemodialysis patient with chronic total occlusion (CTO) of the right brachiocephalic vein and concurrent dialysis access-induced steal syndrome presented with venous hypertension and digital-brachial index (DBI) of 0.42. The brachiocephalic arteriovenous fistula was his sole remaining vascular access. After failed endovascular recanalization, simultaneous extra-anatomic cross-neck cephalic arch-to-contralateral internal jugular vein bypass using a 6-mm polytetrafluoroethylene (PTFE) graft and banding flow reduction were performed. Postoperatively, venous hypertension resolved, DBI improved to 0.78, and steal symptoms remitted. The fistula remained patent at 6-month follow-up, demonstrating combined bypass and flow reduction as an effective salvage strategy for concurrent CTO and steal syndrome.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of a Type II Endoleak from an Atypical Mediastinal Collateral Branch Following Total Arch Replacement with Frozen Elephant Trunk.","authors":"Emiko Chiba, Kohei Hamamoto, Mamoru Arakawa, Satoshi Uesugi, Soichiro Kojima, Ryoma Kobayashi, Tatsuya Ogawa, Hiroyuki Fujii, Mitsuru Matsuki, Harushi Mori","doi":"10.3400/avd.cr.25-00124","DOIUrl":"10.3400/avd.cr.25-00124","url":null,"abstract":"<p><p>We present a rare case of type II endoleak (T2EL) from an atypical mediastinal artery following total arch replacement with a frozen elephant trunk (FET) for chronic aortic dissection. A 63-year-old male with a history of multiple thoracic aortic surgeries, including FET, developed enlargement of an aortic arch aneurysm on follow-up. Computed tomography and diagnostic angiography revealed a T2EL due to a newly developed mediastinal collateral artery arising from the left subclavian artery feeding the sac. Selective transcatheter embolization with N-butyl-2-cyanoacrylate successfully eliminated the endoleak. Recognizing such atypical T2EL sources is crucial for managing post-FET aneurysm expansion.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two Surgical Cases of Thymic Tumor Requiring Resection and Reconstruction of the Superior Vena Cava and the Brachiocephalic Vein.","authors":"Makoto Shirakawa, Hikari Kimura, Ryosuke Amitani, Kenji Suzuki, Yasuo Miyagi, Jiro Honda, Kento Suzuki, Takumi Sonokawa, Yuichiro Machida, Norihito Kawasaki, Jitsuo Usuda, Yosuke Ishii","doi":"10.3400/avd.cr.25-00145","DOIUrl":"10.3400/avd.cr.25-00145","url":null,"abstract":"<p><p>Surgery for thymic tumor involving major vessels remains challenging; however, complete surgical resection is recommended when the resected major vessels can be reconstructed safely. Two cases are described in this report. In Case 1, complete surgical resection followed by reconstruction using an autologous pericardial patch was achieved owing to the temporary bypass assist. In Case 2, complete surgical resection followed by reconstruction using an autologous pericardial roll was achieved owing to the cardiopulmonary bypass assist. Complete surgical resection of thymic tumor involving the major veins can be achieved safely with appropriate extracorporeal circulatory assist. Autologous pericardium is useful for venous reconstruction.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Balloons and Stents in Endovascular Therapy.","authors":"Kenjiro Kaneko, Eisaku Ito, Takao Ohki","doi":"10.3400/avd.ra.26-00065","DOIUrl":"10.3400/avd.ra.26-00065","url":null,"abstract":"<p><p>Endovascular treatment for patients with lower extremity artery disease (LEAD) has expanded its indications owing to the evolution of devices, improvements in techniques, and the establishment of clinical evidence. In particular, improvements in balloon and stent performance have significantly contributed to improved treatment outcomes. Herein, we describe the current status of basic balloon- and stent-related topics for the treatment of LEAD. (This is a translation of Jpn J Vasc Surg 2024; 33: 281-288.).</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Machine Learning Is Not Just for Prediction: Its Role as an Exploratory Analytical Tool in Medicine.","authors":"Sei Komatsu","doi":"10.3400/avd.ra.26-00055","DOIUrl":"10.3400/avd.ra.26-00055","url":null,"abstract":"<p><p>Machine learning (ML) has been primarily used for predictive modeling in medical research, but this reflects only part of its potential. This review proposes a conceptual distinction between predictive ML and exploratory ML. Predictive ML aims to maximize accuracy on unseen data. Exploratory ML focuses on identifying underlying structures in data to generate hypotheses. Exploratory ML plays an important role under conditions where conventional hypothesis-driven statistics have limitations, including high-dimensional data, small sample sizes, and biopsy-inaccessible organs such as the vascular system. Because ML-derived results are based on associations rather than causality, they should be interpreted as hypothesis-generating rather than confirmatory. Methods including unsupervised learning, interpretable supervised learning, and network analysis are discussed as exploratory ML approaches. The differences in objectives and evaluation criteria between exploratory ML and conventional hypothesis-driven statistics are also discussed, together with the structural gap in peer review. The key argument is that studies using exploratory ML should be evaluated not by predictive performance but by the stability, reproducibility, and interpretability of the identified structures. Without this shift, exploratory analyses may be systematically misjudged within current evaluation standards. This perspective may bridge exploratory analysis and confirmatory research and support new study designs in medicine.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intermittent Hematuria and Shock due to Uretero-Arterial Fistula Diagnosed by Provocative Angiography.","authors":"Ren Saito, Yujiro Miura, Naoki Edo, Takuya Matsushiro, Shinichi Imai, Junki Shibata, Tomohiro Matsumoto, Takuji Yamagami, Naoya Ichimura, Rie Yoshimura, Kaya Atagi, Hiroto Osakabe, Satoshi Fukata, Keiji Inoue","doi":"10.3400/avd.cr.26-00104","DOIUrl":"10.3400/avd.cr.26-00104","url":null,"abstract":"<p><p>Uretero-arterial fistula is a rare but life-threatening cause of massive hematuria. A 78-year-old woman with a history of pelvic surgery, radiation therapy, ileal conduit diversion, and long-term ureteral stenting presented with gross hematuria and anemia. Contrast-enhanced computed tomography (CT) and repeated angiography failed to identify the bleeding source. During recurrent hemorrhage, provocative angiography with negative-pressure aspiration through a ureteral catheter demonstrated extravasation from the right common iliac artery. Endovascular stent-graft repair achieved immediate hemostasis. This case highlights the diagnostic value of provocative angiography in challenging cases of uretero-arterial fistula.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}