Annals of Intensive Care最新文献

{"title":"Omics approach to chest electrical impedance tomography reveals physiological cluster of ARDS characterised by increased respiratory drive and effort.","authors":"Tommaso Mauri, Marco Leali, Elena Spinelli, Gaetano Scaramuzzo, Massimo Antonelli, Domenico L Grieco, Savino Spadaro, Giacomo Grasselli","doi":"10.1186/s13613-025-01514-3","DOIUrl":"10.1186/s13613-025-01514-3","url":null,"abstract":"<p><strong>Background: </strong>Non-invasive assessment of respiratory drive and effort in spontaneously breathing ARDS patients is challenging, yet clinically relevant. We explored whether hierarchical clustering applied to electrical impedance tomography (EIT- a radiation-free non-invasive lung imaging technique) identifies ARDS sub-phenotypes with increased drive and effort.</p><p><strong>Results: </strong>Thirty intubated patients with ARDS on assisted mechanical ventilation were monitored by EIT and esophageal pressure during a decremental positive end-expiratory pressure (PEEP) trial. A comprehensive EIT assessment was made (computed variables n = 180) during tidal breathing at different PEEP levels. Agglomerative nesting was applied to scaled data distances. Three clusters of ARDS were identified: inhomogeneous ventilation, unmatched V'/Q, and mismatched V'/Q. The unmatched V'/Q cluster had the highest respiratory drive (p = 0.045) and effort (p = 0.021) at lower PEEP, and experienced longer length of ICU stay (p = 0.019).</p><p><strong>Conclusions: </strong>Higher PEEP levels reduced drive of the unmatched V'/Q cluster, mitigating the physiological differences. Clustering approaches to EIT data identify physiologically and clinically relevant sub-phenotypes of ARDS.</p>","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"90"},"PeriodicalIF":5.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is high flow nasal therapy still warranted for patients with AECOPD and acute hypercapnic respiratory failure?","authors":"Jinlv Qin, Guizuo Wang, Yixing Liao, Wenli Shang, Dong Han","doi":"10.1186/s13613-025-01511-6","DOIUrl":"10.1186/s13613-025-01511-6","url":null,"abstract":"","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"89"},"PeriodicalIF":5.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to post-cardiac arrest care guidelines and impact on survival and neurological outcome.","authors":"Giulia Merigo, Fabiana Madotto, Aurora Magliocca, Gaetano Florio, Alessandra Rosati, Valentina Castagna, Marco Pagliano, Alberto Zanella, Mauro Panigada, Giacomo Grasselli, Giuseppe Ristagno","doi":"10.1186/s13613-025-01508-1","DOIUrl":"10.1186/s13613-025-01508-1","url":null,"abstract":"<p><strong>Background: </strong>Post-cardiac arrest (CA) care guidelines (GLs) have been introduced in 2010 and periodically updated every 5 years since then (in 2015 and 2021). However, the impact of these GLs on patients' outcome remains underexplored. The aim of this study was to comprehensively evaluate and compare the impact of implementation of three consecutive post-CA GLs over 14 years, on patients' survival and neurological recovery.</p><p><strong>Methods: </strong>This retrospective cohort study included adult patients resuscitated from CA and admitted to the intensive care unit (ICU) between 2011 and 2024. Patients were stratified into three cohorts based on the GL in use (GL2010, GL2015, and GL2024). Adherence to GL recommendations was assessed across seven macro-areas: coronary angiography, haemodynamic, ventilation, temperature control, general ICU management, multimodal neuroprognostication, and seizure control. Predictors of survival and favourable neurological outcome at ICU discharge were evaluated using multivariate logistic regression with LASSO selection. Outcome up to 6 months was also evaluated.</p><p><strong>Results: </strong>A total of 275 patients were included over the 14-year period. Survival to ICU discharge increased from 39.5% in cohort 1 to 53.9% in cohort 3, together with favourable neurological outcome that improved from 30.9 to 42.7%. Adherence to GL recommendations significantly improved across most domains, particularly in haemodynamic management (from 32.0% in cohort 1 to 77.3% in cohort 3), temperature control (from 60.6 to 94.4%), and general ICU management (from 56.3 to 77.6%). Among all interventions, adherence to haemodynamic recommendations was independently associated with improved survival (OR = 2.20, 95% CI: 1.01-4.86).</p><p><strong>Conclusions: </strong>Following the implementation of updated post-CA care GLs, adherence to recommendations improved, particularly in haemodynamic management. Although no statistically significant improvements in survival or neurological outcomes were observed, these findings highlight the potential value of sustained GL-based care.</p>","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"88"},"PeriodicalIF":5.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers for intensive care unit-acquired weakness: a systematic review for prediction, diagnosis and prognosis.","authors":"Jiamei Song, Ting Deng, Qingmei Yu, Xun Luo, Yanmei Miao, Leiyu Xie, Yongming Mei, Peng Xie, Shaolin Chen","doi":"10.1186/s13613-025-01500-9","DOIUrl":"10.1186/s13613-025-01500-9","url":null,"abstract":"<p><strong>Background: </strong>Intensive care unit-acquired weakness (ICU-AW) is a common and debilitating complication in critically ill patients, significantly affecting both short- and long-term outcomes. The existing ICU-AW diagnostic methods are not widely accepted and have a narrow application window. Biomarkers offer potential for diagnosing, predicting, and prognosticating ICU-AW, but a comprehensive synthesis of the available evidence is still lacking.</p><p><strong>Methods: </strong>We conducted a systematic search across PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang Database, China Science and Technology Journal Database (VIP Database), and China Biomedical Literature Database (SinoMed Database) from inception to January 23, 2025. Study quality was assessed using the revised Newcastle-Ottawa scale and the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Data extraction included basic characteristics of the included studies, name of biomarkers, objective, specimen types, sampling time, type of biomarker, ICU-AW diagnostic criteria, and outcomes.</p><p><strong>Results: </strong>Out of 5,769 publications screened, 11 studies of moderate to high quality (scores ≥ 6) involving 1,176 critically ill patients were included. Ten biomarkers were identified and categorized into five mechanisms: muscle injury (myoglobin, N-titin, urinary titin), metabolic pathway (glucose transporter protein type-4), neurological injury (neurofilament light/heavy chain), stress response (growth differentiation factor-15), and inflammatory process (monocyte chemoattractant protein-1, NETs marker cfDNA, and miR-181a). Six biomarkers demonstrated strong predictive and diagnostic accuracy with AUC values exceeding 0.80. Notably, growth differentiation factor-15 exhibited excellent clinical utility across diagnostic, predictive, and prognostic applications (AUC ≥ 0.85). The remaining four biomarkers showed moderate performance, with AUC values ranging from 0.60 to 0.80.</p><p><strong>Conclusion: </strong>While ten biomarkers exhibit potential for ICU-AW assessment, their clinical utility remains inconsistent. This highlights the need for large-scale, prospective validation studies and the incorporation of advanced technologies to refine existing biomarkers and identify novel candidates for ICU-AW prediction, diagnosis and management.</p><p><strong>Date of registration: </strong>Registered 1 August 2024.</p><p><strong>Trial registration: </strong>PROSPERO ID: CRD42024574437.</p>","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"86"},"PeriodicalIF":5.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-flow nasal therapy versus non-invasive ventilation for AECOPD: navigating beyond a simple choice- are we asking the right questions??","authors":"Mauro Castro Sayat, Nicolás Colaianni-Alfonso, Adrián Gallardo, Luigi Vetrugno","doi":"10.1186/s13613-025-01510-7","DOIUrl":"10.1186/s13613-025-01510-7","url":null,"abstract":"","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"87"},"PeriodicalIF":5.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial.","authors":"Qin Sun, Rui Zhang, Junyi Zhang, Jianfeng Xie, Yingzi Huang, Yi Yang, Haibo Qiu, Ling Liu, Hui Chen","doi":"10.1186/s13613-025-01501-8","DOIUrl":"10.1186/s13613-025-01501-8","url":null,"abstract":"<p><strong>Background: </strong>Compared with shorter awake prone positioning (APP), prolonged APP (≥ 12 h daily) reduces the intubation rate in patients with COVID-19-related acute hypoxemic respiratory failure (AHRF). However, the optimal APP duration is uncertain. In this secondary analysis, we aimed to explore whether a longer APP duration is associated with improved outcomes and to identify the optimal duration of APP.</p><p><strong>Methods: </strong>Data from a multicenter randomized controlled trial involving nonintubated COVID-19 patients with AHRF were analyzed. Daily APP duration over 7 days after randomization was recorded as the primary exposure in present study. The primary outcome was the time from randomization to APP failure, which was defined as a composite of tracheal intubation or mortality within 28 days. A Cox proportional hazards regression model was employed to elucidate the associations, and the daily duration of APP was treated as time dependent.</p><p><strong>Results: </strong>A total of 409 patients were randomized in the original trial, and 408 were enrolled in this analysis. Among these patients, 105 (25.7%) experienced APP failure. A longer daily APP duration was associated with a lower risk of APP failure, with a hazard ratio (HR) of 0.93 (95% confidence interval (CI): 0.88-0.98), and the association was significant only during the first three days after randomization. There was a nonlinear relationship between the daily APP duration and the risk of APP failure (P = 0.015 for nonlinearity). Compared with patients whose APP duration ranged from 8 to 12 h per day, patients with less than 8 h of APP per day had a greater risk of APP failure (HR 2.44, 95% CI 1.21-4.92), whereas extending APP beyond 12 h per day did not improve the outcomes further (HR 1.03, 95% CI 0.51-2.10, P = 0.932).</p><p><strong>Interpretation: </strong>A longer daily APP duration was associated with a reduced risk of APP failure in COVID-19-related AHRF patients, and the optimal APP duration was 8-12 h per day. Clinical trial ClinicalTrials.gov: NCT05677984, Registered January 3, 2023. https://register.</p><p><strong>Clinicaltrials: </strong>gov/prs/app/action/SelectProtocol?sid=S000CST9&selectaction=Edit&uid=U0000YKY&ts=4&cx=-x0muek.</p>","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"84"},"PeriodicalIF":5.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of Nonagenarian ICU Patients A Bayesian analysis of prospective European studies.","authors":"Daniel Dankl, Raphael Romano Bruno, Michael Beil, Hans Flaatten, Malte Kelm, Sviri Sigal, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Andreas Koköfer, Barbara Schreiber, Franz Singhartinger, Sandra Oeyen, Brian Marsh, Rui Moreno, Susannah Leaver, Dylan W De Lange, Bertrand Guidet, Ariane Boumendil, Christian Jung, Bernhard Wernly","doi":"10.1186/s13613-025-01496-2","DOIUrl":"10.1186/s13613-025-01496-2","url":null,"abstract":"<p><strong>Background: </strong>As the population ages, the number of very elderly patients (≥ 90 years, nonagenarians) admitted to intensive care units (ICUs) is increasing. This trend raises concerns about the appropriateness of ICU care for this age group, especially due to the uncertainty surrounding their prognosis. Some studies suggest that elderly ICU patients have outcomes similar to slightly younger patients, but skepticism remains due to clinical judgment, cultural attitudes, and resource allocation concerns.</p><p><strong>Methods: </strong>We reassessed the 30-day mortality risk of nonagenarians admitted to ICUs using data from the VIP1, VIP2, and COVIP registries. Bayesian statistical methods, including Markov Chain Monte Carlo (MCMC) simulations, were used to estimate the relative risk (RR) of mortality for nonagenarians compared to octogenarians (80-89 years). Various prior assumptions (non-informative, pessimistic, and skeptical) were incorporated. The analysis adjusted for key variables such as SOFA score, frailty, and treatment limitations.</p><p><strong>Results: </strong>A total of 8,408 patients were included, consisting of 807 nonagenarians and 7,601 octogenarians. The 30-day mortality rate was 45% for nonagenarians and 42% for octogenarians (p = 0.12). Bayesian analysis revealed a high probability (81.1-97.9%) that nonagenarians face a higher 30-day mortality risk. However, the probability of a clinically significantly increase in mortality (RR > 1.1) was moderate (28.9-34.7%), and the probability of a substantial increase (RR > 1.2) was very low (0.03-1.9%).</p><p><strong>Conclusion: </strong>Nonagenarians in the ICU have a slightly higher 30-day mortality risk compared to octogenarians, but the increase is unlikely to exceed clinically meaningful thresholds. Bayesian methods offer more refined mortality risk assessment, suggesting that ICU admission decisions should be based on individualized factors, not just age.</p>","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"85"},"PeriodicalIF":5.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of the plasma volume response to crystalloid fluid used for goal-directed fluid therapy.","authors":"Robert G Hahn, Terry O'Brien","doi":"10.1186/s13613-025-01495-3","DOIUrl":"10.1186/s13613-025-01495-3","url":null,"abstract":"<p><strong>Background: </strong>Goal-directed fluid therapy uses repeated bolus infusions of crystalloid or colloid fluid to increase the plasma volume for the purpose of challenging the patient's position on the Frank-Starling curve. Each bolus is assumed to increase cardiac preload to the same degree. We examined whether this view is reasonable by simulating the plasma volume responses to crystalloid and colloid fluid. For this purpose, the volume kinetics of crystalloid fluid was characterized in 103 anaesthetized patients while parameters for colloid (hydroxyethyl starch) were taken from the literature. Simulations focused on the plasma volume response to 3 bolus infusions of 4 mL/kg of crystalloid and 2-4 mL/kg of colloid over 7 min. The boluses were separated by a free interval of 5 min to allow hemodynamic assessment.</p><p><strong>Results: </strong>Crystalloid fluid showed attenuation of the plasma volume response to repeated bolus infusions. The second and third bolus increased the plasma volume by only 51 and 36% as much as the first one. Attenuation also occurred when the boluses were preceded by a constant-rate infusion of 5 mL/kg/h or 10 mL/kg/h of crystalloid over 60 min, while placing the patient in the Trendelenburg body position (head down) reduced the attenuation. Bleeding increased the plasma volume responses, but attenuation still occurred. Colloid fluid did not show attenuation.</p><p><strong>Conclusion: </strong>Attenuation of the plasma volume response to bolus infusions of crystalloid fluid occurs. The second and third bolus might not increase cardiac preload enough to allow a correct diagnosis of fluid responsiveness. This problem is not shared by colloid fluid.</p>","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"83"},"PeriodicalIF":5.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Automatic continuous P_0.1 measurements during weaning from mechanical ventilation: a clinical study.","authors":"Flora Delamaire, Maamar Adel, Guillot Pauline, Quelven Quentin, Coirier Valentin, Painvin Benoit, Tadie Jean-Marc, Terzi Nicolas, Gacouin Arnaud","doi":"10.1186/s13613-025-01497-1","DOIUrl":"10.1186/s13613-025-01497-1","url":null,"abstract":"","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"82"},"PeriodicalIF":5.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding portal vein pulsatility: hemodynamic determinants in a post-hoc analysis of a prospective observational trial.","authors":"Cosmin Balan, Bianca Morosanu, Antonia Fodoroiu, Vlad Dobre, Andrei Dumitrache, Robert Thomas Barbulescu, Liana Valeanu, Cornel Robu, Cristian Boros, Alexandru Nica, Adrian Wong, Francesco Corradi, Ioana Marina Grintescu, Serban-Ion Bubenek-Turconi","doi":"10.1186/s13613-025-01498-0","DOIUrl":"10.1186/s13613-025-01498-0","url":null,"abstract":"<p><strong>Background: </strong>The portal vein pulsatility index (PVPI) reflects systemic congestion and is influenced by both volume status and right ventricular (RV) function. The mean systemic filling pressure analogue (Pmsa), derived from a mathematical model, estimates the interaction between stressed blood volume and systemic vascular compliance, serving as surrogate marker of volume status. This post-hoc analysis of an observational trial investigates the combined role of Pmsa and RV function as determinants of PVPI using echocardiography. Fifty-five mechanically ventilated patients with circulatory failure were included within 6 h of ICU admission following elective open-heart surgery. Fluid-tolerant patients (PVPI < 50%) underwent a passive leg raising (PLR) test; fluid-responsive patients subsequently received 7 mL/kg of Ringer's lactate. PVPI and Pmsa were measured at five timepoints: baseline (T1), after PLR (T2), upon returning to baseline (T3), after fluid administration (T4), and 20 min post-infusion (T5). RV function parameters, including RV to LV end-diastolic area ratio (RVEDA/LVEDA), tricuspid lateral annular systolic velocity (RV S'), RV fractional area change (RVFAC), pulmonary acceleration time (PAT), and right myocardial performance index (RIMP)-were assessed at T1, T4, and T5. Only fluid-responsive patients were evaluated beyond T3.</p><p><strong>Results: </strong>At T1, robust multilinear regression including all patients identified RVEDA/LVEDA (β = 10.38; p < 0.001), RIMP (β = - 6.54; p = 0.002), and RV S' (β = - 0.60; p = 0.002) as significant determinants of squared PVPI. In all patients, repeated measures correlation between Pmsa and PVPI was strong across T1-to-T3 (ρ = 0.785; p < 0.001), increasing from a non-significant correlation at T1 (ρ = 0.215; p = 0.115). Generalized estimating equations conducted only in fluid-responsive patients across T1, T4, and T5 identified Pmsa (β = 4.19; p < 0.001), RV S' (β = - 5.84; p < 0.001), RVEDA/LVEDA (β = 34.85; p = 0.018), and RIMP (β = - 35.28; p = 0.039) as significant determinants of PVPI.</p><p><strong>Conclusion: </strong>RV function and Pmsa are key determinants of PVPI. Their combined assessment may support an individualized congestion management by guiding interventions toward volume status, RV function, or both. Trial registration Primary Trial Registration: NCT06440772. Registered 30 May 2024. Retrospectively registered.</p>","PeriodicalId":7966,"journal":{"name":"Annals of Intensive Care","volume":"15 1","pages":"81"},"PeriodicalIF":5.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}