Surgical gastroenterology最新文献_第3页

Isoamylase determinations in patients undergoing endoscopic retrograde cholangiopancreatography. 内镜逆行胆管造影患者的异淀粉酶测定。

Surgical gastroenterology Pub Date : 1984-01-01

D W Weaver, C Sugawa, D L Bouwman, J Altshuler

引用次数: 0

The effect of 16, 16-dimethyl prostaglandin E2 on experimental bile reflux pancreatitis in the opossum. 16,16 -二甲基前列腺素E2对实验性胆汁反流性胰腺炎负鼠的影响。

Surgical gastroenterology Pub Date : 1984-01-01

R Ramirez, J Brems, T Lee, D L Kaminski

{"title":"The effect of 16, 16-dimethyl prostaglandin E2 on experimental bile reflux pancreatitis in the opossum.","authors":"R Ramirez, J Brems, T Lee, D L Kaminski","doi":"","DOIUrl":"","url":null,"abstract":"Pharmacological attempts to alter the course of experimental pancreatitis in the opossum were made using synthetic 16, 16-dimethyl prostaglandin E2 (16, 16-dm PGE2). Anatomically, the opossum has an elongated ampulla resulting in a supraduodenal pancreatic duct-common bile duct junction allowing for bile reflux pancreatitis to be produced by ligating the distal common bile duct. Preliminary evaluation demonstrated that at 72 hours common bile duct ligation distal to the pancreatic duct orifice produced pancreatitis comparable in severity to that produced by a Pfeffer loop. When the oppossum distal common bile duct was ligated, serum amylase concentrations progressively increased from control values of 182 +/- 43 to 742 +/- 62 Somogyi units/dl at 5 hours. Administration of 0.2 microgram-kg-1-min-1 16, 16-dm PGE2 significantly decreased the hyperamylasemia associated with bile reflux pancreatitis and, in addition, decreased the pancreatic gland weights when compared to control values. Subsequent evaluation of the administration of 75 micrograms-kg-1 16, 16-dm PGE2 every 12 hours for 72 hours to opossums with distal common bile duct ligation demonstrated no significant differences in serum amylase concentrations when compared to control values. Histologic evaluation of the pancreas glands at 72 hours demonstrated increased glandular integrity when the pancreas glands from the opossums receiving 16,16-dm PGE2 were compared to the glands subjected to distal common bile duct ligation alone. This report identifies several favorable characteristics in the course of experimental pancreatitis associated with the administration of a synthesis PGE analog at the onset of the inflammatory process.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":79268,"journal":{"name":"Surgical gastroenterology","volume":"3 2","pages":"60-8"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17152539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The SSAT-AGA (Society for Surgery of the Alimentary Tract-American Gastroenterological Association). New Orleans, May 20-23, 1984. SSAT-AGA(消化道外科学会-美国胃肠病学协会)。1984年5月20日至23日，新奥尔良。

Surgical gastroenterology Pub Date : 1984-01-01

S W Ashley, L Y Cheung

引用次数: 0

The role of HIDA scanning in the assessment of external biliary fistulae. hda扫描在评估胆外瘘中的作用。

Surgical gastroenterology Pub Date : 1984-01-01

G A McPherson, N A Collier, J P Lavender, L H Blumgart

引用次数: 0

PGF2 alpha mediated cytoprotection: a reassessment. PGF2 α介导的细胞保护:重新评估。

Surgical gastroenterology Pub Date : 1984-01-01

H V Gaskill, K R Sirinek, B A Levine

{"title":"PGF2 alpha mediated cytoprotection: a reassessment.","authors":"H V Gaskill, K R Sirinek, B A Levine","doi":"","DOIUrl":"","url":null,"abstract":"Unlabelled: The demonstration of gastrointestinal ctyoprotection by PGF2 alpha (a supposed vasoconstrictor) has been cited as evidence against alteration of mucosal blood flow as a mechanism for the cytoprotection phenomenon. However, cytoprotection by PGF2 alpha has never been demonstrated in a model having concomitant documentation of gastrointestinal blood flow. This experiment was designed to accomplish two objectives. First, the effect of intravenous PGF2 alpha (0.1, 1.0, 10.0 mcg/kg/minute) on blood flow throughout the gastrointestinal tract was documented in a chloralose anesthetized miniature swine model (n = 7). Second, the effect of intravenous PGF2 alpha (1.0 mcg/kg/minute) on both gastric mucosal blood flow and stress ulceration was assessed during a 3-hour period of hemorrhagic shock in the same model (six controls, six PGF2 alpha). The radiolabeled microsphere technique of blood flow determination was employed.Results: Intravenous PGF2 alpha significantly decreased myocardial blood flow at all doses employed. Although blood flow in the gastrointestinal tract tended to decrease with the largest dose of PGF2 alpha, this did not reach statistical significance. During shock PGF2 alpha had no effect on gastrointestinal blood flow. Furthermore, there was no evidence of gastric mucosal cytoprotection compared to controls. These results suggest that PGF2 alpha is neither vasoconstrictive nor cytoprotective when sub maximal doses are used. Dismissal of mucosal blood flow as a possible mechanism of prostaglandin-mediated cytoprotection is premature.","PeriodicalId":79268,"journal":{"name":"Surgical gastroenterology","volume":"3 1","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17653855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0