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Molekuliarna meditsina = Molecular medicine最新文献

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[The participation of nitric oxide in the functions of the central nervous system and the cardiovascular system]. [一氧化氮参与中枢神经系统和心血管系统的功能]。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
I Krushkov, Ts Markova, A Tsankov
{"title":"[The participation of nitric oxide in the functions of the central nervous system and the cardiovascular system].","authors":"I Krushkov,&nbsp;Ts Markova,&nbsp;A Tsankov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nitric oxide (NO) exerts its vasodilatator effect in smooth muscle by activation of guanylyl cyclase. This in turn leads to decreases in intracellular calcium and dephosphorylation of myosin light chains and relaxation. NO is synthesised from L-arginine by a family of enzymes called Nitric oxide synthase (NOS). In the vascular system two isoenzymes of NOS are largely expressed: the constitutive NOS and the inducible NOS. The constitutive NOS identified in the endothelium generates NO continuously providing the vasodilatator tone and modulating platelet function. NOS type 1 is expressed in preoptic and infundibular nucleus of hypothalamus. NO acts as presynaptic agonist of glutamatergic NMDA-receptor mediation in the motor nucleus of nervus vagus. NO decreases the frequency of the spontaneous discharges in the carotid bodies. NO is involved in the processes of synaptic plasticity in the hippocampus.</p>","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 2","pages":"21-7"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19945408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The freeze-etching and freeze-fracturing technics and their use for studying cellular membranes in the central nervous system]. [冷冻蚀刻和冷冻破裂技术及其在中枢神经系统细胞膜研究中的应用]。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
L Surchev
{"title":"[The freeze-etching and freeze-fracturing technics and their use for studying cellular membranes in the central nervous system].","authors":"L Surchev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present review, both subkinds of the method for membrane splitting, namely freeze-etching and freeze-fracturing techniques, are presented. After a brief historical survey, a mechanism of their action is described. Special attention is paid to the consecutive stages in applying these techniques--fixation, fracturing, etching, replication, cleaning and observation. A new idea for a better cleaning of the replicas and an explanation of the different occurrence of intramembranous particles on the membrane fracture faces are proposed. Finally, the application of the freeze-etching and freeze-fracturing techniques to visualize the intramembranous structure of membranes in the central nervous system is outlined.</p>","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 2","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19945410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role of the oxidative modification of LDL in the pathogenesis of atherosclerosis]. 【LDL氧化修饰在动脉粥样硬化发病中的作用】。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
A Gudev
{"title":"[The role of the oxidative modification of LDL in the pathogenesis of atherosclerosis].","authors":"A Gudev","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1","pages":"31-8"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19938133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular medicine]. (分子医学)。
Molekuliarna meditsina = Molecular medicine Pub Date : 1900-01-01 DOI: 10.1007/978-1-4020-6754-9_10664
Matthew J. Potthoff
{"title":"[Molecular medicine].","authors":"Matthew J. Potthoff","doi":"10.1007/978-1-4020-6754-9_10664","DOIUrl":"https://doi.org/10.1007/978-1-4020-6754-9_10664","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"101 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50931203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The T-cell receptor]. (t细胞受体)。
Molekuliarna meditsina = Molecular medicine Pub Date : 1900-01-01 DOI: 10.1007/springerreference_39808
B. Bozhkov
{"title":"[The T-cell receptor].","authors":"B. Bozhkov","doi":"10.1007/springerreference_39808","DOIUrl":"https://doi.org/10.1007/springerreference_39808","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52958060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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