Cardiovascular surgery (London, England)最新文献_第10页

Clinical outcome of aortic valve replacement in the elderly 老年人主动脉瓣置换术的临床疗效分析

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00104-2

Bruno Chiappini, Marcello Bergonzini, Simona Gallieri, Davide Pacini, Angelo Pierangeli, Roberto Di Bartolomeo, Giuseppe Marinelli

{"title":"Clinical outcome of aortic valve replacement in the elderly","authors":"Bruno Chiappini, Marcello Bergonzini, Simona Gallieri, Davide Pacini, Angelo Pierangeli, Roberto Di Bartolomeo, Giuseppe Marinelli","doi":"10.1016/S0967-2109(03)00104-2","DOIUrl":"10.1016/S0967-2109(03)00104-2","url":null,"abstract":"<div>Since elderly patients are being referred for surgery in increasing numbers, we reviewed the clinical outcome of 459 consecutive patients aged 70 to 89 years, who had aortic valve replacement between 1993 and 2000. We subdivided the study population into three groups: in Group 1 we included patients aged 70–74 years old; in Group 2 patients aged 75–79 years old; and in Group 3 patients aged 80 years old or older.An isolated AVR was performed in 289 patients (63%), concomitant coronary artery bypass graft (CABG) in 168 patients (36.6%), an isolated ventricular septal defect (VSD) closure in one patient (0.2%) and an isolated atrial septal defect (ASD) closure in one patient (0.2%). The overall perioperative mortality rate was 7% (32 patients), without significant differences among the three groups (P=0.88).Our study confirms the good outcome of aortic valve replacement in elderly patients even in octagenarians and only concomitant CABG procedures increase the operative risk, reducing long-term survival (P<0.05).</div>","PeriodicalId":79324,"journal":{"name":"Cardiovascular surgery (London, England)","volume":"11 5","pages":"Pages 359-365"},"PeriodicalIF":0.0,"publicationDate":"2003-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0967-2109(03)00104-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22562734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent warm blood cardioplegia induces the expression of heat shock protein-72 by ischemic myocardial preconditioning 间歇性温血停搏通过缺血心肌预处理诱导热休克蛋白-72的表达

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00078-4

M Chello , P Mastroroberto , G Patti , A D’Ambrosio , G Di Sciascio , E Covino

{"title":"Intermittent warm blood cardioplegia induces the expression of heat shock protein-72 by ischemic myocardial preconditioning","authors":"M Chello , P Mastroroberto , G Patti , A D’Ambrosio , G Di Sciascio , E Covino","doi":"10.1016/S0967-2109(03)00078-4","DOIUrl":"10.1016/S0967-2109(03)00078-4","url":null,"abstract":"<div>Objective: Recent studies have demonstrated that the induction of heat shock protein-72 (HSP72) by different stimuli preserves the heart function after cardioplegic arrest. Based on these findings, we investigated whether intermittent warm blood cardioplegia would induce changes in the myocardial expression of HSP72.Methods: Forty patients scheduled for aortocoronary bypass were randomly assigned to receive either cold or warm intermittent blood cardioplegia. In all patients HSP72 and HSP72 mRNA were assayed in biopsies from the right atrium at baseline, and during the reperfusion period. Plasma CK-MB and troponin-T, and myocardial oxygen extraction and lactate release were also measured.Results: In both groups, myocardial expression of HSP72 increased throughout the reperfusion period, but the values of HSP72 band lengths were significantly higher in the warm group. Correspondingly, HSP72 mRNA levels increased progressively in both groups, with significant difference between groups observed in biopsies at the reperfusion. Warm blood cardioplegia was associated with lower levels of CK-MB and troponin-T. Myocardial oxygen extraction and lactate release were higher during intermittent warm cardioplegia, indicating a more profound ischemic anaerobic metabolism in the warm group.Conclusions: Intermittent warm blood cardioplegia induces an increased expression of HSP72 and it is associated with a better myocardial protection, by a mechanism involving a variant of the classical ischemic preconditioning model.</div>","PeriodicalId":79324,"journal":{"name":"Cardiovascular surgery (London, England)","volume":"11 5","pages":"Pages 367-374"},"PeriodicalIF":0.0,"publicationDate":"2003-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0967-2109(03)00078-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22562735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical claudication associated with overuse injury in patients with chronic compartment, functional entrapment, and medial tibial stress syndromes 慢性筋膜室、功能性夹持和胫骨内侧应激综合征患者与过度使用损伤相关的非典型跛行

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00074-7

William D Turnipseed

引用次数: 0

The impact of early ischemic preconditioning on spinal cord injury 早期缺血预处理对脊髓损伤的影响

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00073-5

Ioannis K Toumpoulis, Constantine E Anagnostopoulos∗

引用次数: 0

Neuroprotective effect of N-acetylcysteine and hypothermia on the spinal cord ischemia–reperfusion injury n -乙酰半胱氨酸和低温对脊髓缺血再灌注损伤的神经保护作用

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00077-2

Omer Cakir , Kemalettin Erdem , Ahmet Oruc , Nihal Kılınc , Nesimi Eren

{"title":"Neuroprotective effect of N-acetylcysteine and hypothermia on the spinal cord ischemia–reperfusion injury","authors":"Omer Cakir , Kemalettin Erdem , Ahmet Oruc , Nihal Kılınc , Nesimi Eren","doi":"10.1016/S0967-2109(03)00077-2","DOIUrl":"10.1016/S0967-2109(03)00077-2","url":null,"abstract":"<div>The purpose of this study was to investigate the effect of N-acetylcysteine (NAC) on spinal cord ischemia–reperfusion (I–R) in rabbits. Thirty rabbits were divided into five equal groups, group I (sham-operated, no I–R), group II (control, only I–R), group III (I–R+NAC), group IV (I–R+hypothermia), group V (I–R+NAC+hypothermia). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the aortic bifurcation. Forty-eight hours postoperatively, the motor function of the lower limbs was evaluated in each animal according to Tarlov Score. Spinal cord samples were taken to evaluate the histopathological changes. The sham-operated rabbits (group I) showed no neurologic deficit (Score=4). Paraplegia (Score=0) developed in all rabbits in the control group (group II). Administration of 50 mg/kg of NAC (group III) resulted in significant reduction of motor dysfunction (Score=3.1±1.3, p=0.002). Application of hypothermia alone (group IV) showed significant recovery of motor functions (Score=3.0±1.1, p=0.002), and combination of hypothermia and 50 mg/kg of NAC (group V) showed complete recovery of lower limb motor function (Score=4, p=0.001). Histologic examination of the spinal cord in rabbits with paraplegia revealed several injured neurons. The cords of animals with no motor function deficits showed only minimal cellular infiltrates in the gray matter, and there was good preservation of nerve cells. NAC showed protective effects of the spinal cord. Moderate hypothermia alone also showed protective effects. Combined use of NAC and hypothermia resulted in highly significant recovery of spinal cord function.</div>","PeriodicalId":79324,"journal":{"name":"Cardiovascular surgery (London, England)","volume":"11 5","pages":"Pages 375-379"},"PeriodicalIF":0.0,"publicationDate":"2003-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0967-2109(03)00077-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22562736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation of the variables associated with normal and delayed hospital discharge following first time isolated coronary artery bypass graft surgery 第一次孤立冠状动脉搭桥手术后正常出院和延迟出院相关变量的调查

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00024-3

M.G Cox

引用次数: 0

Oxidative stress and abdominal aneurysms: how aortic hemodynamic conditions may influence AAA disease 氧化应激与腹部动脉瘤:主动脉血流动力学状况如何影响腹主动脉瘤疾病

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00075-9

Ronald L Dalman

引用次数: 0

Evolving techniques for endoscopic radial artery harvesting 内镜下桡动脉采集技术的发展

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00099-1

Roberto P Casula, Pankaj Kumar, Hutan Ashrafian, Thanos Athanasiou

引用次数: 0

Childhood memories of giants in Vascular Surgery: Matas, DeBakey, de Takats, and Ochsner: An interview with Dr. John Ochsner 血管外科巨人的童年记忆:Matas, DeBakey, de Takats和Ochsner:对John Ochsner医生的采访

Cardiovascular surgery (London, England) Pub Date : 2003-10-01 DOI: 10.1016/S0967-2109(03)00082-6

Roger T Gregory

引用次数: 2

Changing surgical management for acute aortic dissection type A improves immediate outcome 改变急性A型主动脉夹层的手术方法可改善即时预后

Cardiovascular surgery (London, England) Pub Date : 2003-09-19 DOI: 10.1016/S0967-2109(03)00129-7

J. Sierra

引用次数: 0