Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology最新文献_第3页

Effect of lindane on galactose and leucine transport in chicken enterocytes. 林丹对鸡肠细胞半乳糖和亮氨酸转运的影响。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

M J Moreno, S Pellicer, A Marti, J C Arenas, M P Fernández-Otero

引用次数: 0

Studies on responses to potassium, noradrenaline, serotonin, histamine and prostaglandin F2 alpha, of isolated pudendal arteries from non-lactating goats. 非哺乳期山羊离体阴部动脉对钾、去甲肾上腺素、血清素、组胺和前列腺素F2 α反应的研究。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

K Jakobsen, E O Mikkelsen, M O Nielsen

{"title":"Studies on responses to potassium, noradrenaline, serotonin, histamine and prostaglandin F2 alpha, of isolated pudendal arteries from non-lactating goats.","authors":"K Jakobsen, E O Mikkelsen, M O Nielsen","doi":"","DOIUrl":"","url":null,"abstract":"The effects of potassium (K+), noradrenaline (NA), serotonin (5-HR), histamine (Hi) and prostaglandin F2 alpha (PGF2 alpha) were studied on isolated pudendal arteries from non-lactating goats. K+, NA, 5-HT, Hi and PGF2 alpha had concentration-dependent contractile effects on the arteries. The developed tensions were, in order of potencies, 5-HT > NA > PGF2 alpha > Hi > K+. NA induced a significantly higher maximal contractile force than K+, 5-HT, PGF2 alpha and Hi. Pretreatment with cocaine was without significant effect on the contractile response to NA. The contractile response to Hi was totally eliminated by mepyramine. Ca2+ had a concentration-dependent contractile effect on arteries depolarized by 125 mM K+. The results indicate that NA, 5-HT and PGF2 alpha may play essential roles in the regulation of goat mammary blood flow. The response to K+ is highly dependent on extracellular Ca2+. The contractile response to histamine may be mediated via H1-receptors. The in vitro method used is well suited to study the vascular reactivity in different regions of the mammary vascular bed.","PeriodicalId":79328,"journal":{"name":"Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology","volume":"109 2","pages":"167-72"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18878802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A comparative study of effect of oral chronic cyanide administration on some rabbit tissue ATPases. 慢性口服氰化物对家兔组织三磷酸腺苷酶影响的比较研究。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

N P Okolie, I O Onoagbe, F A Aisien

引用次数: 0

Insulin-like growth factor-I messenger RNA content in the oviduct of Japanese quail (Coturnix coturnix japonica): changes during growth and development or after estrogen administration. 日本鹌鹑(Coturnix Coturnix japonica)输卵管中胰岛素样生长因子- 1信使RNA含量:在生长发育过程中或雌激素给药后的变化。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

S Kida, M Iwaki, A Nakamura, Y Miura, A Takenaka, S Takahashi, T Noguchi

{"title":"Insulin-like growth factor-I messenger RNA content in the oviduct of Japanese quail (Coturnix coturnix japonica): changes during growth and development or after estrogen administration.","authors":"S Kida, M Iwaki, A Nakamura, Y Miura, A Takenaka, S Takahashi, T Noguchi","doi":"","DOIUrl":"","url":null,"abstract":"Complementary DNA (cDNA) of insulin-like growth factor-I (IGF-I) of Japanese quail was cloned. The nucleotide sequence analysis of the cDNA showed that only seven bases differed from those of chicken IGF-I cDNA in the 440 bases of the cloned region. This difference in nucleotide sequence did not cause changes in the amino acid sequence. Using this cloned cDNA, the changes in IGF-I mRNA content in the tissues of female quail during growth and development were investigated. In the oviduct, IGF-I mRNA was high about 5 weeks after hatching, concomitant with the rapid increase in total DNA content in this tissue (and the increases in total RNA content and RNA/DNA ratio). It decreased after 6 weeks, in accordance with the appearance of ovalbumin mRNA. When immature quails (6-day-old) were injected with diethylstilbestrol (DES), induction of IGF-I mRNA was observed after 24 hr. A few days later, there was a strong induction of ovalbumin mRNA. These two inductions were dependent on the dose of DES. The sequential inductions of these two mRNAs were also noted when DES was re-administered to the immature quail to which it had been first administered and from which then withdrawn. The present results showed that IGF-I gene is expressed extensively during development of the oviduct, probably in accordance with the activity of DNA replication, because the highest IGF-I mRNA content was observed when the total DNA content of the tissues increased extensively. The results suggest that IGF-I in the oviduct of Japanese quail works in an autocrinal or paracrinal mode during the development of this tissue.","PeriodicalId":79328,"journal":{"name":"Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology","volume":"109 2","pages":"191-204"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18881975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfer of fat-soluble vitamins and PCBs from mother to pups in grey seals (Halichoerus grypus). 脂溶性维生素和多氯联苯在灰海豹(Halichoerus grypus)中从母亲到幼崽的转移。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

F J Schweigert, W T Stobo

{"title":"Transfer of fat-soluble vitamins and PCBs from mother to pups in grey seals (Halichoerus grypus).","authors":"F J Schweigert, W T Stobo","doi":"","DOIUrl":"","url":null,"abstract":"Lactation in seals is characterized by a rapid and enormous lipid transfer from mother to pups within a milk rich in lipids. Since grey seals do not feed during lactation, all milk constituents are solely derived from body stores. Monitoring levels of fat-soluble vitamins as well as PCBs in blubber and milk may give an insight into the mechanisms involved in their mobilization from blubber, transfer into milk and deposition in the blubber of pups. During lactation, total lipids in milk increased from 261 to 601 g/l. While the level of PCBs in milk per g lipid remained constant throughout lactation, vitamin E, as well as vitamin A and cholesterol, showed a marked decrease during lactation when expressed as quantity per unit lipid. An incomplete transfer of all components from maternal blubber to milk was observed, except for vitamin E. The milk of pregnant females had vitamin E levels per unit which were three times higher than that in blubber, indicating a mobilization of vitamin E from the liver. During the later stages of lactation, there were no differences between the levels of vitamins A and E per unit lipid in the milk and the blubber of suckling pups. The close correlation of PCBs with total milk lipids and the drastic decrease in all other monitored fat-soluble components in seal milk with the progress of lactation point to different mechanisms of mobilization and transport for triglycerides and PCBs compared to fat-soluble vitamins and cholesterol.","PeriodicalId":79328,"journal":{"name":"Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology","volume":"109 2","pages":"111-7"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18878799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Can hemolytic streptococci be considered "forefathers" of modern phagocytes? Both cell types freely migrate in tissues and destroy host cells by a "synergistic cross-talk" among their secreted agonists. 溶血性链球菌可以被认为是现代吞噬细胞的“祖先”吗?两种类型的细胞在组织中自由迁移，并通过分泌的激动剂之间的“协同串扰”破坏宿主细胞。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

I Ginsburg

引用次数: 0

Caffeine and coffee: effects on health and cardiovascular disease. 咖啡因和咖啡:对健康和心血管疾病的影响。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

T M Chou, N L Benowitz

引用次数: 0

Trypanosoma cruzi: trypanocidal effect of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on several strains of epimastigote and trypomastigote forms. 克氏锥虫:2(3)-叔丁基-4-羟基茴香醚(BHA)对几种拟马马线虫和锥马马线虫的杀虫效果。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

J Aldunate, J M Ojeda, Y Repetto, M E Letelier, P Spencer

引用次数: 0

Toxicity of neomycin on enzyme activities of kidney and duodenal mucosa in vivo: organ specificity and species difference between rats and mice. 新霉素对体内肾脏和十二指肠粘膜酶活性的毒性:大鼠和小鼠的器官特异性和物种差异。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-09-01

S Suzuki, S Hatashima, Y Shinzawa, O Niwa, R Tamatani

{"title":"Toxicity of neomycin on enzyme activities of kidney and duodenal mucosa in vivo: organ specificity and species difference between rats and mice.","authors":"S Suzuki, S Hatashima, Y Shinzawa, O Niwa, R Tamatani","doi":"","DOIUrl":"","url":null,"abstract":"Inhibitory effects of neomycin administration (10-80 mg/kg body weight/day, s.c. for 7 days) on several enzyme activities of kidney and duodenal mucosa were compared between male rats and mice. In Wistar rat kidney, tubular brush border Mg(2+)-dependent, HCO3(-)-stimulated ATPase activity was inhibited by neomycin in a dose-dependent manner, while microsomal Mg(2+)-Na(+)-K(+)-ATPase activity and cytosol carbonic anhydrase (CA) activity were inhibited only by larger doses. In rat duodenal mucosa, Mg(2+)-HCO3(-)-ATPase and CA activities were also inhibited only by larger doses. Serum urea nitrogen (UN) concentration and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity were increased in a dose-dependent manner. In ddY and C57black mice, however, all enzyme activities in kidney and duodenal mucosa were almost unaffected by any dose of neomycin and showed no changes in serum UN concentration and urinary NAG activity except for ddY mice in which NAG activity was only increased by the largest dose of neomycin. In light microscopic analysis, 80 mg neomycin/kg produced necrosis in the greater part of rat proximal tubuli with no changes in duodenal brush border. On the other hand, no histological changes were produced in the renal cortex or duodenal mucosa of mice by any dosage. In conclusion, there are organ-specific and species differences in the effects of neomycin between rats and mice.","PeriodicalId":79328,"journal":{"name":"Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology","volume":"109 1","pages":"77-92"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18878796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine and metabolic responses of intact and hypophysectomized turkey poults given a daily injection of chicken growth hormone. 每日注射鸡生长激素的完整和去垂体火鸡的内分泌和代谢反应。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-09-01

J A Proudman, M C McGuinness, K A Krishnan, L A Cogburn

{"title":"Endocrine and metabolic responses of intact and hypophysectomized turkey poults given a daily injection of chicken growth hormone.","authors":"J A Proudman, M C McGuinness, K A Krishnan, L A Cogburn","doi":"","DOIUrl":"","url":null,"abstract":"Female turkey poults were hypophysectomized at 4-5 weeks of age. Beginning at 6 weeks of age, 20 hypophysectomized and 20 intact birds received a daily intramuscular injection of natural chicken growth hormone (cGH, 100 micrograms/kg body weight) or vehicle for 12 days. Blood samples were taken from each bird just before injection and 4 hr post-injection at 6 and 12 days of treatment. Hypophysectomy reduced the growth rate of turkey poults to 75% of that of intact controls, significantly reduced carcass protein and ash percentages, and significantly lower plasma concentrations of GH, insulin-like growth factor-I, triiodothyronine, thyroxine, insulin, glucose, triglycerides, and non-esterified fatty acids. Hypophysectomy was without effect on liver GH receptor binding activity, but increased liver 5'-monodeiodinase activity. Daily cGH injection had no effect on the average daily gain of either hypophysectomized or intact poults when compared to vehicle-injected controls over 12 days of treatment. Daily cGH administration increased plasma insulin-like growth factor-I levels in intact and hypophysectomized turkeys, and increased plasma triiodothyronine, insulin, glucose, and triglyceride concentrations in hypophysectomized birds, but not in intact birds. Responses of young turkeys to hypophysectomy and GH replacement were consistent with the known metabolic role of GH in other species, but the influence of GH on growth appears to be of less importance in poultry than in mammals.","PeriodicalId":79328,"journal":{"name":"Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology","volume":"109 1","pages":"47-56"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18879520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0