American journal of neuroprotection and neuroregeneration最新文献_第8页

Aquaporin-4 in Cerebral Edema Following Ischemia/Reperfusion Injury: Exploration of Novel Therapeutic Strategies 水通道蛋白-4在脑缺血/再灌注损伤后脑水肿中的作用:探索新的治疗策略

American journal of neuroprotection and neuroregeneration Pub Date : 2012-12-01 DOI: 10.1166/AJNN.2012.1053

P. Bhattacharya, A. Pandey, S. Paul, R. Patnaik

{"title":"Aquaporin-4 in Cerebral Edema Following Ischemia/Reperfusion Injury: Exploration of Novel Therapeutic Strategies","authors":"P. Bhattacharya, A. Pandey, S. Paul, R. Patnaik","doi":"10.1166/AJNN.2012.1053","DOIUrl":"https://doi.org/10.1166/AJNN.2012.1053","url":null,"abstract":"Purpose of Review: Although multifaceted factors contribute towards the high mortality and morbidity associated with cerebral ischemia, the development of cerebral edema with brain swelling remains the most significant predictor of the outcome. The present review summarizes the most recent advances in the understanding of mechanisms associated with development of ischemia/reperfusion induced cerebral edema, and highlights possible therapeutic intervention with a focus on Aquaporin-4 as a target. Recent Findings: Although a many factors have emerged as candidate mediators of cerebral edema inhibition following cerebral ischemia but Aquaporins remain as the most potential mediators amongst all of them. A many pharmacological molecule are used to treat brain swelling after brain stroke but targeting Aquaporin-4 by Piroxicam a NSAID is first to be worked out by us which have novel outcome with multidimensional neuroprotective action following cerebral ischemia in animal model. Summary: Obliterating blood–brain barrier permeability is the most approaching strategy to manage brain edema and associated swelling but acting on protein like Aquaporin-4 may act as a time ahead approach to intervene brain edema following cerebral ischemia and any pharmacological molecule able to modulate this can be a successful therapeutic strategy.","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74411287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Stem Cell Therapies for Neural Degeneration Appears to be Promising 干细胞治疗神经退行性变似乎很有希望

American journal of neuroprotection and neuroregeneration Pub Date : 2012-12-01 DOI: 10.1166/AJNN.2012.1059

H. Sharma

引用次数: 0

Glycolytic and Proteolytic Metabolism in Erythrocytes from Elderly and Demented Patients 老年和痴呆患者红细胞的糖酵解和蛋白水解代谢

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1039

Y. Kaminsky, A. Poghosyan, L. Tikhonova, Hector H. Palacios, M. Kamal, E. Kosenko, G. Aliev

{"title":"Glycolytic and Proteolytic Metabolism in Erythrocytes from Elderly and Demented Patients","authors":"Y. Kaminsky, A. Poghosyan, L. Tikhonova, Hector H. Palacios, M. Kamal, E. Kosenko, G. Aliev","doi":"10.1166/AJNN.2012.1039","DOIUrl":"https://doi.org/10.1166/AJNN.2012.1039","url":null,"abstract":"Background: Accumulating evidence implicates a role for altered energy and proteolytic metabolism in the pathogenesis of Alzheimer disease (AD), but the involvement of erythrocytes (RBC) remains to be completely understood. The objective stands to test a hypotheses that erythrocytic glycolytic and proteolytic metabolism is disturbed in the elderly and in AD patients. Methods: This pilot study analyzed the levels of the key glycolytic and proteolytic enzymes and metabolites in RBC from patients with AD and non-Alzheimer’s dementia (NA), from age-matched (AC) and young adult (YC) controls. Results: Glycolytic enzymes displayed lower activities in AC, and similar or higher activities in AD and NA, as compared to those in YC. Caspase-3 and calpain activities in AC were about 3 times those of YC. There were no differences between AC, AD and NA in proteolytic enzymes. Conclusion: Among glycolytic parameters studied in four subject groups, only hexokinase activity specifically increases in AD. Changes in other glycolytic and proteolytic enzyme activities and metabolite concentrations in RBC were not specific to dementias but characteristics for aging.","PeriodicalId":7964,"journal":{"name":"American journal of neuroprotection and neuroregeneration","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79644376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The Status of Research on Mechanism of Action of Methylprednisolone (MP) in the Treatment of Spinal Cord Injury 甲基强的松龙治疗脊髓损伤作用机制的研究现状

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1045

Xu Junkui, Dong Jun, W. Dong, He Xijing

引用次数: 1

Experimental Models of Neurodegenerative Diseases: A Simple Method to Check Both Viability of Neural Tissue and Cannulae Location After Stereotaxic Surgeries 神经退行性疾病的实验模型:一种检测立体定向手术后神经组织活力和套管位置的简单方法

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1037

Sebastián García, Federico Nanfaro, S. Casas, R. Cabrera, R. Yunes

引用次数: 0

Spectrum from Obesity to Neurodegenerative Disorder 从肥胖到神经退行性疾病

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1042

A. Diwan, K. Aziz, P. Rishi, K. Kavita, C. K. Firoz, M. Kamal

引用次数: 7

The Morphological Study on Naotaitong Granule Treating Ischemic Stroke 脑台通颗粒治疗缺血性脑卒中的形态学研究

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1044

Zhou Haizhe, Y. Puwei, Chen Mengyuan, Li Jun, Zhao Huan, C. Yongsheng, He Xijing

引用次数: 0

Analysis of Therapeutic Efficacy of Citicoline in Patients with Vertigo of Central Origin and Vascular Aetiology 胞磷胆碱治疗中枢性眩晕的疗效及血管病因分析

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1043

D. Petrova, D. Maslarov, I. Angelov, D. Zekin

引用次数: 8

Novel Therapeutic Strategies for Neural Degeneration Following Traumatic Injuries or Age Related Disorders Are the Need of the Hour 创伤性损伤或年龄相关疾病后神经退行性变的新治疗策略是当前的需要

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1058

H. Sharma

引用次数: 0

Mechanisms of Hypothermia, Delayed Hyperthermia and Fever Following CNS Injury 中枢神经系统损伤后的低温、延迟性高热和发热机制

American journal of neuroprotection and neuroregeneration Pub Date : 2012-10-01 DOI: 10.1166/AJNN.2012.1040

C. Gordon, L. Katz, L. Leon

引用次数: 1