Muscle & nerve. Supplement最新文献_第6页

Measurement of synthesis rates of specific muscle proteins using needle biopsy samples. 使用针活检样本测量特定肌肉蛋白的合成速率。

Muscle & nerve. Supplement Pub Date : 1997-01-01

O E Rooyackers, P Balagopal, K S Nair

引用次数: 0

Inclusion of ethnic minorities in sarcopenia research: challenges and strategies. 将少数民族纳入肌肉减少症研究:挑战和策略。

Muscle & nerve. Supplement Pub Date : 1997-01-01

H P Hazuda

引用次数: 0

Confounding variables and comorbidity in sarcopenia research. 肌肉减少症研究中的混杂变量和合并症。

Muscle & nerve. Supplement Pub Date : 1997-01-01

J P Miller

引用次数: 0

Measurement of muscle strength and power. 肌肉力量和力量的测量。

Muscle & nerve. Supplement Pub Date : 1997-01-01

E J Bassey

引用次数: 0

Excitation-Ca2+ release-contraction coupling in single aged human skeletal muscle fiber. 单个老年人骨骼肌纤维的兴奋- ca2 +释放-收缩耦合。

Muscle & nerve. Supplement Pub Date : 1997-01-01 DOI: 10.1002/(sici)1097-4598(1997)5+<88::aid-mus21>3.0.co;2-u

O Delbono, M Renganathan, M L Messi

引用次数: 68

Summary of work group II: small-scale clinical studies. 第二工作组总结:小规模临床研究。

Muscle & nerve. Supplement Pub Date : 1997-01-01 DOI: 10.1002/(sici)1097-4598(1997)5+<117::aid-mus28>3.0.co;2-2

C Dutta, N B Alexander

引用次数: 0

Botulinum toxin: chemistry, pharmacology, toxicity, and immunology. 肉毒杆菌毒素:化学、药理学、毒性和免疫学。

Muscle & nerve. Supplement Pub Date : 1997-01-01

M F Brin

{"title":"Botulinum toxin: chemistry, pharmacology, toxicity, and immunology.","authors":"M F Brin","doi":"","DOIUrl":"","url":null,"abstract":"The seven serotypes of botulinum toxin (BTX) produced by Clostridium botulinum exert their paralytic effect by inhibiting acetylcholine release at the neuromuscular junction. Each of these zinc endopeptidases cleaves one or more proteins involved in vesicle transport and membrane fusion. The extent of paralysis depends on both doses and volume; the duration of paralysis is further dependent on the serotype employed. Restoration of neuromuscular function follows axon terminal sprouting. The two major commercial preparations of BTX-A appear to differ in their relative potencies, despite a common unit labeling system. Adverse effects are a consequence of the drug's mechanism of action, and can usually be tolerated or mitigated through dosing changes. Patients who are pregnant or lactating, or who have a neuromuscular disease, may not be appropriate candidates for BTX therapy. Development of resistance to BTX-A therapy, characterized by absence of any beneficial effect and by lack of muscle atrophy following the injection, is an important clinical issue. The incidence of antibody-mediated resistance, as determined by the mouse lethality assay, is reported between 3% and 10%. Use of the smallest possible effective dose and longer treatment intervals may reduce the likelihood of antibody development. Other serotypes may benefit those who have developed antibody resistance.","PeriodicalId":79355,"journal":{"name":"Muscle & nerve. Supplement","volume":"6 ","pages":"S146-68"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20737207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clinical overview of treatment decisions in the management of spasticity. 痉挛治疗决策的临床综述。

Muscle & nerve. Supplement Pub Date : 1997-01-01

M E Gormley, C F O'Brien, S A Yablon

引用次数: 0

Cerebral palsy: a rational approach to a treatment protocol, and the role of botulinum toxin in treatment. 脑瘫:一种合理的治疗方案，以及肉毒毒素在治疗中的作用。

Muscle & nerve. Supplement Pub Date : 1997-01-01

B S Russman, A Tilton, M E Gormley

{"title":"Cerebral palsy: a rational approach to a treatment protocol, and the role of botulinum toxin in treatment.","authors":"B S Russman, A Tilton, M E Gormley","doi":"","DOIUrl":"","url":null,"abstract":"Cerebral palsy (CP) is characterized by aberrant control of movement or posture and appears early in life secondary to central nervous system damage. The symptoms of CP fall into four groups: symptoms due to loss of selective motor control; symptoms due to abnormal muscle tone; symptoms due to imbalance between muscle agonists and antagonists; and symptoms due to impaired balance. The goals of treatment are to maximize function and minimize the development of joint contracture and other secondary problems. Development of a treatment plan begins with the definition of objectives and consideration of the effects of growth and development on the patient's abilities. The role of botulinum toxin in CP treatment has grown in recent years. The patient who could benefit most from botulinum toxin treatment is one who is hypertonic and whose abnormal muscle tone is interfering with function, or who is expected to develop joint contracture with growth because of this abnormal tone. By altering this muscle tone, function can be enhanced or additional therapeutic modalities can be employed. Assessing treatment outcomes for BTX injection involves the same set of questions and measurements as for other types of treatments and depends on the careful definition of treatment objectives beforehand.","PeriodicalId":79355,"journal":{"name":"Muscle & nerve. Supplement","volume":"6 ","pages":"S181-93"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20737210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying physical functional performance in older adults. 量化老年人的身体机能表现。

Muscle & nerve. Supplement Pub Date : 1997-01-01

M E Cress

引用次数: 0