Annals of hepatology最新文献

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Serum bilirubin concentrations and their association with clinical and radiological outcomes in multiple sclerosis: A large cohort study. 血清胆红素浓度及其与多发性硬化症临床和放射预后的关系:一项大型队列研究。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-22 DOI: 10.1016/j.aohep.2025.102117
Tomáš Uher, Pavlína Kleinová, Jana Woronyczová, Lubomír Štěpánek, Manuela Vaněčková, Jan Krásenský, Renata Cífková, Dana Horáková, Eva Havrdová, David Hoskovec, Martin Leníček, Libor Vítek
{"title":"Serum bilirubin concentrations and their association with clinical and radiological outcomes in multiple sclerosis: A large cohort study.","authors":"Tomáš Uher, Pavlína Kleinová, Jana Woronyczová, Lubomír Štěpánek, Manuela Vaněčková, Jan Krásenský, Renata Cífková, Dana Horáková, Eva Havrdová, David Hoskovec, Martin Leníček, Libor Vítek","doi":"10.1016/j.aohep.2025.102117","DOIUrl":"10.1016/j.aohep.2025.102117","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Bilirubin is negatively associated with neurodegenerative diseases, including multiple sclerosis (MS). Since previous studies were small or did not evaluate all diagnostic aspects, the objective of the present study was to assess a large cohort of MS patients with multiple determinations of serum bilirubin.</p><p><strong>Patients and methods: </strong>The study was carried out in 2,696 consecutive MS patients (median age=37.1 years, disease duration=6.8 years, follow-up duration=7.2 years, and Expanded Disability Status Scale (EDSS)=2.5) with 28,501 visits. Individuals from the Czech post-MONICA study representing the general Czech population (n=2,621) were used as controls. Serum bilirubin concentrations in study subjects were compared with multiple diagnostic and clinical parameters.</p><p><strong>Results: </strong>Serum bilirubin concentrations in MS patients were significantly lower compared to the general population (8.3 vs. 9.6 μmol/L, P<0.001). Hyperbilirubinemia >17 µmol/L in MS patients was much less frequent compared to the general population (8.2 vs. 12.5 %, P<0.001). An increase in disease duration by 10 years was associated with an 8 % decrease in bilirubin concentration (p<0.0001). Ten percent higher serum bilirubin concentration was associated with a 9 % decrease in EDSS (p=0.001) and a 1.5 % decrease in normalized brain volume (p<0.0001). The frequencies of individual UGT1A1 (TA)n/n genotypes did not differ between MS patients and the control population.</p><p><strong>Conclusions: </strong>MS patients have markedly lower serum bilirubin concentrations, most likely due to consumption during the increased oxidative stress since the frequencies of UGT1A1 were comparable in the MS and control populations. Higher serum bilirubin is associated with lower disability and lower brain atrophy.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102117"},"PeriodicalIF":4.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug pricing for hepatitis B and C in Australia and Japan. 澳大利亚和日本乙型和丙型肝炎的药物定价。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-22 DOI: 10.1016/j.aohep.2025.102118
Maito Suoh, Saeed Esmaili, Mohammed Eslam, Jacob George
{"title":"Drug pricing for hepatitis B and C in Australia and Japan.","authors":"Maito Suoh, Saeed Esmaili, Mohammed Eslam, Jacob George","doi":"10.1016/j.aohep.2025.102118","DOIUrl":"10.1016/j.aohep.2025.102118","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102118"},"PeriodicalIF":4.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of metabolic dysfunction-associated steatotic liver disease by triglyceride glucose-body mass index: A systematic review and meta-analysis. 通过甘油三酯-葡萄糖-体重指数诊断代谢功能障碍相关的脂肪变性肝病:一项系统回顾和荟萃分析
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-14 DOI: 10.1016/j.aohep.2025.102122
Kexin Du, Yafang Huang, Yanhui Yu, Jianrong Guo, Jianmei Feng, Feng Jiang
{"title":"Diagnosis of metabolic dysfunction-associated steatotic liver disease by triglyceride glucose-body mass index: A systematic review and meta-analysis.","authors":"Kexin Du, Yafang Huang, Yanhui Yu, Jianrong Guo, Jianmei Feng, Feng Jiang","doi":"10.1016/j.aohep.2025.102122","DOIUrl":"10.1016/j.aohep.2025.102122","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly common globally, but current diagnostic methods are inaccessible. This study aims to evaluate the efficacy of triglyceride glucose-body mass index (TyG-BMI) as a noninvasive diagnostic tool for MASLD.</p><p><strong>Materials and methods: </strong>Embase, PubMed, Cochrane Library, and Web of Science up to July 2025 were searched for related studies. Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 was utilized for quality assessment. The effect size, odds ratio (OR), specificity, sensitivity, positive/negative likelihood ratios, diagnostic odds ratio, and heterogeneity were pooled using Stata18.0 and Meta-Disc1.4. The summary receiver operating characteristic (SROC) curves were plotted and the area under the curve (AUC) values were calculated. Random- or fixed-effects models were adopted based on the results of the heterogeneity test. Moreover, we investigated the source and influence of heterogeneity by subgroup and sensitivity analyses, and examined publication bias.</p><p><strong>Results: </strong>Twenty-nine studies were included. The meta-analysis revealed a higher TyG-BMI in MASLD patients than in non-MASLD patients (SMD 3.09, 95 % CI 2.49-3.68, P < 0.001). For each one-unit increase in TyG-BMI, the MASLD risk rose by 5 % (OR 1.05, 95 % CI 1.04-1.07, P < 0.001). The pooled sensitivity, specificity, and AUC of the diagnostic efficacy of TyG-BMI were 0.81 (95 % CI 0.77-0.85), 0.72 (95 % CI 0.67-0.77), and 0.83 (95 % CI 0.80-0.86), respectively. The stratified analysis by sex revealed that the diagnostic efficacy was superior in females (sensitivity: 0.82, specificity: 0.80).</p><p><strong>Conclusions: </strong>TyG-BMI, a cost-efficient and convenient indicator, is favorable for diagnosing MASLD, especially in females, which is worth popularizing.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102122"},"PeriodicalIF":4.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognosis of hepatocellular carcinoma in the French overseas territories and comparison with a tertiary center in mainland France. 法国海外地区肝细胞癌的预后及与法国本土三级中心的比较。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-12 DOI: 10.1016/j.aohep.2025.102120
Alolia Aboikoni, Manon Allaire, Dominique Louvel, Marthe Alogo A Nwatsok, Paul Ngock Dime, Ala Ouni, Larissa Tangan, Magaly Zappa, Kinan Drak Alsibai, Maylis Douine, Mathieu Nacher, Lucie Catherine, Cecilia Busso, Nathalie Ganne, Moana Gelu-Simeon
{"title":"Prognosis of hepatocellular carcinoma in the French overseas territories and comparison with a tertiary center in mainland France.","authors":"Alolia Aboikoni, Manon Allaire, Dominique Louvel, Marthe Alogo A Nwatsok, Paul Ngock Dime, Ala Ouni, Larissa Tangan, Magaly Zappa, Kinan Drak Alsibai, Maylis Douine, Mathieu Nacher, Lucie Catherine, Cecilia Busso, Nathalie Ganne, Moana Gelu-Simeon","doi":"10.1016/j.aohep.2025.102120","DOIUrl":"10.1016/j.aohep.2025.102120","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Limited data are available on the prognosis of hepatocellular carcinoma (HCC) in the French overseas territories (FOT). This study aimed to describe the characteristics and outcomes of patients diagnosed with HCC in FOT, comparing them to those from a tertiary center located in Île-de-France (IDF).</p><p><strong>Materials and methods: </strong>We retrospectively included all patients with HCC diagnosis between 2013 and 2023 in the FOT and IDF. Socio-demographic and medical data were collected, with the first treatment performed and survival data. Overall survival was analyzed using Kaplan- Meier methods and Cox proportional hazards models.</p><p><strong>Results: </strong>A total of 1114 patients were included (FOT 11%, IDF 89%). FOT patients had higher rates of hepatitis B (36% vs. 16%, p<0.001) and worse liver function (defined by higher MELD scores and fewer Child A cases) at HCC diagnosis. In contrast, IDF patients had a higher prevalence of MASLD (29% vs. 16%, p=0.004). HCC was diagnosed at more advanced stages in FOT compared to IDF, with 71% vs. 49% (p<0.001) of cases outside Milan criteria and 29% vs. 5% (p<0.001) in BCLC-D, leading to a significantly lower survival in FOT (median 9 vs. 23 months, p=0.02).</p><p><strong>Conclusions: </strong>HCC patients in FOT have a poorer prognosis compared to IDF, with diagnoses at more advanced stages, limiting curative treatment options. These findings highlight the need for improved access to care and screening strategies for earlier diagnosis of HCC in FOT.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102120"},"PeriodicalIF":4.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Development of a prediction index for persistent acute kidney injury following orthotopic liver transplant". “原位肝移植术后持续性急性肾损伤预测指标的建立”评论。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-11 DOI: 10.1016/j.aohep.2025.102109
Zhaoyan Ding, Yunping Li, Yuanming Yang
{"title":"Comment on \"Development of a prediction index for persistent acute kidney injury following orthotopic liver transplant\".","authors":"Zhaoyan Ding, Yunping Li, Yuanming Yang","doi":"10.1016/j.aohep.2025.102109","DOIUrl":"10.1016/j.aohep.2025.102109","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102109"},"PeriodicalIF":4.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Situational panorama of chronic liver diseases: A single-center experience at a university hospital in northeast Mexico (1995-2019). 慢性肝病的情境全景:墨西哥东北部大学医院的单中心体验(1995-2019)。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-11 DOI: 10.1016/j.aohep.2025.102116
Paula Cordero-Perez, Liliana Torres-González, Samuel Rivas-López, Carolina Treviño-García, Airam Regalado-Ceballos, Jaime R Zúñiga-Noriega, Ingrid G López-Reyna, Luz M Barbosa-Castillo, Isai E Hernández-Padilla, Linda E Muñoz-Espinosa
{"title":"Situational panorama of chronic liver diseases: A single-center experience at a university hospital in northeast Mexico (1995-2019).","authors":"Paula Cordero-Perez, Liliana Torres-González, Samuel Rivas-López, Carolina Treviño-García, Airam Regalado-Ceballos, Jaime R Zúñiga-Noriega, Ingrid G López-Reyna, Luz M Barbosa-Castillo, Isai E Hernández-Padilla, Linda E Muñoz-Espinosa","doi":"10.1016/j.aohep.2025.102116","DOIUrl":"10.1016/j.aohep.2025.102116","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Chronic liver disease (CLD) is characterized by a progressive decline in liver function, accompanied by inflammation, destruction, and scarring of the hepatic parenchyma. The most common etiologies of CLD globally include hepatitis B (HBV), hepatitis C (HCV), alcohol-related liver disease, autoimmune liver disease, and, more recently, metabolic dysfunction-associated steatotic liver disease (MASLD). The aim was to analyze the main etiologies of CLD observed in a Hepatology Center over a 25-year period.</p><p><strong>Materials and methods: </strong>A retrospective and observational study was conducted with 2679 patients with CLD, recruited between January 1995 and December 2019. The patients were classified into three time periods: Group A (1995-2003), Group B (2004-2011), and Group C (2012-2019). A one-way analysis of variance was used to assess the differences between the groups.</p><p><strong>Results: </strong>Significant differences were found in HCV, HBV, and MASLD between the analyzed periods (p = 0.0019, p < 0.001, and p < 0.001, respectively). Tukey's post hoc test revealed significant differences in HCV and HBV between group A and groups B and C (p < 0.01 and p < 0.001, respectively). For MASLD, a progressive increase was observed in each period (p < 0.01 for A vs. B; p ≤ 0.001 for A vs. C; p = 0.0042 for B vs. C).</p><p><strong>Conclusions: </strong>Between 1995 and 2007, the predominant CLD in our clinic was caused by HCV. However, since 2008, MASLD has become the most frequent etiology (33 %), reaching 45 % in 2019 as the leading cause of CLD. By 2012, cirrhosis due to MASLD had the highest incidence among the analyzed etiologies, followed by HCV.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102116"},"PeriodicalIF":4.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous physical and nutritional intervention reduces frailty in patients with cirrhosis listed for liver transplantation: a randomized controlled trial. 同时进行身体和营养干预可减少肝硬化肝移植患者的虚弱:一项随机对照试验。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-11 DOI: 10.1016/j.aohep.2025.102114
Carlos Benítez, Diego Reyes, Catalina Grandy, Isidora Thomas, Nicolás Lavados, Nicole Kim, Anny Gálvez, Silvana Valdés, Soledad Contreras, Roberto Candia
{"title":"Simultaneous physical and nutritional intervention reduces frailty in patients with cirrhosis listed for liver transplantation: a randomized controlled trial.","authors":"Carlos Benítez, Diego Reyes, Catalina Grandy, Isidora Thomas, Nicolás Lavados, Nicole Kim, Anny Gálvez, Silvana Valdés, Soledad Contreras, Roberto Candia","doi":"10.1016/j.aohep.2025.102114","DOIUrl":"10.1016/j.aohep.2025.102114","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Frailty is associated with an increased morbidity and mortality among patients with cirrhosis. However, no specific treatment strategy has been formally recommended for these patients. This study aims to evaluate the effectiveness of a strategy based on exercise and nutritional intervention improving frailty in cirrhotic patients listed for transplantation.</p><p><strong>Patients and methods: </strong>Patients with increased Liver Frailty Index (LFI) (≥3.2) were randomized to a control group (standard exercise and nutritional counseling) or intervention group (guided by physical therapist and dietitian) for 12 weeks, LFI was measured, and patients were classified as frail or prefrail. The change in LFI was assessed at the end of study.</p><p><strong>Results: </strong>Sixty-six patients were included (34 to the control group and 32 to the intervention group), age 59.3 ± 8.8, male 51.5 %, main etiologies: MASLD (40.9 %), ALD (15.2 %), MetALD (6.1 %), PBC (6.1 %), autoimmune hepatitis (4.5 %), MELD Na 17.2 ± 5, Child Pugh A/B/C 13.6 %/57.6 %/28.8 %, Na 137±3 mEq/L, creatinine 0.8 ± 0.3 mg/dL, bilirubin 3.3 ± 3 mg/dL, INR 1.5 ± 0.4, albumin 3.3 ± 0.5 g/dL, LFI 4.23 ± 0.5, frail/prefrail (%) 34.8/65.2. There was a significant improvement in LFI at the end of the study in the intervention group (ΔLFI 0.4 vs ΔLFI 0.14, p = 0.02). Notably, we found a significant reduction in the proportion of frail patients in the intervention group vs control group (28.1 % vs 8.8 %, p = 0.02) at the end of the study.</p><p><strong>Conclusions: </strong>This randomized controlled trial conducted in patients listed for liver transplantation demonstrates that a dual intervention can effectively reduce frailty in this population.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102114"},"PeriodicalIF":4.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bidirectional association between chronic liver disease and chronic kidney disease: a longitudinal study based on CHARLS 2011-2020 data. 慢性肝病与慢性肾病的双向关联:基于CHARLS 2011-2020数据的纵向研究
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-11 DOI: 10.1016/j.aohep.2025.102115
Yuan He, Fan Zhang, Zixuan Zhang, Xianwen Zhang, Yifei Zhong
{"title":"Bidirectional association between chronic liver disease and chronic kidney disease: a longitudinal study based on CHARLS 2011-2020 data.","authors":"Yuan He, Fan Zhang, Zixuan Zhang, Xianwen Zhang, Yifei Zhong","doi":"10.1016/j.aohep.2025.102115","DOIUrl":"10.1016/j.aohep.2025.102115","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Chronic liver disease (CLD) and chronic kidney disease (CKD) are major public health concerns with significant morbidity and mortality worldwide. This study aimed to investigate the bidirectional association between CLD and CKD.</p><p><strong>Patients and methods: </strong>We conducted two longitudinal studies using data from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020. Participants without baseline CKD were analyzed for the risk of CKD associated with CLD, and participants without baseline CLD were assessed for the risk of CLD associated with CKD. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (95% CIs).</p><p><strong>Results: </strong>Of 3651 participants without baseline CKD, 575 developed CKD over a median follow-up of 9 years. The incidence of CKD was significantly higher in those with baseline CLD (37.25 vs. 18.08 per 1000 population). Baseline CLD was independently associated with an elevated risk of incident CKD (adjusted HR=1.93; 95% CI: 1.37-2.72; P < 0.001). Conversely, of 5530 participants without baseline CLD, 474 developed CLD. Participants with CKD had a significantly higher incidence of CLD (13.56 vs. 8.89 per 1000 population). Baseline CKD was independently associated with an increased risk of incident CLD (adjusted HR=1.68; 95% CI: 1.31-2.16; P < 0.001). The bidirectional associations remained robust in sensitivity analyses, and the association persisted across different subgroups.</p><p><strong>Conclusions: </strong>This study provides evidence of a bidirectional relationship between CLD and CKD. These findings highlight the importance of integrated management strategies targeting both liver and kidney health.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102115"},"PeriodicalIF":4.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Suoh et al. 回复Suoh等人。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-10 DOI: 10.1016/j.aohep.2025.102119
Stephen E Congly, Leah Yao
{"title":"Reply to Suoh et al.","authors":"Stephen E Congly, Leah Yao","doi":"10.1016/j.aohep.2025.102119","DOIUrl":"10.1016/j.aohep.2025.102119","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102119"},"PeriodicalIF":4.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of artificial liver support systems on nosocomial infections and mortality in non-transplanted liver failure patients. 人工肝支持系统对非移植性肝衰竭患者院内感染和死亡率的影响。
IF 4.4 3区 医学
Annals of hepatology Pub Date : 2025-09-09 DOI: 10.1016/j.aohep.2025.102113
Yuan Li, Xiaoting Wang, Junkai Fan, Jiale Xie, Huimin Liu, Chunrong Ping, Zhijie Feng, Yan Wang
{"title":"Effects of artificial liver support systems on nosocomial infections and mortality in non-transplanted liver failure patients.","authors":"Yuan Li, Xiaoting Wang, Junkai Fan, Jiale Xie, Huimin Liu, Chunrong Ping, Zhijie Feng, Yan Wang","doi":"10.1016/j.aohep.2025.102113","DOIUrl":"10.1016/j.aohep.2025.102113","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Artificial liver support systems (ALSS) offer a technical solution for patients with liver failure (LF), serving as a bridge to recovery or transplantation. However, the number of LF patients eligible for transplants is limited. This study investigates the incidence of nosocomial infections and survival outcomes in LF patients treated with ALSS who do not undergo liver transplantation.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was conducted on LF patients receiving standard medical care (SMC) with ALSS versus those treated only with SMC. General and laboratory data were collected from all LF patients. A logistic regression model was used to assesse the risk of nosocomial infections associated with ALSS use, while Cox proportional hazards models was used to evaluate mortality risk in LF patients undergoing ALSS treatment. Survival times for both groups were calculated using Kaplan-Meier analysis.</p><p><strong>Results: </strong>A total of 306 LF patients were analyzed, comprising 200 males (65.4%) and 106 females (34.6%), with an average age of 49.9 years (95% CI = 48.2-51.6). Multivariate logistic regression analysis showed that ALSS was not linked to the risk of nosocomial infections (odds ratio =1.189, 95%CI=0.442-3.202, p=0.732). However, hazard ratio (HR) results indicated that ALSS is a protective factor for survival in LF patients (HR=0.533, 95%CI=0.374-0.760, p=0.001), supported by Kaplan-Meier curve analysis demonstrating prolonged survival time in the ALSS group among LF patients.</p><p><strong>Conclusions: </strong>ALSS is not an independent risk factor for nosocomial infections and could effectively prolong the lifespan of LF patients without liver transplantation. Further intervention studies are needed to validate these findings.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"102113"},"PeriodicalIF":4.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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