Analytical Chemistry Research最新文献_第6页

Development and validation of a high performance liquid chromatography method for oligodeoxynucleotides determination in a novel coagel-based formulation 高效液相色谱法在新型混凝制剂中测定寡脱氧核苷酸的建立与验证

Analytical Chemistry Research Pub Date : 2015-06-01 DOI: 10.1016/J.ANCR.2015.03.003

G. Ullio-Gamboa, J. Llabot, María F. Sanchez-Vallecillo, B. Maletto, S. Palma, D. Allemandi

引用次数: 0

Detection of flutamide in pharmaceutical dosage using higher electrospray ionization mass spectrometry (ESI-MS) tandem mass coupled with Soxhlet apparatus 电喷雾质谱串联质谱联用索氏仪器检测氟他胺药物剂量

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2015.01.001

Nadeem Khan , Hani Nasser Abdelhamid , Ja-Yi Yan , Fon-Tsai Chung , Hui-Fen Wu

引用次数: 36

An improved extraction method of rapeseed oil sample preparation for the subsequent determination in it of azole class fungicides by gas chromatography 一种改进的菜籽油样品提取制备方法，用于随后气相色谱法测定菜籽油中唑类杀菌剂的含量

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.11.004

Mikhail F. Zayats , Sergey M. Leschev , Marina A. Zayats

{"title":"An improved extraction method of rapeseed oil sample preparation for the subsequent determination in it of azole class fungicides by gas chromatography","authors":"Mikhail F. Zayats , Sergey M. Leschev , Marina A. Zayats","doi":"10.1016/j.ancr.2014.11.004","DOIUrl":"10.1016/j.ancr.2014.11.004","url":null,"abstract":"<div><p>The distribution of 19 azole class pesticides in hexane/aqueous–organic mixtures systems and rapeseed oil (or oil solution in hexane)/organic solvents has been studied at 20±1°C. The distribution constants (<em>P</em>) and coefficients (<em>D</em>) between hydrocarbon and polar phase are calculated. It is found that all the studied pesticides are hydrophobic, i.e., in hexane–water system log≫0. Replacement of water by organic solvents results in sharp log  <!-->kg<sup>−1</sup>, are below the maximum residue levels (MRLs) set by the European Union for the majority of pesticides. The developed method was successfully applied to different rapeseed oil samples.</p></div>","PeriodicalId":7819,"journal":{"name":"Analytical Chemistry Research","volume":"3 ","pages":"Pages 37-45"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ancr.2014.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80422873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Unambiguous evaluation of the relative photolysis rates of nitro indolinyl protecting groups critical for brain network studies 明确评价硝基吲哚啉保护基团的相对光解速率对脑网络研究至关重要

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.11.001

Richard L. Comitz , Yannick P. Ouedraogo , Nasri Nesnas

{"title":"Unambiguous evaluation of the relative photolysis rates of nitro indolinyl protecting groups critical for brain network studies","authors":"Richard L. Comitz , Yannick P. Ouedraogo , Nasri Nesnas","doi":"10.1016/j.ancr.2014.11.001","DOIUrl":"10.1016/j.ancr.2014.11.001","url":null,"abstract":"<div><p>Nitrated indolinyl photoprotecting groups are crucial tools extensively used in the study of neuronal signal transduction. Mononitrated photolabile protecting groups have been used effectively, however, recent advances in the introduction of a second nitro group have shown improvement in the photo efficiency of neurotransmitter (agonist) release, albeit, to varying extents, depending on the assessment methods employed. An unambiguous method is discussed based on Nuclear Magnetic Resonance (NMR), which is shown to be an effective technique in the relative overall rate comparison amongst varying nitrated protecting groups. Mononitrated and dinitrated photolabile protecting groups such as CDNI-Glu and MNI-Glu are used as an example to assess the relative value of adding a second nitro group in photoactive cage designs. Using this technique, it was shown that the second nitro group in CDNI systems enhances the overall relative rate of photocleavage by a factor of 5.8. This reported method can also be used to unambiguously determine relative rate of agonist photorelease.</p></div>","PeriodicalId":7819,"journal":{"name":"Analytical Chemistry Research","volume":"3 ","pages":"Pages 20-25"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ancr.2014.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91393560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Spectrophotometric determination of iridium after complexation and membrane filtration 络合膜滤后分光光度法测定铱

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.10.001

A.S. Amin , I.A. Zaafarany

{"title":"Spectrophotometric determination of iridium after complexation and membrane filtration","authors":"A.S. Amin , I.A. Zaafarany","doi":"10.1016/j.ancr.2014.10.001","DOIUrl":"10.1016/j.ancr.2014.10.001","url":null,"abstract":"<div><p>A simple, ultra sensitive and selective method for the spectrophotometric determination of Ir<sup>3+</sup> in various synthetic and environmental samples was reported. The analyte ions were collected on a membrane filter in the form of their red complex with 5-(2-benzothiazolyl-azo)8-hydroxy-quinoline (BTAHQ), and the absorption spectra of the colored membrane filters were acquired. Effects of pH value, sample volume, and amount of BTAHQ were examined in order to optimize sensitivity. The interference by common other ions was eliminated using appropriate masking agents. The absorbance is linearly related to the concentration of Ir<sup>3+</sup> in the ranges from 0.1 to 0.8μg/L, and from 1.0 to 7.0μg/L, respectively, the correlation coefficients (R<sup>2</sup>) being 0.9996 and 0.9994. The molar absorptivities were calculated to be 4.81×10<sup>5</sup> and 4.26×10<sup>7</sup>  cm<sup>−1</sup> at 563nm, whereas Sandell sensitivity was found as 0.391 and 0.004ngcm<sup>−2</sup>, respectively. The novelty and advantages of the proposed method is the highly sensitivity of the proposed method compared with all previously cited methods for iridium determination. Under the optimal conditions, the detection limit is 0.03μg/L. The recoveries in case of spiked samples are between 98.7% and 101.5%, and the relative standard deviations range from 1.21% to 1.75%.</p></div>","PeriodicalId":7819,"journal":{"name":"Analytical Chemistry Research","volume":"3 ","pages":"Pages 77-81"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ancr.2014.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82435906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Screening of polychlorinated biphenyls in insulating oil using a microfluidic based pretreatment and immunoassay 用微流体预处理和免疫分析法筛选绝缘油中的多氯联苯

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.11.002

Arata Aota , Yasumoto Date , Shingo Terakado , Naoya Ohmura

{"title":"Screening of polychlorinated biphenyls in insulating oil using a microfluidic based pretreatment and immunoassay","authors":"Arata Aota , Yasumoto Date , Shingo Terakado , Naoya Ohmura","doi":"10.1016/j.ancr.2014.11.002","DOIUrl":"10.1016/j.ancr.2014.11.002","url":null,"abstract":"<div><p>Polychlorinated biphenyls (PCBs) are persistent organic pollutants in insulating oil of a large number of transformers. A rapid and economical analytical method to detect PCB contamination is still required. To address this issue, we propose here the first microfluidic screening method for PCB contamination in insulating oil. The insulating oil was pretreated using a multilayer capillary column and a microfluidic liquid–liquid partitioning. PCBs in the pretreated oil were measured using a microfluidic kinetic exclusion assay. In order to detect PCBs with high sensitivity, conditions of the microfluidic kinetic exclusion assay were optimized. Measurements were rapidly completed (within 43min). The measurement range was estimated to be 0.26–3.3mg/kg defined as the relative absorbance from 20% to 80%. The screening performance (false positive and false negative rates) was tested on fifty real oil samples; results about these tests were discussed in detail, especially suitable cutoff by comparing with the data analyzed using high-resolution-gas-chromatography/high-resolution-mass-spectrometry. Finally, the screening performance was confirmed using our proposed stochastic screening model. A cutoff of 0.3 to judge as positive is suitable considering the risk of the PCB release into the environment.</p></div>","PeriodicalId":7819,"journal":{"name":"Analytical Chemistry Research","volume":"3 ","pages":"Pages 13-19"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ancr.2014.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77035863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Micellar high performance liquid chromatographic determination of flunixin meglumine in bulk, pharmaceutical dosage forms, bovine liver and kidney 胶束高效液相色谱法测定原料药、药品剂型、牛肝脏和牛肾脏中氟尼辛大聚胺的含量

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.12.003

Fathalla F. Belal , Sawsan A. Abd El-Razeq , Manal M. Fouad , Fatma A. Fouad

{"title":"Micellar high performance liquid chromatographic determination of flunixin meglumine in bulk, pharmaceutical dosage forms, bovine liver and kidney","authors":"Fathalla F. Belal , Sawsan A. Abd El-Razeq , Manal M. Fouad , Fatma A. Fouad","doi":"10.1016/j.ancr.2014.12.003","DOIUrl":"10.1016/j.ancr.2014.12.003","url":null,"abstract":"<div><p>A simple, sensitive and rapid liquid chromatographic method was developed and validated for the analysis of flunixin meglumine (flunixin-M) in bulk, pharmaceutical dosage forms, bovine liver and kidney. Analytical separation was performed in less than 4min using a C<sub>18</sub> column with UV detection at 284nm. A micellar solution composed of 0.15M sodium dodecyl sulphate, 8% <em>n</em>-butanol and 0.3% triethylamine in 0.02M phosphoric acid buffered at pH 7.0 was used as the mobile phase. The method was fully validated in accordance with the International Conference on Harmonization (ICH) guidelines. The limit of detection and the limit of quantitation were 0.02 and 0.06μgmL<sup>−1</sup>, respectively. The recoveries obtained were in range of 95.58–106.94% for bovine liver and kidney. High extraction efficiency was obtained without matrix interference in the extraction process and in the subsequent chromatographic determination. The method showed good repeatability, linearity and sensitivity according to the evaluation of the validation parameters.</p></div>","PeriodicalId":7819,"journal":{"name":"Analytical Chemistry Research","volume":"3 ","pages":"Pages 63-69"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ancr.2014.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85921663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Analysis of cave atmospheres by comprehensive two-dimensional gas chromatography (GC×GC) with flame ionization detection (FID) 综合二维气相色谱-火焰电离检测(FID)分析洞穴大气(GC×GC)

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.09.002

Ryan C. Blase, Edward L. Patrick, Joseph N. Mitchell, Mark Libardoni

{"title":"Analysis of cave atmospheres by comprehensive two-dimensional gas chromatography (GC×GC) with flame ionization detection (FID)","authors":"Ryan C. Blase, Edward L. Patrick, Joseph N. Mitchell, Mark Libardoni","doi":"10.1016/j.ancr.2014.09.002","DOIUrl":"10.1016/j.ancr.2014.09.002","url":null,"abstract":"<div><p>In this paper, we describe a simple method for sampling, pre-concentrating, and separating volatile and semi-volatile components from two different cave atmospheres. Sampling is performed by capturing a volume of cave atmosphere in a Tedlar bag or Suma canister for sample storage and transport back to the laboratory. Loading a portion of the sample on a multi-bed sorption trap allows for sample pre-concentration prior to separation and detection of components on a comprehensive two-dimensional gas chromatograph (GC×GC). Comparison of two Texas caves reveals the power of comprehensive two-dimensional gas chromatography (GC×GC) for volatile separation and detection, and to our knowledge marks the first use of GC×GC for the analysis of cave atmospheres. Analysis of the results revealed 138 and 146 chromatographic signals over an S/N threshold of 500 and direct comparison of the two samples revealed 50 identical chromatographic signals. This study is a first step toward demonstrating the ability of GC×GC to separate the complex volatiles and semi-volatiles in the cave atmosphere as a fingerprinting tool.</p></div>","PeriodicalId":7819,"journal":{"name":"Analytical Chemistry Research","volume":"3 ","pages":"Pages 54-62"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ancr.2014.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72924523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Analysis for commonly prescribed non-sedating antihistamines 常用非镇静性抗组胺药的分析

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.11.003

Michael E. El-Kommos, Samia M. El-Gizawy, Noha N. Atia, Noha M. Hosny

引用次数: 9

Investigation of cobalt porphyrin doped polymer membrane films for the optical sensing of imidazole and its derivatives 掺杂钴卟啉聚合物膜膜对咪唑及其衍生物光学传感的研究

Analytical Chemistry Research Pub Date : 2015-03-01 DOI: 10.1016/j.ancr.2014.12.002

Yueyang Tan, Nicole Escorcia, Alison Hyslop, Enju Wang

{"title":"Investigation of cobalt porphyrin doped polymer membrane films for the optical sensing of imidazole and its derivatives","authors":"Yueyang Tan, Nicole Escorcia, Alison Hyslop, Enju Wang","doi":"10.1016/j.ancr.2014.12.002","DOIUrl":"10.1016/j.ancr.2014.12.002","url":null,"abstract":"<div><p>A cobalt(II) porphyrin was successfully incorporated into polymer membranes for the optical sensing of imidazole and its derivatives. This research has led to a better understanding of the behavior of Co(II) porphyrin in solution and in polymeric membranes. In aprotic dichloromethane (DCM), the Co(II) tetraphenylporphyrin (CoTPP) and Co(II) octaethylporphyrin (CoOEP) show a sensitive response to imidazole due to the strong ligation of the N-3 on the imidazole ring to the Co(II) center, which induces an absorbance change to the Soret band. However, when doped in polymeric films, only the CoTPP exhibits moderate sensitivity towards aqueous imidazole, histamine and histidine. This weakened coordination ability of CoTPP towards imidazole in the polymer films may be due to the coordination of the plasticizer, the impurities from the THF and polymer matrix at the Co(II) center. The selectivity of the polymer films towards imidazole over common anions is high. Lifetime of the cobalt(II) porphyrin incorporated polymer film was relatively short.</p></div>","PeriodicalId":7819,"journal":{"name":"Analytical Chemistry Research","volume":"3 ","pages":"Pages 70-76"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ancr.2014.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73755198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12