Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis最新文献_第7页

A review of leukofiltration therapy for decreasing the morbidity associated with cardiopulmonary bypass and acute inflammatory bowel disease. 白细胞滤过治疗降低体外循环和急性炎症性肠病相关发病率的综述。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00338.X

G. Ortolano, A. Capetandes, B. Wenz

{"title":"A review of leukofiltration therapy for decreasing the morbidity associated with cardiopulmonary bypass and acute inflammatory bowel disease.","authors":"G. Ortolano, A. Capetandes, B. Wenz","doi":"10.1046/J.1526-0968.2002.00338.X","DOIUrl":"https://doi.org/10.1046/J.1526-0968.2002.00338.X","url":null,"abstract":"Complications of cardiopulmonary bypass (CPB) and acute inflammatory bowel disease (IBD) are associated with increased morbidity and cost. During reperfusion post-CPB, activated neutrophils adhere to microvascular endothelial cells mediated by cell adhesion molecules (CAMs) and cytokines/chemokines with subsequent myocardial damage caused by activated neutrophil-derived oxidants and enzymes. Leukofiltration was shown to reduce myocardial reperfusion injury and improve gas exchange as suggested by improvements in surrogate markers of inflammation and clinical end points. In acute IBD, characterized by rectal bleeding and protracted hospital stays, circulating neutrophils emigrate to the inflamed colon and adhere to microvascular endothelial cells by CAMs. Multiple treatments with leukofiltration in IBD were shown to induce long-term remission of acute IBD. Hence, leukofiltration may reduce reperfusion injury and rectal bleeding in CPB and IBD, respectively, and therefore decrease the morbidity and cost associated with these diseases.","PeriodicalId":79755,"journal":{"name":"Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis","volume":"8 1","pages":"119-29"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78488406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Antibody reactivity of a standardized human serum protein solution against a spectrum of microbial pathogens and toxins: comparison with fresh frozen plasma. 标准化人血清蛋白溶液对一系列微生物病原体和毒素的抗体反应性:与新鲜冷冻血浆的比较

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00347.X

H. Schmidt, R. Lissner, W. Struff, O. Thamm, H. Karch

{"title":"Antibody reactivity of a standardized human serum protein solution against a spectrum of microbial pathogens and toxins: comparison with fresh frozen plasma.","authors":"H. Schmidt, R. Lissner, W. Struff, O. Thamm, H. Karch","doi":"10.1046/J.1526-0968.2002.00347.X","DOIUrl":"https://doi.org/10.1046/J.1526-0968.2002.00347.X","url":null,"abstract":"In this study, we compared a standardized solution of human serum protein (HSP) and fresh frozen plasma (FFP) with regard to the antibody specificity against a number of microbial pathogens and some important pathogenicity factors of bacterial pathogens. Due to the clinical use of HSP and FFP for therapeutical plasma exchange, we have chosen a spectrum of microbial pathogens for serological analysis that is critical in clinical settings. With the enzyme-linked immunosorbent assay technique, we could show that HSP contains marked IgG antibody reactivity against antigens of Escherichia coli, Campylobacter jejuni, Enterobacter sakazakii, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, S. epidermidis, Streptococcus pneumoniae, Enterococcus faecalis, Chlamydia pneumoniae, and Candida albicans. Although no IgM antibodies against the pathogens tested could be detected in HSP, moderate IgA reactivity was found against 4 of 12 microbial antigens. Immunoblot analysis demonstrated specific IgA and IgG responses against the endoproteinase Glu-C and the superantigens enterotoxin A and B of S. aureus, the IgA-protease of Neisseria gonorrhoeae, and Shiga toxin 2 of enterohemorrhagic E. coli. By using 3 different HSP batches in parallel, we could demonstrate antibody reactivity against important microbial pathogens and toxins. This antibody profile is essentially more homogeneous than that of 3 batches of FFP.","PeriodicalId":79755,"journal":{"name":"Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis","volume":"41 1","pages":"145-53"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81619752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Prions and blood: the impact on apheresis technology development. 朊病毒与血液:对分离技术发展的影响。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00228.X

P. Malchesky

引用次数: 0

Plasma exchange versus double filtration plasmapheresis in the treatment of Guillain-Barré syndrome. 血浆置换与双滤过血浆置换治疗格林-巴-罗综合征。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00382.X

R. Lyu, Wei-Hung Chen, S. Hsieh

{"title":"Plasma exchange versus double filtration plasmapheresis in the treatment of Guillain-Barré syndrome.","authors":"R. Lyu, Wei-Hung Chen, S. Hsieh","doi":"10.1046/J.1526-0968.2002.00382.X","DOIUrl":"https://doi.org/10.1046/J.1526-0968.2002.00382.X","url":null,"abstract":"Previous studies have shown that both plasma exchange (PE) and double filtration plasmapheresis (DFPP) are effective treatments in Guillain-Barré syndrome (GBS). Whether PE and DFPP have similar effects in GBS is not clear. This report compares the therapeutic effectiveness of PE and DFPP in GBS patients treated in 3 major hospitals in northern Taiwan. A total of 102 patients were included in this survey, including 39 with PE (hereafter PE group) and 63 with DFPP (hereafter DFPP group). Both groups showed significant improvement of disability scores after treatment. However, time to onset of effect was shorter (5.6 +/- 3.5 versus 7 +/- 3.4 days, p < 0.05), and changes of disability scores were more prominent (1.3 +/- 0.8 versus 0.8 +/- 0.8, p < 0.05) in the PE group than the DFPP group. Mortality and outcome after 6 months were not different between the 2 groups. In conclusion, both PE and DFPP are effective treatments in GBS. PE was superior to DFPP in short-term effectiveness. The long-term effectiveness was not different.","PeriodicalId":79755,"journal":{"name":"Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis","volume":"6 1","pages":"163-6"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75286719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Removal of endotoxin in blood by polymyxin B immobilized polystyrene-derivative fiber. 多粘菌素B固定化聚苯乙烯衍生物纤维去除血液中内毒素的研究。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00411.X

K. Teramoto, Y. Nakamoto, T. Kunitomo, H. Shoji, T. Tani, K. Hanazawa, M. Kodama

引用次数: 14

Comparison of different treatment regimens in a case of homozygous familial hypercholesterolemia. 纯合子家族性高胆固醇血症1例不同治疗方案的比较。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00345.X

J. Palcoux, M. Meyer, P. Jouanel, P. Vanlieferinghen, G. Malpuech

{"title":"Comparison of different treatment regimens in a case of homozygous familial hypercholesterolemia.","authors":"J. Palcoux, M. Meyer, P. Jouanel, P. Vanlieferinghen, G. Malpuech","doi":"10.1046/J.1526-0968.2002.00345.X","DOIUrl":"https://doi.org/10.1046/J.1526-0968.2002.00345.X","url":null,"abstract":"The laboratory results of five periods of different treatment regimens were compared in a 19-year-old girl with homozygous familial hypercholesterolemia (FH): weekly low-density lipoprotein (LDL) apheresis sessions with dextran sulfate columns (LA 15, Kaneka Corporation, Osaka, Japan) without statin administration; weekly LDL apheresis with polyacrylate columns (DALI, Fresenius Adsorber Technology, Bad Homburg, Germany) without statin; LDL apheresis as in Period 2 with 40 mg atorvastatin daily; LDL apheresis as in Period 2 with 80 mg atorvastatin daily; and fortnightly LDL apheresis sessions with polyacrilate and administration of 80 mg atorvastatin daily. The five treatments were given in the above order, and each lasted at least 2 months. To compare the effectiveness of the different methods, the blood levels of total cholesterol, LDL-cholesterol and high-density lipoprotein (HDL)-cholesterol were measured before each session, and the percentage decreases in the blood levels of total cholesterol and LDL-cholesterol were recorded during sessions in Periods 1 and 2. In Periods 1 and 2, the biological effectiveness of LDL apheresis was comparable. Atorvastatin (40 mg daily) improved the blood levels of total cholesterol and LDL-cholesterol, but lowered HDL-cholesterol values. Increasing the daily dose of atorvastatin from 40 mg to 80 mg did not significantly improve LDL-cholesterol levels. When the time between two sessions was longer (Period 5), the total cholesterol and LDL-cholesterol values worsened and were comparable to those of Period 2 during which there was no atorvastatin treatment. In this case of homozygous FH, weekly sessions of LDL apheresis in association with atorvastatin at dose of 40 mg per day gave the best results.","PeriodicalId":79755,"journal":{"name":"Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis","volume":"19 1","pages":"136-9"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78430439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Endotoxin and cytokine removal in sepsis. 脓毒症的内毒素和细胞因子去除。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00413.X

C. Tetta, R. Bellomo, P. Inguaggiato, M. Wratten, C. Ronco

{"title":"Endotoxin and cytokine removal in sepsis.","authors":"C. Tetta, R. Bellomo, P. Inguaggiato, M. Wratten, C. Ronco","doi":"10.1046/J.1526-0968.2002.00413.X","DOIUrl":"https://doi.org/10.1046/J.1526-0968.2002.00413.X","url":null,"abstract":"Sepsis, the leading cause of mortality in intensive care units, is a complex series of interrelated effects caused by the overproduction of multiple mediators and their unrestrained biological activity. Both proinflammatory and antiinflammatory mediators participate in the high complexity of sepsis and explain the failure of specific therapies to improve survival. Continuous extracorporeal therapies have been proposed as therapeutic options and as tools for blood purification in sepsis. Along these lines and in order to achieve higher clearances and mass removal rates, we studied the effects of plasmafiltration coupled with adsorption and provided in vitro and in vivo evidence that adsoprtion of multiple cytokines, activated complement components, and lipid mediators such as the platelet-activating factor occurs. We also showed that such treatment may lead to improved survival in a rabbit model of sepsis and to improved hemodynamics, reduced norepinephrine dose, and restoration of near-to-normal responsiveness of blood leukocytes to endotoxin in humans. It is anticipated that treatment of plasma, as a modular device to conventional hemofiltration, may pave the way to innovative approaches in the extracorporeal treatment of septic patients.","PeriodicalId":79755,"journal":{"name":"Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis","volume":"31 1","pages":"109-15"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90175372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

The effectiveness of intravenous human immunoglobulin treatment after plasmapheresis in restoring serum immunoglobulin levels: a preliminary study. 血浆置换后静脉注射人免疫球蛋白治疗恢复血清免疫球蛋白水平的有效性:初步研究。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00297.X

Y. Moriya, K. Yamaji, Y. Kanai, H. Tsuda

{"title":"The effectiveness of intravenous human immunoglobulin treatment after plasmapheresis in restoring serum immunoglobulin levels: a preliminary study.","authors":"Y. Moriya, K. Yamaji, Y. Kanai, H. Tsuda","doi":"10.1046/J.1526-0968.2002.00297.X","DOIUrl":"https://doi.org/10.1046/J.1526-0968.2002.00297.X","url":null,"abstract":"This study was performed to examine the effects of intravenous human immunoglobulin (IVIG) on the level of serum immunoglobulin G (IgG) and its subclasses after plasmapheresis in patients with autoimmune disorders. Twenty-nine patients with predominantly rheumatoid arthritis were enrolled in this study. The plasmapheresis was performed by the use of double-filtration plasmapheresis (DFPP). Immediately after DFPP, IVIG (2.5 g, 50 ml) was intravenously administered. The treatment with IVIG had almost no effect on subjective and objective symptoms. Immediately after DFPP, the total of serum IgG was decreased by approximately 40%. After 24 h, the total of serum IgG recovered to 16% reduction in IVIG-treated patients whereas it remained at 32% reduction in nontreated patients. The beneficial effect of IVIG was significantly observed in patients who had shown 1,000-1,800 mg/dl IgG in their sera. After DFPP, IgG subclasses were decreased without change in the ratio of subclasses. Twenty percent to 30% of IgG subclasses were supplemented by the treatment with IVIG without change in the ratio of subclasses. These results suggested that the treatment with IVIG at minimal amount was safe and effective to supplement IgG for hypogammaglobulinemia after DFPP.","PeriodicalId":79755,"journal":{"name":"Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis","volume":"10 1","pages":"154-8"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83761232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Rapid and persistent reduction of proteinuria following plasma exchange in a case of steroid-resistant focal segmental glomerulosclerosis. 类固醇抵抗局灶节段性肾小球硬化1例血浆置换后蛋白尿快速持续减少。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00348.X

E. Ishii, Y. Ando, K. Tamba, Y. Masunaga, E. Kusano, Y. Asano

{"title":"Rapid and persistent reduction of proteinuria following plasma exchange in a case of steroid-resistant focal segmental glomerulosclerosis.","authors":"E. Ishii, Y. Ando, K. Tamba, Y. Masunaga, E. Kusano, Y. Asano","doi":"10.1046/J.1526-0968.2002.00348.X","DOIUrl":"https://doi.org/10.1046/J.1526-0968.2002.00348.X","url":null,"abstract":"We report on the case of a 45 year old male with focal segmental glomerulosclerosis (FSGS) in whom steroid-resistant proteinuria was reduced rapidly by plasma exchange. In 1994, he was admitted to our hospital because of massive proteinuria of several years' duration. Renal biopsy confirmed the diagnosis of FSGS. Proteinuria was suppressed partially with the use of dipyridamole. Though oral prednisolone (PSL, 30 mg/day) was effective initially, relapse occurred during PSL tapering. Doses of PSL up to 30 mg/day or additional mizoribine were ineffective. The patient was readmitted for a trial of plasma exchange in April 2000. Four sessions of plasma exchange with albumin replacement over 2 weeks immediately reduced the proteinuria from 3.2 g/day to 0.6 g/day without any change in medication. After discharge, proteinuria remained suppressed for more than 6 months despite a reduction of PSL dose to 15 mg. The rapid and long lasting effect of plasma exchange in the present case argues for the role of a putative circulatory factor in the pathogenesis of proteinuria in FSGS.","PeriodicalId":79755,"journal":{"name":"Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis","volume":"36 1","pages":"174-7"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81627936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The erythrocyte adhesiveness/aggregation test to reveal real-time information of rheological relevance in patients with familial and primary hypercholesterolemia before and following plasma exchange. 红细胞粘附/聚集试验揭示家族性和原发性高胆固醇血症患者血浆置换前后流变学相关性的实时信息。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-04-01 DOI: 10.1046/J.1526-0968.2002.00364.X

T. Hershcovici, K. Elishkevitz, R. Rotstein, R. Fusman, D. Zeltser, I. Shapira, N. Arber, D. Avitzour, S. Berliner, Y. Beigel

引用次数: 20