Mund-, Kiefer- und Gesichtschirurgie : MKG最新文献

{"title":"[Exploration of tumor suppressors p16INK4a and p14ARF in oral leukoplakias].","authors":"Matthias Nitsche,&nbsp;Susanne Koy,&nbsp;Michael Mörz,&nbsp;Rainer Koch,&nbsp;Uwe Eckelt","doi":"10.1007/s10006-007-0086-0","DOIUrl":"https://doi.org/10.1007/s10006-007-0086-0","url":null,"abstract":"<p><p>The inactivation of p16 and p14ARF is considered to be an important step in the carcinogenesis of oropharygeal carcinomas. This consideration is supported by the observation of multiple allelic losses in the coding loci of chromosome 9p21 in squamous cell carcinomas and in dysplastic premalignant lesions. The present study hypothesized that comparable alterations already occur in leukoplakia, which are seen as potential predecessors of oral squamous cell carcinomas and that it is possible to differ leukoplakia with from leukoplakia without further malignant transformation. Furthermore we evaluated, whether such leukoplakia show sequence alterations in the genes p16 and p14ARF, which are capable to cause a limitation in gene function. The results show that the LOH pattern in genes p16 and p14ARF occur as well in leuplakia with malignant transformation as in leukoplakia, that do not show clinical alterations. The rate of allelic loss did not differ significantly. Overall, the incidence of allelic loss was lower in leuplakia compared to succeeding squamous-cell carcinomas (p<0,05). The results further illustrated an increase in LOH patterns in dyplastic leukoplakia, without reaching statistical significance. Significant increases in allelic losses were found in heavy smokers, (p < 0,05). PCR analysis of the exons 1-alpha, exon 1-beta and exon 2 in leukoplakia, containing LOH patterns did not show genetic alterations. Thus we concluded, that gene deletion and gene mutation have a minor role in the inactivation process of p16 and p14ARF in oral leukoplakia. Representing an early process in carcinogenesis, gene deletion and mutation occur in leukoplakia with and without malignant transformation. Therefore, taken as a singular parameter they represent an uncertain criteria to assess the potential of malignant transformation. However they could provide information in combination with other genetic factors like chromosomal methylation patterns and histology.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":" ","pages":"317-26"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0086-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41021147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of hydrophilicity and microtopography of titanium implant surfaces on initial supragingival plaque biofilm formation. A pilot study.","authors":"F Schwarz,&nbsp;A Sculean,&nbsp;M Wieland,&nbsp;N Horn,&nbsp;E Nuesry,&nbsp;C Bube,&nbsp;J Becker","doi":"10.1007/s10006-007-0079-z","DOIUrl":"https://doi.org/10.1007/s10006-007-0079-z","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present pilot study is to investigate the effects of hydrophilicity and microtopography of titanium implant surfaces on initial supragingival plaque biofilm formation.</p><p><strong>Materials and methods: </strong>Test specimens were manufactured from commercially pure grade 2 titanium according to one of the following procedures: polished (P), acid-etched (A), chemically modified (mod) A (modA), sand-blasted large grit and A (SLA), and modSLA. Intraoral splints were used to collect an in vivo supragingival plaque biofilm in each group at 12, 24, and 48 h. Stained plaque biofilm (PB) areas (%) were morphometrically assessed.</p><p><strong>Results: </strong>All groups exhibited significant increases of mean PB areas over time (p < 0.001; respectively). Morphometrical analysis revealed the following mean PB areas: 12h: SLA = modSLA > P > A =modA (p < 0.001; respectively); 24h: SLA > modSLA = P > A = modA (p < 0.001; respectively); 48h: SLA = modSLA = P > A = modA (p < 0.001; respectively).</p><p><strong>Conclusions: </strong>Within the limits of a pilot study, it could be concluded that hydrophilicity had no apparent effect, while microtopography had a highly uneven and unpredictable influence on supragingival plaque biofilm formation.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":"11 6","pages":"333-8"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0079-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27051328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Immunohistochemical study on collagen I content in the gingiva in cleidocranial dysplasia].","authors":"Tobias Ach,&nbsp;Uwe Baumert,&nbsp;Christian Morsczeck,&nbsp;Regine Dahse,&nbsp;Torsten Eugen Reichert,&nbsp;Oliver Driemel","doi":"10.1007/s10006-007-0088-y","DOIUrl":"https://doi.org/10.1007/s10006-007-0088-y","url":null,"abstract":"<p><strong>Background: </strong>Patients with cleidocranial dysplasia (CCD) present a thickend and fibrotic gingiva.</p><p><strong>Purpose: </strong>To the best of our knowledge it was analysed for the first time, whether this is correlated with an increased rate of collagen I in oral mucosa.</p><p><strong>Patients and methods: </strong>27 soft tissue biopsies of six CCD-patients and 17 tissue samples of 12 healthy persons were labled with a monoclonal antibody against collagen I and the bound antibodies were detected with alkaline phosphatase-anti-alkaline phophatase-kit. The histological slices were analysed by a digital image recognition software under a fully automated microscope and the rate of collagen I was converted into amounts of grey tones.</p><p><strong>Results: </strong>The amount of grey tones reached from 11.909 to 15.319 in the CCD-group, and from 2752 to 12.556 in the control group. The U-Test of Mann, Whitney and Wilcoxon for two independent samples generated a rank sum of 91,50 for CCD-patients, and of 79,50 for the control group. The Z-value was 3,246, the p-value 0,005. \"Fisher's exact test\" identified a p-value of 0,0003.</p><p><strong>Conclusions: </strong>The rate of collagen I in the oral mucosa seems to be increased significantly in CCD. This could explain the typical thick and fibrotic consistency of the gingiva and could be one reason for the delayed or missing dentition.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":" ","pages":"349-54"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0088-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41024259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Severe upper airway obstruction due to retropharyngeal haematoma formation following cervical trauma].","authors":"Stephan Haarmann,&nbsp;Andi Setiawan Budihardja,&nbsp;Thomas Mücke,&nbsp;Christian Schwaegerl,&nbsp;Klaus Dietrich Wolff","doi":"10.1007/s10006-007-0085-1","DOIUrl":"https://doi.org/10.1007/s10006-007-0085-1","url":null,"abstract":"<p><p>Mechanical airway obstruction secondary to retropharyngeal bleeding is rare. In most cases such a complication is described after head and neck trauma. Complicating factors include anticoagulant therapy, tumour, aneurysm, infection or major cervical spine injury. A precise initial diagnosis is necessary to avoid a life-threatening situation. Lateral X-ray and computed tomography is essential for safe management.Treatment depends upon size of the haematoma as well as the clinical course of the patient. Smaller haematomas may be observed. Lager haematomas and those that fail to reabsorb should undergo drainage.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":" ","pages":"363-7"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0085-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41021148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Identification of a recurrent oral squamous cell carcinoma by brush cytology].","authors":"Antonios Moralis, Martin Kunkel, Torsten Eugen Reichert, Hartwig Kosmehl, Oliver Driemel","doi":"10.1007/s10006-007-0080-6","DOIUrl":"10.1007/s10006-007-0080-6","url":null,"abstract":"<p><strong>Background: </strong>Large oral lesions comprise the risk that an incisional biopsy does not reveal the most aggressive site in spite of carefully selecting the place of biopsy.</p><p><strong>Case report: </strong>The first incisional biopsy of a large, clinically suspect, oral lesion could not identify the subepidermal spread of a recurrent oral squamous cell carcinoma. Atypical cells obtained by a simultaneous brush biopsy prompted a renewed, incisional biopsy which finally established the diagnosis of a recurrent, oral squamous cell carcinoma.</p><p><strong>Conclusions: </strong>The presented case emphasizes the value of brush biopsy in the follow-up of oral squamous cell carcinoma, especially in examination of oral lesions covering a large area.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":"11 6","pages":"355-8"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0080-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27041531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Patient satisfaction after oral and maxillofacial procedures under clinical hypnosis].","authors":"Dirk Hermes,&nbsp;Daniel Trübger,&nbsp;Samer G Hakim","doi":"10.1007/s10006-007-0083-3","DOIUrl":"https://doi.org/10.1007/s10006-007-0083-3","url":null,"abstract":"<p><p>The Department of Maxillofacial Surgery of the University Hospital Schleswig-Holstein/Campus Lübeck offers intraoperative hypnosis since 2002. Besides clinical evaluation by controlled studies, patients attitudes should be included in the judgement on such adjuvant procedure not established in general.70 patients of the department treated under combined local anaesthesia/hypnosis rated their individual postoperative patient satisfaction by standardised questionnaires. A control group of equal size and demographic/surgical features consisted of patients that were treated without hypnosis in the same interval. Results of the inquiry indicate that intraoperative hypnosis increases significantly postoperative satisfaction of oral and maxillofacial patients. Satisfaction is attributed decisively on the adjuvant procedure.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":"11 6","pages":"309-15"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0083-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27062164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Secondary reconstruction of the mandible with a 2,7-mm-bridging-plate].","authors":"Sven Dannemann,&nbsp;Mario Hakim Abu-Id,&nbsp;Thomas Kreusch","doi":"10.1007/s10006-007-0089-x","DOIUrl":"https://doi.org/10.1007/s10006-007-0089-x","url":null,"abstract":"<p><p>The two-phase reconstruction of the mandible with a 2.7-mm-Martin-reconstruction-plate creates a tumor free period that is followed by bone grafting to the embedded plate. We have treated 61 patients following this pattern from 2000 to 2005, follow-up was done in 56. 14 patients had received radiotherapy of 70 Gy. 43 plates healed in without any complications. Until 2005 bone grafting had been performed in 18 patients, in ten patients the plate had been removed.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":" ","pages":"339-43"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0089-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41024258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Rare case of an infiltration and invasion of a dental root by a mucosal melanoma of the oral cavity].","authors":"Karin Linkeschova,&nbsp;Sebastian Hoefert,&nbsp;Walter Wierich,&nbsp;Harald Eufinger","doi":"10.1007/s10006-007-0076-2","DOIUrl":"https://doi.org/10.1007/s10006-007-0076-2","url":null,"abstract":"<p><p>Malignant melanoma of the oral cavity is a rare disease with high lethality, rapid progression and frequently seen lymph node metastases. The clinical appearance of the mucosal melanoma is mostly irregular in shape and dark blue, brown or black in colour. During early stages the lesions are painless with a tendency to spontaneous bleeding. Mucosal melanoma shows expansive and infiltrative growth into neighbouring structures, with the result of bone destruction and loss of teeth. We present a case of a female patient with a primary mucosal melanoma. A local infiltration and invasion of a tooth could be seen. Although many publications deal with oral mucosal melanoma with local destruction of bone, there are no reports on an infiltration into dental roots. Aspects of this unusual infiltration of hard tissues are discussed.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":" ","pages":"345-8"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0076-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41003135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The state of the art in human dental stem cell research].","authors":"Christian Morsczeck,&nbsp;Torsten Eugen Reichert,&nbsp;Florian Völlner,&nbsp;Till Gerlach,&nbsp;Oliver Driemel","doi":"10.1007/s10006-007-0071-7","DOIUrl":"https://doi.org/10.1007/s10006-007-0071-7","url":null,"abstract":"<p><p>This review article arranges the current results of stem cell biology for their use in dentistry. There are different types of stem cells, which are applicable for dental treatments. The use of embryonic stem cells, whose possibilities for breeding an artificial tooth were hardly evaluated, is however ethically precarious. On the other side the ethically harmless adult stem cells, which were isolated for example from bone marrow, were little examined for their capability of differentiation into dental tissues. Therefore their forthcoming use in dentistry is rather improbable. However, dental ectomesenchymal stem cells are more promising for dentistry in future. For example dental pulp stem cells (DPSCs) are capable to differentiate into dentin under in vitro conditions. Moreover it is possible to use periodontal ligament (PDL) stem cells and dental follicle precursors for periodontal tissue differentiations in vitro. Recently new populations of stem cells were isolated from the dental pulp and the PDL. These cells distinguish from the initially isolated DPSCs and PDL stem cells in growth and cell differentiation. Therefore stem cell markers are very important for the characterization of dental stem cells. A significant marker for dental stem cells is STRO-1, which is also a marker for bone marrow derived mesenchymal stem cells. Nonetheless dental stem cells are CD45 negative and they express rarely hematopoietic stem cell markers. These research results plead for the participation of dental stem cells in dental practice in future.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":" ","pages":"259-66"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0071-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41030365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of hyperbaric oxygen therapy in treatment of patients with osteomyelitis of the mandible].","authors":"Jörg Handschel,&nbsp;Sabine Brüssermann,&nbsp;Rita Depprich,&nbsp;Michelle Ommerborn,&nbsp;Christian Naujoks,&nbsp;Norbert R Kübler,&nbsp;Ulrich Meyer","doi":"10.1007/s10006-007-0073-5","DOIUrl":"https://doi.org/10.1007/s10006-007-0073-5","url":null,"abstract":"<p><strong>Background: </strong>Chronic osteomyelitis of the jaw is a relapsing disease with multiple treatment strategies described in the literature. Hyperbaric oxygen therapy is one of them. The purpose of this study was to evaluate the clinical outcome of hyperbaric oxygen therapy in these patients.</p><p><strong>Method: </strong>All patients with a chronic osteomyelitis of the mandible who received in our department hyperbaric oxygen therapy between 2000 and 2004 were included in this study. The clinical outcome (lack of symptoms e.g. pain, swelling, etc.) was the pivotal evaluation parameter. All patients were divided in three groups according to their medical history. Group 1: All patients with osteomyelitis of the mandible, who received no treatment before. Group 2: All patients with one local relapse, who received only antimicrobial treatment. Group 3: Patients with at least one local relapse after antimicrobial and surgical treatment.</p><p><strong>Results: </strong>27 patients were evaluated in this study. Seven out of 13 patients in group 1 were relapse free after performing 40 hyperbaric oxygen therapies. However, only 4 of 9 patients in group 3 were relapse free after treatment. In group 2 the hyperbaric oxygen therapy was successful particularly in the younger patients (3 of 4).</p><p><strong>Conclusion: </strong>Adjuvant hyperbaric oxygen therapy was successful in the treatment of patients with chronic recurrent osteomyelitis of the mandible. Therefore, it is an treatment option which can avoid ablative surgery in some cases.</p>","PeriodicalId":79515,"journal":{"name":"Mund-, Kiefer- und Gesichtschirurgie : MKG","volume":"11 5","pages":"285-90"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10006-007-0073-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26971385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}