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Molekuliarna meditsina = Molecular medicine最新文献

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[Molecular medicine]. (分子医学)。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
{"title":"[Molecular medicine].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19938130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The insulin transduction system]. 胰岛素转导系统。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
V Mitev
{"title":"[The insulin transduction system].","authors":"V Mitev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Insulin is a key hormone regulating glucose homeostasis and has many cellular effects on metabolism, growth, and differentiation. Insulin action is mediated through a specific cell-surface receptor. The first step following insulin binding consists in receptor autophosphorylation and stimulation of its tyrosine kinase activity. Among the multiple substrates, the insulin receptor substrate-1 (IRS-1) is the major cytoplasmic substrate for insulin. IRS-1 binds several Src homology 2 (SH2) proteins through its multiple tyrosine phosphorylation sites: phosphatidylinositol 3-kinase (PI 3-kinase), the Ras guanine-nucleotide-releasing complex Grb2-SOS, the tyrosine phosphatase Syp, and the adapter protein Nck. IRS-1 is essential for many, but not all of the insulin's biological responses. Recently, a primary alternative substrate, i.e. IRS-2, was purified and cloned. Numerous biochemical abnormalities of the insulin signaling system lead to insulin resistance. No doubt, the recent data about the molecular mechanisms of insulin action will provide new insights into the pathophysiology and therapy of diabetes and other insulin resistant states.</p>","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 2","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19946037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The T-cell receptor--its participation in the pathological immune response]. [t细胞受体——它参与病理性免疫反应]。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
B Bozhkov
{"title":"[The T-cell receptor--its participation in the pathological immune response].","authors":"B Bozhkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This work reviews clonal rearrangements of T-cell receptor genes in peripheral T-cells of patients with lymphoproliferative diseases. The role of T-cell genes for predisposition to autoimmune diseases is analysed. Methodological approaches for analysis of T-cell receptor repertoire and autoimmune diseases are presented. The role of T-cell receptor-antigen recognitions in IgE mediated allergic reactions is described.</p>","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 2","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19946038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Candidate genes for the familial forms of breast and ovarian carcinomas (BRCA)]. [家族性乳腺癌和卵巢癌(BRCA)的候选基因]。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
A Markov
{"title":"[Candidate genes for the familial forms of breast and ovarian carcinomas (BRCA)].","authors":"A Markov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19938127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The atrial natriuretic factor]. 心房利钠因子。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
Iu Brankova
{"title":"[The atrial natriuretic factor].","authors":"Iu Brankova","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1","pages":"21-30"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19938128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The T-cell receptor]. (t细胞受体)。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
B Bozhkov
{"title":"[The T-cell receptor].","authors":"B Bozhkov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19938135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The catabolism of polyamines]. [多胺的分解代谢]
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
V Pavlov, O Dimitrov
{"title":"[The catabolism of polyamines].","authors":"V Pavlov,&nbsp;O Dimitrov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The important role of the natural polyamines putrescine, spermidine and spermine in the normal and pathological cell growth is the main reason for the active investigation of their metabolism. The essential catabolic reactions of polyamine interconversion and terminal oxidation as well as data for the catabolic enzymes and the regulatory mechanisms of their activities are reviewed. The importance of catabolic reactions for the maintenance of the optimal polyamine concentrations during the cell growth and differentiation is also presented. The role of the essential catabolic enzymes spermidine/spermine N1-acetyltransferase, polyamine oxidase and diamine oxidase in normal and pathological cell growth is discussed.</p>","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 2","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19945405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The molecular structure of the opioid receptors]. 阿片受体的分子结构。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
L Sirakov
{"title":"[The molecular structure of the opioid receptors].","authors":"L Sirakov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19938134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular medicine--a challenge of the 21st century]. [分子医学——21世纪的挑战]。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
S Danev
{"title":"[Molecular medicine--a challenge of the 21st century].","authors":"S Danev","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 2","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19945411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Achondroplasia--new research and future goals]. 软骨发育不全——新的研究和未来目标。
Molekuliarna meditsina = Molecular medicine Pub Date : 1996-01-01
I Stoilov, M Velinov, P Tsipuras
{"title":"[Achondroplasia--new research and future goals].","authors":"I Stoilov,&nbsp;M Velinov,&nbsp;P Tsipuras","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79449,"journal":{"name":"Molekuliarna meditsina = Molecular medicine","volume":"1 1","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19938126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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