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Progress in cell cycle research最新文献

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The actin cytoskeleton as a therapeutic target: state of the art and future directions. 肌动蛋白细胞骨架作为治疗靶点的研究现状及未来发展方向。
Progress in cell cycle research Pub Date : 2003-01-01
Adeline Giganti, Evelyne Friederich
{"title":"The actin cytoskeleton as a therapeutic target: state of the art and future directions.","authors":"Adeline Giganti,&nbsp;Evelyne Friederich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the control of a large number of actin-associated proteins. In cancer cells, structural and functional perturbations of the actin cytoskeleton correlate with higher proliferation rates and uncontrolled movement. Therefore, small molecules that act on the actin cytoskeleton of tumour cells and thus inhibit cell division and movement, may be of high therapeutic value. The dynamic properties of the actin cytoskeleton and the mechanism of action of actin-targeting drugs will be described.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"511-25"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tubulin and microtubules as targets for anticancer drugs. 微管和微管作为抗癌药物的靶点。
Progress in cell cycle research Pub Date : 2003-01-01
John A Hadfield, Sylvie Ducki, Nicholas Hirst, Alan T McGown
{"title":"Tubulin and microtubules as targets for anticancer drugs.","authors":"John A Hadfield,&nbsp;Sylvie Ducki,&nbsp;Nicholas Hirst,&nbsp;Alan T McGown","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Microtubules are intracellular organelles formed from the protein tubulin. These organelles have a number of essential cellular functions including chromosome segregation, the maintenance of cell shape, transport, motility, and organelle distribution. Drugs that affect the tubulin-microtubule equilibrium (taxol, vinca alkaloids) are effective anticancer drugs. This review describes the molecular target, methods used in screening, the structures of compounds known to interact with tubulin, and the clinical use of these agents. In addition the ability of these agents to destroy tumour vasculature is described. This represents an exciting new molecular target in the design of anticancer drugs.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"309-25"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis. 有丝分裂过程中极光激酶对组蛋白和组蛋白样蛋白的磷酸化作用。
Progress in cell cycle research Pub Date : 2003-01-01
Gaetan Pascreau, Yannick Arlot-Bonnemains, Claude Prigent
{"title":"Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis.","authors":"Gaetan Pascreau,&nbsp;Yannick Arlot-Bonnemains,&nbsp;Claude Prigent","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Successful cell division requires that daughter cells inherit not only a complete set of chromosomes, but also only one centrosome, and similar amounts of organelles and cytoplasmic components. The different mitotic processes are driven by cell cycle-regulated protein kinases and phosphatases and their fidelity is closely monitored by a number of checkpoint mechanisms. Histone H3 is phosphorylated during mitosis, but the kinases involved were not known until recently. Recent work has revealed that Aurora kinases are required for mitotic phosphorylation of histone H3 and of its centromeric variant CENP-A. This finding has stimulated functional studies of the role(s) of Aurora kinases and H3 phosphorylation during mitosis, which are reviewed in this chapter.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"369-74"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulators of nucleolar functions. 核仁功能的调节者。
Progress in cell cycle research Pub Date : 2003-01-01
Danièle Hernandez-Verdun, Pascal Roussel
{"title":"Regulators of nucleolar functions.","authors":"Danièle Hernandez-Verdun,&nbsp;Pascal Roussel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The nucleolus is the ribosome factory and also a multifunctional domain that plays an important role in nuclear organization and function. Interestingly, ribosome biogenesis appears directly related to cell growth and proliferation. The nucleolus corresponds to a very dynamic nuclear domain resulting from an equilibrium between the level of ribosomal RNA synthesis and the efficiency of ribosomal RNA processing. Ribosome biogenesis is regulated throughout interphase and stops during mitosis. The mitotic silencing of transcription, the distribution of the processing machinery, as well as the link between transcription and processing were found to be dependent on cyclin-dependent kinase(s).</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"301-8"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation. 寄生原生动物的细胞周期:化疗开发的潜力。
Progress in cell cycle research Pub Date : 2003-01-01
Tansy C Hammarton, Jeremy C Mottram, Christian Doerig
{"title":"The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation.","authors":"Tansy C Hammarton,&nbsp;Jeremy C Mottram,&nbsp;Christian Doerig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is an urgent need to develop new drugs against eukaryotic parasitic protozoa such as Plasmodium, Trypanosoma and Leishmania, which cause the diseases malaria, trypanosomiasis and the leishmaniases respectively. The biology of these organisms has many unusual facets that might be exploited for drug design, and the recent availability of parasite genome sequence data has facilitated the search for novel drug targets. Here we review current understanding of the cell cycle in these parasites and show that important structural and functional differences exist between parasite and mammalian cell cycle control machineries and signal transduction pathways, which might be utilised for rational drug design. Potential targets include protein kinases from the cyclin-dependent kinase, cAMP-dependent kinase and mitogen activated protein kinase families.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"91-101"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of experimental antimitotic agents: classical and combinatorial methods. 实验抗有丝分裂药物的优化:经典与组合方法。
Progress in cell cycle research Pub Date : 2003-01-01
Nathanael S Gray
{"title":"Optimization of experimental antimitotic agents: classical and combinatorial methods.","authors":"Nathanael S Gray","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Compounds that affect the progress of the cell cycle have served as useful tools for elucidating biological function and as leads for pharmacological agents. Historically, natural products derived from terrestrial and aquatic organisms have been the richest source of lead compounds and novel pharmacophores. Discovery and development of lead compounds from natural products has traditionally involved isolation of a natural product with the biochemical activity of interest, elucidation of its structure, development of chemical or biosynthetic methods for producing the compound and related compounds in larger quantities, and eventually examination of structure-activity relationships and pharmacological properties. Combinatorial chemistry has emerged as a powerful tool for the assembly of large collections of synthetic molecules; as such, it has been adopted in grand style by the pharmaceutical industry. Combinatorial chemistry can be applied in two modes: a diversity-generating mode, where known or novel scaffolds are elaborated into libraries and screened for new activities; or a focused mode, where attention is centered on a particular site in an effort to enhance a particular property (activity, selectivity, solubility, stability, bioavailability). In either mode, identification and development of compounds of interest is dependent on iterative rounds of compound optimization based on efficient and reliable biochemical, cellular, and phenotypic assays.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"135-43"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of the eukaryotic cell cycle. 真核细胞周期的调节。
Progress in cell cycle research Pub Date : 2003-01-01
Clare H McGowan
{"title":"Regulation of the eukaryotic cell cycle.","authors":"Clare H McGowan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The sundry cellular processes required to successfully replicate and divide cells are driven by the sequential activation and inactivation of a family of cyclin dependent kinases. Activation is driven predominately by the periodic expression of the cyclin subunit and requires activating phosphorylation of the kinase subunit. Inactivation is controlled by inhibitory phosphorylation of the kinase subunit, by ubiquitin-mediated degradation of the cyclin subunit and by interaction of the complex with small inhibitory proteins. The mechanisms that coordinate cell cycle progression under favorable and adverse conditions are reviewed.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From DNA damage to G2 arrest: the many roles of topoisomerase II. 从DNA损伤到G2阻滞:拓扑异构酶II的许多作用。
Progress in cell cycle research Pub Date : 2003-01-01
Annette K Larsen, Alexandre E Escargueil, Andrzej Skladanowski
{"title":"From DNA damage to G2 arrest: the many roles of topoisomerase II.","authors":"Annette K Larsen,&nbsp;Alexandre E Escargueil,&nbsp;Andrzej Skladanowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>DNA topoisomerase II inhibitors are among the most widely used anticancer agents. These drugs are potent inducers of DNA strand breaks and G2 arrest. However, topoisomerase II is not only a target for anti-cancer drugs but also part of the cellular response to different types of DNA damage. Topoisomerase II forms molecular complexes with important cell cycle regulators including the p53 oncogene suppressor, the BRCT-containing protein TopBP1, 14-3-3 epsilon and Cdc2 kinase. The association between topoisomerase II and Cdc2 kinase likely represents the earliest step in mitotic chromatin condensation. Therefore, regulation of the topoisomerase II/Cdc2 interaction could represent a novel mechanism to delay mitotic onset.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"295-300"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24055043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rho family-associated kinases PAK1 and rock. Rho家族相关激酶PAK1和rock。
Progress in cell cycle research Pub Date : 2003-01-01
Hiroshi Maruta, Thao V Nheu, Hong He, Yumiko Hirokawa
{"title":"Rho family-associated kinases PAK1 and rock.","authors":"Hiroshi Maruta,&nbsp;Thao V Nheu,&nbsp;Hong He,&nbsp;Yumiko Hirokawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rho family GTPases (Rho, Rac and CDC42) share around 30% sequence identity with RAS family GTPases, and are essential for RAS-induced malignant transformation, i.e., aberrant serum/anchorage-independent growth and actin cytoskeleton-linked morphological changes. Oncogenic RAS mutants such as v-Ha-RAS trigger cell cycle entry (G0-G1 transition) mainly by up-regulating cyclin D1, an activator of cyclin-dependent kinases (CDK), and down-regulating p27, a CDK inhibitor. Although both Rac and CDC42 are clearly activated by RAS, there is so far no evidence that RAS activates Rho. In this chapter, we will discuss the role of these Rho family GTPases and their effectors, in particular the Ser/Thr kinases PAK1 and Rock, in RAS-induced serum/anchorage-independent cell cycling, and discuss several potential therapeutics, peptides or chemical compounds, that could block this oncogenic cell cycle signalling pathway.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"203-10"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell cycle deregulation: a common motif in cancer. 细胞周期失调:癌症中的一个共同基序。
Progress in cell cycle research Pub Date : 2003-01-01
Marcos Malumbres, Amancio Carnero
{"title":"Cell cycle deregulation: a common motif in cancer.","authors":"Marcos Malumbres,&nbsp;Amancio Carnero","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Uncontrolled proliferation is a hallmark of cancer cells. Molecular analysis of human tumors and animal models have provided a clear basis for the understanding of the cellular processes that govern cell cycle progression in normal and tumor cells. Many cell cycle regulators controlling the correct entry and progression through the cell cycle are altered in tumors. In fact, most, if not all, human cancers show a deregulated control of G1 progression, a period when cells decide whether to start proliferation or to stay quiescent. In addition, tumor cells have impaired cell cycle checkpoints, resulting in the accumulation of genetic aberrations. Manipulation of these control mechanisms provides new avenues for the design of advanced therapeutic strategies against tumor development.</p>","PeriodicalId":79529,"journal":{"name":"Progress in cell cycle research","volume":"5 ","pages":"5-18"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24054605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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