{"title":"Reflections on the WHI findings: avoiding a pill scare and taking sensible steps forward.","authors":"Paul D Blumenthal","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"7 4","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22142156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of long-term continuous combined hormone replacement therapy with estradiol valerate and either dienogest or norethisterone acetate on mammographic density in postmenopausal women.","authors":"Dimiter B Georgiev, Nikolai A Manassiev","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The potential effect of hormone replacement therapy (HRT) on the appearance of the breast on screening mammography is of considerable interest and may have important practical implications.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the changes in the mammographic breast density during long-term continuous combined HRT with 2 different preparations.</p><p><strong>Material and methods: </strong>Nineteen patients were studied. Fifteen were treated with Climodien (Schering, 2 mg estradiol and 2 mg dienogest [E2/dienogest]), and 4 patients were treated with Kliogest (Novo Nordisk, 2 mg estradiol and 1 mg norethisterone acetate [E2/NETA]). All were followed with yearly mammography for 4 years.</p><p><strong>Results: </strong>Increase in the mammographic density was noted in 3 patients (15.8%). The change was evident after the first year of treatment with no further change during the rest of the study period.</p><p><strong>Conclusions: </strong>Long-term therapy with continuous combined HRT (E2/dienogest or E2/NETA) increased breast density in 3/19 (15.8%) of the patients. Our results suggest that the effect of these HRT preparations on mammographic density may be less significant than suggested by the results of similarly designed trials evaluating different HRT preparations.</p>","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"7 4","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22142233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Healthcare utilization among women with physical disabilities.","authors":"Catherine P Coyle, Mayra C Santiago","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Current published data indicate barriers and deficiencies in healthcare for women with physical disabilities. Yet, information regarding the influence of secondary conditions and demographic variables on the actual utilization of general health and rehabilitative services is limited. This research examined this issue.</p><p><strong>Design: </strong>Survey research</p><p><strong>Setting: </strong>Metropolitan Philadelphia region</p><p><strong>Participants: </strong>170 women between 21 and 65 years of age with physical disabilities</p><p><strong>Results: </strong>Most (96%) women had seen a general healthcare provider (eg, personal physician or gynecologist) in the past 6 months, with 60% reporting seeing such a provider 3 or more times. Despite this high frequency, many women had not had routine preventive gynecologic cancer screening services in the past 5 years. Additionally, respondents reported experiencing on average 12 secondary complications in the past year that moderately impaired their functioning. Many of these complications (fatigue, spasticity, deconditioning, joint pain, depression, social isolation) are preventable. Despite these complications, only about half of the women had seen a rehabilitative service provider (eg, physical therapist, mental health worker) in the past 6 months. Women who saw their general healthcare provider most frequently were more likely to also be receiving services from a rehabilitative service provider.</p><p><strong>Conclusion: </strong>General healthcare providers are frequently seeing women with physical disabilities. Healthcare providers have the ability and opportunity to enhance the health and wellness of this population. Particular attention should be focused on providing preventive healthcare services, including gynecologic cancer screenings and prevention and management of secondary conditions that accompany disability.</p>","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"7 4","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22142236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Be careful of what you wish for: putting the WHI Estrogen/Progestin and HERS II Trials in perspective.","authors":"John F Randolph","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"7 4","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2002-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22142152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An ecological approach to physical activity in African American women.","authors":"J. Walcott-Mcquigg, J. Zerwic, A. Dan, M. Kelley","doi":"10.1037/e322352004-249","DOIUrl":"https://doi.org/10.1037/e322352004-249","url":null,"abstract":"Physical activity in women has assumed increasing significance as a policy issue as a result of the release of the 1996 Surgeon General's Report on Physical Activity and Health. This report revealed that women in the United States were less likely than men to adhere to the recommended guidelines for physical activity. African American women are less likely than white women to participate in leisure time physical activity across age, occupational, and income groups. The purpose of this study was to use the Ecological Model of Health Promotion to explore policy, environmental, and individual factors influencing physical activity of middle- to older-aged African American women in a mixed income community in a large midwestern city. Focus group discussions were held with 3 groups of women -- administrators/community leaders, exercisers, and nonexercisers. Thirty-three women between the ages of 40 and 78 participated in the study. The women identified 6 themes influencing physical activity: perceptions of physical activity and exercise; perceived barriers to exercise; perceived benefits of and motivators to exercise; past and present opportunities for exercise; factors that enhance the successful delivery of an exercise program; and coalition building to deliver an exercise program to women in the community. The results of this study reveal that to successfully increase physical activity in an ethnic urban community, researchers and other concerned individuals need to collaborate at multiple ecological levels, with an initial emphasis on establishing coalitions between institutions, community groups, policy makers, and individuals.","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"6 6 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1037/e322352004-249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57755254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The parathyroid hormones: bone-forming agents for treatment of osteoporosis.","authors":"J F Whitfield, P Morley, G E Willick","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a 3-part article. Part 1 is an overview of bone formation and resorption and the consequences of estrogen loss on bone. Part 2 comprehensively reviews the most current data on the ability of a family of potent osteoblast-stimulating bone-builders, the native 84-amino-acid parathyroid hormone (PTH), and certain of its 31- to 38- amino-acid fragments to stimulate the growth of animal and human bones. These PTHs are currently in, or about to enter, clinical trial as treatment for postmenopausal osteoporosis. Part 3 provides a detailed consideration of how these PTHs might stimulate bone growth via PTH receptor signaling.</p>","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"5 5","pages":"E5"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21936777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk factors for osteoporosis: prevalence, change, and association with bone density.","authors":"J R Guthrie, P R Ebeling, L Dennerstein, J D Wark","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To describe the prevalence of risk factors for osteoporosis in a population-based cohort of Australian-born midlife women; determine the effect of these risk factors on premenopausal and early perimenopausal bone mineral density (BMD); and describe changes in risk factors and any effect of these on bone loss.</p><p><strong>Design: </strong>4-year longitudinal community-based study. BMD of the lumbar spine (LS) and femoral neck (FN) was measured using dual x-ray absorptiometry (DXA).</p><p><strong>Setting: </strong>Melbourne, Australia</p><p><strong>Participants: </strong>224 Australian-born women aged 46-56 years</p><p><strong>Main outcome measures: </strong>Risk factors for osteoporosis, LS-BMD, FN-BMD, and change in risk factors and BMD.</p><p><strong>Results: </strong>At baseline, 52% reported a calcium intake of less than 800 mg/day and 46% reported a caffeine intake of more than 360 mg/day; 29% exercised less than 1.5 hours/week; 5% had a body mass index (BMI) of less than 20; 14% were current smokers; 23% were past smokers; 10% reported abnormal menstrual histories; and 25% reported a family history of osteoporosis. BMD was positively associated with weight; BMI; and waist, hip, and trunk skin-fold measure (P less than .0005). At 4-year follow-up, there were increases in weight (P less than .0005), waist/hip ratio (P less than. 05), trunk skin-fold measurements (P less than.005), and calcium intake (P less than.05). In women who became late perimenopausal or postmenopausal, bone loss was associated with time in relation to the final menstrual period but not with other variables.</p><p><strong>Conclusions: </strong>There are multiple risk factors for osteoporosis in this Australian-born population of midlife women, but only anthropometric variables were associated with BMD at baseline. Significant changes during the menopausal transition in anthropometric variables and calcium intake were in the direction that could decrease the risk of osteoporosis but were not found to affect menopausal bone loss.</p>","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"5 5","pages":"E2"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21936774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breast cancer risk reduction: what do we know and where should we go?","authors":"M N Prout","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinicians should be aware of the advances in breast cancer risk assessment and risk-reduction therapy. The modified Gail model is appropriate for predicting the risk of developing breast cancer within the next 5 years for most women between ages 35 and 75. Tamoxifen has been approved by the U.S. Food and Drug Administration (FDA) for reduction of breast cancer risk in women aged 35 and older who meet the threshold risk for breast cancer. Raloxifene is being compared with tamoxifen in the clinical trial, STAR (a Study of Tamoxifen and Raloxifene), which is now enrolling postmenopausal women aged 35 or older. The risks and benefits of therapy to reduce breast cancer risk are reviewed here. Processes for comparison of risks and benefits and for shared decision making are outlined.</p>","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"5 5","pages":"E4"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21936773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physical activity and the prevention of breast cancer.","authors":"A McTiernan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Epidemiologists have identified several risk factors for breast cancer, yet clinical advice to women to change these risk factors has been uncommon. Physical activity promises to be one modifiable risk factor through which women can reduce their risk for breast cancer. Clinicians can now advise women that reducing risk for breast cancer may be one additional reason to adopt an active lifestyle. There are still questions about the type and amount of exercise needed, the ages at which exercise should be done, and the interactions with other risk factors such as reproductive and menstrual history, diet, body mass, alcohol intake, genetics, and hormone therapy. Finding answers to these questions will require a research agenda focused on the biology of exercise and breast cancer.</p>","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"5 5","pages":"E1"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21936775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk factors for osteoporosis: A review.","authors":"J R Guthrie, L Dennerstein, J D Wark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Skeletal fragility and falls are the 2 most potent factors leading to osteoporotic fractures. The aim of this article is to review factors associated with women's risk of developing skeletal fragility and subsequent osteoporosis. Many factors have been implicated, but the evidence for some is unsubstantial. Low premenopausal bone mineral density (BMD), a decrease in BMD, and an increase in bone fragility -- which occur as a result of both aging and the menopause -- are major determinants of subsequent risk for osteoporotic fracture. In addition, low body mass index (BMI), low calcium intake, low physical activity, and smoking can affect BMD. The relative importance of the effects these physical and lifestyle factors have on BMD in midlife women is not fully established. The impact of gynecologic history (parity, lactation, oral contraceptive use, age of menarche) on BMD is uncertain.</p>","PeriodicalId":79687,"journal":{"name":"Medscape women's health","volume":"5 4","pages":"E1"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21933808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}