Annals of hepatology最新文献

筛选
英文 中文
A comprehensive meta-analysis of stem cell therapy for liver failure: Assessing treatment efficacy and modality 干细胞治疗肝衰竭的综合荟萃分析:评估治疗效果和方式。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-16 DOI: 10.1016/j.aohep.2024.101586
Shenglong Lin , Haibing Gao , Huaxi Ma , Ziyuan Liao , Dongqing Zhang , Jinshui Pan , Yueyong Zhu
{"title":"A comprehensive meta-analysis of stem cell therapy for liver failure: Assessing treatment efficacy and modality","authors":"Shenglong Lin ,&nbsp;Haibing Gao ,&nbsp;Huaxi Ma ,&nbsp;Ziyuan Liao ,&nbsp;Dongqing Zhang ,&nbsp;Jinshui Pan ,&nbsp;Yueyong Zhu","doi":"10.1016/j.aohep.2024.101586","DOIUrl":"10.1016/j.aohep.2024.101586","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>This meta-analysis aims to evaluate the efficacy of stem cell therapy (SCT) for liver failure.</div></div><div><h3>Materials and Methods</h3><div>The study adhered to the recommended guidelines of the PRISMA statement. Eligible studies published prior to May 13, 2023, were comprehensively searched in databases including PubMed, Web of Science, and Embase. Quality assessment was conducted using the Cochrane risk-of-bias tool, and the standard mean differences were calculated for the clinical parameters. The hazard ratios were determined by extracting individual patient data from the Kaplan-Meier curve.</div></div><div><h3>Results</h3><div>A total of 2,937 articles were retrieved, and eight studies were included in the final analysis. Most of the studies focused on HBV-related liver failure and were randomized controlled trials. All studies utilized mesenchymal stem cells (MSCs), with the majority (62.5%) being allogeneic. The analysis revealed that combining stem cell therapy with standard medical treatment or plasma exchange significantly enhanced patient survival and reduced MELD scores. Specifically, allogeneic stem cells showed superior efficacy in improving survival outcomes compared to autologous stem cells. Furthermore, deep vessel injection plus a single injection demonstrated better effectiveness than peripheral vessel injection plus multiple injections in reducing MELD scores.</div></div><div><h3>Conclusions</h3><div>This comprehensive analysis underscores the potential of MSC therapy in significantly improving survival and clinical outcomes in patients with liver failure, highlighting the superior benefits of allogeneic MSCs and deep vessel plus single injection administration.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 2","pages":"Article 101586"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A landscape of liver cirrhosis and transplantation in Mexico: Changing leading causes and transplant as response 墨西哥的肝硬化和移植情况:主要病因的变化和作为应对措施的移植。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-13 DOI: 10.1016/j.aohep.2024.101562
Icela Palma-Lara , María Guadalupe Ortiz-López , José Bonilla-Delgado , Juanita Pérez-Escobar , Ricardo Godínez-Aguilar , Claudia Luévano-Contreras , Ana María Espinosa-García , Javier Pérez-Durán , Patricia García Alonso-Themann , Manuel Nolasco-Quiroga , Javier Flores-Estrada , Paulina Carpinteyro-Espin , Daniel Juárez-Ascencio , Nayeli Goreti Nieto-Velazquez , Carmen Palacios-Reyes
{"title":"A landscape of liver cirrhosis and transplantation in Mexico: Changing leading causes and transplant as response","authors":"Icela Palma-Lara ,&nbsp;María Guadalupe Ortiz-López ,&nbsp;José Bonilla-Delgado ,&nbsp;Juanita Pérez-Escobar ,&nbsp;Ricardo Godínez-Aguilar ,&nbsp;Claudia Luévano-Contreras ,&nbsp;Ana María Espinosa-García ,&nbsp;Javier Pérez-Durán ,&nbsp;Patricia García Alonso-Themann ,&nbsp;Manuel Nolasco-Quiroga ,&nbsp;Javier Flores-Estrada ,&nbsp;Paulina Carpinteyro-Espin ,&nbsp;Daniel Juárez-Ascencio ,&nbsp;Nayeli Goreti Nieto-Velazquez ,&nbsp;Carmen Palacios-Reyes","doi":"10.1016/j.aohep.2024.101562","DOIUrl":"10.1016/j.aohep.2024.101562","url":null,"abstract":"<div><div>Liver cirrhosis causes include alcoholism, viral infections (hepatitis B virus (HBV) and hepatitis C virus (HCV)), alcohol-associated liver disease (ALD), and metabolic dysfunction associated with steatotic liver disease (MASLD), among others. Cirrhosis frequency has increased in recent years, with a prevalence of 1395 cases per 100,000 and a mortality rate of 18 per 100,000, which corresponded to 1,472,000 deaths during 2017. In Mexico, liver disease is a public health problem since it was associated to 41,890 deaths in 2022, including liver cirrhosis (&gt;25,000) and ALD (14,927). This represents 114 daily deaths due to these causes, and corresponds to the 4th or 5th place of all causes. The global prevalence of MASLD is estimated to affect 25% of the world's population, while in the pediatric population it could be higher. In Mexican population it is more prevalent since estimations were around 41.3% in 2023. Alcohol consumption, a global health issue due to its high prevalence and associated morbidities, is associated to ALD in 32.9%, with a mortality rate of 23.9%, primarily due to liver-related causes. In Mexico, ALD is present in 23% of all cirrhosis cases, already surpassed by hepatitis B cases in 2009. HCV and HBV frequencies changed due to programs implementing screening detection, vaccines and direct-acting antivirals during the last years. A switch of causes has occurred, increasing MASLD and diminishing viral causes. Efficient performed liver transplantation has grown as a response to increasing cirrhosis cases, including recent authorized centers. These efforts are necessary, whereas preventive strategies should be implemented according to leading causes.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 1","pages":"Article 101562"},"PeriodicalIF":3.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the prediction model of liver cancer based on chronic liver disease and the related molecular mechanism. 基于慢性肝病的肝癌预测模型及相关分子机制研究。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-13 DOI: 10.1016/j.aohep.2024.101572
Xiaojing Zhang, Xinye Chen
{"title":"Study on the prediction model of liver cancer based on chronic liver disease and the related molecular mechanism.","authors":"Xiaojing Zhang, Xinye Chen","doi":"10.1016/j.aohep.2024.101572","DOIUrl":"https://doi.org/10.1016/j.aohep.2024.101572","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Due to the high heterogeneity of HCC, which leads to poor prognostic outcomes for patients, there is a need to develop a novel predictive model for accurate classification of HCC in order to improve patient survival rates.</p><p><strong>Materials and methods: </strong>The data of the HCV, cirrhosis, and HCC were obtained from TCGA and GEO databases. Multivariable Cox regression analysis and survival analysis was conducted to assess the prognostic relevance of these differentially expressed genes. Single-cell sequencing was used to explore the intercellular interaction patterns and identify relevant signaling pathways. Drug sensitivity analysis was conducted to determine personalized treatment strategies for patients.</p><p><strong>Results: </strong>In this study, we conducted integrated analysis of hepatitis, cirrhosis, and hepatocellular carcinoma datasets and identified 10 liver disease progression genes associated with prognosis. These genes exhibited significant downregulation in expression as the disease advanced, suggesting their crucial involvement in HCC development. By performing multivariable Cox analysis, we established a prognostic model for liver disease progression to predict the prognosis of HCC patients. The model was validated using ROC analysis, demonstrating good accuracy and stability in prognostic evaluation. Single-cell sequencing analysis revealed that these genes primarily exert their effects through the MIF signaling pathway during HCC progression. Furthermore, we observed that patients in the low-risk group exhibited higher sensitivity to TACE treatment, while patients in the high-risk group showed better response to sorafenib treatment.</p><p><strong>Conclusions: </strong>In summary, we have elucidated the key genes involved in the progression of liver diseases and established a precise prognostic model for assessing the prognosis of HCC patients. Our study provides novel insights and strategies for the treatment of HCC.</p>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":" ","pages":"101572"},"PeriodicalIF":3.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study 饮用软饮料与非酒精性脂肪肝风险的增加:卫生工作者队列研究的结果。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-12 DOI: 10.1016/j.aohep.2024.101566
Edgar Denova-Gutiérrez , Berenice Rivera-Paredez , Amado D. Quezada-Sánchez , Brianda I. Armenta-Guirado , Paloma Muñoz-Aguirre , Yvonne N. Flores , Rafael Velázquez-Cruz , Jorge Salmerón
{"title":"Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study","authors":"Edgar Denova-Gutiérrez ,&nbsp;Berenice Rivera-Paredez ,&nbsp;Amado D. Quezada-Sánchez ,&nbsp;Brianda I. Armenta-Guirado ,&nbsp;Paloma Muñoz-Aguirre ,&nbsp;Yvonne N. Flores ,&nbsp;Rafael Velázquez-Cruz ,&nbsp;Jorge Salmerón","doi":"10.1016/j.aohep.2024.101566","DOIUrl":"10.1016/j.aohep.2024.101566","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Nonalcoholic fatty liver disease (NAFLD) is a common clinical condition and an important public health problem. Some epidemiological studies have suggested that soft drinks (SD) intake is associated with NAFLD. However, the evidence is inconsistent. Our objective was to assess the association between SD consumption and the risk of NAFLD in a Mexican adult population.</div></div><div><h3>Materials and Methods</h3><div>A total of 1,759 participants from the Health Workers Cohort Study (HWCS) were included in the analyses. SD intake was measured using a validated food frequency questionnaire. We classified SD consumption as follows: a) less than 1 serving per week, b) 1 to less than 3.5 servings per week, and c) 3.5 or more servings per week. Hepatic steatosis index (HSI) was calculated based on sex, BMI, and blood transaminase levels, and was categorized as NAFLD ≥ 36. To assess the relation between SD and NAFLD, we followed two approaches: fixed effects logistic regression and generalized estimating equations.</div></div><div><h3>Results</h3><div>After adjusting for demographic characteristics, lifestyle factors, and dietary intake, the odds ratio (OR) and 95 % confidence interval (95 % CI) for NAFLD were 1.26 (95 % CI: 1.08, 1.48) for 1 to less than 3.5 servings per week and 1.42 (95 % CI: 1.19, 1.69) for ≥3.5 servings/week category in both sexes. When stratifying the analysis by sex, we observed that the association tended to be greater in men than in women.</div></div><div><h3>Conclusions</h3><div>The results from our prospective study indicate that SD consumption is associated with an increased risk of NAFLD.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 1","pages":"Article 101566"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EIF3B affects the invasion and metastasis of hepatocellular carcinoma cells via the TGFBI/MAPK/ERK pathway EIF3B 通过 TGFBI/MAPK/ERK 通路影响肝癌细胞的侵袭和转移。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-12 DOI: 10.1016/j.aohep.2024.101564
Ling Wang , Chuanzhong Huang , Wansong Lin , Zhifeng Zhou , Jieyu Li , Mingshui Chen , Lingyu Zhang , Yunbin Ye
{"title":"EIF3B affects the invasion and metastasis of hepatocellular carcinoma cells via the TGFBI/MAPK/ERK pathway","authors":"Ling Wang ,&nbsp;Chuanzhong Huang ,&nbsp;Wansong Lin ,&nbsp;Zhifeng Zhou ,&nbsp;Jieyu Li ,&nbsp;Mingshui Chen ,&nbsp;Lingyu Zhang ,&nbsp;Yunbin Ye","doi":"10.1016/j.aohep.2024.101564","DOIUrl":"10.1016/j.aohep.2024.101564","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>To study the effect of eukaryotic initiation factor 3B (EIF3B) on the invasion and migration of hepatocellular carcinoma (HCC) and its potential mechanism.</div></div><div><h3>Materials and Methods</h3><div>The clinical significance of EIF3B expression was studied with The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interaction Analysis datasets. Immunohistochemical staining and western blotting were used to examine EIF3B expression in cell lines and tissues from HCC patients. The scratch assay and transwell assay were used to measure the invasion and metastasis of different HCC cell lines <em>in vitro</em>. The molecular mechanism of EIF3B was determined using RNA-seq and identification of dysregulated signaling pathways. Western blotting was used to verify the alterations of EIF3B signaling functioned in the promotion of HCC progression.</div></div><div><h3>Results</h3><div>Elevated expression of EIF3B in HCC correlated significantly with aggressive clinicopathologic characteristics, including advanced tumor grade and poor prognosis. Studies with cultured cells indicated that <em>EIF3B</em> knockdown inhibited HCC cell invasion and metastasis by depressing the epithelial-mesenchymal transition (EMT). EIF3B also activated the TGFBI/MAPK/ERK signaling pathway by increasing the levels of pMEK and pERK.</div></div><div><h3>Conclusions</h3><div>Our results indicate that <em>EIF3B</em> functions as an oncogene in HCC that accelerates cell invasion, metastasis, and the EMT by stimulation of the TGFBI/MAPK/ERK signaling pathway. EIF3B is a potential target for the treatment of HCC.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 1","pages":"Article 101564"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of sleep patterns and disorders with metabolic dysfunction-associated steatotic liver disease and liver fibrosis in contemporary American adults 当代美国成年人的睡眠模式和失调与代谢功能障碍相关的脂肪肝和肝纤维化的关系
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-12 DOI: 10.1016/j.aohep.2024.101583
Guannan Zong , Wangjia Mao , Ming Wen , Xiaoyun Cheng , Guanghui Liu
{"title":"Association of sleep patterns and disorders with metabolic dysfunction-associated steatotic liver disease and liver fibrosis in contemporary American adults","authors":"Guannan Zong ,&nbsp;Wangjia Mao ,&nbsp;Ming Wen ,&nbsp;Xiaoyun Cheng ,&nbsp;Guanghui Liu","doi":"10.1016/j.aohep.2024.101583","DOIUrl":"10.1016/j.aohep.2024.101583","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>The impact of sleep on metabolic dysfunction-associated steatotic liver disease (MASLD) in American adults remains unclear. This study aimed to address the relationship of sleep patterns and disorders with MASLD and liver fibrosis comprehensively.</div></div><div><h3>Materials and Methods</h3><div>This cross-sectional study included adult participants from the National Health and Nutrition Examination Survey 2017-2020. Multivariate adjusted regression analysis were used to examine the association of sleep with MASLD and liver fibrosis. We further addressed these associations using restricted cubic splines, mediation analysis, stratified analysis and multiple sensitivity analysis.</div></div><div><h3>Results</h3><div>We enrolled 5368 participants. Certain sleep disorders, sleep duration, high sleep debt and specific sleep-wake time were associated with MASLD. Late workday sleep was a shared risk factor for MASLD and liver fibrosis. Short sleep on workdays and free days favored MASLD, whereas average weekly long sleep protected against MASLD. Workday, free day and average weekly optimal sleep duration was 7.5 h, 8 h and 7.78 h, respectively. Mediation analysis suggested that fasting glucose and high-density lipoprotein cholesterol indirectly mediated the relationship between sleep duration and MASLD, whereas stratified analysis showed that sex influenced the relationship, and that the correlation was only observed in women and specific age groups.</div></div><div><h3>Conclusions</h3><div>Sleep duration independently affected MASLD but only in women and specific age groups. Moreover, late sleep on workdays was a shared risk factor for MASLD and liver fibrosis. These results suggest targeting sleep behaviors for MASLD prevention and developing age- and sex-specific strategies.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 2","pages":"Article 101583"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gilberta Bensabath – Centenary of the discoverer of the high prevalence of hepatitis B and Delta in the Amazon – On the path to elimination as a public health problem! 吉尔伯塔-本萨巴斯(Gilberta Bensabath)--亚马逊地区乙型肝炎和三角洲肝炎高发病率发现者一百周年--在消除这一公共卫生问题的道路上!
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-12 DOI: 10.1016/j.aohep.2024.101575
João Renato Rebello Pinho, Michele Gomes-Gouvêa, Flair José Carrilho
{"title":"Gilberta Bensabath – Centenary of the discoverer of the high prevalence of hepatitis B and Delta in the Amazon – On the path to elimination as a public health problem!","authors":"João Renato Rebello Pinho,&nbsp;Michele Gomes-Gouvêa,&nbsp;Flair José Carrilho","doi":"10.1016/j.aohep.2024.101575","DOIUrl":"10.1016/j.aohep.2024.101575","url":null,"abstract":"","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"29 6","pages":"Article 101575"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Toulouse algorithm identifies patients with increased risk of cardiac decompensation only in patients with TIPS for refractory ascites 图卢兹算法只识别因难治性腹水而接受 TIPS 治疗的患者中心脏失代偿风险增加的患者。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-12 DOI: 10.1016/j.aohep.2024.101568
Emma Vanderschueren , Youri Bekhuis , Jan Clerick , Jappe Decock , Philippe Meersseman , Alexander Wilmer , Eveline Claus , Lawrence Bonne , Guido Claessen , Chris Verslype , Geert Maleux , Wim Laleman
{"title":"The Toulouse algorithm identifies patients with increased risk of cardiac decompensation only in patients with TIPS for refractory ascites","authors":"Emma Vanderschueren ,&nbsp;Youri Bekhuis ,&nbsp;Jan Clerick ,&nbsp;Jappe Decock ,&nbsp;Philippe Meersseman ,&nbsp;Alexander Wilmer ,&nbsp;Eveline Claus ,&nbsp;Lawrence Bonne ,&nbsp;Guido Claessen ,&nbsp;Chris Verslype ,&nbsp;Geert Maleux ,&nbsp;Wim Laleman","doi":"10.1016/j.aohep.2024.101568","DOIUrl":"10.1016/j.aohep.2024.101568","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>TIPS placement is an effective, possibly life-saving, treatment for complications of portal hypertension. The pressure shift induced by the stent can lead to cardiac decompensation (CD). We investigated the incidence of CD, possible variables associated with CD and the validity of the Toulouse algorithm for risk prediction of CD post-TIPS.</div></div><div><h3>Patients and Methods</h3><div>A total of 106 patients receiving TIPS for variceal bleeding (VB, 41.5%) or refractory ascites (RA, 58.5%) with available echocardiography and NT-proBNP results were included and retrospectively reviewed. Development of CD between time of TIPS placement and occurrence of liver transplantation, death or loss-to-follow-up was recorded. Competing risk regression analysis was performed to assess which baseline variables predicted occurrence of CD post-TIPS.</div></div><div><h3>Results</h3><div>A total of 12 patients (11.3%) developed CD after a median of 11.5 days (IQR 4 to 56.5) post-TIPS. Multivariate regression showed age (HR 1.06, <em>p</em> = 0.019), albumin (HR 1.10, <em>p</em> = 0.009) and NT-proBNP (HR 1.00, <em>p</em> = 0.023) at baseline predicted CD in the RA group. No clear predictors were found in those receiving TIPS for VB. Correspondingly, the Toulouse algorithm successfully identified patients at risk for CD, however only in the RA population (zero risk 0% vs. low risk 12.5% vs. high risk 35.3% with CD; <em>p</em> = 0.003).</div></div><div><h3>Conclusions</h3><div>CD is not an infrequent complication post-TIPS occurring in 1/10 patients. The Toulouse algorithm can identify patients at risk of CD, though only in patients receiving TIPS for RA. Allocation to the high-risk category warrants close monitoring but should not preclude TIPS placement.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 1","pages":"Article 101568"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease 乙醇与硫代乙酰胺的酒精性肝病小鼠模型确定了作为人类疾病靶点的肝脏通路。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-12 DOI: 10.1016/j.aohep.2024.101565
Ashi Mittal , Nishu Choudhary , Sudrishti Chaudhary , Anupama Kumari , Archana Rastogi , Guresh Kumar , Jaswinder Singh Maras , Shiv K Sarin , Shvetank Sharma
{"title":"Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease","authors":"Ashi Mittal ,&nbsp;Nishu Choudhary ,&nbsp;Sudrishti Chaudhary ,&nbsp;Anupama Kumari ,&nbsp;Archana Rastogi ,&nbsp;Guresh Kumar ,&nbsp;Jaswinder Singh Maras ,&nbsp;Shiv K Sarin ,&nbsp;Shvetank Sharma","doi":"10.1016/j.aohep.2024.101565","DOIUrl":"10.1016/j.aohep.2024.101565","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>Hepatic proteome and gut microbiota alterations are known in alcohol-associated hepatitis (AAH). Current animal models sparsely mimic human AAH. We aimed to develop an murine model that closely resembled human AAH.</div></div><div><h3>Materials and Methods</h3><div>Male C57BL/6N mice were pair-fed control/incremental ethanol Lieber-DeCarli diets and thioacetamide (TAA) for 12-weeks to induce AAH. Hepatic proteome was analyzed using LC-MS/MS. Gut-bacteria was determined using 16s-rRNA sequencing.</div></div><div><h3>Results</h3><div>Mice exposed to EtOH+TAA displayed higher expression of liver triglycerides (1.5-fold, <em>p</em> = 0.001), pro-inflammatory (IL6, 1.5-fold, <em>p</em> = 0.002 and TNFα, 1.7-fold, <em>p</em> = 0.01), fibrotic (TGF-β, 2.7-fold, <em>p</em> = 0.01 and Col1α1, 2-fold, <em>p</em> = 0.01) and oxidative markers (GSH and SOD (-1.5 fold, <em>p</em> = 0.004 &amp; 0.005 respectively)) as compared to EtOH alone. Histology of EtOH+TAA liver displayed pericellular liver fibrosis, increased steatosis, and neutrophil infiltration, which resembled human AAH. In the 12wk EtOH+TAA group, Desulfobacteria, Campylobacteria, and Patescibacteria increased by 2-fold (<em>p</em> = 0.02). Pathway combined score (CS, log10) in EtOH+TAA treatment showed upregulated hepatic ethanol oxidation (CS=1.93), fatty acid biosynthesis (CS=2.48), necrosis (CS=1.59), collagen formation (CS=1.28) and hypoxia (CS=0.68) and downregulated fatty acid beta-oxidation (CS=2.37), PPAR signaling (CS=1.35) fatty acid degradation (CS=2.35), bile acid metabolism (CS=1.87), and oxidative phosphorylation (CS=1.50), as observed in human disease.</div></div><div><h3>Conclusions</h3><div>Using an ethanol-thioacetamide combination in mice results in a faster establishment of AAH with fibrosis than previously known models. Differential protein expression strongly correlates with pathways found altered in human AAH, thus making the model mimic human disease better than other known models., respectively. Thioacetamide (TAA) was administered to enhance liver fibrosis and mimic human AAH.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 1","pages":"Article 101565"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Camrelizumab combined with transcatheter arterial chemoembolization and sorafenib or lenvatinib for unresectable hepatocellular carcinoma: A multicenter, retrospective study 康瑞珠单抗联合经导管动脉化疗栓塞术、索拉非尼或来伐替尼治疗不可切除肝细胞癌: 一项多中心回顾性研究。
IF 3.7 3区 医学
Annals of hepatology Pub Date : 2024-09-12 DOI: 10.1016/j.aohep.2024.101578
Xiumei Jiang , Pan Wang , Ke Su , Han Li , Hao Chi , Fei Wang , Yu Liu , Ke Xu
{"title":"Camrelizumab combined with transcatheter arterial chemoembolization and sorafenib or lenvatinib for unresectable hepatocellular carcinoma: A multicenter, retrospective study","authors":"Xiumei Jiang ,&nbsp;Pan Wang ,&nbsp;Ke Su ,&nbsp;Han Li ,&nbsp;Hao Chi ,&nbsp;Fei Wang ,&nbsp;Yu Liu ,&nbsp;Ke Xu","doi":"10.1016/j.aohep.2024.101578","DOIUrl":"10.1016/j.aohep.2024.101578","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><div>We initiated this study to explore the efficacy of camrelizumab combined with transcatheter arterial chemoembolization (TACE) plus sorafenib or lenvatinib versus TACE plus sorafenib or Lenvatinib for unresectable hepatocellular carcinoma (HCC).</div></div><div><h3>Materials and Methods</h3><div>From June 2019 to November 2022, 127 advanced HCC patients were retrospectively analyzed in this study. This consisted of 44 patients that received camrelizumab plus TACE plus sorafenib or lenvatinib (triple therapy group) and 83 patients that received TACE plus sorafenib or lenvatinib (double treatment group). The overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR) were compared between the two patient groups.</div></div><div><h3>Results</h3><div>Our findings demonstrated that patients received the triple therapy exhibited superior median OS (15.8 vs. 10.3 months, P=0.0011) and median PFS (7.2 vs. 5.2 months, P=0.019) compared to the double treatment group. In addition, the triple therapy group exhibited better 6-month (93.5% vs. 66.3%), 12-month (67.2% vs. 36.3%), and 24-month (17.2% vs. 7.6%) survival rates than the double treatment group. However, the ORR (43.2% vs. 28.9%, P = 0.106) and DCR (93.2% vs. 81.9%, P = 0.084) of the two groups were similar. Subgroup analysis showed that compared with the double treatment group, the triple therapy group had a better mOS for HCC with HBV (15.8 vs. 9.6 months, P = 0.0015) and tumor diameter ≥ 5cm (15.3 vs. 9.6 months, P = 0.00055).</div></div><div><h3>Conclusions</h3><div>Camrelizumab plus TACE and sorafenib or lenvatinib may be a promising treatment approach for the clinical management of unresectable HCC patients.</div></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":"30 2","pages":"Article 101578"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信