American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction最新文献_第4页

Stimulation and scavestrogen-induced inhibition of reactive oxygen species generated by rat sertoli cells 大鼠支持细胞产生活性氧的刺激和雌激素诱导的抑制

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2002-09-01 DOI: 10.1034/j.1600-0897.2002.t01-2-00001.x

U. Hipler, G. Schreiber, W. Romer

引用次数: 9

Oxidative stress may develop endometrial autoimmune disorders 氧化应激可导致子宫内膜自身免疫性疾病

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2002-09-01 DOI: 10.1034/J.1600-0897.2002.T01-2-00008.X

A. Iborra, J. R. Palacio, M. Mayorga, E. Garcia, Z. Ulčová-Gallová, P. Martínez

引用次数: 0

Concentrations of interferon-gamma-induced protein-10 (IP-10), an antiangiogenic substance, are decreased in peritoneal fluid of women with advanced endometriosis. 晚期子宫内膜异位症患者腹膜液中干扰素- γ诱导蛋白-10(一种抗血管生成物质)的浓度降低。

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2002-09-01 DOI: 10.1016/S0015-0282(02)04100-6

O. Yoshino, Y. Osuga, K. Koga, Yasushi Hirota, O. Tsutsumi, T. Yano, Y. Morita, M. Momoeda, T. Fujiwara, K. Kugu, Y. Taketani

引用次数: 18

Autologous Endometrial Coculture in Patients with In Vitro‐Fertilization (IVF) Failure: Correlations of Outcome with Leukemia Inhibiting Factor (LIF) Production 1 体外受精(IVF)失败患者的自体子宫内膜共培养:结果与白血病抑制因子(LIF)产生的相关性

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2001-12-01 DOI: 10.1034/j.1600-0897.2001.d01-27.x

S. Spandorfer, J. Navarro, D. Levy, A. R. Black, H.‐C. Liu, L. Veeck, S. Witkin, Z. Rosenwaks

{"title":"Autologous Endometrial Coculture in Patients with In Vitro‐Fertilization (IVF) Failure: Correlations of Outcome with Leukemia Inhibiting Factor (LIF) Production 1","authors":"S. Spandorfer, J. Navarro, D. Levy, A. R. Black, H.‐C. Liu, L. Veeck, S. Witkin, Z. Rosenwaks","doi":"10.1034/j.1600-0897.2001.d01-27.x","DOIUrl":"https://doi.org/10.1034/j.1600-0897.2001.d01-27.x","url":null,"abstract":"PROBLEM: To determine if LIF produced by autologous endometrial co‐culture (ECC) was associated with outcome in 46 patients with a history of multiple IVF failures.\u2028 METHOD OF STUDY: The conditioned media (CM) from ECC cells exposed or non‐exposed to human embryos was analyzed for LIF.\u2028 RESULTS: Exposure or non‐exposure to an embryo did not result in differing levels of LIF in the CM. LIF levels were significantly greater in the CM than in the serum controls (LIF was not found in the serum controls). Embryos grown on ECC demonstrated a significant improvement in number of blastomeres and fragmentation when compared to embryos grown in conventional media without ECC (6.7±1.3 vs. 5.6±1.2 blastomeres and 17.6%±9.3 vs. 26.4%±9.8 fragmentation; P<0.05). When LIF levels were detectable in the CM, the embryos grown in ECC were of improved quality as compared to the embryos grown only in conventional media and demonstrated a non‐significant increase in pregnancy rates (60 vs. 48%, P=0.50).\u2028 CONCLUSIONS: We have demonstrated a significant improvement in embryo quality with ECC. The cells in the ECC express LIF. The presence of LIF in the CM was associated with embryonic development and clinical pregnancy.","PeriodicalId":79203,"journal":{"name":"American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1034/j.1600-0897.2001.d01-27.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57495784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Selective vasodilator effect of magnesium sulfate in human placenta. 硫酸镁在人胎盘中的选择性血管扩张作用。

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2001-12-01 DOI: 10.1016/S0002-9378(01)80578-0

G. Holcberg, O. Sapir, M. Hallak, A. Alaa, Haj-Yhia Shorok, Yohay David, M. Katz, M. Huleihel

引用次数: 10

Expression of Interleukin‐1β mRNA in Murine Uterine and Gestational Tissues: Relationship with Gestational Age 1 白细胞介素- 1β mRNA在小鼠子宫和妊娠组织中的表达:与胎龄的关系

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2001-12-01 DOI: 10.1034/j.1600-0897.2001.d01-33.x

Timothy A. Sato, Deepak K. Gupta, J. Keelan, K. Marvin, M. Mitchell

{"title":"Expression of Interleukin‐1β mRNA in Murine Uterine and Gestational Tissues: Relationship with Gestational Age 1","authors":"Timothy A. Sato, Deepak K. Gupta, J. Keelan, K. Marvin, M. Mitchell","doi":"10.1034/j.1600-0897.2001.d01-33.x","DOIUrl":"https://doi.org/10.1034/j.1600-0897.2001.d01-33.x","url":null,"abstract":"PROBLEM: The pro‐inflammatory cytokine interleukin (IL)‐1β has been shown to stimulate the production of prostaglandins (PG) in gestational tissues. Increased PG synthesis is considered a key step in the initiation of labor both at term and preterm. In this study, IL‐1β mRNA in the uterus and gestational tissues of mice during mid to late pregnancy was studied to characterize its tissue specific as well as gestational age expression.\u2028 METHOD OF STUDY: Gestational tissues (placenta, decidual cap and fetal membranes), uterus, and cervix were collected from pregnant mice during gestation. Total RNA was isolated and probed for the expression of IL‐1β mRNA.\u2028 RESULTS: There was a significantly increased expression of IL‐1β mRNA in the uterus on day 18 of pregnancy. In the decidual caps, there was increased expression of IL‐1β mRNA on day 14 of pregnancy and a decrease in expression with the onset of labor. In the fetal membranes and placenta, IL‐1β mRNA expression significantly increased on days 14 and 18 of pregnancy, respectively, and then remained elevated for the duration of pregnancy. In the cervix, there was a decrease in expression with labor onset.\u2028 CONCLUSIONS: The increases in IL‐1β mRNA in the fetal membranes and placenta late in pregnancy are consistent with a localized, tissue specific inflammatory activation involved in the initiation of parturition.","PeriodicalId":79203,"journal":{"name":"American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1034/j.1600-0897.2001.d01-33.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57496614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Expression of Integrin Receptors on Peripheral Lymphocytes: Correlation with Endometrial Receptivity 1 外周淋巴细胞整合素受体的表达与子宫内膜容受性的关系

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2001-09-01 DOI: 10.1034/j.1600-0897.2001.d01-2.x

V. R. Reddy, Sadhana M. Gupta, P. Meherji

{"title":"Expression of Integrin Receptors on Peripheral Lymphocytes: Correlation with Endometrial Receptivity 1","authors":"V. R. Reddy, Sadhana M. Gupta, P. Meherji","doi":"10.1034/j.1600-0897.2001.d01-2.x","DOIUrl":"https://doi.org/10.1034/j.1600-0897.2001.d01-2.x","url":null,"abstract":"PROBLEM: To investigate the expression of integrin (ITG) cell adhesion molecules on peripheral blood lymphocytes (PBL) and their correlation with endometrial cell ITG expression in fertile and infertile women during peak uterine receptive period (day 19/20).\u2028 METHOD OF STUDY: Surface marker expression and quantification of α6, α4 and β3 ITG subunits was done by immunohistochemistry, indirect immunofluroscence and cell‐enzyme‐linked immunosorbent assay methods using endometrial cells and PBL obtained from fertile and infertile (unexplained infertility) women.\u2028 RESULTS: The expression of ITGs was significantly (P<0.001) decreased in the endometrial cells of infertile women compared to normal fertile women. These results correlated well with the data obtained using PBL‐ITG expression.\u2028 CONCLUSIONS: If these preliminary data are consistent in a larger group of patients, the expression of α4 and β3‐ITG subunits on PBL may be used as clinical markers to assess endometrial receptivity in infertile women. Moreover, frequent blood sampling is advantageous over repeated endometrial biopsies as the former approach is easier, non‐traumatic and avoids intra‐uterine infections.","PeriodicalId":79203,"journal":{"name":"American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1034/j.1600-0897.2001.d01-2.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57495354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Charles E. Culpeper Scholarships in Medical Science 查尔斯·e·卡尔佩珀医学奖学金

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2001-08-01 DOI: 10.1210/endo.143.5.9997

Charles E. Culpeper

{"title":"Charles E. Culpeper Scholarships in Medical Science","authors":"Charles E. Culpeper","doi":"10.1210/endo.143.5.9997","DOIUrl":"https://doi.org/10.1210/endo.143.5.9997","url":null,"abstract":"The Rockefeller Brothers Fund is currently accepting applications for its 2003 Charles E. Culpeper Scholarships in Medical Science Program designed to support the career development of academic physicians. Up to four awards of $100,000 per year for 3 years will be made to United States medical schools or equivalent United States educational institutions on behalf of candidates who are U.S. citizens or aliens who have been granted permanent U.S. residence (proof required); who have received their M.D. from a U.S. medical school or the equivalent of an M.D. from an educational institution equivalent to a United States Medical School in 1994 or later (except under extraordinary circumstances, as approved by the Fund before submittal); and who are judged worthy of support by virtue of the quality of their research proposals. All scientific research relevant to human health is eligible for consideration. No institution may nominate more than one candidate. In selecting awardees, emphasis will be on identifying young physicians with clear potential for making substantial contributions to science as academic physicians. Since January 1988, 49 physicians have been selected as Charles E. Culpeper Medical Scholars. Deadline for applications is August 15, 2002. Awards will be announced in January 2003, for activation on or about July 1, 2003. Application forms and instructions may be obtained on the Web at www.rbf.org or by contacting:","PeriodicalId":79203,"journal":{"name":"American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66005551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unique Susceptibility of the Fetal Thymus to Feline Immunodeficiency Virus Infection: An Animal Model for HIV Infection In Utero 1 胎儿胸腺对猫免疫缺陷病毒感染的独特易感性:子宫内HIV感染的动物模型

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2001-05-01 DOI: 10.1111/j.8755-8920.2001.450503.x

Calvin M. Johnson, P. C. Crawford, G. Papadi, S. Bortnick

{"title":"Unique Susceptibility of the Fetal Thymus to Feline Immunodeficiency Virus Infection: An Animal Model for HIV Infection In Utero 1","authors":"Calvin M. Johnson, P. C. Crawford, G. Papadi, S. Bortnick","doi":"10.1111/j.8755-8920.2001.450503.x","DOIUrl":"https://doi.org/10.1111/j.8755-8920.2001.450503.x","url":null,"abstract":"PROBLEM: Human infants infected in utero with HIV develop thymus insufficiency and progress to AIDS sooner than infants infected peripartum. However, direct analysis of the thymus is difficult due to limited tissue access and variable timing of vertical transmission.\u2028 METHOD OF STUDY: Fetal and neonatal cats were inoculated with feline immunodeficiency virus (FIV) at an equivalent infectious dose. The thymus, blood, and lymph nodes were harvested and compared at 23 and 46 days post‐inoculation (p.i.) and also compared to sham‐inoculated, age‐matched controls. Lymphocyte phenotypes were analyzed by flow cytometry and virus burden was quantified in histologic sections and by virus isolation from plasma.\u2028 RESULTS: Fetal cats inoculated with FIV had acute thymus atrophy at birth, which coincided with peak viremia. At 46 days p.i., thymus size and cell composition rebounded and supported increased productive infection. In contrast, neonatal cats inoculated with FIV developed chronic thymus atrophy and degeneration, which was associated with decreasing productive infection and low‐level viremia.\u2028 CONCLUSIONS: The fetal thymus is uniquely vulnerable to acute, transient depletion and high‐level productive infection. The neonatal thymus is less vulnerable to acute changes, and responds through progressive atrophy and declining productive infection. Reduced immune competence, as reflected by the failure to control virus replication, may contribute to the accelerated progression of FIV and HIV infections in utero.","PeriodicalId":79203,"journal":{"name":"American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.8755-8920.2001.450503.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63729118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The effects of pregnancy on myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats: suppression of clinical disease, modulation of cytokine expression in the spinal cord inflammatory infiltrate and suppression of lymphocyte proliferation by pregnancy sera. 妊娠对髓鞘碱性蛋白诱导的Lewis大鼠实验性自身免疫性脑脊髓炎的影响:妊娠血清对临床疾病的抑制、对脊髓炎症浸润细胞因子表达的调节以及对淋巴细胞增殖的抑制。

American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Pub Date : 2001-01-01 DOI: 10.1111/%28ISSN%291600-0897

J. Harness, P. Mccombe

{"title":"The effects of pregnancy on myelin basic protein-induced experimental autoimmune encephalomyelitis in Lewis rats: suppression of clinical disease, modulation of cytokine expression in the spinal cord inflammatory infiltrate and suppression of lymphocyte proliferation by pregnancy sera.","authors":"J. Harness, P. Mccombe","doi":"10.1111/%28ISSN%291600-0897","DOIUrl":"https://doi.org/10.1111/%28ISSN%291600-0897","url":null,"abstract":"PROBLEM The present study was performed to explore the effects of pregnancy on experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats by inoculation with myelin basic protein (MBP) (MBP-EAE). METHOD OF STUDY MBP-EAE was induced in pregnant and non-pregnant rats and severity of disease evaluated. Serum from pregnant and non-pregnant rats was used in standard lymphocyte proliferation assays. Real-time polymerase chain reaction (PCR) was used to investigate the expression of cytokine mRNA in the inflammatory cells obtained from the spinal cord of rats on day 15 after inoculation. RESULTS Pregnant rats developed less severe disease than non-pregnant rats. Serum from pregnant rats suppressed the proliferation of T lymphocytes in response to MBP. There was significantly increased expression of IL-4, IL-10 and TNF-alpha mRNA in the spinal cord infiltrate of pregnant rats. CONCLUSION Circulating humoral factors and alteration in cytokine production by inflammatory cells may contribute to the suppression of EAE in pregnant rats.","PeriodicalId":79203,"journal":{"name":"American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction","volume":"46 6 1","pages":"405-12"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62971646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7