慢性口服氰化物对家兔组织三磷酸腺苷酶影响的比较研究。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-10-01

N P Okolie, I O Onoagbe, F A Aisien

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摘要

研究了口服KCN对家兔组织中Na(+)-K(+)- atp酶、Ca(2+)- atp酶和Mg(2+)- atp酶活性的影响。一般情况下，酶的活性顺序为肾脏>肝脏>回肠>结肠。与对照组相比，kcn处理兔组织中所有atp酶活性均显著降低(P < 0.05)。Na(+)-K(+)- atp酶和Ca(2+)- atp酶活性的降低在肝脏和肾脏中最为明显。atp酶的减少表明由于氰化物的毒性作用，膜功能受损。

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A comparative study of effect of oral chronic cyanide administration on some rabbit tissue ATPases.

The effect of oral KCN administration on Na(+)-K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase activities was studied in some rabbit tissues. Generally, the order of activity of the enzymes was kidney > liver > ileum > colon. There were significant decreases (P < 0.05) in the activities of all the ATPases in the tissues of KCN-treated rabbits relative to controls. The decreases in Na(+)-K(+)-ATPase and Ca(2+)-ATPase activities were most pronounced in liver and kidney. The decreases in ATPases suggest impairment of membrane function as a result of the toxic effect of cyanide.

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Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology

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