严重联合免疫缺陷女性携带者造血细胞中X染色体失活模式。

Immunodeficiency Pub Date : 1993-01-01

R W Hendriks, M E Kraakman, R K Schuurman

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引用次数: 0

摘要

我们评估了DXS255位点甲基化分析作为x连锁严重联合免疫缺陷(XSCID)携带者检测方法的使用。我们还研究了XSCID携带者的几个造血细胞系中X失活模式的变化，无论是在XSCID谱系内还是在XSCID谱系之间。

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Patterns of X chromosome inactivation in haematopoietic cells of female carriers of X linked severe combined immunodeficiency.

We evaluated the use of methylation analysis at the DXS255 locus as a method for carrier detection in X-linked severe combined immunodeficiency (XSCID). We also investigated the variations of X inactivation patterns in several haematopoietic cell lineages of XSCID carriers, both within and between XSCID pedigrees.

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Immunodeficiency

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