Supplement ... to the European journal of neuroscience最新文献_第4页

Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. 电刺激加速并增加再生大鼠股运动神经元中BDNF和trkB mRNA的表达。

Supplement ... to the European journal of neuroscience Pub Date : 2000-12-01 DOI: 10.1046/J.1460-9568.2000.01341.X

A. Al-Majed, T. Brushart, T. Gordon

{"title":"Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons.","authors":"A. Al-Majed, T. Brushart, T. Gordon","doi":"10.1046/J.1460-9568.2000.01341.X","DOIUrl":"https://doi.org/10.1046/J.1460-9568.2000.01341.X","url":null,"abstract":"Electrical stimulation promotes the speed and accuracy of motor axonal regeneration. The positive effects of stimulation are mediated at the cell body. Here we characterize the effect of electrical stimulation on motoneuronal expression of BDNF and its receptor, trkB, two genes whose expression levels in motoneurons correlate with regeneration and are regulated by electrical activity in a variety of neurons. We used semiquantitative in situ hybridization to measure expression of mRNA encoding BDNF and the full-length trkB receptor at intervals of 8 h, 2 days and 7 days after unilateral femoral nerve cut, suture, and stimulation. Expression in regenerating motoneurons was compared to that of contralateral intact motoneurons. BDNF and trkB signals were not significantly upregulated 8 h and 2 days after femoral nerve suture and sham stimulation. By 7 days, there was a 2-fold increase in both BDNF and trkB mRNA expression. In contrast, stimulation of cut and repaired nerves for only 1 h led to rapid upregulation of BDNF and trkB mRNA by 3-fold and 2-fold, respectively, within the first 8 h. The stimulation effect peaked at 2 days with 6-fold and 4-fold increases in the signals, respectively. Thereafter, the levels of BDNF and trkB mRNA expression declined to equal the 2-fold increase seen at 7 days after nerve repair and sham-stimulation. We conclude that brief electrical stimulation stimulates BDNF and trkB expression in regenerating motoneurons. Because electrical stimulation is known to accelerate axonal regeneration, we suggest that changes in the expression of BDNF and trkB correlate with acceleration of axonal regeneration.","PeriodicalId":79424,"journal":{"name":"Supplement ... to the European journal of neuroscience","volume":"16 1","pages":"4381-90"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72648411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 392

Distribution of glycine receptor subunits on primate retinal ganglion cells: a quantitative analysis. 灵长类动物视网膜神经节细胞甘氨酸受体亚基的分布:定量分析。

Supplement ... to the European journal of neuroscience Pub Date : 2000-12-01 DOI: 10.1046/J.1460-9568.2000.01311.X

Bin Lin, Paul R. Martin, Samuel G. Solomon, Ulrike Grünert

{"title":"Distribution of glycine receptor subunits on primate retinal ganglion cells: a quantitative analysis.","authors":"Bin Lin, Paul R. Martin, Samuel G. Solomon, Ulrike Grünert","doi":"10.1046/J.1460-9568.2000.01311.X","DOIUrl":"https://doi.org/10.1046/J.1460-9568.2000.01311.X","url":null,"abstract":"This study investigates the distribution of inhibitory neurotransmitter receptors on sensory neurons. Ganglion cells in the retina of a New World monkey, the common marmoset Callithrix jacchus, were injected with Lucifer yellow and Neurobiotin and subsequently processed with antibodies against one (alpha1), or against all subunits, of the glycine receptor, or against the anchoring protein gephyrin. Immunoreactive (IR) puncta representing glycine receptor or gephyrin clusters were found on the proximal and the distal dendrites of all ganglion cell types investigated. For both parasol and midget cells, the density of receptor clusters was greater on distal than proximal dendrites for all antibodies tested. In parasol cells the average density for the alpha1 subunit of the glycine receptor was 0.087 IR puncta/microm of dendrite, and for all subunits it was 0.119 IR puncta/microm of dendrite. Thus, the majority of glycine receptors on parasol cells contain the alpha1 subunit. For parasol cells, we estimated an average of 1.5 glycinergic synapses/100 microm2 dendritic membrane on proximal dendrites and about 9.4 glycinergic synapses/100 microm2 on distal dendrites. The segregation of receptors to the distal dendrites appears to be a common feature of inhibitory neurotransmitter input to parasol and midget cells, and might be associated with the receptive field surround mechanism.","PeriodicalId":79424,"journal":{"name":"Supplement ... to the European journal of neuroscience","volume":"46 1","pages":"4155-70"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74151431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Federation of European Neuroscience Societies (FENS) millennium meeting. 24-28 June 2000, Brighton, United Kingdom. Abstracts. 欧洲神经科学学会联合会(FENS)千年会议。2000年6月24日至28日，英国布莱顿。摘要。

Supplement ... to the European journal of neuroscience Pub Date : 2000-01-01

引用次数: 0

1998 Forum of European Neuroscience. Berlin, June 27-July 1, 1998. Abstracts. 1998欧洲神经科学论坛。柏林，1998年6月27日至7月1日。摘要。

Supplement ... to the European journal of neuroscience Pub Date : 1998-01-01

引用次数: 0

Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids. 大麻素刺激CB1受体后中前额叶多巴胺能活性增加。

Supplement ... to the European journal of neuroscience Pub Date : 1998-01-01 DOI: 10.1046/j.1460-9568.1998.00292.x

M. Diana, M. Melis, G. Gessa

{"title":"Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids.","authors":"M. Diana, M. Melis, G. Gessa","doi":"10.1046/j.1460-9568.1998.00292.x","DOIUrl":"https://doi.org/10.1046/j.1460-9568.1998.00292.x","url":null,"abstract":"The intravenous administration of the psychoactive constituent of marijuana, delta9-tetrahydrocannabinol (delta9-THC) (62.5-1000 microg/kg), and the synthetic cannabinoid agonist WIN 55212,2 (WIN) (62.5-500 microg/kg), produced a dose-related increase in the firing rate and burst firing in the majority of antidromically identified meso-prefrontal dopaminergic neurons. In a restricted number of neurons (n=4), WIN administration did not increase firing rate but produced an increment of bursting activity. These effects of the cannabinoids were reversed by the intravenous administration of SR 141716 A, a selective cannabinoid antagonist (1 mg/kg), per se ineffective to modify the electrical activity of dopaminergic neurons. The results indicate that stimulation of cannabinoid CB1 receptors produces an activation of meso-prefrontal dopaminergic transmission. Considering that supranormal stimulation of D1 dopamine receptors in the prefrontal cortex has been shown to impair working memory, the present results suggest that the negative effects of cannabinoids on cognitive processes might be related to the activation of dopaminergic transmission in the prefrontal cortex.","PeriodicalId":79424,"journal":{"name":"Supplement ... to the European journal of neuroscience","volume":"5 1","pages":"2825-30"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83568107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 69

Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses. 阻断m2样毒蕈碱受体可增强皮质纹状体突触的长期增强。

Supplement ... to the European journal of neuroscience Pub Date : 1998-01-01 DOI: 10.1046/j.1460-9568.1998.00348.x

P. Calabresi, D. Centonze, P. Gubellini, A. Pisani, G. Bernardi

{"title":"Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses.","authors":"P. Calabresi, D. Centonze, P. Gubellini, A. Pisani, G. Bernardi","doi":"10.1046/j.1460-9568.1998.00348.x","DOIUrl":"https://doi.org/10.1046/j.1460-9568.1998.00348.x","url":null,"abstract":"Acetylcholine (ACh) exerts a crucial role in learning and memory. The striatum contains the highest concentration of this transmitter in the brain. This structure expresses two different forms of synaptic plasticity, long-term depression (LTD) and long-term potentiation (LTP), which might contribute to the storage of motor skills and some cognitive processes. We have investigated the role of M2-like muscarinic receptors in striatal LTP by utilizing intracellular recordings in vitro from a rat corticostriatal slice preparation. Methoctramine (250 nM), an antagonist of M2-like muscarinic receptors, enhanced striatal LTP induced in the absence of external magnesium (Mg2+) by high-frequency stimulation (HFS) of corticostriatal fibres. Methoctramine did not affect the amplitude of excitatory postsynaptic potentials (EPSPs) when bath applied either before or after the conditioning tetanus suggesting that a critical increase of ACh concentrations is produced only during HFS. Methoctramine per se failed to enhance the NMDA-mediated EPSPs recorded in the absence of external Mg2+ and in the presence of 10 microM CNQX. Methoctramine antagonized the presynaptic inhibitory action of neostigmine, an inhibitor of ACh-esterase, and oxotremorine, an agonist of M2-like muscarinic receptors. These data indicate that the activation of M2-like muscarinic receptors exerts a negative influence on striatal LTP, probably by reducing the release of glutamate from corticostriatal fibres and they suggest a complex modulatory effect of ACh in striatal synaptic plasticity.","PeriodicalId":79424,"journal":{"name":"Supplement ... to the European journal of neuroscience","volume":"68 1","pages":"3020-3"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72862930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Responses of human primary sensorimotor and supplementary motor areas to internally triggered unilateral and simultaneous bilateral one-digit movements. A high-resolution EEG study. 人体主要感觉运动和辅助运动区域对内部触发的单侧和同时的双侧一指运动的反应。一项高分辨率脑电图研究。

Supplement ... to the European journal of neuroscience Pub Date : 1997-07-01 DOI: 10.1016/S0013-4694(97)88726-7

A. Urbano, C. Babiloni, P. Onorati, F. Carducci, A. Ambrosini, L. Fattorini, F. Babiloni

引用次数: 57

Abstracts of the 17th annual meeting of the European Neuroscience Association and 26th annual meeting of the European Brain and Behaviour Society and the meeting of the Austrian Neuroscience Association. Vienna, 4-8 September 1994. 第17届欧洲神经科学协会年会和第26届欧洲脑与行为学会年会以及奥地利神经科学协会会议摘要。维也纳，1994年9月4日至8日。

Supplement ... to the European journal of neuroscience Pub Date : 1994-01-01

引用次数: 0

16th Annual meeting of the European Neuroscience Association. Madrid, Spain, 18-21 September 1993. Abstracts. 第16届欧洲神经科学协会年会。1993年9月18日至21日，西班牙马德里。摘要。

Supplement ... to the European journal of neuroscience Pub Date : 1993-01-01

引用次数: 0