Advances in neuroimmunology最新文献_第4页

Neuroimmune and neuropsychiatric aspects of chronic fatigue syndrome 慢性疲劳综合征的神经免疫和神经精神方面

Advances in neuroimmunology Pub Date : 1996-01-01 DOI: 10.1016/0960-5428(96)00014-9

Lauren B. Krupp, Dean Pollina

引用次数: 17

Psychoneuroimmunology and cancer: Historical perspectives and current research 心理神经免疫学和癌症:历史观点和当前研究

Advances in neuroimmunology Pub Date : 1996-01-01 DOI: 10.1016/0960-5428(96)00016-2

Alison Fife, Pamela J. Beasley, Debra L. Fertig

引用次数: 30

Prolactin increases the susceptibility of primary leukemia cells to NK and LAK effectors 催乳素增加原发性白血病细胞对NK和LAK效应物的易感性

Advances in neuroimmunology Pub Date : 1996-01-01 DOI: 10.1016/S0960-5428(96)00019-8

E. Oberholtzer , M. Contarini , F. Veglia , A. Cossarizza , C. Franceschi , M. Geuna , M. Provinciali , G. Di Stefano , J. Sissom , M.F. Brizzi , L. Pegoraro , L. Matera

{"title":"Prolactin increases the susceptibility of primary leukemia cells to NK and LAK effectors","authors":"E. Oberholtzer , M. Contarini , F. Veglia , A. Cossarizza , C. Franceschi , M. Geuna , M. Provinciali , G. Di Stefano , J. Sissom , M.F. Brizzi , L. Pegoraro , L. Matera","doi":"10.1016/S0960-5428(96)00019-8","DOIUrl":"10.1016/S0960-5428(96)00019-8","url":null,"abstract":"<div><p>Our previous studies have shown that prolactin (PRL), a pituitary and lymphocyte hormone and a ligand of the cytokine/hemopoietin receptors (R) superfamily, acts synergistically with interleukin (IL)-2 on the development of lymphokine activated killer (LAK) cells and enhances the effects of GM-CSF and IL-3 on myeloid progenitors' proliferation and differentiation. More recently, we have demonstrated that GM-CSF and IL-3 increase the sensitivity of acute myeloid leukemic (AML) cells to LAK activity. Together, these findings have prompted us to study the role of PRL on the target arm of the LAK response. We show here that CD33+ blasts from AML patients express membrane PRL-R and that the PRL/PRL-R interaction is followed by increased susceptibility to natural killer (NK) (<em>p</em> < 0.02) and LAK (<em>p</em> < 0.001) cells. As predicted from the dimerization model of PRL-R and in agreement with previous reports, the response of AML blasts to PRL was bell-shaped with a trend peak at 25 ng/ml. Although enhanced lysis occurred at the target recognition level, it was not accompanied by changes in the MHC class I, cellular adhesion molecules, or myeloid differentiation antigens. Cell cycle recruitment and lysis increased concurrently in three cases studied, suggesting a modulatory action of PRL on the expression of putative cycle-related NK/LAK-target structures. Together, these data strengthen the role of PRL in the LAK response.</p></div>","PeriodicalId":79314,"journal":{"name":"Advances in neuroimmunology","volume":"6 3","pages":"Pages 233-247"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0960-5428(96)00019-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19930689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Regulation of astrocyte cell biology by the cAMP/protein kinase A signaling pathway cAMP/蛋白激酶A信号通路对星形胶质细胞生物学的调控

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00022-T

Brandon S. Huneycutt, Etty N. Benveniste

引用次数: 11

NO-synthase: What can research on invertebrates add to what is already known? no -合成酶:对无脊椎动物的研究能给已知的东西增加什么?

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00027-5

Kjell U.I. Johansson, Mats Carlberg

引用次数: 30

Towards a molecular biology of the circadian clock and sleep of mammals 研究哺乳动物的生物钟和睡眠的分子生物学

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00011-P

Priyattam J. Shiromani , William J. Schwartz

引用次数: 4

Sleep regulation: Interactions among cytokines and classical neurotransmitters 睡眠调节:细胞因子与经典神经递质的相互作用

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00008-P

Maria Grazia De Simoni , Luca Imeri , Walter De Matteo , Carlo Perego , Sylvie Simard , Salvatore Terrazzino

引用次数: 22

Role of nitric oxide in cell-mediated tumor cytotoxicity 一氧化氮在细胞介导的肿瘤细胞毒性中的作用

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00028-3

M.Grazia Cifone , Luisa Cironi , M.Antonietta Meccia , Paola Roncaioli , Claudio Festuccia , Gasperina De Nuntiis , Simona D'Aló , Angela Santoni

引用次数: 59

Nitric oxide: An ancestral immunocyte effector molecule 一氧化氮:一种古老的免疫细胞效应分子

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00029-1

Antonella Franchini, Angela Conte, Enzo Ottaviani

{"title":"Nitric oxide: An ancestral immunocyte effector molecule","authors":"Antonella Franchini, Angela Conte, Enzo Ottaviani","doi":"10.1016/0960-5428(95)00029-1","DOIUrl":"10.1016/0960-5428(95)00029-1","url":null,"abstract":"<div><p>The presence and the role of nitric oxide synthase (NOS) were investigated in the molluscan hemocytes by immunocytochemical, biochemical and functional approaches. Using an anti-NOS polyclonal antibody, immunoreactivity was observed in the hemocytes, and this reactivity increased after stimulation of the animals with <em>Escherichia coli</em>, indicating that this enzyme is inducible. The NOS inducibility was also histochemically demonstrated by detection of NADPH-diaphorase activity. Biochemical studies show that the enzyme is 70% cytoplasmatic and 30% membrane bound and that the inducible form is mainly cytoplasmatic. The nitrite + nitrate and citrulline formation, the inhibition by N<sup>θ</sup>-nitro-<span>l</span>-arginine, the Km value for arginine, the calcium and co-enzyme dependence show that the molluscan NOS shares the same properties as the NOS isoenzymes so far studied. However, it cannot be identified with any of these enzymes. It appears to be in some way similar to an inducible form of human hepatocyte NOS. Also cytokines are able to induce NOS. <em>In vitro</em> studies have shown that hemocytes produce nitric oxide (NO), a bactericide substance, and that there is a relationship between the NO system and phagocytosis. The presence of NO in the invertebrate hemocyte demonstrates that critical molecules have been conserved over the course of evolution.</p></div>","PeriodicalId":79314,"journal":{"name":"Advances in neuroimmunology","volume":"5 4","pages":"Pages 463-478"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0960-5428(95)00029-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19719027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Neuroprotective and deleterious effects of nitric oxide on focal cerebral ischemia-induced neurone death 一氧化氮对局灶性脑缺血诱导的神经元死亡的神经保护和有害作用

Advances in neuroimmunology Pub Date : 1995-01-01 DOI: 10.1016/0960-5428(95)00023-2

C. Verrecchia, R.G. Boulu, M. Plotkine

引用次数: 28