Metabolic bone disease & related research最新文献

Background review for the '2015 European guideline on the management of Chlamydia trachomatis infections'. 2015 年欧洲沙眼衣原体感染管理指南 "背景回顾。

IF 1.4

Metabolic bone disease & related research Pub Date : 2015-11-24 DOI: 10.1177/0956462415618838

E Lanjouw, S Ouburg, H J de Vries, A Stary, K Radcliffe, M Unemo

{"title":"Background review for the '2015 European guideline on the management of Chlamydia trachomatis infections'.","authors":"E Lanjouw, S Ouburg, H J de Vries, A Stary, K Radcliffe, M Unemo","doi":"10.1177/0956462415618838","DOIUrl":"10.1177/0956462415618838","url":null,"abstract":"SummaryChlamydia trachomatis infections are major public health concerns globally. Of particular grave concern is that the majority of persons with anogenital Chlamydia trachomatis infections are asymptomatic and accordingly not aware of their infection, and this silent infection can subsequently result in severe reproductive tract complications and sequelae. The current review paper provides all background, evidence base and discussions for the 2015 European guideline on the management of Chlamydia trachomatis infections (Lanjouw E, et al. Int J STD AIDS 2015). Comprehensive information and recommendations are included regarding the diagnosis, treatment and prevention of anogenital, pharyngeal and conjunctival Chlamydia trachomatis infections in European countries. However, Chlamydia trachomatis also causes the eye infection trachoma, which is not a sexually transmitted infection. The 2015 European Chlamydia trachomatis guideline provides up-to-date guidance regarding broader indications for testing and treatment of Chlamydia trachomatis infections; clearer recommendation of using validated nucleic acid amplification tests only for diagnosis; advice on (repeated) Chlamydia trachomatis testing; recommendation of increased testing to reduce the incidence of pelvic inflammatory disease and prevent exposure to infection and recommendations to identify, verify and report Chlamydia trachomatis variants. Improvement of access to testing, test performance, diagnostics, antimicrobial treatment and follow-up of Chlamydia trachomatis patients are crucial to control its spread.","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2015-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75173131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expansion of the medullary cavity at the expense of cortex in postmenopausal osteoporosis 绝经后骨质疏松症中以皮层为代价的髓腔扩张

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90063-8

N.M. Keshawarz, R.R. Recker

{"title":"Expansion of the medullary cavity at the expense of cortex in postmenopausal osteoporosis","authors":"N.M. Keshawarz, R.R. Recker","doi":"10.1016/0221-8747(84)90063-8","DOIUrl":"10.1016/0221-8747(84)90063-8","url":null,"abstract":"<div>Transilial biopsies from postmenopausal osteoporotic patients showed that static features and remodeling activity tended tended to form a pattern, with the area midway between the cortices having less bone and lower remodeling activity than the area closer to the inner boundary of the cortex. The appearance, enlargement, and coalescence of the resorption cavities within the subendosteai area of the cortex lead to negative bone balance and a progressive trabeculation of the cortex, resulting in the formation of a transitional zone. Therefore, in most cases we can distinguish two different zones, transitional and trabecular zones, within the area usually known as the trabecular bone area. The transitional zone undergoes more active remodeling than the trabecular zone and has an important role in evaluation of the traditional trabecular bone volume and remodeling dynamics depending on the field selection for this evaluation, i.e., the proportion between transitional and trabecular zones within the selected fields.We postulate that the appearance of resorption cavities in the subendosteal area of the cortex depends on osteoclast work, and bone loss in the resulting transitional zone depends on a combination of excessive osteoclast work and defective osteoblast work, with the osteoclast excessive work predominating.</div>","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 5","pages":"Pages 223-228"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0221-8747(84)90063-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17549256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 118

Microdissection-elemental analysis of the mineralizing growth cartilage of the normal and rachitic chick 正常和佝偻病鸡矿化生长软骨的显微解剖-元素分析

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90019-5

I.M. Shapiro , A. Boyde

{"title":"Microdissection-elemental analysis of the mineralizing growth cartilage of the normal and rachitic chick","authors":"I.M. Shapiro , A. Boyde","doi":"10.1016/0221-8747(84)90019-5","DOIUrl":"10.1016/0221-8747(84)90019-5","url":null,"abstract":"<div>The concentrations of elements in avian growth cartilage were studied by electron probe x-ray emission microanalysis (EDX). The cartilage was prepared for analysis by freezing, freeze-fracturing, freeze-drying, and carbon coating techniques. Cells and matrix fragments were removed from the tissue by microdissection with a tungsten needle in a scanning electron microscope (SEM) equipped with a real-time stereoscopic viewing facility. The samples were analyzed in the same SEM by EDX. Elemental analyses were performed on each fragment at a distance from the tissue sample, and hence background radiation due to the sample was eliminated. An important finding was that the intracellular potassium concentration of chondrocytes in calcified cartilage was similar to the levels in the premineralized zones. This observation supports the view that chondrocytes do not die in the process of, or as a consequence of, mineralization of the surrounding matrix. Calcium peaks were seen in the matrix at all levels and in chondrocytes immediately prior to mineralization. In contrast, phosphorus levels were always high in cells and low or absent from the premineralized matrix. At the mineralization front the appearance of a phosphorus peak in the matrix just preceded the deposition of mineral. We propose that the transfer of phosphorus from cell to matrix is a rate-limiting step in mineralization. Finally, when rachitic and normal cartilage were compared, little difference was seen in the profile of either intracellular or extracellular elements. However, in rickets the mineralized matrix remained soft in consistency. We suggest that this may reflect a phosphorus-related calcification defect that prevents growth and interlocking of the apatite crystallites.</div>","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 6","pages":"Pages 317-326"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0221-8747(84)90019-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17552537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Changes in activity of chicken medullary bone cell populations in relation to the egg-laying cycle 鸡髓骨细胞群活性变化与产蛋周期的关系

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90029-8

J.P. van de Velde, J.P.W Vermeiden, J.J.A. Touw , J.P. Veldhuijzen

引用次数: 52

Lack of effects of 1,25- and 24,25-dihydroxyvitamin D on parathyroid hormone response to hypocalcemia in cattle 缺乏1,25-和24,25-二羟基维生素D对牛甲状旁腺激素对低钙血症反应的影响

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90025-0

B. Voumard , U. Trechsel , J.A. Fischer , J.W. Blum

{"title":"Lack of effects of 1,25- and 24,25-dihydroxyvitamin D on parathyroid hormone response to hypocalcemia in cattle","authors":"B. Voumard , U. Trechsel , J.A. Fischer , J.W. Blum","doi":"10.1016/0221-8747(84)90025-0","DOIUrl":"10.1016/0221-8747(84)90025-0","url":null,"abstract":"<div>Effects of 1,25(OH)2D3 or 24,25(OH)2D3 on plasma PTH were examined following induced hypocalcemia with EGTA. EGTA infusions caused an elevation of plasma PTH within 10 min. Sixty min after the start of EGTA infusions, 1,25(OH)2D3 or 24,25(OH)2D3 were IV administered. Transient (within 5 min) elevations in plasma PTH were observed in two of five animals following the administration of 1,25(OH)2D3 or of 24,25(OH)2D3. Neither secosterol had an effect on the induced elevations in plasma PTH during the remaining 60 min of the EGTA infusions. Twenty-two hr following 24,25(OH)2D3 administration, plasma PTH, ionized and total calcium, inorganic phosphate, and magnesium were normal, while plasma 24,25(OH)2D was elevated. The plasma PTH response to EGTA-induced hypocalcemia was not significantly altered from that observed prior to the administration of 24,25(OH)2D3. Animals, which were IV injected with 1,25(OH)2D3 received the same amount IM 60 min later. Twenty-two h following IM 1,25(OH)2D3, plasma 1,25(OH)2D, ionized and total calcium, and plasma inorganic phosphate were elevated. Plasma PTH and magnesium were lowered. The PTH response to EGTA-induced hypocalcemia was significantly reduced in these animals. A similar reduction in the PTH response to induced hypocalcemia was observed in animals receiving 7 hr IV infusions of calcium chloride. The findings suggest that the blunted response was, in part, the consequence of the preceding hypercalcemia. These results indicate that 1,25(OH)2D3 does not directly regulate plasma PTH secretion and that 24,25(OH)2D3 has no effect on plasma PTH during induced hypocalcemia in the bovine species.</div>","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 4","pages":"Pages 171-175"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0221-8747(84)90025-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17488316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Reliability of element analysis in enamel 釉质中元素分析的可靠性

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90051-1

M.V. Stack

引用次数: 0

Volume 5 contents 第五卷目录

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90020-1

引用次数: 0

Volume 5 contents and author/keyword index 卷5内容和作者/关键字索引

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90001-8

引用次数: 0

Sequential treatment of paget's disease with human calcitonin and dichloromethylene diphosphonate (CI2MDP) 人降钙素与二氯甲基二磷酸盐(CI2MDP)序贯治疗paget病

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90012-2

S. Adami , G. Guarrera , G. Salvagno , G. Spiazzi , G. Marini , S. Rosini , V. Lo Cascio

引用次数: 19

Correlation of skeletal uptake of 99mTc-diphosphonate and alkaline phosphatase before and after oral diphosphonate therapy in Paget's disease 佩吉特病口服二膦酸盐治疗前后骨骼摄取99mtc -二膦酸盐与碱性磷酸酶的相关性

Metabolic bone disease & related research Pub Date : 1984-01-01 DOI: 10.1016/0221-8747(84)90024-9

M.L. Smith , I. Fogelman , S. Ralston , B.F. Boyce , I.T Boyle

{"title":"Correlation of skeletal uptake of 99mTc-diphosphonate and alkaline phosphatase before and after oral diphosphonate therapy in Paget's disease","authors":"M.L. Smith , I. Fogelman , S. Ralston , B.F. Boyce , I.T Boyle","doi":"10.1016/0221-8747(84)90024-9","DOIUrl":"10.1016/0221-8747(84)90024-9","url":null,"abstract":"<div>In Paget's disease of bone, quantitation of skeletal uptake of radiolabeled diphosphonate has been proposed as a means of monitoring response to therapy. However, the validity of such techniques has been questioned during oral diphosphonate therapy because of possible interaction between oral and radiolabeled diphosphonate.In the present study 18 patients with Paget's disease received a 6 month course of oral diphosphonate therapy. Measurements of 24 h whole body retention (WBR) of 99mTc-labeled hydroxyethylidene diphosphonate (HEDP), serum alkaline phosphatase (SAP), and urinary hydroxyproline excretion were obtained before, during, and after treatment. WBR correlated well with SAP and urinary hydroxyproline throughout the course of therapy. In addition, the relationship between WBR and SAP was maintained aftercessation of oral diphosphonate.It would thus appear that in Paget's disease 24 h WBR of HEDP, a quantitative measure of skeletal uptake of diphosphonate, will reflect disease activity even in the presence of an oral diphosphonate load.</div>","PeriodicalId":79235,"journal":{"name":"Metabolic bone disease & related research","volume":"5 4","pages":"Pages 167-170"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0221-8747(84)90024-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17488315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18