Metabolic, pediatric, and systemic ophthalmology最新文献_第4页

Erythrocyte membrane 2', 3'-cyclic nucleotide 3'-phosphodiesterase activity in multiple sclerosis. 多发性硬化症红细胞膜2'，3'-环核苷酸3'-磷酸二酯酶活性。

Metabolic, pediatric, and systemic ophthalmology Pub Date : 1983-01-01

R L Jones, E K Wong, K H Ibsen, I H Leopold

引用次数: 0

Aspirin and prostacyclin treatment of diabetic dogs. 阿司匹林和前列环素治疗糖尿病犬。

Metabolic, pediatric, and systemic ophthalmology Pub Date : 1983-01-01

M B Waitzman, H Kaplan, L Cornelius, B Evatt, B Hunt

{"title":"Aspirin and prostacyclin treatment of diabetic dogs.","authors":"M B Waitzman, H Kaplan, L Cornelius, B Evatt, B Hunt","doi":"","DOIUrl":"","url":null,"abstract":"Spontaneously diabetic dogs were treated initially (the first 1/2 yr) with i.v. prostacyclin and oral aspirin and then for 1 yr with varying doses of aspirin alone. At this time cataracts prevented visualization of retinae, and one eye of each animal was removed for examination of the vasculature of the trypsin digested retinae. Studies of the blood during the course of treatment showed an elevation of plasma cyclic adenylic acid and marked lowering of inordinately high platelet count and platelet aggregation. Treatment was stopped and after an additional 1/2 year the animals were euthanized and the fellow eye removed for retinal study. Although just three diabetic animals survived for binocular retinal histology, there were no discernible differences in the retinal vasculature in the fellow eyes of a given animal, and in only one of these three animals were there clear signs of diabetic retinopathy. We must conclude, therefore, that in spite of relative normalization of platelet function in the parameters measured during the course of treatment, we cannot yet claim a salutary effect of treatment on the diabetic retina. Cataracts prevented us from having better information on diabetic retinae prior to treatment and a redesigned study would have to include unilateral histological retinal examination before any treatment is started to determine if, indeed, improved platelet physiology slows or reverses changes in the diabetic retina.","PeriodicalId":79237,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology","volume":"7 3","pages":"153-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17378988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth of Pseudomonas aeruginosa and secretion of protease in the presence of the protease inhibitors. 在蛋白酶抑制剂存在下铜绿假单胞菌的生长和蛋白酶的分泌。

Metabolic, pediatric, and systemic ophthalmology Pub Date : 1982-01-01

E Kessler, M Safrin

{"title":"Growth of Pseudomonas aeruginosa and secretion of protease in the presence of the protease inhibitors.","authors":"E Kessler, M Safrin","doi":"","DOIUrl":"","url":null,"abstract":"The compounds benzyloxycarbonyl-L-leucyl-hydroxamate (Z-Leu-NHOH), benzyloxycarbonyl-glycyl-hydroxamate (Z-Gly-NHOH) and 2-mercaptoacetyl-L-phenylalanyl-L-leucine (HSAc-Phe-Leu) are potent inhibitors of Pseudomonas aeruginosa elastase. The effect of these inhibitors on growth and protease secretion by the bacteria was studied under conditions where the organisms secrete elastase as the major proteolytic constituent. Z-Gly-NHOH and Z-Leu-NHOH inhibited bacterial growth and enzyme secretion by 40 and 30%, respectively, although the inhibition by Z-Leu-NHOH was expressed only when growth was in dialysed medium. Inhibition of growth by both compounds was first observed at the end of the logarithmic phase of growth, suggesting that these compounds are not toxic to the bacteria. HSAc-Phe-Leu did not inhibit growth or enzyme secretion. The level of HSAc-Phe-Leu in the medium decreased constantly during incubation, probably because of gradual oxidation of the -SH group. The rate of this decrease was markedly enhanced in presence of the bacteria, suggesting that HSAc-Phe-Leu is either consumed or destroyed by the organisms. We propose that the partial reduction of growth exerted by the hydroxamate derivatives is the result of inhibition of the extracellular proteases by these compounds. HSAc-Phe-Leu failed to inhibit growth because of its rapid loss during incubation with the bacteria. Since the three inhibitors have no antibacterial effects, their therapeutic potential should be examined in combination with antibiotics. Experimental treatment with HSAc-Phe-Leu should be frequent in order to overcome its loss in presence of the organisms.","PeriodicalId":79237,"journal":{"name":"Metabolic, pediatric, and systemic ophthalmology","volume":"6 3-4","pages":"331-6"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17873353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct and photosensitized UV radiation and the eye: experimental and clinical observations. 直接和光敏紫外线辐射与眼睛:实验和临床观察。

Metabolic, pediatric, and systemic ophthalmology Pub Date : 1982-01-01

S Lerman

引用次数: 0

The effect of oral treatment with beta blockers on the tear secretion. 口服受体阻滞剂对泪液分泌的影响。

Metabolic, pediatric, and systemic ophthalmology Pub Date : 1982-01-01

Y Almog, M Monselise, C Almog, Y R Barishak

引用次数: 0

Genetics of ocular inflammatory diseases. 眼部炎症性疾病的遗传学。

Metabolic, pediatric, and systemic ophthalmology Pub Date : 1982-01-01

J François