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Noshuyo byori = Brain tumor pathology最新文献

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Radioimmunolocalization of human brain tumor: fundamental studies with indium-111 labeled monoclonal antibody G-22. 人脑肿瘤的放射免疫定位:用铟-111标记的单克隆抗体G-22进行基础研究。
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
T Wakabayashi, J Yoshida, M Mizuno, K Sugita, K Itoh, M Tadokoro, M Oshima
{"title":"Radioimmunolocalization of human brain tumor: fundamental studies with indium-111 labeled monoclonal antibody G-22.","authors":"T Wakabayashi,&nbsp;J Yoshida,&nbsp;M Mizuno,&nbsp;K Sugita,&nbsp;K Itoh,&nbsp;M Tadokoro,&nbsp;M Oshima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monoclonal antibody (MCA) G-22 reacts selectively with human glioblastoma. Whole immunoglobulin G (IgG) and the F(ab')2 fragment of G-22 were labeled with indium-111, and injected into athymic nude mice bearing xenografts of a human glioblastoma cell line (U-251-MG). Radiolabeled G-22 retained its antigen-binding activity allowing clear visualization of transplanted tumors. Although the 111In-labeled F(ab')2 fragment had a higher tumor-to-tissue ratio than whole IgG, tumor concentration of 111In-labeled G-22 MCA was higher in the latter and it provided much better images for a longer time when visualized by gamma-scintigraphy. These results suggest that 111In-labeled G-22 may be a useful agent for brain tumor imaging.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 2","pages":"177-80"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18891698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factor VIII can be positive in a special type of malignant lymphoma, intravascular malignant lymphomatosis: an immunohistochemical investigation. 因子VIII可在一种特殊类型的恶性淋巴瘤，血管内恶性淋巴瘤中呈阳性:免疫组织化学研究。
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
M Kano, J Yoshida, Y Hashizume, K Sugita
{"title":"Factor VIII can be positive in a special type of malignant lymphoma, intravascular malignant lymphomatosis: an immunohistochemical investigation.","authors":"M Kano,&nbsp;J Yoshida,&nbsp;Y Hashizume,&nbsp;K Sugita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report presents seven cases of intravascular malignant lymphomatosis (IML). The patients exhibited clinical signs and symptoms of multiple cerebral infarctions and polyradiculopathy, but in each case the diagnosis of IML was only established by postmortem examination. The autopsies revealed that almost every organ was involved and that there were atypical cells which had proliferated intravascularly. This was especially remarkable in the central nervous system. Extravascular extension of the tumor cells was rarely observed. It was documented by immunohistochemical studies that the abnormal cells were B cell lymphoma cells with a high proliferative capacity. Factor VIII, an endothelial cell-related antigen, was detected in the cytoplasm of the tumor cells of two cases (28%), but this finding was considered to represent a non-specific absorption of factor VIII from the thrombi.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 2","pages":"135-41"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18893000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of cerebellar neuroectomesenchymoma in an infant. 婴儿小脑神经切除间质瘤1例。
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
J Akimoto, T Nakamura, O Utsugi, H Ito, Y Ebihara, M Kudo
{"title":"A case of cerebellar neuroectomesenchymoma in an infant.","authors":"J Akimoto,&nbsp;T Nakamura,&nbsp;O Utsugi,&nbsp;H Ito,&nbsp;Y Ebihara,&nbsp;M Kudo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This case report concerns a congenital cerebellar tumor in an infant. The tumor consisted of small, immature lymphocyte-like cells, medium-sized, rhabdoid cell-like cells, and large, polymorphic gemistocytic astrocyte-like cells, which were admixed in motley form on a background of neuronal matrix and dural and collagen fibrous tissues. Immunohistochemical studies revealed that the cytoplasm of rhabdoid cells had conspicuous structures, resembling weakly eosinophilic homogeneously amorphous inclusion bodies, and that the strongly eosinophilic cytoplasm, seen abundantly in the gemistocytic astrocyte-like cells, was a mixture of components that were positive for glial fibrillary acidic protein (GFAP) and vimentin and of components positive for myoglobin. Because of the simultaneous expression of both, neuroectodermal and mesenchymal characteristics the reported tumor was not a mixed tumor of independent neuroectodermal and mesenchymal tumor components, but a very rare neuroectomesenchymoma derived from immature cells with pluripotential differentiating capabilities.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 1","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19152672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Two cases of craniopharyngioma associated with Rathke's cleft cyst]. 颅咽管瘤合并Rathke裂隙囊肿2例
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
T Nakajou, M Morimoto, M Kurisaka, K Mori
{"title":"[Two cases of craniopharyngioma associated with Rathke's cleft cyst].","authors":"T Nakajou,&nbsp;M Morimoto,&nbsp;M Kurisaka,&nbsp;K Mori","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two rare cases of craniopharyngioma associated with Rathke's cleft cyst are reported. The patients were 74-year-old female and 12-year-old boy. The former complained bilateral impaired visual acuity and visual field disturbance with hypoprolactinemia, the latter complained diabetes insipidus and growth retardation. MR images of these cases demonstrated sellar resion tumors, which were composed with both cystic and solid component. Transsphenoidal tumor removal were performed to both cases, and their tumor tissues were studied by light and electron microscopy. The cyst wall were composed of three kinds of epithelial cells such as ciliated columnar cells, mucous cells and basal cells. The solid components were composed of stratified squamous cells. These two components shifted each other. For these facts, to consider that both Rathke's cleft cyst and craniopharyngioma originate in remnants of Rathke's pouch, it is concluded that Rathke's cleft cyst cells sometimes cause differentiation to craniopharyngioma on its growth process.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 1","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19153230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinico-pathological study of malignant lymphoma of the central nervous system. 中枢神经系统恶性淋巴瘤的临床病理研究。
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
O Kubo, Y Muragaki, Y Tajika, H Uchinuno, H Hiyama, T Tohyama, M Shimoda, Y Shimada, K Takakura
{"title":"Clinico-pathological study of malignant lymphoma of the central nervous system.","authors":"O Kubo,&nbsp;Y Muragaki,&nbsp;Y Tajika,&nbsp;H Uchinuno,&nbsp;H Hiyama,&nbsp;T Tohyama,&nbsp;M Shimoda,&nbsp;Y Shimada,&nbsp;K Takakura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report describes the clinico-pathological features of a group of 36 patients with malignant lymphoma of the central nervous system (CNS) who were treated at one institution between 1970 and 1993. All cases were B cell type lymphomas. The authors summarize the most salient findings with respect to clinical course, pathology, treatment and disease outcome, and emphasize the value of diagnostic and therapeutic modalities in the management of patients with primary CNS lymphoma.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 2","pages":"157-60"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18893004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular differentiation, secretory and proliferative activities of craniopharyngiomas. 颅咽管瘤的细胞分化、分泌和增殖活性。
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
Y Uematsu, N Komai, Y Tanaka, M Shimizu, D Naka, S Yukawa, T Itakura, S Hayashi
{"title":"Cellular differentiation, secretory and proliferative activities of craniopharyngiomas.","authors":"Y Uematsu,&nbsp;N Komai,&nbsp;Y Tanaka,&nbsp;M Shimizu,&nbsp;D Naka,&nbsp;S Yukawa,&nbsp;T Itakura,&nbsp;S Hayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cellular differentiation of craniopharyngiomas was studied immunohistochemically by determining the expression of cytokeratins. Alcian-Blue staining was used to assess secretory activity and expression of AgNORs and PCNA as indicators of proliferative activity. Both, tumors of the adamantinomatous type and of the squamous type expressed complex type cytokeratins, with skin type differentiation being noted in some cases. In addition, epidermal differentiation of cytokeratins was found in the squamous types. Intracellular Alcian-Blue staining was limited to apical cells of tumors of the squamous type. Neither AgNORs staining nor PCNA staining proved statistically significant results with respect to the histological type of tumor or patient's age. However, PCNA staining was predominantly noted in basal cells of the squamous type tumors. Although their ultimate significance remains to be established, the results presented provide additional evidence with regard to the possible origin of both craniopharyngioma types, and suggest the potential value of some of the parameters studied as prognostic indicators.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 1","pages":"43-50"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18907563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunohistochemical and ultrastructural studies of intracranial immature teratoma--a comparative observation on neuroblastoma, PNET and ependymal tumor, with a special reference to rosette structures]. 【颅内未成熟畸胎瘤的免疫组织化学和超微结构研究——神经母细胞瘤、PNET和室管膜肿瘤的比较观察，特别参考玫瑰花结结构】。
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
S Yagishita
{"title":"[Immunohistochemical and ultrastructural studies of intracranial immature teratoma--a comparative observation on neuroblastoma, PNET and ependymal tumor, with a special reference to rosette structures].","authors":"S Yagishita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immature teratoma occurs occasionally in the brain of children and contains a large amount of immature neuronal tissue. These primitive neuronal components are a good target for studying the morphology of primitive neuroectodermal tumors, including neuroblastoma, ependymoblastoma, medulloepithelioma and so on. Primitive neural tubes are immunohistochemically and ultrastructurally studied in two cases of primary immature teratoma of the child brains, compared to true rosettes in a case of neuroblastoma, primitive neural tube in the fetal rat brain (9 to 13 days of gestational age). The study also extends to the pathology of PNET. Ultrastructurally the primitive neural tube like structures in two teratomas were virtually identical those of developing fetal rat brains and true rosettes in a neuroblastoma. However, these tubular structures are different from each other in immunohistochemistry. These differences are considered to reflect the different developmental lineage of the tumor cells, that is, neuroblastoma produces only neuroblastic cells, and primitive neural tubes in teratoma both neuroblastic and glioblastic cells. Rejuvenation of neuroblastoma cells seems to render a VIM-positivity of the tumor cells.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 1","pages":"71-5"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19153228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical study of basic fibroblast growth factor and erythropoietin in cerebellar hemangioblastomas. 小脑血管母细胞瘤中碱性成纤维细胞生长因子和促红细胞生成素的免疫组化研究。
Noshuyo byori = Brain tumor pathology Pub Date : 1994-01-01
O Tachibana, T Yamashima, J Yamashita, K Takinami
{"title":"Immunohistochemical study of basic fibroblast growth factor and erythropoietin in cerebellar hemangioblastomas.","authors":"O Tachibana,&nbsp;T Yamashima,&nbsp;J Yamashita,&nbsp;K Takinami","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report deals with immunohistochemical studies performed on 21 cases of cerebellar hemangioblastomas. Antibodies against basic fibroblast growth factor, glial fibrillary acidic protein, vimentin, factor VIII, and erythropoietin were used. A considerable number of stromal cells and some endothelial cells were positive for basic fibroblast growth factor in all cases studied. The stromal cells of four cases were positive for erythropoietin; two of these cases were associated with secondary polycythemia. Our data suggest that basic fibroblast growth factor may contribute to angiogenesis in cerebellar hemangioblastomas.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"11 2","pages":"169-72"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18893006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive meningiomas in relation to high proliferating potential. 侵袭性脑膜瘤与高增殖潜能的关系。
Noshuyo byori = Brain tumor pathology Pub Date : 1993-01-01
T Suwa, N Kawano, T Kameya, H Ito, H Oka, K Yada
{"title":"Invasive meningiomas in relation to high proliferating potential.","authors":"T Suwa,&nbsp;N Kawano,&nbsp;T Kameya,&nbsp;H Ito,&nbsp;H Oka,&nbsp;K Yada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We conducted a study to investigate whether an association exists among histologic findings, labeling index determined by the labeling index (LI) of proliferating cell nuclear antigen (PCNA) and recurrence in a population of 30 meningioma patients. All of 6 patients (invasive meningioma) with brain invasion had a PCNA LI in excess of 5%. Recurrence was found in 4 of these patients. In 24 patients who did not have brain invasion, PCNA LI was 4% or less and only 1 case had recurrence. Recurrence occurred in 3 of 25 patients who underwent macroscopic total resection and all of these 3 cases had brain invasion and a PCNA LI in excess of 5%. The findings of this study indicated the existence of a close correlation between peripheral invasiveness of meningioma and its biological behavior.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"10 1","pages":"63-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18695512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiosensitive squamous cell craniopharyngioma: clinical and pathological comparison with the adamantinomatous type. 放射敏感性鳞状细胞颅咽管瘤:与金刚烷瘤型临床病理比较。
Noshuyo byori = Brain tumor pathology Pub Date : 1993-01-01
H K Inoue, M Nakamura, N Ono, H Kohga, T Kakegawa, I Naitou, J Tamada, I Handa
{"title":"Radiosensitive squamous cell craniopharyngioma: clinical and pathological comparison with the adamantinomatous type.","authors":"H K Inoue,&nbsp;M Nakamura,&nbsp;N Ono,&nbsp;H Kohga,&nbsp;T Kakegawa,&nbsp;I Naitou,&nbsp;J Tamada,&nbsp;I Handa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Five patients with the squamous cell type of craniopharyngioma were examined clinically and pathologically, and comparisons were made with the adamantinomatous type of craniopharyngioma. In three patients, the tumor remaining after partial or subtotal resection was treated with conventional radiation therapy, and all three lesions disappeared completely. The squamous cell tumors consisted of basal cubodial cells and polygonal superficial cells with areas of cellular detachment and degeneration. Our findings suggest that these tumors are more radiosensitive than adamantinomatous craniopharyngiomas and represent a distinct clinical entity.</p>","PeriodicalId":79360,"journal":{"name":"Noshuyo byori = Brain tumor pathology","volume":"10 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19209757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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