Advances in neuroimmunology最新文献_第7页

Interactions between cytokines and nitric oxide 细胞因子和一氧化氮之间的相互作用

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00009-Q

Foo Y. Liew

引用次数: 52

Detection of endothelial cell-derived nitric oxide: Current trends and future directions 内皮细胞源性一氧化氮的检测:当前趋势和未来方向

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00030-5

Harold I. Magazine

引用次数: 54

The hypothalamic-pituitary-adrenocortical system and sleep in man 下丘脑-垂体-肾上腺皮质系统与人的睡眠

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00003-K

Elisabeth Friess, Klaus Wiedemann, Axel Steiger, Florian Holsboer

引用次数: 105

Fatal familial insomnia: Sleep, neuroendocrine and vegetative alterations 致命的家族性失眠:睡眠、神经内分泌和植物性改变

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(94)00042-M

P. Montagna , P. Cortelli , P. Gambetti , E. Lugaresi

{"title":"Fatal familial insomnia: Sleep, neuroendocrine and vegetative alterations","authors":"P. Montagna , P. Cortelli , P. Gambetti , E. Lugaresi","doi":"10.1016/0960-5428(94)00042-M","DOIUrl":"10.1016/0960-5428(94)00042-M","url":null,"abstract":"<div><p>Fatal Familial Insomnia (FFI) is an autosomal dominant prion disease, characterized by prominent degeneration of the thalamus and involving impaired control of the sleep-wake cycle and of autonomic and endocrine functions. Profound alterations in the sleep-wake cycle consist of progressive decrease or complete absence of sleep activity and loss of any intrinsic cyclic organization of residual sleep. Unbalanced sympathergic activation with preserved parasympathetic drive, associated with chronic secondary hypertension and loss of the physiological nocturnal decrease in blood pressure constitute the characteristic autonomic changes. Neuroendocrine studies document hypercortisolism with abnormal feed-back suppression of adrenocorticotrophic hormone, constantly elevated catecholamine levels and abnormal secretory patterns of growth hormone, prolactin and melatonin. Advanced stages of the disease are invariably characterized by the disappearance of any circadian autonomic and neuroendocrine rhythmicity.</p><p>FFI represents a model disease emphasizing the correlations among the different sleep, autonomic and neuroendocrine functions. Clinico-pathological correlations demonstrate the role of the thalamus as an integrative neural structure placed between the limbic system and the hypothalamus and controlling the homeostatic balance of the organism.</p></div>","PeriodicalId":79314,"journal":{"name":"Advances in neuroimmunology","volume":"5 1","pages":"Pages 13-21"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0960-5428(94)00042-M","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18795873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Mechanisms for nitric oxide-induced cell death: Involvement of apoptosis 一氧化氮诱导细胞死亡的机制:凋亡的参与

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00025-9

Pierluigi Nicotera , Emanuela Bonfoco , Bernhard Brüne

引用次数: 127

Interactions of human immunodeficiency virus type 1 transactivator of transcription protein with signal transduction pathways 人类免疫缺陷病毒1型转录蛋白反激活因子与信号转导途径的相互作用

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00014-S

Hildegardo H. Garza Jr , Daniel J.J. Carr

引用次数: 4

Neuroimmunomodulation: classical and non-classical cellular activation 神经免疫调节:经典和非经典细胞激活

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00018-W

Albert Agro , Andrzej M. Stanisz

{"title":"Neuroimmunomodulation: classical and non-classical cellular activation","authors":"Albert Agro , Andrzej M. Stanisz","doi":"10.1016/0960-5428(95)00018-W","DOIUrl":"10.1016/0960-5428(95)00018-W","url":null,"abstract":"<div><p>As neuroimmunologists, we are often faced with the fact that some substances can either enhance or inhibit particular immune/inflammatory cell functions. This ‘duality’ could only partially be explained by a dose-dependency and the fact that in a variety of systems, heterogenous cell populations are commonly used. For example it has been repetitively shown that cell proliferation, immunoglobulin synthesis and NK (natural killer) activity could be enhanced, inhibited or not affected at all by such neuropeptides as somatostatin (SOM) or vasoactive intestinal peptide (VIP), depending on the experimental conditions. Even substance P (SP), which, in general, stimulates lymphocyte activity, can, under certain conditions, possess an inhibitory activity. These apparent discrepancies between various groups and experimental conditions met with a strong reservation among ‘classical’ immunologists as they questioned the true physiological role that neuro-immune interactions play in normal and disease states. However, upon a detailed analysis of the data, it become obvious why such discrepancies abounded. Not only are we comparing totally different responses in different species, but almost always we compare different experimental conditions. In lieu of this, the reproducibility of the experiments within the same laboratory is in fact very high.</p><p>One fundamental and striking observation is the fact that at the level of a homogeneous cell population, a differential response could be evoked by the same neuropeptide over a range of concentrations.</p><p>For the purpose of this brief report we will focus on the cellular responses to the neuropeptide substance P and we will try to illustrate why such differential responses are possible. Some of the physiological data relating to the effects of SP on cell function will be discussed. This will be followed by a synopsis of SP receptor mechanisms on effector cells and finally the mechanism by which SP activates secondary messenger systems in these cells.</p></div>","PeriodicalId":79314,"journal":{"name":"Advances in neuroimmunology","volume":"5 3","pages":"Pages 311-319"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0960-5428(95)00018-W","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19721297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Multifunctional calcium and calmodulin-dependent kinase II in neuronal function and disease 多功能钙和钙调素依赖性激酶II在神经元功能和疾病中的作用

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00016-U

Severn B. Churn

引用次数: 26

The stress response and autoimmunoregulation 应激反应与自身免疫调节

Advances in neuroimmunology Pub Date : 1994-01-01 DOI: 10.1016/S0960-5428(06)80187-7

Gregory L. Fricchione , George B. Stefano

引用次数: 57

Immunocytochemical localization of endogenous codeine and morphine 内源性可待因和吗啡的免疫细胞化学定位

Advances in neuroimmunology Pub Date : 1994-01-01 DOI: 10.1016/S0960-5428(05)80003-8

Enrica Bianchi , Massimo Guarna , Alessandro Tagliamonte

引用次数: 53