Metabolic bone disease & related research最新文献_第2页

Mechanism of action of stanozolol in the treatment of osteoporosis 斯坦诺唑尔治疗骨质疏松症的作用机制

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90039-0

A.J.P. Yates, R.E.S. Gray, R.C. Percival, K.I. Muncy, J.H. Galloway, M. Couch, R. Vaishnav, J.A. Gallagher, J.N. Beresford, R.G.G. Russell, J.A. Kanis

引用次数: 0

Vitamin A, bone resorption and hyperparathyroidism in uraemia 尿毒症患者的维生素A、骨吸收和甲状旁腺功能亢进

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90050-X

T. Cundy, J.A. Kanis, M. Earnshaw, G. Heynen

引用次数: 0

Measurement of total resorption surface in iliac crest trabecular bone in man 人髂骨小梁骨总吸收面测定

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90014-6

S. Vedi, J.R. Tighe, J.E. Compston

引用次数: 16

Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids 人骨细胞体外产生骨钙素的研究。1,25(OH)2D3、24,25(OH)2D3、甲状旁腺激素和糖皮质激素的作用

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-04-15 DOI: 10.1016/0221-8747(84)90064-X

J.N. Beresford , J.A. Gallagher , J.W Poser , R.G.G. Russell

引用次数: 502

Osteoporosis associated with pregnancy and lactation: Bone biopsy and skeletal features in three patients 妊娠和哺乳期骨质疏松:3例患者的骨活检和骨骼特征

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90023-7

H.E. Gruber , D.H. Gutteridge , D.J. Baylink

{"title":"Osteoporosis associated with pregnancy and lactation: Bone biopsy and skeletal features in three patients","authors":"H.E. Gruber , D.H. Gutteridge , D.J. Baylink","doi":"10.1016/0221-8747(84)90023-7","DOIUrl":"10.1016/0221-8747(84)90023-7","url":null,"abstract":"<div><p>Case reports of three young patients who developed vertebral fractures and skeletal complications during pregnancy and/or lactation are presented. Radiologic features are described. All three had severe disease with three to nine vertebral fractures at presentation postpartum. In two patients, follow-up for 5–7.8 yr (including further pregnancy in each) revealed no further fractures. In general, serum and urine features were normal, the exceptions being a low serum 25-hydroxyvitamin D level (plus intermittent elevation of serum parathyroid hormone) in one, a tendency to low plasma alkaline phosphatase in another, and in the third (the most severely affected patient) a transient rise in urinary hydroxyproline and plasma alkaline phosphatase during a phase of bone loss following her second and third pregnancies.</p><p>Bone biopsies performed 1 to <span><math><mtext>6-</mtext><mtext>1</mtext><mtext>2</mtext></math></span> yr after parturition showed quantitative bone histologic features and bone formation rates that, as a group, were not significantly different from either normal or postmenopausal osteoporotic subjects. These patients did not have osteomalacia and did not show high turnover osteoporotic features. It is possible that this type of osteoporosis may be somewhat self-limiting, although this hypothesis is subject to great influence by any adaptive lifestyle changes introduced by the patient. The severe fracture history of these patients emphasizes the gravity of their bone disease and stresses the need for further study on the etiology and treatment of this form of osteoporosis.</p></div>","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 4","pages":"Pages 159-165"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0221-8747(84)90023-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17791060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 78

Congenitally osteopetrotic (op/op) mice are not cured by transplants of spleen or bone marrow cells from normal littermates 先天性骨质疏松(op/op)小鼠不能通过从正常窝友身上移植脾脏或骨髓细胞来治愈

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90027-4

S.C. Marks Jr., M.F Seifert, J.L. McGuire

引用次数: 55

Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone 人合成甲状旁腺激素治疗大鼠骨小梁骨量增加

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90026-2

M. Gunness-Hey , J.M. Hock

{"title":"Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone","authors":"M. Gunness-Hey , J.M. Hock","doi":"10.1016/0221-8747(84)90026-2","DOIUrl":"10.1016/0221-8747(84)90026-2","url":null,"abstract":"<div><p>Although PTH inhibits bone collagen synthesis acutely, prolonged administration of PTH increases trabecular bone mass. The objectives of this study were to develop a simple method to quantitate the anabolic response of cortical and trabecular bone, to determine if the trabecular bone response is at the expense of cortical bone, and to correlate the bone response with changes in serum calcium or phosphate. Subcutaneous injections of 2 to 16 μg/100 g body weight hPTH(1–34) were given daily to weanling rats for 12 days. The trabecular and cortical bone were manually separated from the distal femur, and calcium, hydroxyproline, and extracted dry weight were measured. Growth and renal function were not impaired. Serum calcium (range: 8.9–9.5 mg%) and serum phosphate (range: 7.7–8.5 mg%) did not differ significantly from control serum calcium, 9.1 mg%, or serum phosphate, 8.1 mg%. A dose-related anabolic response was observed in calcium, hydroxyproline, and dry weight of trabecular bone. At the highest dose of hPTH for 12 days, these values were increased above control by 26%, 33%, and 26%, respectively (<em>P</em> < .01). While cortical bone values increased over 12 days, only the dry weight increase was significant (<em>P</em> < .01). Our method showed an increase in trabecular bone mass after daily subcutaneous injections of hPTH (1–34) at doses that were neither toxic nor hypercalcemic. Although the absolute change of cortical bone mass was greater than that of trabecular bone, it was more variable and not statistically significant. Nevertheless, these results indicate that trabecular bone mass did not increase at the expense of cortical bone.</p></div>","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 4","pages":"Pages 177-181"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0221-8747(84)90026-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17791831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 205

Biliary excretion of vitamin d metabolites following oral and parenteral vitamin D 口服和静脉注射维生素d后维生素d代谢物的胆道排泄

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90047-X

M.R. Clements, T.M. Chalmers, D.R. Fraser

引用次数: 0

Effects of phosphate on calcium release, lysosomal enzyme activity in the medium, and osteoclast morphometry in cultured fetal rat bones 磷酸盐对培养胎鼠骨中钙释放、溶酶体酶活性和破骨细胞形态的影响

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90028-6

J.A. Lorenzo , M.E. Holtrop , L.G. Raisz

{"title":"Effects of phosphate on calcium release, lysosomal enzyme activity in the medium, and osteoclast morphometry in cultured fetal rat bones","authors":"J.A. Lorenzo , M.E. Holtrop , L.G. Raisz","doi":"10.1016/0221-8747(84)90028-6","DOIUrl":"10.1016/0221-8747(84)90028-6","url":null,"abstract":"<div><p>The relationship between changes in medium phosphate concentration and three indices of cell-mediated resorption in fetal rat bone cultures—calcium release, the activity of the lysosomal enzyme β-glucuronidase in the medium, and the morphology of osteoclasts—has been investigated. Bones treated with either 1 mM or 4 mM phosphate, with or without parathyroid hormone, were examined. After 2 h of culture we found the predominant effect of changes in medium phosphate to be on non-cell-mediated resorption. However, after 24 h changes in medium phosphate affected both cell-mediated and non-cell-mediated resorptive mechanisms. The 24 h effects of phosphate were not associated with either a change in the activity of β-glucuronidase in the medium or in the area of the ruffled border of osteoclasts, but 4 mM phosphate did prevent parathyroid hormone from increasing the area of the clear zone of osteoclasts. These results imply that changes in medium phosphate alter cell-mediated resorption by affecting mechanisms that are independent of increases in β-glucuronidase activity or changes in the ruffled border of osteoclasts but that may involve effects on the clear zone of osteoclasts.</p></div>","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 4","pages":"Pages 187-190"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0221-8747(84)90028-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17791832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Fibrogenesis imperfecta ossium 骨纤维发育不全

Metabolic bone disease & related research Pub Date : 1984-01-01 Epub Date: 2004-05-18 DOI: 10.1016/0221-8747(84)90053-5

M. Byron, C.G. Woods, R. Smith

引用次数: 5