Immunodeficiency最新文献

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Effects of interleukin 2 therapy in patients with common variable immunodeficiency (CVID). 白细胞介素2治疗对常见变异性免疫缺陷(CVID)患者的影响。
Immunodeficiency Pub Date : 1993-01-01
J A Rump, A Jahreis, M Schlesier, S Stecher, R Dräger, W G Struff, H H Peter
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引用次数: 0
Induction of responsiveness in lymphocytes of immunodeficient patients' cells implanted with foreign plasma membranes. 外源质膜植入免疫缺陷患者细胞淋巴细胞反应性的诱导。
Immunodeficiency Pub Date : 1993-01-01
D Levy, Y Porat, I Pick, Z T Handzel, M Schlesinger, A Tanay, I Zan-Bar
{"title":"Induction of responsiveness in lymphocytes of immunodeficient patients' cells implanted with foreign plasma membranes.","authors":"D Levy, Y Porat, I Pick, Z T Handzel, M Schlesinger, A Tanay, I Zan-Bar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patients with common variable immunodeficiency (CVID) display aberrant IL-2 and IFN-gamma mRNA levels. 常见变异性免疫缺陷(CVID)患者表现出异常的IL-2和ifn - γ mRNA水平。
Immunodeficiency Pub Date : 1993-01-01
I Hauber, M B Fischer, M M Eibl
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引用次数: 0
Genetic analysis of the human CD3-epsilon gene in a T cell receptor/CD3 immunodeficiency. 人CD3-epsilon基因在T细胞受体/CD3免疫缺陷中的遗传分析。
Immunodeficiency Pub Date : 1993-01-01
C Soudais, J P De Villartay, F Le Deist, A Fischer, B Lisowska-Grospierre
{"title":"Genetic analysis of the human CD3-epsilon gene in a T cell receptor/CD3 immunodeficiency.","authors":"C Soudais, J P De Villartay, F Le Deist, A Fischer, B Lisowska-Grospierre","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chimerism and immune reconstitution following allogeneic bone marrow transplantation for severe combined immunodeficiency disease. 同种异体骨髓移植治疗严重联合免疫缺陷病后的嵌合和免疫重建。
Immunodeficiency Pub Date : 1993-01-01
J M Vossen, J E van Leeuwen, M J van Tol, A M Joosten, H van den Berg, E J Gerritsen, A Haraldsson, P M Khan
{"title":"Chimerism and immune reconstitution following allogeneic bone marrow transplantation for severe combined immunodeficiency disease.","authors":"J M Vossen, J E van Leeuwen, M J van Tol, A M Joosten, H van den Berg, E J Gerritsen, A Haraldsson, P M Khan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of CVID patients' T cells with conventional antigens and superantigens. 用常规抗原和超抗原激活CVID患者的T细胞。
Immunodeficiency Pub Date : 1993-01-01
M B Fischer, I Hauber, H Eggenbauer, V Thon, J Lokaj, H M Wolf, J W Mannhalter, M M Eibl
{"title":"Activation of CVID patients' T cells with conventional antigens and superantigens.","authors":"M B Fischer,&nbsp;I Hauber,&nbsp;H Eggenbauer,&nbsp;V Thon,&nbsp;J Lokaj,&nbsp;H M Wolf,&nbsp;J W Mannhalter,&nbsp;M M Eibl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Defects in T cell function are known to be present in a subset of patients with CVID, but the true nature of these defects still has to be revealed. In prior studies we described that T cells from these patients show an impaired proliferative response following activation with recall antigens (E. coli, Tet. Tox., TBE and PPD). Gene expression of IL2 and IFN-gamma in patients' T cells following antigenic stimulation was significantly reduced compared to controls, while IL-2R transcripts were normal. To further characterize the defect we examined T cell responses to bacterial enterotoxins, collectively termed superantigens. Following stimulation with optimal (10 ng/ml p < 0.05) as well as suboptimal (1 ng/ml p < 0.0025) concentrations of staphylococcal enterotoxin A (SEA), proliferative response and cytokine release (IL-2 and IFNg) were significantly decreased in patients' T cells as compared to controls'. When patients' T cells were stimulated with staph. enterotox. C3 (SEC3) an even more pronounced difference between patients' and controls' T cells could be observed (10 ng/ml p < 0.002, 1 ng/ml p < 0.0005). Our data indicate that, in addition to the defect in antigen-induced T cell activation, T cells of CVID patients express a broader impairment in the interaction between the antigen presenting cell and the TCR.</p>","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19159043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous immunoglobulin therapy in patients with multiple myeloma. 多发性骨髓瘤患者静脉注射免疫球蛋白治疗。
Immunodeficiency Pub Date : 1993-01-01
H M Chapel, R Hargreaves, M Lee, D Pamphilon
{"title":"Intravenous immunoglobulin therapy in patients with multiple myeloma.","authors":"H M Chapel,&nbsp;R Hargreaves,&nbsp;M Lee,&nbsp;D Pamphilon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical and genetic mapping in the region of Xq12-21, which contains the locus for X-linked severe combined immunodeficiency. Xq12-21区域的物理和遗传定位,该区域包含x连锁严重联合免疫缺陷的位点。
Immunodeficiency Pub Date : 1993-01-01
A Jones, T Morris, M de Alwis, S Malcolm, R J Levinsky, C Kinnon
{"title":"Physical and genetic mapping in the region of Xq12-21, which contains the locus for X-linked severe combined immunodeficiency.","authors":"A Jones,&nbsp;T Morris,&nbsp;M de Alwis,&nbsp;S Malcolm,&nbsp;R J Levinsky,&nbsp;C Kinnon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of X chromosome inactivation in haematopoietic cells of female carriers of X linked severe combined immunodeficiency. 严重联合免疫缺陷女性携带者造血细胞中X染色体失活模式。
Immunodeficiency Pub Date : 1993-01-01
R W Hendriks, M E Kraakman, R K Schuurman
{"title":"Patterns of X chromosome inactivation in haematopoietic cells of female carriers of X linked severe combined immunodeficiency.","authors":"R W Hendriks,&nbsp;M E Kraakman,&nbsp;R K Schuurman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We evaluated the use of methylation analysis at the DXS255 locus as a method for carrier detection in X-linked severe combined immunodeficiency (XSCID). We also investigated the variations of X inactivation patterns in several haematopoietic cell lineages of XSCID carriers, both within and between XSCID pedigrees.</p>","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic granulomatous disease: mutations in cytochrome b558. 慢性肉芽肿病:细胞色素b558的突变。
Immunodeficiency Pub Date : 1993-01-01
D Roos, M De Boer, A De Klein, B G Bolscher, R S Weening
{"title":"Chronic granulomatous disease: mutations in cytochrome b558.","authors":"D Roos,&nbsp;M De Boer,&nbsp;A De Klein,&nbsp;B G Bolscher,&nbsp;R S Weening","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79340,"journal":{"name":"Immunodeficiency","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19158251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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